sera – Page 68 – Communicable Diseases Research

Preexisting and de novo humoral immunity to SARS-CoV-2 in humans

인간의 SARS-CoV-2에 대한 기존 및 새로운 체액 면역

Report

Published on 2020-12-112022-09-10
Journal: Science (New York, N.y.) [Category] Fulltext, MERS, SARS, 조류인플루엔자, 진단, 치료제,

Characterization of a Pan-Immunoglobulin Assay Quantifying Antibodies Directed against the Receptor Binding Domain of the SARS-CoV-2 S1-Subunit of the Spike Protein: A Population-Based Study

Article

Published on 2020-12-092022-10-30
Journal: Journal of Clinical Medicine [Category] COVID-19,

[키워드] 95% CI 95% confidence interval acute respiratory syndrome antibody antibody level antibody reactivity area under the curve association Characteristics characterization Clinical characteristics clinically coronavirus coronavirus disease COVID-19 cross-reactivity detect diagnostic Diagnostic accuracy disease severity electrochemiluminescence immunoassay Epitopes evaluate Evidence Fever Follow-up help hospitalized patient identify IgA IgG IgM immunoassay individual interquartile range IQR Laboratory median offer Outpatient Patient predictive values proportion Quantitative RBD Receptor binding domain SARS-CoV-2 SARS-COV-2 infection sensitivity sera serology significantly increased smoker smoking specificity sustained symptom onset symptomatic tested the S1 subunit the SARS-CoV-2 the Spike the spike protein without symptom
[DOI] 10.3390/jcm9123989 PMC 바로가기 [Article Type] Article

Serological cross-reactivity using a SARS-CoV-2 ELISA test in acute Zika virus infection, Colombia

콜롬비아 급성 지카바이러스 감염에서 SARS-CoV-2 ELISA 검사를 이용한 혈청학적 교차반응

Article

Published on 2020-12-012022-09-12
Journal: International Journal of Infectious Diseases [Category] MERS, SARS, 진단,

Clinical performance of three fully automated anti‐SARS‐CoV‐2 immunoassays targeting the nucleocapsid or spike proteins

Research Article

Published on 2020-12-012022-10-04
Journal: Journal of medical virology [Category] MERS, SARS, 진단, 치료법,

Neutralizing antibodies for the treatment of COVID-19

COVID-19 치료를 위한 중화 항체

Article

Published on 2020-12-012022-09-12
Journal: Nature biomedical engineering [Category] MERS, SARS, 신약개발, 임상, 진단, 치료법,

[키워드] antibody clinical trial COVID-19 determine neutralizing monoclonal antibody Patient populations Prevent reduce SARS-CoV-2 antigen sera severity the disease Treatment
[DOI] 10.1038/s41551-020-00660-2 PMC 바로가기 [Article Type] Article

Clinical and laboratory evaluation of SARS-CoV-2 lateral flow assays for use in a national COVID-19 seroprevalence survey

국가 COVID-19 혈청 유병률 조사에 사용하기 위한 SARS-CoV-2 측면 흐름 분석의 임상 및 실험실 평가

Article

Published on 2020-12-012022-09-11
Journal: Thorax [Category] MERS, SARS, 진단, 치료기술,

[키워드] 95% CI 95%CI Analysis antibody Antibody test antibody tests approach best Blood clinic clinical clinical epidemiology Cohort Community Concordance conducted COVID-19 detectable ELISA ELISAs evaluated Finger prick FIVE highlighting Hospitalised patients house immunoassay individuals Infection Laboratory Lateral lateral flow Lateral flow immunoassays LFIA LFIAs moderate MONITOR National non-hospitalised pandemic Participants PCR-confirmed Phase I positive reported required respiratory respiratory infection reverse transcription PCR SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 pandemic sensitivity Sensitivity analyses sensitivity analysis sera seroprevalence survey serum significantly specificity symptom onset tested the SARS-CoV-2 Viral viral infection was performed were assessed
[DOI] 10.1136/thoraxjnl-2020-215732 PMC 바로가기 [Article Type] Article

Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severity

COVID-19 환자의 바이러스 에피토프 프로파일링은 교차 반응성과 심각도의 상관 관계를 보여줍니다

Research Article

Published on 2020-11-272022-09-12
Journal: Science (New York, N.y.) [Category] Fulltext, SARS, 진단,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect age Alanine Analysis antibody Antibody detection antibody epitope antibody epitopes antibody repertoire Antibody Response Antibody responses Antibody-dependent enhancement antiviral antibodies antiviral antibody Asymptomatic caused circulating clinical outcomes colds common-cold Control controls coronavirus coronavirus disease Coronavirus disease 2019 coronavirus strains Coronaviruses correlation Course covariates COVID-19 COVID-19 patient COVID-19 severity Critical cross-react cross-reactive antibody cross-reactivity cytomegalovirus death deep Demographic variables detect diagnostic diagnostics disease disease severity distress enzyme-linked immunosorbent assays epitope epitope mapping Epitopes exacerbate examination exhibited explain females Fever functional Gender generate gold herpes simplex herpes simplex virus Herpes Simplex Virus 1 Hospitalization Hospitalized hospitalized patients human coronaviruses human sera humans humoral Humoral response humoral responses hypothese hypotheses immune immunogenicity incidence individual individuals infect infected with SARS-CoV-2 Infection infections interactions Isolation knowledge machine machine-learning male mapped Mild Mutagenesis Neutralizing Neutralizing antibodies neutralizing antibody not need notable nucleoprotein ORF1 outcome outcomes Patient patient cohort peptide peptides performed predicted probe Profiling Protein proteome proteomes raise rationale required respiratory respiratory distress Respiratory system response responses reveal SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 antibody response SARS-CoV-2 peptide SARS-CoV-2 peptides SARS-CoV-2 proteome Science screened sensitivity Sequence conservation sera serological Serological assay severe acute respiratory syndrome Coronavirus severe COVID-19 severe infections severity severity of COVID-19 specificity Spike protein stratified strength suggested target targets tested the antibody response the SARS-CoV-2 the spike protein Therapeutics Therapies two groups understanding Vaccine Vaccines Viral virus
[DOI] 10.1126/science.abd4250 PMC 바로가기 [Article Type] Research Article

Natural versus Recombinant Viral Antigens in SARS-CoV-2 Serology: Challenges in Optimizing Laboratory Diagnosis of COVID-19

SARS-CoV-2 혈청학에서 천연 바이러스 항원 대 재조합 바이러스 항원: COVID-19에 대한 실험실 진단 최적화의 과제

Original Article

Published on 2020-11-262022-09-10
Journal: Clinics [Category] MERS, SARS, 진단, 치료기술, 치료법,

[키워드] anti-SARS-CoV-2 IgG antibodies anti-SARS-CoV-2 IgG antibody Antigen assays asymptomatic patient Brazil challenge choice commercialization control groups COVID-19 COVID-19 diagnosis COVID-19 negative criteria dependent on develop Diagnosis diagnosis of COVID-19 diagnostic ELISA estimation exhibited false-negative false-negatives False-positive false-positives fraction house IgG IgG antibodies in-house ELISA in-house ELISAs infected patient infected patients Infection information International Laboratory laboratory diagnosis natural nucleocapsid protein pandemic Patient performed public health emergency qPCR recombinant Recombinant nucleocapsid protein recombinant proteins SARS-CoV-2 SARS-CoV-2 Whole Viral Antigen sera serological test serology susceptibility the SARS-CoV-2 Viral Viral antigen viral antigens
[DOI] 10.6061/clinics/2020/e2290 PMC 바로가기 [Article Type] Original Article

Estimated SARS-CoV-2 Seroprevalence in the US as of September 2020

Research

Published on 2020-11-242022-10-30
Journal: JAMA Internal Medicine [Category] COVID-19, Fulltext, MERS,

[키워드] acute respiratory syndrome adjust age antibody Biweekly calculated change Clinical management conducted coronavirus cross-sectional detectable District estimate Estimated estimates Evidence exposure finding groups helping immunoassays Importance individual infected with SARS-CoV-2 Infection infections Laboratory less measure objective Older over participant Point presence of antibody Prevalence proportion provided ranged regions Relevance repeated Result Sample SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-COV-2 infection sera Seroprevalence seroprevalence survey serum serum sample setting Sex specimen specimens Spread submitted Surveillance tested was used while women
[DOI] 10.1001/jamainternmed.2020.7976 PMC 바로가기 [Article Type] Research

An Original ELISA-Based Multiplex Method for the Simultaneous Detection of 5 SARS-CoV-2 IgG Antibodies Directed against Different Antigens

Article

Published on 2020-11-212022-10-30
Journal: Journal of Clinical Medicine [Category] COVID-19,