Analysis of the Long-Term Impact on Cellular Immunity in COVID-19-Recovered Individuals Reveals a Profound NKT Cell ImpairmentCOVID-19에서 회복된 개인의 세포 면역에 대한 장기적인 영향 분석은 심각한 NKT 세포 손상을 보여줍니다Research Article Published on 2021-04-272022-09-10 Journal: mBio [Category] MERS, SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected analyzed caused CD4 CD4 and CD8 T cells CD8 T cell CD8 T cells Cell cell death cells cellular cellular immunity characterized Concomitant convalescence coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19-convalescent individual COVID-19-convalescent individuals cytokine Cytokines decrease defined disease expression frequencies Frequency granzyme B GzmB immune signature immune system immunological change immunological changes Impact increase in increases in individual Interaction Ki67 Ki67 expression mononuclear cell mononuclear cells NKT NKT cell pandemic Patient Peripheral blood Peripheral blood mononuclear cells proliferate reduction in Regulatory Regulatory T cell respiratory SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus Significant significant decrease significantly sustained T cell T cell receptor T cells TCR the disease the patient while Wuhan [DOI] 10.1128/mBio.00085-21 PMC 바로가기 [Article Type] Research Article
Investigating Cellular Trajectories in the Severity of COVID-19 and Their Transcriptional Programs Using Machine Learning Approaches기계 학습 접근 방식을 사용하여 COVID-19의 심각도와 그 전사 프로그램의 세포 궤적 조사Article Published on 2021-04-242022-09-10 Journal: Genes [Category] MERS, 유전자 메커니즘, [키워드] Algorithm applied BALF Bronchoalveolar lavage fluid cellular change Complement pathway COVID-19 COVID-19 infection COVID-19 pathogenesis COVID-19 patient COVID-19 patients COVID-19 severity deep learning disease severity driver Drivers function functions GATA3 Gene Expression identify Infection machine learning machine learning algorithm Machine learning algorithms Macrophage macrophages marker mechanism MITF pathway Program RNA sequencing SARS-CoV-2 virus SARS-CoV-2 virus infection severity single cell RNA-seq single-cell Single-cell RNA sequencing T cells the disease the SARS-CoV-2 virus tissue Trajectories trajectory trajectory inference transcription factor transcription factors transcriptional transcriptomic virus infection [DOI] 10.3390/genes12050635 PMC 바로가기 [Article Type] Article
Cell-Type Apoptosis in Lung during SARS-CoV-2 InfectionArticle Published on 2021-04-232022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] activated acute respiratory distress Alter alveolar cell Apoptosis ARDS bronchial epithelial cell Cell cells co-culture co-cultured COVID-19 patient Endothelial cell epithelial cell examined extrinsic apoptotic pathway help Human immunofluorescence assay induce Infection intrinsic lung lung tissue macrophages non-human primate non-human primate model nucleotide Pathogenesis pathology reduced SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pandemic SRAS-CoV-2 syndrome T cells Treatment TUNEL assay umbilical vascular endothelial cell Vero Cell virus western blotting [DOI] 10.3390/pathogens10050509 PMC 바로가기 [Article Type] Article
Single-cell multi-omics analysis of the immune response in COVID-19COVID-19의 면역 반응에 대한 단일 세포 다중 오믹스 분석Article Published on 2021-04-202022-09-10 Journal: Nature Medicine [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, 치료기술, [키워드] accompanied acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alteration alveolar alveolar macrophage Analysis Antigen antigen receptor B lymphocyte blood immune cell blood sample Blood samples C1QA cause CD16 CD34 CD8 Cell cellular component characterized circulating Cohort complement contribute coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pathogenesis cross-sectional disease disease severity effector memory effector T cell effector T cells expansion expressing follicular Haematopoiesis helper T cell hematopoietic progenitor cell highlight IgA2 Immune cell immune cells immune response individuals with COVID-19 Infection lymphocyte Macrophage megakaryopoiesis memory T cells Mild Mild disease monocyte Monocytes mononuclear cell mononuclear cells Patient performed Peripheral blood Peripheral blood mononuclear cells Plasma cells plasmablast plasmablasts Platelet platelet activation Platelets predicted proteome proteomic provide receptor reveal RNA sequencing SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe disease severity single-cell symptomatic disease T cell T cells therapy transcript Transcriptome Viral viral infection viral infections [DOI] 10.1038/s41591-021-01329-2 PMC 바로가기 [Article Type] Article
Upregulation of CCR4 in activated CD8 + T cells indicates enhanced lung homing in patients with severe acute SARS‐CoV‐2 infection활성화된 CD8 + T 세포에서 CCR4의 상향 조절은 중증 급성 SARS-CoV-2 감염 환자에서 향상된 폐 귀환을 나타냅니다Clinical Trial Published on 2021-04-192022-08-13 Journal: European Journal of Immunology [Category] MERS, SARS, 임상, 진단, [키워드] activated Activation affected antibody antibody secreting cell antibody secreting cells bilateral pneumonia CCR4 CD4 CD4 and CD8 T cells CD8 CD8 T cell CD8 T cells Chemokine receptor chemokine receptor CCR4 contribute COVID‐19 COVID‐19 patient COVID‐19 patients COVID‐19 differentiation disease effective effector cell expressed healthy donor healthy donors helper cells homing homing receptors hyperinflammation Hypothesis immune activation immune system immunological change immunological changes immunological phenotype independent independent of indicate lung Lung homing lung trafficking Lungs majority Mild NK‐/B‐cell Pathogenesis Patient Phenotypes Pneumonia proliferation promote pulmonary complication pulmonary complications pulmonary symptom pulmonary symptoms pulmonary toxicity raise receptor Respiratory failure responses SARS‐CoV‐2 infection SARS‐CoV2 infection SARS‐CoV‐2 severity significantly T cell T cells T‐cell T‐cell activation T‐cell exhaustion T‐follicular helper cell T‐follicular helper cells T‐cell activation therapeutic agents upregulation [DOI] 10.1002/eji.202049135 PMC 바로가기 [Article Type] Clinical Trial
Targeting SLC1A5 and SLC3A2/SLC7A5 as a Potential Strategy to Strengthen Anti-Tumor Immunity in the Tumor MicroenvironmentImmunology Published on 2021-04-192022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, [키워드] accumulating Acidic activate addition Amino acid amino acid transporter anti-tumor immunity c-MYC Cancer caused Cell cell metabolism chimeric antigen receptor demonstrated ENhance Evidence Express expression function functions Glucose Glutamine growth hypoxic Immune cell immune cells immunometabolism Immunotherapy induce infiltration Invasion leucine limitation metabolism metabolites mTORC1 Natural killer cells nutrient transporters overcome plasma membrane Potential proliferation promote regulatory pathway required robust SLC1A5 SLC3A2 SLC7A5 Strategy subcellular subunit T cells targeting therapy transcription factor Tumor tumor microenvironment tumors [DOI] 10.3389/fimmu.2021.624324 PMC 바로가기 [Article Type] Immunology
CD8 + T cells specific for an immunodominant SARS-CoV-2 nucleocapsid epitope display high naive precursor frequency and TCR promiscuityArticle Published on 2021-04-152023-06-14 Journal: Immunity [Category] MERS, SARS, [키워드] COVID-19 immunodominant SARS-CoV-2-specific CD8+ T cells TCR [DOI] 10.1016/j.immuni.2021.04.009 PMC 바로가기 [Article Type] Article
SARS-CoV-2 genome-wide T cell epitope mapping reveals immunodominance and substantial CD8 + T cell activation in COVID-19 patientsResearch Articles Published on 2021-04-142022-10-28 Journal: Science Immunology [Category] COVID-19, MERS, SARS, [키워드] Activation CD8 Complete complex COVID-19 COVID-19 patient COVID-19 patients disease disease severity effective epitope epitope mapping Epitopes evaluated Frame healthy donor Immunity immunodominance immunodominant immunodominant epitopes immunogenic in healthy individuals lymphocyte MHC MOST ORF ORF1 ORF3 outcomes overlapping Patient peptide phenotype Population Region reveal robust SARS-CoV-2 SARS-CoV-2 genome SARS-COV-2 infection severe disease significantly subset T cell T cell activation T cell epitopes T cell phenotype T cell response T cells the SARS-CoV-2 genome viral clearance virus-infected cell with COVID-19 with mild disease [DOI] 10.1126/sciimmunol.abf7550 PMC 바로가기 [Article Type] Research Articles
The Cancer Cell Dissemination Machinery as an Immunosuppressive Niche: A New Obstacle Towards the Era of Cancer ImmunotherapyReview Published on 2021-04-132023-08-30 Journal: Frontiers in Immunology [Category] E형 간염, [키워드] Cancer immunotherapy endothelial anergy lymphocyte exclusion lymphocyte exhaustion macrophages Metastasis T cells tumor microenvironment [DOI] 10.3389/fimmu.2021.654877 PMC 바로가기 [Article Type] Review
The role of CD4 + FoxP3 + regulatory T cells in the immunopathogenesis of COVID-19: implications for treatmentCOVID-19의 면역 병인 발생에서 CD4 + FoxP3 + 조절 T 세포의 역할: 치료에 대한 의미Review Published on 2021-04-102022-08-31 Journal: International Journal of Biological Sciences [Category] MERS, SARS, 바이오마커, [키워드] “cytokine storm” acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus adalimumab addressed Antiviral ARDS attenuation Azithromycin CD4 CD4+FoxP3+ regulatory T cells Chloroquine Coagulopathy coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cytokine Cytokine release syndrome Cytokine storm Defense deficiencies deficiency Dexamethasone early stage FOXP3 Hydroxychloroquine IL-2 immune Immune homeostasis immune response immune responses Immunopathogenesis immunopathology implication Infection Inflammatory responses introduced involved late stage low dose maintenance mechanisms organ damage organ injury Patient Perspective problem problems Regulatory Regulatory T cell regulatory T cells respiratory respiratory distress Respiratory distress syndrome sarilumab SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Severe case severe cases syndrome T cell T cells tetrandrine therapeutic agent therapeutic agents Therapies Tocilizumab transfer Treatment Treg Treg cell Treg cells Tregs Vitamin D [DOI] 10.7150/ijbs.59534 PMC 바로가기 [Article Type] Review