A bioinformatic approach of targeting SARS-CoV-2 replication by silencing a conserved alternative reserve of the orf8 gene using host miRNAs숙주 miRNA를 사용하여 orf8 유전자의 보존된 대체 예비를 억제함으로써 SARS-CoV-2 복제를 표적으로 하는 생물정보학적 접근Article Published on 2022-06-012022-09-11 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 변종, [키워드] adopted approach binding affinity causative agent compensating conserved COVID-19 COVID-19 pandemic deleting docked exhibit functional gene sequence gene silencing Genes homology Host host immunity host miRNA Hypothesis indels Interaction miRNA miRNAs modulate molecular docking mRNA multiple mutation multiple mutations mutations omicron Omicron variant ORF7a ORF7a gene ORF8 ORF8 gene partial sequence responsible Result SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 virus screened sequence similarity the SARS-CoV-2 the SARS-CoV-2 virus Therapeutic approach variant variants viral genome viral replication viral strain virus while wild type without affecting Wuhan [DOI] 10.1016/j.compbiomed.2022.105436 PMC 바로가기 [Article Type] Article
Epidemiology of COVID-19 Among Indigenous Populations in BrazilObservational Study Published on 2022-06-012022-10-05 Journal: Journal of racial and ethnic health disparities [Category] COVID19(2023년), SARS, 임상, [키워드] adopted age Alto Brazil carried Community Complication Coronavirus infections COVID-19 death diagnosed with COVID-19 disease District dry cough ENhance Epidemics epidemiological situation Evolution female Fever headache Health of ethnic minorities Health of indigenous people. individual Infection Isolation lack Ministry of Health Most patient observation occurred Population populations reducing reported Rio Symptom [DOI] 10.1007/s40615-021-01035-2 PMC 바로가기 [Article Type] Observational Study
LNP-CpG ODN-adjuvanted varicella-zoster virus glycoprotein E induced comparable levels of immunity with Shingrix™ in VZV-primed miceArticle Published on 2022-06-012022-10-05 Journal: Virologica Sinica [Category] 두창, 비임상, 수두, 진단, 홍역, [키워드] adjuvant adopted Affect approved AS01B carriers CD4+ T cell Cell-mediated immunity Cell-mediated immunity (CMI) CMI comparable component COVID-19 mRNA vaccine CpG CpG oligodeoxynucleotide (CpG ODN) Efficacy ELISA enzyme-linked immunosorbent FDA hepatitis B herpes zoster Humoral immunity IFN-γ IgG antibody IL-2 Immunity Latent Lipid nanoparticle Lipid nanoparticle (LNP) LNP mice MOST motif number preclinical study proportion secreting splenocyte subunit Subunit vaccine T helper Th1 Vaccine Varicella zoster virus (VZV) virus virus glycoprotein [DOI] 10.1016/j.virs.2022.06.002 [Article Type] Article
Detection of SARS-CoV-2 RNA in wastewater and importance of population size assessment in smaller cities: An exploratory case study from two municipalities in Latvia폐수 내 SARS-CoV-2 RNA 검출 및 소도시 인구 규모 평가의 중요성: 라트비아의 두 지방 자치 단체의 탐색적 사례 연구Article Published on 2022-06-012022-09-11 Journal: The Science of the total environment [Category] Coronavirus, COVID19(2023년), SARS, 치료기술, [키워드] 5-HIAA 5-hydroxyindoleacetic acid Accuracy adopted Analysis approach copy number COVID-19 COVID-19 outbreak COVID-19 pandemic crisis management cumulative cumulative incidence ddPCR detection disease Disease prevalence epidemiological situation Epidemiology estimation exploratory Factors hydroxyindoleacetic acid IMPROVE incidence Latvia less management measure mobile phone mobile phone data Mobility moderate outcome population movement Population size Precipitation Prevalence SARS-CoV-2 SARS-CoV-2 RNA significantly the disease wastewater WBE [DOI] 10.1016/j.scitotenv.2022.153775 PMC 바로가기 [Article Type] Article
A Model for Highly Fluctuating Spatio-Temporal Infection Data, with Applications to the COVID EpidemicCOVID 전염병에 대한 적용과 함께 변동이 심한 시공간 감염 데이터에 대한 모델Article Published on 2022-05-302022-09-11 Journal: International Journal of Environmental Research an [Category] COVID19(2023년), SARS, 변종, [키워드] adaptive adopted Alpha variant alternation application autoregressive case study coefficient COVID Endemic endemicity England Epidemic expected feature Fluctuating followed by implication Infection infection level infection levels London Metrics Model Poisson model regime-switching short term spatio-temporal spillover Spread the epidemic transformations [DOI] 10.3390/ijerph19116669 PMC 바로가기 [Article Type] Article
Single-cell transcriptome profiling of the immune space-time landscape reveals dendritic cell regulatory program in polymicrobial sepsis면역 시공간 환경의 단일 세포 전사체 프로파일링은 다균성 패혈증에서 수지상 세포 조절 프로그램을 보여줍니다Article Published on 2022-05-292022-09-11 Journal: Theranostics [Category] 치료제, [키워드] activated adopted alteration Analysis applied available data Cancer canonical CD4 cDCs characterized co-cultured comprehensive view conserved COVID-19 patients Cytometry demonstrated dendritic dendritic cell dendritic cells described determined by dissect experiment experiments expression Flow flow cytometry generate Genes heterogeneity Host immune response hyperinflammation identify IFNGR2 immune Immune cell immune cell types immune cells immunofluorescence Immunosuppression indicated inhibitory initiated Intracellular majority maturation morbidity multiplex immunofluorescence myeloid cells naïve natural killer observation organ dysfunction pathway Pathways progression promoted protein level Puncture rationale Regulatory regulatory T cells reveal scRNA-seq ScRNA-seq analysis Sepsis septic septic patients signaling pathway single-cell single-cell analysis Single-cell RNA sequencing specific type staining STAT3 subset T cell T cells tissue tissue sites Transcriptome unique upregulation [DOI] 10.7150/thno.72760 PMC 바로가기 [Article Type] Article
Implementation of the ERAS (Enhanced Recovery After Surgery) protocol for hysterectomy in the Piedmont Region with an audit&feedback; approach: Study protocol for a stepped wedge cluster randomized controlled trial. A study of the EASY-NET project감사 및 피드백과 함께 Piedmont 지역의 자궁절제술을 위한 ERAS(수술 후 회복 강화) 프로토콜 구현 접근 방식: 계단형 쐐기형 클러스터 무작위 대조 시험을 위한 연구 프로토콜. EASY-NET 프로젝트 연구Article Published on 2022-05-272022-09-11 Journal: PLoS ONE [Category] 임상, [키워드] activate adopted all the patients approach approved assigned changes in Clinical outcome Clinical studies clinical study clinically Cluster Committee Compliance complications Controlled trial COVID-19 pandemic detect effect size endpoints enhanced ERAS ethical committee expected four groups healthcare hospital Hospital stay Hospitalized Hysterectomy implementation Intervention involved LOS management multicenter outcome Patient peer-reviewed Piedmont positive Primary outcome promote protocol provide Randomized controlled trial randomized trial Randomly reduce reduction Region Result Sample size Satisfaction secondary Secondary outcomes selected Statistical power stratified Stress stress response Study protocol surgery surgical Surgical stress the patient Volume women [DOI] 10.1371/journal.pone.0268655 PMC 바로가기 [Article Type] Article
Discovery of new drug indications for COVID-19: A drug repurposing approachCOVID-19에 대한 신약 적응증의 발견: 약물 용도 변경 접근Article Published on 2022-05-242022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 신약개발, 진단, 치료제, [키워드] addition adopted Analysis anti-SARS-CoV-2 antiviral activity approach approved Baricitinib benefit binding energy calculated candidate drugs carried caused Cluster cluster analysis Clustering Combination Compound coronavirus demonstrated Dexamethasone docking result docking results docking study Doxorubicin drug drugs effective embedding Final generate generic drugs Health help in-silico In-vitro indication Interaction likelihood measure optics Ordering outbreak outlier performed Point PubChem public health Remdesivir Research Safety measures SARS-CoV-2 similarity stochastic Structure suggested Symptom Target genes therapy unique utility [DOI] 10.1371/journal.pone.0267095 PMC 바로가기 [Article Type] Article
Explorative-descriptive study on the effects of COVID-19 on access to antiretroviral therapy services: the case of a teaching hospital in GhanaCOVID-19가 항레트로바이러스 치료 서비스에 대한 접근에 미치는 영향에 대한 탐색-기술적 연구: 가나의 한 교육 병원 사례Article Published on 2022-05-242022-09-11 Journal: BMJ Open [Category] 치료제, [키워드] acceptability Accessibility accommodation addressed adopted affected affecting AIDS Analysis antiretroviral Antiretroviral therapy Antiretrovirals ART Cape Care clinic visit coast contracting the virus COVID-19 COVID-19 pandemic Data analysis Data collection deficiencies deficiency delivery Effect facility Health Health services health worker healthcare HIV HIV & hospital impacted indicated intervals Intervention knowledge Organisation of health services pandemic participant Perspective PLWH protocols Public public health qualitative research recorded remained reported resources service Strategy Teaching technique the patient Thoma Thomas was done with HIV [DOI] 10.1136/bmjopen-2021-056386 PMC 바로가기 [Article Type] Article
The assistance gaps in combating COVID-19 in Brazil: for whom, where and when vaccination occurs브라질의 COVID-19 퇴치를 위한 지원 격차: 예방 접종이 누구를 위해, 어디서, 언제 발생합니까?Article Published on 2022-05-172022-09-11 Journal: BMC Infectious Diseases [Category] COVID19(2023년), SARS, 치료기술, [키워드] adopted age analysed Analysis AstraZeneca Brazil calculated carried Cluster Clusters combating Complete CoronaVac country Coverage COVID-19 COVID-19 pandemic COVID-19 pandemics deaths detect dose epidemiological Evolution expected Final first dose followed by group groups healthcare worker Healthcare workers highest highlight identify immunisation Immunisation programs indicated Kernel lowest number of infected occur P-value pandemic performed Point Poisson Population Prevent Probability Region regions second dose Social vulnerability Spatial analysis Temporal Temporal analysis the vaccine vaccination vaccination coverage vaccination rate vaccination rates vaccination schedule Vaccine was performed [DOI] 10.1186/s12879-022-07449-5 PMC 바로가기 [Article Type] Article