Cost effectiveness of pneumococcal urinary antigen in Emergency Department: a pragmatic real-life studyarticle Published on 2018-01-312024-09-01 Journal: Internal and Emergency Medicine [Category] 폐렴구균 감염증, [키워드] Bacterial Clinical management community-acquired pneumonia Cost effectiveness Infectious diseases [Article Type] article
A two-step transport pathway allows the mother cell to nurture the developing spore in Bacillus subtilis2단계 수송 경로를 통해 모세포가 Bacillus subtilis에서 발달 중인 포자를 양육할 수 있습니다.Research Article Published on 2017-09-252022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accumulate accumulation Bacillus anthracis Bacillus subtilis Bacteria Bacterial Cell Clostridium difficile complex Concentration conserved Culture culture medium dehydration desiccation dipicolinic acid displace dormancy dormant dry weight engulfment enzyme Enzymes Evidence Express Factor forespore hallmark hallmarks homolog homologs idea late stage mechanism medium membrane membranes molecular basis Morphological mother mother cell Mutagenesis non-pathogenic bacteria nucleoside pathogenic pathway predicted produced Protective Protein pyridine-2,6-dicarboxylic acid remained required residue residues small molecule spore spore core spores sporulation Support translocated Transport vegetative growth water [DOI] 10.1371/journal.pgen.1007015 PMC 바로가기 [Article Type] Research Article
The mecillinam resistome reveals a role for peptidoglycan endopeptidases in stimulating cell wall synthesis in Escherichia coli메실리남 저항체는 대장균에서 세포벽 합성을 자극하는 펩티도글리칸 엔도펩티다제의 역할을 밝힙니다Research Article Published on 2017-07-272022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activating Activation addition allele Analysis Antibiotics approach Bacterial bacterial cell bacterial cells Beta Beta-lactam beta-lactam antibiotics beta-lactam mecillinam biogenesis build Cell cell wall cell wall synthesis cells characterization cleave cleaving complexes comprehensive resource contrary crosslink crosslinking crosslinks dataset downstream analysis drug drug resistance E . coli effective enzyme Enzymes Escherichia coli expand generate Genetic genetic background genetic loci Genome identify implicated induction inhibit involved killing loci locus mechanism mecillinam modulating mutant mutants organism overproduction PBP2 PBPs penicillin penicillin-binding protein penicillin-binding proteins performed PG synthase PG synthesis probe promote Reasoning required resource response reveal Stress stress response subset Synthase target the cell Tn-seq Tn-Seq analysis transpeptidase utility wild-type cells [DOI] 10.1371/journal.pgen.1006934 PMC 바로가기 [Article Type] Research Article
A conserved mitochondrial surveillance pathway is required for defense against Pseudomonas aeruginosa녹농균에 대한 방어를 위해서는 보존된 미토콘드리아 감시 경로가 필요합니다Research Article Published on 2017-06-292022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activate activated Activation addition Bacterial battery Caenorhabditis Caenorhabditis elegans Cell cellular structure conserved Critical cytological damage Defense defense mechanisms described Diseases dysfunction Effect elegan elegans element Ethanol expand exposure to family functions genetics Health heat homeostasis Host host defense human pathogen hypothermia hypoxia Imbalance immune responses include increasingly indicate Infection innate immune response Innate immunity Interaction intestinal kill leads liquid mammals mechanism mechanisms mitigate mitochondrial organelle organism Organisms overlap overlapping oxidative damage P . aeruginosa pathogen Pathogens pathway Physiology Prevent Protein Pseudomonas aeruginosa pyoverdine recognizing Regulation required respond response secreted selective shown Stress stress response Surveillance threat Toxicity transcriptomics unique upregulation variety virulence [DOI] 10.1371/journal.pgen.1006876 PMC 바로가기 [Article Type] Research Article
Biofilm microenvironment induces a widespread adaptive amino-acid fermentation pathway conferring strong fitness advantage in Escherichia coli생물막 미세 환경은 대장균에 강력한 적합성을 부여하는 광범위한 적응 아미노산 발효 경로를 유도합니다Research Article Published on 2017-05-192022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] 1-propanol adaptive aerobic Amino acid amino-acid Bacterial bacterial communities balance biofilm cellular change characterized Clostridia competition complex condition conditions contribute Degradation E . coli Enterobacteriaceae Escherichia coli exploration Genetic modifications growth hypoxic hypoxic condition hypoxic conditions identify induce liquid cultures maintain metabolic pathway metabolic pathways metabolism microenvironment pathway physiological responses produced propanol provide reducing threonine Trigger widespread [DOI] 10.1371/journal.pgen.1006800 PMC 바로가기 [Article Type] Research Article
Evidence for the evolutionary steps leading to mecA -mediated β-lactam resistance in staphylococci포도상구균에서 mecA 매개 β-락탐 내성으로 이어지는 진화 단계에 대한 증거Research Article Published on 2017-04-102022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accumulation acquisition adaptation Amino acid Analysis antibiotic Antibiotic resistance Antibiotics Author Bacteria Bacterial Bayesian analysis binding binding domain cell wall cell wall synthesis changes in chromosome Community core genome development domain driving epidemiologically Evolution exposure to food additives gene encoding Genetic genetic background genomes highlight homologue identify involved isolates livestock mechanism mechanisms methicillin methicillin-resistant Staphylococcus aureus Mortality MRSA mutation rate Mutation rates non-binding nucleotide occur occurred oxacillin Pandemics PBP penicillin phenotype Phylogenetic analysis precursor predicted profiles promoter promoters Protein representing resistance gene resource responsible S . aureus SCC selective sequence sequence alignments sequenced genome single-nucleotide polymorphism SNP species Spread Staphylococcus Staphylococcus aureus strain Substitution substitutions susceptibility variety was performed [DOI] 10.1371/journal.pgen.1006674 PMC 바로가기 [Article Type] Research Article
A genetic switch controls the production of flagella and toxins in Clostridium difficile유전자 스위치는 Clostridium difficile의 편모 및 독소 생성을 제어합니다Research Article Published on 2017-03-272022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activate addition antibiotic Bacteria Bacterial Bacterial infection bacterial pathogen cause characterization Clostridium difficile colonization Control Coordinate Course degrade described determinant determine detrimental effect diarrheal diarrheal disease disease early stage Effect engage enzyme epithelial cells Evidence expressed expression Factor flagella flagellar flagellar gene flagellum Gene Expression Gene regulation Genes Genetic growth Host host tissue Impact in vitro inactivation independent independent of Infection intestinal intestinal epithelial cells intestine inversion isolates mechanism motility mRNA Mutagenesis occur Orientation pathogen phase produced promote regulate Regulation regulator Regulatory responsible secrete secreted secretion sequence severity SigD Structure toxin toxins tyrosine upstream virulence virulence factors [DOI] 10.1371/journal.pgen.1006701 PMC 바로가기 [Article Type] Research Article
Development of the full-length cDNA clones of two porcine epidemic diarrhea disease virus isolates with different virulenceResearch Article Published on 2017-03-162022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] 48 hours BAC Bacterial caused Cell culture Chinese chromosome clone Cluster CMV promoter development diarrhea disease Epidemic epidemic diarrhea fatality full-length cDNA genetics Genome intestinal epithelium isolate isolates pandemic parental PEDV platform replicate rescued virus Strains survived tested the vaccine tissue damage variant virulence virulent virus virus isolate [DOI] 10.1371/journal.pone.0173998 PMC 바로가기 [Article Type] Research Article
Analysis of the human monocyte-derived macrophage transcriptome and response to lipopolysaccharide provides new insights into genetic aetiology of inflammatory bowel disease인간 단핵구 유래 대식세포 전사체 및 지질다당류에 대한 반응 분석은 염증성 장 질환의 유전적 병인에 대한 새로운 통찰력을 제공합니다Research Article Published on 2017-03-062022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] 48 hours Activation adaptation aetiology Analysis appearance arise Arthritis Bacteria Bacterial bacterial cells bacterial lipopolysaccharide bacterial stimuli Blood CAGE CAGE-based transcriptional profiling candidate candidate gene Candidates cascade Cell cells chronic inflammatory bowel diseases Cluster colony-stimulating factor complex component components Course Crohn’s disease CSF1 CSF1-dependent monocyte-macrophage transition CSF1-dependent monocyte-macrophage transitions Defense differentiation dysregulation enhancer enhancers eRNA transcription Families form function gastrointestinal mucosa Gene Expression Genetic genetic risk Genome genome-wide association Genome-wide association studies Gut gut wall GWA human cell human cells human monocyte human monocyte-derived macrophage human monocyte-derived macrophages hypothesised IBD IBD loci identify Immune cell immune cells Inflammatory bowel disease inflammatory bowel diseases inflammatory disease inheritance initiate inflammation intestinal lamina propria intestine involved lipopolysaccharide loci locus long non-coding RNA LPS Macrophage macrophage colony-stimulating factor macrophage differentiation macrophages majority MARA modulate monocyte monocyte differentiation monocyte-derived macrophage monocyte-specific genes Monocytes motif motif activity response analysis Pathogens positive produced promoter promoters provide Region regulated Regulation Regulatory responsible rheumatoid arthritis shown successive wave successive waves Support susceptibility susceptibility loci These data this system tissue damage tissues traits transcription factor transcription factors transcriptional activation transcriptional regulation Transcriptome transcriptome dataset transcripts transient gene expression ulcerative colitis utilised wall [DOI] 10.1371/journal.pgen.1006641 PMC 바로가기 [Article Type] Research Article
Report from the World Health Organization’s third Product Development for Vaccines Advisory Committee (PDVAC) meeting, Geneva, 8–10th June 2016Article Published on 2017-03-032023-06-16 Journal: Vaccine [Category] MERS, [키워드] Bacterial LMICs PDVAC Product development SAGE Vaccine Viral [DOI] 10.1016/j.vaccine.2016.10.090 PMC 바로가기