Zinc pyrithione is a potent inhibitor of PL Pro and cathepsin L enzymes with ex vivo inhibition of SARS-CoV-2 entry and replication아연 피리티온은 SARS-CoV-2 진입 및 복제를 생체 외에서 억제하는 PL Pro 및 카텝신 L 효소의 강력한 억제제입니다.Article Published on 2022-12-012022-09-11 Journal: Journal of Enzyme Inhibition and Medicinal Chemist [Category] COVID19(2023년), SARS, 치료제, [키워드] analogue Anti-SARS-CoV-2 Activity Antiviral antiviral activity Antiviral agents assays cathepsin L comparable complex complexes contrary COVID-19 effective enzyme Enzymes evaluated Ex vivo expressed human lung tissue in vitro inhibition inhibitor involved Ligand media Pro pyrithione Replication ruthenium SARS-CoV-2 SARS-CoV-2 entry stability synthesised therapeutic therapeutic agent Zinc Zinc complexes Zinc pyrithione [DOI] 10.1080/14756366.2022.2108417 PMC 바로가기 [Article Type] Article
Identification of Small Molecules with Improved Potency against Orthopoxviruses from Vaccinia to SmallpoxArticle Published on 2022-11-152023-06-10 Journal: Antimicrobial Agents and Chemotherapy [Category] Fulltext, 원숭이두창, [키워드] Antiviral agents Chemical synthesis Chemistry poxvirus [DOI] 10.1128/aac.00841-22 PMC 바로가기
Reemergence of monkeypox: prevention and managementReview Published on 2022-11-012023-06-09 Journal: Expert review of anti-infective therapy [Category] 원숭이두창, [키워드] antibodies Antiviral agents Herbs Monkeypox Therapeutics Vaccines [DOI] 10.1080/14787210.2022.2128763 [Article Type] Review
Randomised controlled trial: effect of metformin add-on therapy on functional cure in entecavir-treated patients with chronic hepatitis BRandomized Controlled Trial Published on 2022-11-012023-06-12 Journal: Annals of hepatology [Category] B형 간염, [키워드] Antiviral agents clinical trial Hepatitis B surface antigens Hepatitis B virus Immunotherapy [DOI] 10.1016/j.aohep.2022.100745 [Article Type] Randomized Controlled Trial
Harnessing the Therapeutic Potential and Biological Activity of Antiviral PeptidesArticle Published on 2022-10-192023-07-10 Journal: Chembiochem [Category] COVID19(2023년), [키워드] Antiviral agents drug design peptides peptidomimetics viruses [DOI] 10.1002/cbic.202200415
Discovery of potent benzoxaborole inhibitors against SARS-CoV-2 main and dengue virus proteasesSARS-CoV-2 주요 및 뎅기 바이러스 프로테아제에 대한 강력한 벤족사보롤 억제제의 발견Article Published on 2022-10-052022-09-11 Journal: European journal of medicinal chemistry [Category] COVID19(2023년), SARS, 치료제, [키워드] antiviral agent Antiviral agents biochemical assay Cell Cell culture class contribute cytotoxicity demonstrated Dengue dengue virus DENV-2 Drug development evaluated had no Health inhibit inhibitor M pro membrane MOST penetration protease Proteases Replication RNA virus RNA viruses SARS-CoV-2 stability synthesis target targets [DOI] 10.1016/j.ejmech.2022.114585 PMC 바로가기 [Article Type] Article
Care for adults with COVID-19: living guidelines from the National COVID-19 Clinical Evidence TaskforceArticle Published on 2022-10-032022-11-15 Journal: The Medical journal of Australia [Category] COVID19(2023년), SARS, 진단, [키워드] Analysis anticoagulation Antiviral agents Baricitinib benefit change clinical clinical trial Combination coronavirus disease Corticosteroids COVID-19 disease disease severity drug treatment eight Endotracheal intubation Evidence facilitated Health include Inhaled maintain management Mild molnupiravir nine Patient people with COVID-19 positive airway pressure Primary Health Care prone positioning Prophylactic Prophylaxis Public public health randomised recommendation recommendations Remdesivir Respiratory Support sarilumab subsequent supplemental oxygen Support supportive care systemic corticosteroids therapy Tocilizumab Treatment trials Venous Thromboembolism with COVID-19 [DOI] 10.5694/mja2.51718 PMC 바로가기
Recent clinical findings on the role of kinase inhibitors in COVID-19 managementCOVID-19 관리에서 키나제 억제제의 역할에 대한 최근 임상 결과Review Published on 2022-10-012022-09-11 Journal: Life sciences [Category] 변종, 신약개발, 임상, 치료제, [키워드] activator affected alleviate Anti-inflammatory anti-viral effects antiviral agent Antiviral agents BTK clinical evidence Clinical finding Clinical practice clinical trial Complication complications Consequences coronavirus disease COVID-19 COVID-19 patient COVID-19 patients CRS cytokine release storm drug Efficacy glycogen synthase GSK-3 highly pathogenic inhibitor inhibitors JAK/STAT janus Janus kinase kinase Kinase inhibitor kinase inhibitors kinases management MAPK Novel coronavirus novel coronavirus disease outbreak p38 MAPK pandemic paradigm shift performed pharmacological pharmacological intervention protein kinase recent Signaling STAT therapy Transcription trials Viral load [DOI] 10.1016/j.lfs.2022.120809 PMC 바로가기 [Article Type] Review
Hepatitis B e antigen and e antibody in a multi-ethnic cohort of adult chronic hepatitis B virus patients followed at a single liver unit for a period of 20 yearsArticle Published on 2022-10-012023-06-11 Journal: Journal of viral hepatitis [Category] B형 간염, [키워드] Antiviral agents HBeAg HBsAg hepatitis B [DOI] 10.1111/jvh.13731
Virtual screening and molecular dynamics simulation for identification of natural antiviral agents targeting SARS-CoV-2 NSP10Short communication Published on 2022-10-012022-10-05 Journal: Biochemical and Biophysical Research Communication [Category] COVID19(2023년), SARS, 치료제, [키워드] Analysis Antiviral agents binding binding energy calculated Candidates complexes Compound COVID-19 docking enzymatic activity global pandemic inhibitor Interaction molecular dynamics Molecular dynamics simulation natural antiviral New nsp10 Protein RNA replication SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 viral selected stimulate suggested Vaccine Vaccine development Variation Virtual screening was performed ZINC database [DOI] 10.1016/j.bbrc.2022.08.029 [Article Type] Short communication