Systems Immunology Analysis Reveals the Contribution of Pulmonary and Extrapulmonary Tissues to the Immunopathogenesis of Severe COVID-19 Patients시스템 면역학 분석, 중증 COVID-19 환자의 면역병인 발생에 대한 폐 및 폐외 조직의 기여도 밝혀Immunology Published on 2021-06-282022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 바이오마커, 유전자 메커니즘, [키워드] activated addition Analysis APOA4 applied ASS1 B-cell B-cells BCL3 caused CBM CCL11 CD34 characterized CHI3L1 chronic inflammation complex contribute COVID-19 COVID-19 pandemic COVID-19 patient COVID19 CXCL1 cytokine cytokine production Cytokine storm Cytokines Cytokines storm DCLRE1C death dendritic cells dramatic increase dysregulated dysregulation eosinophil exacerbated Extrapulmonary extrapulmonary tissue extrapulmonary tissues Health heart heart tissue HLX HSP90AB1 IL2RA IL6 immune response immune responses immunology immunomodulatory effect Immunopathogenesis Inflammation inhibitor investigation ISG20 kidney LILRA5 liver lung lung tissue lung; modulate Monocytes MUC16 MUC17 MUC3A MUC4 MUC5B mucin multi-organ dysfunction NF-κB NF-κB signaling NFASC overexpression PARP14 potential mechanism potential mechanisms PTPN1 pulmonary resulting S100A12 SARS-CoV-2 SARS-COV-2 infection System T-cell T-cells the cytokine storm tissue tissues triggered upregulated WIPF3 [DOI] 10.3389/fimmu.2021.595150 PMC 바로가기 [Article Type] Immunology
Key Considerations for the Development of Safe and Effective SARS‐CoV‐2 Subunit Vaccine: A Peptide‐Based Vaccine Alternative안전하고 효과적인 SARS -COV -2 서브 유닛 백신 개발을위한 주요 고려 사항 : 펩티드 기반 백신 대안Review Published on 2021-06-272022-09-01 Journal: Advanced Science [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] angiotensin‐converting enzyme 2 antibody‐dependent enhancement Antigen antigens B‐cell clinical symptom conserved COVID‐19 critical binding residues deleted development developmental disorder Economy effective effective vaccine Effective vaccines Epitopes exhibit focus genetic material global health Health immune response immune responses immunogenic immunopathological Infection mechanisms mutant Neutralizing Neutralizing antibodies nonstructural protein peptide peptide vaccine Peptide vaccines Protective protective role Protein Proteins Receptor binding domain Safe SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 similarities similarity Spike protein T‐cell type‐I interferons Vaccine vaccine antigen Vaccines Viral Viral protein Viral proteins virus [DOI] 10.1002/advs.202100985 PMC 바로가기 [Article Type] Review
RIG-I-Like Receptor-Mediated Recognition of Viral Genomic RNA of Severe Acute Respiratory Syndrome Coronavirus-2 and Viral Escape From the Host Innate Immune Responses중증 급성 호흡기 증후군 코로나바이러스-2의 바이러스 게놈 RNA의 RIG-I 유사 수용체 매개 인식 및 숙주 선천 면역 반응으로부터의 바이러스 탈출Immunology Published on 2021-06-252022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘, 진단, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus antiviral responses caused CCL5 coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus-2 cytokine cytokine expression cytoplasmic destabilized epithelial cell epithelial cells escape expression fragment of genomic RNA Host host response human cells IFN-β immune responses in some induce infected cells inhibited Innate innate immune response innate immune responses Innate immunity Interaction involved IP-10 knockout MAVS MDA5 mechanism mRNA expression pandemic Particle Phosphorylation Protein Recognition recognize Region required respiratory response RIG-I RIG-I-like receptor RIG-I-like receptors RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-infected cell SARS-CoV-2-infected cells Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 TBK1 total RNA total RNAs transfection Trigger Type I IFN type I interferon Viral viral double-stranded RNA viral escape Viral RNA was reduced [DOI] 10.3389/fimmu.2021.700926 PMC 바로가기 [Article Type] Immunology
Live Virus Neutralisation of the 501Y.V1 and 501Y.V2 SARS-CoV-2 Variants following INO-4800 Vaccination of Ferrets흰 족제비의 INO-4800 백신 접종 후 501Y.V1 및 501Y.V2 SARS-CoV-2 변이체의 살아있는 바이러스 중화Immunology Published on 2021-06-252022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 변종, 진단, [키워드] 501Y.V1 501Y.V2 affecting biomolecular modelling comparable Course COVID-19 COVID-19 pandemic COVID-19 vaccine COVID-19 vaccines DNA vaccine dose effective ferret ferrets immune responses in silico Influenza influenza pandemic INO-4800 investigated less media morbidity and mortality neutralisation neutralisation titre Neutralisation titres Neutralising Antibodies neutralising antibody nucleic acid nucleic acid vaccine Nucleic acid-based vaccines over pandemic PROTECT reported SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 variant SARS-CoV-2 variants sera supported titre titres vaccine-induced immune response Vaccine-induced immunity variant variants virus isolate [DOI] 10.3389/fimmu.2021.694857 PMC 바로가기 [Article Type] Immunology
The Role of Neuropilin-1 (NRP-1) in SARS-CoV-2 Infection: ReviewReview Published on 2021-06-242022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] acute respiratory syndrome analgesic effect Angiogenesis appear association bind Central nervous system coronavirus coronavirus disease COVID-19 database facilitate functions glycoprotein host cell host cell membrane host cell receptor immune responses implicated Infection inhibitor interact literature nasal neurological manifestation neuronal Neuropilin-1 NRP-1 Olfactory epithelium pandemic pathological change Protein receptor Regulation responsible Retina review role SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection significantly Spread subunit therapeutic strategy Treatment virus was used [DOI] 10.3390/jcm10132772 PMC 바로가기 [Article Type] Review
The Fc-mediated effector functions of a potent SARS-CoV-2 neutralizing antibody, SC31, isolated from an early convalescent COVID-19 patient, are essential for the optimal therapeutic efficacy of the antibody초기 회복기 COVID-19 환자로부터 분리 된 강력한 SARS-COV-2 중화 항체, SC31의 FC- 매개 이펙터 기능은 항체의 최적의 치료 효능에 필수적이다.Research Article Published on 2021-06-232022-08-13 Journal: PLoS ONE [Category] Biochemistry, MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] ACE2 addition Administered animal models Anti-SARS-CoV-2 Activity anti-viral immune responses antibody Antibody-dependent enhancement Antibody-mediated neutralization convalescent convalescent patient COVID-19 COVID-19 patient demonstrated dose-dependent efficacy effective Efficacy epitope evidenced exhibited Fc-mediated effector function Fc-mediated effector functions Fc-null LALA variant Histopathology IFNγ immune responses Inflammatory responses K18-human ACE2 transgenic mice LALA variant Lower respiratory tract lung Lungs mice neutralization ability Neutralizing antibodies neutralizing antibody occur preclinical studies preclinical study prevented pro-inflammatory response pro-inflammatory responses promote Protein Receptor-binding domain reduced viral load reduced viral loads reduction respiratory rhesus macaques SARS-CoV-2 SARS-CoV-2 neutralizing antibody SARS-CoV-2 spike protein SARS-CoV-2-infected hamsters SARS-CoV-2-neutralizing antibodies SARS-CoV-2-neutralizing antibody SC31 SC31 treatment severity of COVID-19 significantly spike Spike protein sub-therapeutic doses the receptor-binding domain the SARS-CoV-2 therapeutic therapeutic efficacy therapeutic potential Therapeutics transgenic mice treated treatment with SC31 undetectable Viral Viral load viral loads viral-induced viral-induced lung inflammatory responses weight loss [DOI] 10.1371/journal.pone.0253487 PMC 바로가기 [Article Type] Research Article
Protective efficacy of Ad26.COV2.S against SARS-CoV-2 B.1.351 in macaques원숭이에서 SARS-CoV-2 B.1.351에 대한 Ad26.COV2.S의 보호 효능Article Published on 2021-06-232022-09-10 Journal: Nature [Category] MERS, SARS, 변종, 비임상, 유전자 메커니즘, 진단, [키워드] Ad26 Ad26.COV2.S Ad26.COV2.S vaccine B.1.1.7 B.1.351 B.1.351 variant binding Bronchoalveolar lavage CAL.20C variants CD4 CD8 Cellular immune response comparable COVID-19 COVID-19 vaccine cross-react demonstrated Efficacy elicit elicited evade expresse Human humoral Humoral and cellular immune responses immune responses implication induce Infection macaque nasal swab nasal swabs Neutralizing antibodies neutralizing antibody P.1 PROTECT Protective provided rhesus macaque rhesus macaques robust SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sequenced South Africa Spike protein stabilized spike protein symptomatic symptomatic COVID-19 T cell T cell response These data Vaccine Vaccines virus virus replication viruses WA1/2020 [DOI] 10.1038/s41586-021-03732-8 PMC 바로가기 [Article Type] Article
Detection and Neutralization of SARS-CoV-2 Using Non-conventional Variable Lymphocyte Receptor Antibodies of the Evolutionarily Distant Sea Lamprey진화적으로 먼 바다 칠면조의 비전통적인 가변 림프구 수용체 항체를 사용한 SARS-CoV-2의 검출 및 중화Immunology Published on 2021-06-212022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, 치료기술, 치료제, [키워드] antibody Betacoronavirus Biomedical research causative agent COVID-19 pandemic detection diagnostic diagnostic reagent Distant Epitopes Evidence immune responses immunized immunoglobulins Isolation lamprey lymphocyte monoclonal monoclonal antibody neutralization neutralize other coronaviruses pathogen provide receptor recognize recognizing SARS-CoV-2 SARS-CoV-2 detection sea lamprey (Petromyzon marinus) Spike protein spike protein of SARS-CoV-2 the spike protein therapeutic unique vaccine-induced immune response variable variable lymphocyte receptor Vertebrate Viral viral spike protein virus [DOI] 10.3389/fimmu.2021.659071 PMC 바로가기 [Article Type] Immunology
Safety and immunogenicity of the ChAdOx1 nCoV-19 (AZD1222) vaccine against SARS-CoV-2 in HIV infection: a single-arm substudy of a phase 2/3 clinical trialHIV 감염에서 SARS-COV-2에 대한 Chadox1 NCOV-19 (AZD1222) 백신의 안전성 및 면역 원성 : 2/3 상 임상 시험의 단일 암 보체.Clinical Trial Published on 2021-06-182022-08-13 Journal: The Lancet. HIV [Category] MERS, SARS, 임상, 진단, [키워드] ACHE age All participants analysed analyses anti-Spike IgG anti-spike IgG response Anti-spike IgG responses antibody Antiretroviral therapy ART AstraZeneca available data AZD1222 CD4 CD4 cell CD4 count CD4 counts Cell cell-mediated immune response Cell-mediated immune responses cellular response Cellular responses ChAdOx1 ChAdOx1 nCoV-19 chill chills Clinical research clinical trial Coalition Comorbidity determined by dose Eligible participants ELISA ELISPOT enrolled enrolment enzyme enzyme-linked immunospot assay fatigue finding FIVE frequencies Frequency functional funding General population headache HIV HIV clinics HIV-negative HIV-uninfected humoral Humoral response humoral responses IFN-γ IgG response IgG responses immune responses Immunity immunogenic immunogenicity injection injection site Innovation IQR joint joint pain less Live virus Local London magnitude malaise male median median age muscle ache nausea network neutralisation NIHR NIHR Oxford Biomedical Research Centre no correlation no difference occurred Open-label outcome Oxford Pain participant Participants peaked people with HIV persistence phase 2/3 phase 2/3 trial plasma Primary outcome Primary outcomes prime-boost regimen proliferation proliferative protocol reactogenicity Registered reported required response Safe Safety SARS-CoV-2 SARS-CoV-2 spike-specific Serious Adverse Event Serious Adverse Events single-arm South sustained systemic reaction systemic reactions T-cell the vaccine undetectable vaccination Vaccine vaccine immunogenicity Valley Viral Viral load were measured with HIV [DOI] 10.1016/S2352-3018(21)00103-X PMC 바로가기 [Article Type] Clinical Trial
Clinical Evaluation of the Abbott Alinity SARS-CoV-2 Spike-Specific Quantitative IgG and IgM Assays among Infected, Recovered, and Vaccinated GroupsAbbott Alinity SARS-CoV-2 스파이크 특이적 정량적 IgG 및 IgM 분석의 감염, 회복 및 백신 접종 그룹의 임상 평가Article Published on 2021-06-182022-09-11 Journal: Journal of Clinical Microbiology [Category] MERS, SARS, 진단, 치료법, [키워드] Abbott acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibody Antibody Response Antibody responses Antibody test booster clinical clinical sensitivity Cohort collected Combination Containment coronavirus coronavirus disease Coronavirus infections COVID-19 COVID-19 vaccines cross-reactivity dampened response dose group Health IgG IgG and IgM IgM immune responses Immunity immunoassays individual individuals Infection Laboratory nucleocapsid pandemic participant Quantitative recovered respiratory response SARS-CoV-2 sensitivity serologic assay Serological assay serological response serology assay serology assays severe acute respiratory syndrome Coronavirus significant increase spike Spike protein unique utility vaccination Vaccine while [DOI] 10.1128/JCM.00388-21 PMC 바로가기 [Article Type] Article