Certainty of success: three critical parameters in coronavirus vaccine developmentReview Article Published on 2020-05-252022-10-30 Journal: NPJ Vaccines [Category] COVID-19, [키워드] biological parameter certainty circulating coronavirus vaccine Coronavirus vaccines COVID-19 vaccine Critical death disease effective Efficacy force of infection humans Incubation period intensity pandemic parameter pathogen predicted Protective reduce SARS-CoV-2 SARS-COV-2 infection severity turn Vaccine Vaccine development Vaccines viral infection viral pathogen virus [DOI] 10.1038/s41541-020-0193-6 PMC 바로가기 [Article Type] Review Article
COVID-19: Learning from Lessons To Guide Treatment and Prevention InterventionsMinireview Published on 2020-05-132022-10-30 Journal: mSphere [Category] COVID-19, MERS, SARS, [키워드] absence acute respiratory syndrome affected appear approved benefit Care caused China clinical trial Combination confirmed case coronavirus Coronavirus disease 2019 country COVID-19 COVID-19 disease COVID-19 pandemic COVID-19 patients COVID19 deaths develop drug drugs effective effective therapy effort Evidence guide Health authority highlight increase in Influenza learning lesson Local mortality rate Novel coronavirus other disease outbreak Pandemics Prevent prevention Prophylaxis reducing respond SARS-CoV-2 Spread spread to tested the disease Treatment urgency Vaccine Vaccine development Vaccines virus while Wuhan [DOI] 10.1128/mSphere.00317-20 PMC 바로가기 [Article Type] Minireview
COVID-19 pandemic: an overview of epidemiology, parthenogenesis, diagnostics and potential vaccines and therapeuticsReview Published on 2020-05-132022-10-28 Journal: Therapeutic Delivery [Category] COVID-19, SARS, [키워드] Abstract against SARS-CoV antimalarial antivirals bevacizumab clinical evaluation clinical therapy coronavirus COVID-19 death diagnostics Epidemic Epidemiology evaluated Favipiravir FDA-approved drug Genetic highlight Hydroxychloroquine immunomodulator Infection Middle East pandemic Patient preventive measures recent Remdesivir repurposed therapies Respiratory Coronavirus SARS-CoV SARS-CoV-2 shown similarity syndrome Tocilizumab Vaccine Vaccine development viruses [DOI] 10.4155/tde-2020-0035 PMC 바로가기 [Article Type] Review
Highlight of Immune Pathogenic Response and Hematopathologic Effect in SARS-CoV, MERS-CoV, and SARS-Cov-2 InfectionImmunology Published on 2020-05-122022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] acute respiratory distress addition ARDS Care caused clinical trial combined treatment Complication complications coronavirus Coronavirus infection COVID-19 Cytokine storm direct infection Effect global healthcare global pandemic Guidance hematopathologic effect Host immune response immune Immune cell immune response immune responses immune therapy infection mechanism infection-induced lymphopenia Invasion killing mechanism medication MERS-CoV molecular mechanism Novel coronavirus outbreak Patient Potential treatment Prevent Prophylactic pulmonary fibrosis reduce Replication required response responses resulting risk SARS-CoV SARS-CoV-2 SARS-CoV-2 infected patient Severe case severe respiratory syndrome Spread syndrome the disease Therapeutic approach therapeutic approaches therapy Vaccine Vaccine development Wuhan, China [DOI] 10.3389/fimmu.2020.01022 PMC 바로가기 [Article Type] Immunology
SARS-CoV-2/COVID-19: Viral Genomics, Epidemiology, Vaccines, and Therapeutic InterventionsReview Published on 2020-05-102022-10-28 Journal: Viruses [Category] COVID-19, MERS, SARS, [키워드] acute respiratory distress Analysis approach asymptomatic infection caused coronavirus COVID-19 COVID-19 pandemic database diagnostics Drug discovery Epidemiology etiology fatality genomic Genomics help Impact Infection information Lower respiratory tract mild respiratory symptom molecular novel SARS-CoV-2 virus pandemic protein interactions provide resource SARS-CoV-2 Scientific community severe pneumonia Symptom therapeutic intervention therapeutic interventions transcriptomic transcriptomics Transmission Treatment Vaccine Vaccine development viral genomics viral pathogenicity virus [DOI] 10.3390/v12050526 PMC 바로가기 [Article Type] Review
Immune cell profiling of COVID-19 patients in the recovery stage by single-cell sequencingArticle Published on 2020-05-042022-10-31 Journal: Cell Discovery [Category] COVID-19, [키워드] affected Analysis antibody B cells BCR caused CD14 CD4 CD8 Cell change classical Course COVID-19 COVID-19 patient COVID-19 patients early recovery Evidence expressed frequencies Gene Expression greater hospital discharge identification IGHV3-15 IGHV3-23 IGHV3-30 IGHV3-7 IGKV3-11 IL-18 IL-1β IL-2 IL-4 IL1β Immune cell immune signature immunology indicated Inflammatory inflammatory gene inflammatory storm isotype M-CSF Mechanisms of disease monoclonal monocyte mononuclear cell naïve B cell Patient Peripheral blood Plasma cell predicted provide reported SARS-CoV-2 Sequencing Signaling significantly single-cell Single-cell RNA sequencing specificity subset T cell target gene TNFSF13 transcriptional change Treatment Vaccine Vaccine development virus [DOI] 10.1038/s41421-020-0168-9 PMC 바로가기 [Article Type] Article
Rapid reconstruction of SARS-CoV-2 using a synthetic genomics platform Research Published on 2020-05-042022-10-05 Journal: Nature [Category] SARS, 변종, 유전자 메커니즘, 치료제, [키워드] acute respiratory syndrome benefit caused clinical sample clone cloned Community coronavirus coronavirus disease Coronaviruses COVID-19 DNA Escherichia coli facilitate Flaviviridae functional generate genetics Genome maintain outbreak pandemic platform Rapid rapid response Recombination Research RNA RNA virus RNA viruses robust Saccharomyces cerevisiae SARS-CoV-2 synthetic DNA fragments T7 RNA polymerase the Coronaviridae Vaccine development variant viral DNA viral isolates viral pathogenesis virus yeast artificial chromosome [DOI] 10.1038/s41586-020-2294-9 [Article Type] Research
Coronavirus Pandemic—Therapy and VaccinesReview Published on 2020-05-032022-10-28 Journal: Biomedicines [Category] COVID-19, [키워드] accelerated addition angiotensin receptor blocker Antiviral antiviral drug approach contributed coronavirus country COVID-19 COVID-19 pandemic drug effort Epitopes example gene silencing Gene therapy genetics globe glycoprotein Infection lack monoclonal antibodies Panic peptide vaccine Psychological raised RNA interference Spread therapeutic Vaccine Vaccine development viral infection viral replication viral vectors worsened Wuhan, China [DOI] 10.3390/biomedicines8050109 PMC 바로가기 [Article Type] Review
A Comprehensive Review of Severe Acute Respiratory Syndrome Coronavirus 2Internal Medicine Published on 2020-05-032022-10-31 Journal: Cureus [Category] COVID-19, [키워드] ACE2 angiotensin-converting enzyme 2 cause Comprehensive Consensus coronavirus 2 coronavirus disease coronavirus disease (COVID-19) cough country COVID-19 diagnostic Dyspnea enzyme Epidemiology Evidence Fever infected individual mean incubation period multiorgan failure Novel coronavirus pathophysiology receptor protein Research respiratory Respiratory failure review SARS-CoV-2 sars-cov-2 (severe acute respiratory syndrome coronavirus -2) SARS-COV-2 infection spread to Symptom the disease Transmission transmitted Treatment Vaccine development variety viral entry virus while Wuhan, China [DOI] 10.7759/cureus.7943 PMC 바로가기 [Article Type] Internal Medicine
COVID-19 vaccines: breaking record times to first-in-human trialsComment Published on 2020-04-302022-10-04 Journal: NPJ Vaccines [Category] 임상, [키워드] contributed COVID-19 COVID-19 pandemic demonstrated Genetic RNA vaccines Trial Vaccine development viral infection [DOI] 10.1038/s41541-020-0188-3 PMC 바로가기 [Article Type] Comment