Hypothesis: Pentoxifylline is a potential cytokine modulator therapeutic in COVID‐19 patientsReview Published on 2020-07-262022-10-29 Journal: Pharmacology Research & Perspectives [Category] COVID-19, MERS, [키워드] adenosine Alpha approach clinical clinically complementary COVID‐19 COVID‐19 patient COVID‐19 current cytokine effective Efficacy host response host responses Human Hypothesis immunomodulation immunomodulator inhibitor interferon gamma lung damage Necrosis pathway Pentoxifylline Pneumonia positive Radiation randomized trial reduce SARS‐CoV‐2 infection SARS‐CoV‐2 Support the cytokine storm therapeutic tissue damage Tolerability Trial Viral [DOI] 10.1002/prp2.631 PMC 바로가기 [Article Type] Review
Purinergic signaling in infectious diseases of the central nervous system중추신경계 감염성 질환의 퓨린성 신호전달Article Published on 2020-07-242023-06-18 Journal: Brain, behavior, and immunity [Category] MERS, SARS, 말라리아, [키워드] ACE2, angiotensin-converting enzyme 2 adenosine ADO, Adenosine ADP, adenosine diphosphate AIDS, acquired immunodeficiency syndrome AMP, adenosine monophosphate ARDS, acute respiratory distress syndrome ATP, adenosine triphosphate BBB, blood-brain barrier BBG, Brilliant Blue G BCSFB, Blood-cerebrospinal fluid barrier BMDM, Bone marrow-derived macrophage CAT, Catalase enzyme CBD, cannabidiol CCL2, Chemokine (C–C motif) ligand 2 CD39 CD73 CD73, Ecto-5′-nucleotidase Cerebral toxoplasmosis, Zika, SARS-CoV-2 CLP, Cecal ligation and puncture CNS, Central Nervous System COVID-19, Coronavirus disease 2019 DV, dengue virus E-NTPDase, Ecto-nucleoside triphosphate diphosphohydrolase GP120, Envelope glycoprotein 120 HIV, Human immunodeficiency virus HSV-1, Herpes simplex virus type 1 ICAM-1, Intercellular adhesion molecule 1 IL, interleukin INF-γ, Interferon gamma ME49, Type 2 Toxoplasma gondii strain MS, multiple sclerosis neuroinfections Neuroinflammation NLRP3, Nucleotide-binding domain leucine-rich repeat (NLR) and pyrin domain containing receptor 3 NMS, Neuroleptic malignant syndrome NO, Nitric Oxide Ox-ATP, Oxidized ATP P1, Purinergic P1 receptors P2 receptor P2, Purinergic P2 receptors PM, Pneumococcal meningitis PNS, Peripheral nervous system POM-1, Sodium polyoxotungstate RH, Type 1 Toxoplasma gondii strain RNS, Reactive nitrogen species ROS, reactive oxygen species SAE, Sepsis Associated Encephalopathy SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 ShRNA, Short hairpin RNA SOD, Superoxide dismutase TAT, HIV trans-activator of transcription THP1, Human monocytic cell line TMEV, Theiler’s murine encephalomyelitis virus TNF-α, tumor necrosis factor alpha UDP, Uridine diphosphate VCAM-1, Vascular cell adhesion molecule-1 WT, wild type ZIKV, Zika virus [DOI] 10.1016/j.bbi.2020.07.026 PMC 바로가기 [Article Type] Article
Targeting adenosinergic pathway and adenosine A 2A receptor signaling for the treatment of COVID-19: A hypothesisArticle Published on 2020-06-192023-07-01 Journal: Medical Hypotheses [Category] SARS, [키워드] adenosine CD39 CD73 COVID-19 Immunotherapy [DOI] 10.1016/j.mehy.2020.110012 PMC 바로가기 [Article Type] Article
Genome-wide identification of short 2′,3′-cyclic phosphate-containing RNAs and their regulation in aging짧은 2',3'-사이클릭 인산염 함유 RNA의 게놈 전체 식별 및 노화 조절Research Article Published on 2019-11-132022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accumulated adapter ligation adenosine advent aging Analysis biogenesis can not capture characterized cleavage cytidine cytoplasmic Degradation Determination effort event Evolution expressed expression expression level expression levels functional hidden identify ligation reaction mRNAs ncRNAs next-generation sequencing technology non-coding RNA Non-coding RNAs pathway phosphate physiological produced random reduction regulated Regulation remained ribonuclease RNA RNA molecule RNA molecules RNA-Seq RNAs rRNAs sequence standard RNA tissues Transcriptome tRNAs [DOI] 10.1371/journal.pgen.1008469 PMC 바로가기 [Article Type] Research Article
Extracellular adenosine produced by ecto-5′-nucleotidase (CD73) regulates macrophage pro-inflammatory responses, nitric oxide production, and favors Salmonella persistencearticle Published on 2018-01-312024-09-01 Journal: Nitric Oxide [Category] 살모넬라증, [키워드] adenosine Inflammatory-responses Macrophage nitric oxide Salmonella [Article Type] article
MicroRNA-275 targets sarco/endoplasmic reticulum Ca 2+ adenosine triphosphatase (SERCA) to control key functions in the mosquito gutMicroRNA-275는 모기장에서 주요 기능을 제어하기 위해 sarco/endoplasmic reticulum Ca 2+ adenosine triphosphatase(SERCA)를 표적으로 합니다.Research Article Published on 2017-08-072022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Actin activating active transport addition adenosine Aede affecting approach Arboviruses assembly Blood blood meal cancers cardiac hypertrophy caused Chikungunya Combination conserved contribute contributing to correlated Critical cytosol decoy decrease Dengue deplete digestion digestive digestive enzyme enzyme female Fever fevers finding function functions Gut gut microbiota guts heart failure homeostasis human diseases humans implicated injection Injections investigated involved knowledge leads maintenance mechanism microRNA miRNA Mosquito mRNA Notch pathogen pathogen transmission Pathogens phenotype Proteases Protein protein level protein levels reduction regulate Regulation remained repeated required rescued RNA sequence SERCA shown signaling pathway significantly spatiotemporal target the mosquito tissue Transcription transgenic Transport trypsin vectors yeast yellow fever yellow fevers Zika [DOI] 10.1371/journal.pgen.1006943 PMC 바로가기 [Article Type] Research Article
Ecto-5′-nucleotidase CD73 modulates the innate immune response to influenza infection but is not required for development of influenza-induced acute lung injuryArticle Published on 2015-10-022023-06-23 Journal: American journal of physiology. Lung cellular and [Category] 신종인플루엔자, [키워드] acute lung injury adenosine CD73 Influenza mouse [DOI] 10.1152/ajplung.00130.2015 PMC 바로가기
Extracellular Adenosine Generation in the Regulation of Pro-Inflammatory Responses and Pathogen Colonization세포외 아데노신 생성이 염증 유발 반응 및 병원체 집락화 조절에서의 역할Review Published on 2015-05-052023-08-29 Journal: Biomolecules [Category] E형 간염, 살모넬라증, [키워드] adenosine adenosine receptors bacterial-persistence CD39 CD73 cytokine immune response Inflammation Lymphocytes Macrophage [DOI] 10.3390/biom5020775 PMC 바로가기 [Article Type] Review
Identification through structure-based methods of a bacterial NAD+-dependent DNA ligase inhibitor that avoids known resistance mutations알려진 저항 돌연변이를 피하는 세균 NAD+-의존적 DNA 리가제 억제제를 구조 기반 방법을 통해 식별journal-article Published on 2014-01-012024-08-04 Journal: Bioorganic & Medicinal Chemistry Letters [Category] 폐렴구균 감염증, [키워드] adenosine Antibacterial NAD(+)-dependent ligase resistance Thienopyridine. [DOI] 10.1016/j.bmcl.2013.11.007 [Article Type] journal-article