Understanding the impact of interruptions to HIV services during the COVID-19 pandemic: A modelling studyResearch Paper Published on 2020-07-312022-10-31 Journal: EClinicalMedicine [Category] COVID-19, [키워드] accompanied affected antiretroviral Antiretroviral therapy ART assumption caused country COVID-19 COVID-19 pandemic death deaths determine disrupt element finding FIVE foundation funding HIV increase in increases in individual infections male mathematical Mathematical modelling Melinda Gate Mortality nine outcome pandemic Prophylaxis reduced social distancing South Africa sub-Saharan Africa Treatment Uganda understanding widespread Zimbabwe [DOI] 10.1016/j.eclinm.2020.100483 PMC 바로가기 [Article Type] Research Paper
Pre-exposure prophylaxis with hydroxychloroquine for high-risk healthcare workers during the COVID-19 pandemic: A structured summary of a study protocol for a multicentre, double-blind randomized controlled trialLetter Published on 2020-07-292022-10-29 Journal: Trials [Category] COVID-19, SARS, [키워드] 1:1 acute respiratory syndrome Adults adverse event antiretroviral Antiviral Arm Barcelona blinded Blood Breastfeeding Chloroquine condition confirmed case confirmed COVID-19 case Contact Control control group Controlled clinical trial coronavirus coronavirus disease Corticosteroid COVID-19 declining defined develop disease dissemination double-blind double-blinded Efficacy element eligibility Epidemic equipment evaluate Follow-up group healthcare worker Healthcare workers high risk hospital Hydroxychloroquine hydroxychloroquine treatment identify incidence Infection Intervention intervention group investigator marker multicentre National number Nurse objective Occurrence Older outcome participant Participants PCR physical Placebo placebo tablet polymerase chain positive PCR PPE pre-exposure predict predictor Pregnancy primary endpoint Prophylaxis protocol random randomisation randomised randomised controlled trial Randomized Randomized controlled trial Rapid diagnostic test RDT reached receive recruited reducing Registered Repository Research risk Sample size SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 PCR Secondary endpoints Seroconversion serological serology serum sample Spain Spanish Standard of care status Study protocol Symptom Tablet the placebo group the SARS-CoV-2 Treatment Trial website with COVID-19 [DOI] 10.1186/s13063-020-04621-7 PMC 바로가기 [Article Type] Letter
Rampant C→U Hypermutation in the Genomes of SARS-CoV-2 and Other Coronaviruses: Causes and Consequences for Their Short- and Long-Term Evolutionary TrajectoriesResearch Article Published on 2020-06-242022-10-30 Journal: mSphere [Category] COVID-19, SARS, [키워드] acute respiratory syndrome adaptive Amino acid amino acid change Analysis antiretroviral Antiviral APOBEC cause change comparable Complete consequence coronavirus COVID-19 curated Defense directional driven by Effect event Evidence Evolution Frequency G+C content Genome HCoV-NL63 Host host cell hosts human coronavirus hypermutation implication initial Intensive mechanism Middle East Molecular epidemiology motif Mutation Neutral normalized nucleotide occurred Occurrence Other other coronavirus pandemic proportion Proteins provide SARS SARS coronavirus 2 SARS-CoV SARS-CoV-2 SARS-CoV-2 sequence SARS-CoV-2 variant sequence Spread substitutions syndrome virus widespread [DOI] 10.1128/mSphere.00408-20 PMC 바로가기 [Article Type] Research Article
Adding Colchicine to the Antiretroviral Medication – Lopinavir/Ritonavir (Kaletra) in Hospitalized Patients with Non-Severe Covid-19 Pneumonia: A Structured Summary of a Study Protocol for a Randomized Controlled TrialLetter Published on 2020-06-052022-10-29 Journal: Trials [Category] Coronavirus, SARS, [키워드] 1:1 added Adding anti-inflammatory effect Antibiotics anticipated antioxidant antioxidants antiretroviral blinded both group CDC center change Clinical course Clinical improvement Colchicine component Consensus Controlled COVID-19 COVID-19 infection COVID-19 patients digoxin dissemination dosage double blind double-blind study element enrolled equation estimate Final GFR glomerular filtration rate group help Hospital stay hospitalized COVID-19 patients hypersensitivity hypoxic in both group infected with COVID-19 Inflammation inflammatory disorders Inpatient interleukin-8 intubation invasive Iran Kaletra kidney transplant recipients Lopinavir/ritonavir lung Lung CT MDA mechanism Minerals Nasopharyngeal swab National number objective outcome oxidative stress Oxygenation pandemic parallel group participant pathologic pathway Patient patients percentage Pneumonia positive Prospective protocol QTc randomised randomised controlled trial randomization Randomized Rate Ratio receive recruited recruitment reducing reduction Registered RT -PCR Sample size serum creatinine status Tehran time tomography Trace element treat treated Treatment two group two groups Vitamin website WHO guideline with COVID-19 [DOI] 10.1186/s13063-020-04455-3 PMC 바로가기 [Article Type] Letter
What does the COVID-19 pandemic mean for HIV, tuberculosis, and malaria control?Short Report Published on 2020-05-132022-10-28 Journal: Tropical Medicine and Health [Category] COVID-19, [키워드] accompanied Acquired Africa age Analysis antiretroviral Care children clinical feature complex coronavirus disease country COVID-19 COVID-19 cases COVID-19 pandemic curative death disease dose drug Drug efficacy drugs Epidemic epidemic disease epidemiological Evidence Health health systems HIV Human immunodeficiency virus implication include malaria measure Medicines Patient Population pregnant women Prophylactic PROTECT reduced regions response retrieved similarity substandard Support Treatment Tuberculosis with HIV [DOI] 10.1186/s41182-020-00219-6 PMC 바로가기 [Article Type] Short Report
Efficacy and safety of lower dose tenofovir disoproxil fumarate and efavirenz versus standard dose in HIV-infected, antiretroviral-naive adults: a multicentre, randomized, noninferiority trialHIV 감염, 항레트로바이러스 경험이 없는 성인에서 표준 용량 대비 저용량 테노포비르 디소프록실 푸마르산염 및 에파비렌즈의 효능 및 안전성: 다기관, 무작위, 비열등성 시험Article Published on 2020-05-042022-09-06 Journal: Emerging Microbes & Infections [Category] Communicable Disease, [키워드] 95% CI adverse event adverse events antiretroviral ARV assigned change comparable dose drug efavirenz Efficacy evaluate filtration rate fumarate glomerular filtration rate HIV HIV-1 HIV-1 infection infected patients initial intention-to-treat analysis lamivudine low dose lower dose lower toxicity multicentre non-inferiority non-inferiority margin non-inferiority trial occurred Open-label participant primary endpoint proportion Randomized Randomly receive receiving reduced regimen safety profile Standard dose Support tenofovir tenofovir disoproxil tenofovir disoproxil fumarate therapy Toxicity Treatment treatment difference Trial two groups [DOI] 10.1080/22221751.2020.1752609 PMC 바로가기 [Article Type] Article
Epidemiologic Features and Clinical Course of Patients Infected With SARS-CoV-2 in SingaporeResearch Published on 2020-04-212022-11-01 Journal: JAMA [Category] COVID-19, SARS, [키워드] acute respiratory syndrome antiretroviral Blood case sery China clinical clinical feature Clinical features Clinical outcome collected Confirmed coronavirus coronavirus disease Course COVID-19 deaths detectable diagnosed diarrhea exposure Features Fever Final finding Follow-up hospital hospitalized patient human-to-human transmission Importance individual Infection initial intensive care Laboratory Liver function Lopinavir-ritonavir management measure median age mild respiratory Nasopharyngeal swab nasopharynx nausea objective outbreak outcome oxygen participant Patient patients patients treated PCR PCR cycle PCR-confirmed Point polymerase chain progressive respiratory failure prolonged viral shedding radiologic Relevance required requiring supplemental oxygen resolved respiratory tract infection Result SARS-CoV-2 SARS-COV-2 infection setting Singapore Spread Stool supplemental oxygen sustained threshold value treated Treatment upper respiratory tract Urine viral shedding vomiting was reduced women Wuhan, China [DOI] 10.1001/jama.2020.3204 PMC 바로가기 [Article Type] Research
Systematic review of the efficacy and safety of antiretroviral drugs against SARS, MERS or COVID‐19: initial assessmentReview Published on 2020-04-012022-10-31 Journal: Journal of the International AIDS Society [Category] COVID-19, SARS, [키워드] antiretroviral antiretroviral drug Antiretroviral therapy Antiretrovirals benefit caused certainty of evidence Clinical improvement Clinical outcome clinical trials control group coronavirus COVID‐19 COVID‐19 database Efficacy and safety Evidence high risk HIV improve clinical outcome Infection initial limited sample size MERS Mortality observational study outcome outcomes Patient patients with SARS Prevent Prophylaxis protective effect provided Randomized randomized trial receive reported Result SARS SARS‐CoV‐2 screened Standard of care statistically significant statistically significant difference Symptom the disease treated Treatment Trial [DOI] 10.1002/jia2.25489 PMC 바로가기 [Article Type] Review
Predicting commercially available antiviral drugs that may act on the novel coronavirus (SARS-CoV-2) through a drug-target interaction deep learning modelCommunications Published on 2020-03-302022-10-31 Journal: Computational and Structural Biotechnology Journal [Category] COVID-19, [키워드] addition antiretroviral Antiviral agents antiviral drug Atazanavir China complex component coronavirus COVID-19 deep learning drug Drug repurposing drug-target effective HIV Human immunodeficiency virus identify incidence rate Infection inhibit SARS-CoV-2 inhibitory potency Interaction Kaletra lack medication molecule MT-DTI Novel coronavirus predicted Prevent proteinase Remdesivir Replication Ritonavir SARS-CoV-2 target tested the SARS-CoV-2 treat Treatment treatment strategy Viral protein was used Wuhan [DOI] 10.1016/j.csbj.2020.03.025 PMC 바로가기 [Article Type] Communications
GOT SHINGLES? TEST FOR HIV. Severe shingles as first presenting infection in HIV/AIDS patientArticle Published on 2020-02-202024-09-04 Journal: IDCases [Category] 대상포진, [키워드] antiretroviral cutaneous infection Diagnosis herpes zoster HIV Screening [DOI] 10.1016/j.idcr.2020.e00725 PMC 바로가기 [Article Type] Article