Persistent Symptoms in Adult Patients 1 Year After Coronavirus Disease 2019 (COVID-19): A Prospective Cohort Study코로나바이러스 감염증 2019(COVID-19) 1년 후 성인 환자의 지속적인 증상: 전향적 코호트 연구Article Published on 2022-04-092022-09-12 Journal: Clinical Infectious Diseases: An Official Publicat [Category] COVID19(2023년), SARS, 진단, [키워드] acute COVID-19 acute respiratory syndrome ANA titers Analysis analyzed antibody Autoimmunity cofactor cohort of patient Concentration coronavirus coronavirus disease Coronavirus disease 2019 (COVID-19) Course COVID COVID-19 symptom defined Dyspnea elevations etiology Exercise capacity fatigue females follow-up study Frequency Hospitalized Infection laboratory parameter life quality Long Long COVID long-COVID males mental life neurocognitive not differ Patient persistence persistent physical problem Prospective Quality of life reduce reduced SARS-CoV-2 SARS-CoV-2 antibody significantly significantly higher significantly more Symptom symptom onset Symptoms with COVID-19 without symptoms Year [DOI] 10.1093/cid/ciab611 PMC 바로가기 [Article Type] Article
The use of standardized Brazilian green propolis extract (EPP-AF) as an adjunct treatment for hospitalized COVID-19 patients (BeeCovid2): a structured summary of a study protocol for a randomized controlled trial입원한 COVID-19 환자(BeeCovid2)의 보조 치료제로 표준화된 브라질 녹색 프로폴리스 추출물(EPP-AF)의 사용: 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약Article Published on 2022-04-042022-09-11 Journal: Trials [Category] 임상, [키워드] 1:1 2019 coronavirus disease ACE2 acute COVID-19 Acute kidney injury adjunct Administered adults hospitalized Affect affected age anti-inflammatory agents association Bacterial balloon pump Brazil Cancer patients chronic disease Chronic diseases Chronic kidney disease clinical study conducted coronavirus disease COVID-19 demonstrated diagnosis of COVID-19 double-blinded ECMO Effectiveness Evidence experimental evidence extracorporeal membrane oxygenation Fungal infection groups heart failure HIV patients Hospital stay hospitalized COVID-19 patient hospitalized patients immunoregulation Immunosuppression impacts impossibility include Infection intra-aortic balloon pump Kidney disease Liver disease mechanical ventilation medication moderate moderate to severe outcome PAK1 PAK1 blocker pandemic Patient patients hospitalized Placebo placebo-controlled clinical study pregnant women Primary outcome Propolis protocol randomization Randomized Randomized controlled trial receive reducing renal replacement therapy replacement therapy secondary Secondary infection Secondary outcomes severe liver disease Spread standard care Study protocol Symptom targets TMPRSS2 Treatment Trial vasoactive drugs with COVID-19 [DOI] 10.1186/s13063-022-06176-1 PMC 바로가기 [Article Type] Article
Detection of SARS-CoV-2 nucleocapsid antigen from serum can aid in timing of COVID-19 infection혈청에서 SARS-CoV-2 뉴클레오캡시드 항원 검출은 COVID-19 감염 시기에 도움이 될 수 있습니다Article Published on 2022-04-012022-09-11 Journal: Journal of virological methods [Category] COVID19(2023년), SARS, 진단, 치료기술, 치료법, [키워드] acute COVID-19 Analytical specificity Antibody testing Antigen antigenemia Combination convalescent phase COVID-19 COVID-19 disease COVID-19 infection COVID-19 patient demonstrated detection diagnostic disease enzyme enzyme immunoassay enzyme-linked immunosorbent enzyme-linked immunosorbent assay information Kinetics marker median N antigen nucleocapsid nucleocapsid antigen onset of disease onset of symptoms Patient PCR PCR positive PCR-confirmed PCR-confirmed COVID-19 plasma samples positive positive PCR resolved respiratory respiratory sample Respiratory samples RNA SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 nucleocapsid SARS-CoV-2 RNA sensitivity serum serum and plasma serum sample serum samples specificity specimen specimens upper respiratory tract URT was collected [DOI] 10.1016/j.jviromet.2022.114469 PMC 바로가기 [Article Type] Article
Longitudinal Plasma Proteomics Analysis Reveals Novel Candidate Biomarkers in Acute COVID-19세로형 플라즈마 단백질체학 분석, 급성 코로나19에서 새로운 후보 바이오마커 밝혀Article Published on 2022-04-012022-09-11 Journal: Journal of Proteome Research [Category] MERS, 바이오마커, 유전자 메커니즘, 진단, [키워드] abundance ACEi acquisition Activation acute COVID-19 acute inflammatory response Admission amyloid Analysis angiotensin angiotensin receptor blocker Angiotensin receptor blockers Angiotensin-converting enzyme angiotensin-converting enzyme inhibitors ARB baseline Blood blood plasma candidate cascade cell proliferation complement Complement activation COVID-19 COVID-19 patients decrease degranulation exposure to fluctuation followed by fructose functions healthy control healthy controls healthy individual healthy individuals host response humoral immune response Infection Inflammatory Inflammatory response inhibitors longitudinal longitudinal analysis mechanism mechanisms nonsurvivors novel on admission pathophysiology Patient patients Platelet profile Protein Proteins proteomic proteomics Quantitative Receptor Blockers Regulation smooth muscle survivor targeted quantitative proteomics. [DOI] 10.1021/acs.jproteome.1c00863 PMC 바로가기 [Article Type] Article
Prospective Validation of a Rapid Host Gene Expression Test to Discriminate Bacterial From Viral Respiratory Infection바이러스성 호흡기 감염에서 박테리아를 구별하기 위한 신속한 숙주 유전자 발현 검사의 전향적 검증Multicenter Study Published on 2022-04-012022-09-11 Journal: JAMA Network Open [Category] 유전자 메커니즘, 진단, [키워드] 95% CI absence acute COVID-19 acute respiratory illness age Analysis antibacterial therapy antibiotic ARI Asian Bacterial Bacterial infection black Care cause Characteristics children clinical clinically Cohort Concordance diagnostic Emergency Departments enrolled Enrollment entire cohort Ethnicity expression febrile female followed by group groups Hispanic Host host gene host gene expression host response IMPROVE individual IQR less likelihood male median age Messenger RNA multicenter Native Negative predictive value NPV offer outcome outcomes participant Participants pathogen Patient patients with ARI patients with COVID-19 performance Positive predictive value Predictive value primary analysis Probability procalcitonin Prospective quantified Rapid reported respiratory Respiratory illness resulting sensitivity specificity stratified Test the median validation Viral viral infection white with COVID-19 [DOI] 10.1001/jamanetworkopen.2022.7299 PMC 바로가기 [Article Type] Multicenter Study
Health Status, Persistent Symptoms, and Effort Intolerance One Year After Acute COVID-19 InfectionObservational Study Published on 2022-04-012022-10-04 Journal: Journal of General Internal Medicine [Category] COVID19(2023년), SARS, 임상, [키워드] 1.26 95% CI acute COVID-19 adjusted relative risk age Clinical data condition COVID-19 COVID-19 infection COVID-19 pandemic Department described Deterioration effort Emergency female Health Health status high-risk comorbid hospital Hospitalization Hospitalized implication increased risk individuals Infection intolerance limitation mechanical ventilation median time Observational cohort study PASC Patient patients people with HIV persistent persistent symptoms physician Prevalence reported risk factor severe COVID-19 illness significantly more status survey survivor Symptom Symptoms these symptom Tolerance unvaccinated population Vaccine Year [DOI] 10.1007/s11606-021-07379-z PMC 바로가기 [Article Type] Observational Study
Safety and long-term improvement of mesenchymal stromal cell infusion in critically COVID-19 patients: a randomized clinical trialClinical Trial Published on 2022-03-212022-10-05 Journal: Stem Cell Research & Therapy [Category] Coronavirus, SARS, 임상, [키워드] acute COVID-19 biochemical Blood caused cell subpopulation Cell therapy clinical clinician complex consequence COVID-19 COVID-19 patients Critically ill CT scan cytokine D-dimer decrease diagnosed with COVID-19 disease disorder dose dosing interval double-blind early stages Efficacy extension ferritin Follow-up IL-6 immune dysregulation immunomodulatory property increase in Inflammatory intensive care intravenous dose invasive mechanical knowledge Laboratory testing lung damage lymphocyte Mesenchymal stromal cell Mesenchymal stromal cells MSC MSCs neutrophil organ parameter PASC Patient Placebo placebo-controlled clinical trial Postacute sequelae. Prevent Randomized randomized clinical trial reactive reduction reduction in Registered registry Safe Safety SARS-CoV-2 Severe case severe complication single-center stromal cell Surveillance Symptom Symptoms TCD4 therapy tissue damage tissue injury Treatment UC-MSC UC-MSCs umbilical Viral load with COVID-19 [DOI] 10.1186/s13287-022-02796-1 PMC 바로가기 [Article Type] Clinical Trial
Performance of colorimetric reverse transcription loop-mediated isothermal amplification as a diagnostic tool for SARS-CoV-2 infection during the fourth wave of COVID-19 in Thailand태국의 코로나19 4차 유행 중 SARS-CoV-2 감염 진단 도구로서의 비색 역전사 루프 매개 등온 증폭 성능Article Published on 2022-03-012022-09-11 Journal: International Journal of Infectious Diseases [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, 치료기술, 치료제, [키워드] 95% CI accounted acute COVID-19 caused Chain Reaction Colorimetric RT-LAMP Coverage COVID-19 COVID-19 infection cycle threshold diagnostic Diagnostic method diagnostic methods false false-negative false-negative results Infection isothermal amplification LAMP Loop-mediated isothermal amplification Mass screening nasopharyngeal swabs ORF1ab gene Patient performance regions reverse transcriptase reverse transcriptase-polymerase chain reaction reverse transcription RNA sample RT-LAMP RT-PCR RT-PCR assay SARS-CoV-2 SARS-COV-2 infection sensitivity Sensitivity and specificity specificity Spread variants Viral Viral load Viral RNA virus [DOI] 10.1016/j.ijid.2021.12.351 PMC 바로가기 [Article Type] Article
Sustained Impairment in Cardiopulmonary Exercise Capacity Testing in Patients after COVID-19: A Single Center ExperienceCOVID-19 이후 환자의 심폐 운동 능력 테스트에서 지속적인 손상: 단일 센터 경험Research Article Published on 2022-03-012022-09-10 Journal: Canadian Respiratory Journal [Category] MERS, SARS, 진단, 치료기술, [키워드] acute COVID-19 Capacity cardiopulmonary exercise testing center Chronic fatigue comparable correlated COVID-19 COVID-19 infection described Deterioration Ejection fraction evaluate exercise Exercise capacity Exercise limitation experience female patient Follow-up Gas exchange Improvements Infection initial limitation limitations Limited magnetic resonance imaging male MRI objective offered oxygen pathologic Patient patients performed pulse reduced Result severity of COVID-19 Stress Symptom syndrome Testing Vascular ventilatory was related [DOI] 10.1155/2022/2466789 PMC 바로가기 [Article Type] Research Article
Quantification and prognostic significance of interferon-γ secreting SARS-CoV-2 responsive T cells in hospitalized patients with acute COVID-19급성 COVID-19로 입원한 환자에서 SARS-CoV-2 반응성 T 세포를 분비하는 인터페론-γ의 정량화 및 예후 의의Comment Published on 2022-03-012022-09-12 Journal: The Journal of Infection [Category] MERS, SARS, 진단, [키워드] acute COVID-19 hospitalized patient interferon-γ prognostic SARS-CoV-2 secreting T cell [DOI] 10.1016/j.jinf.2021.11.010 PMC 바로가기 [Article Type] Comment