Type I Interferon Induction and Exhaustion during Viral Infection: Plasmacytoid Dendritic Cells and Emerging COVID-19 Findings바이러스 감염 중 I 형 인터페론 유도 및 피로Review Published on 2021-09-152022-09-10 Journal: Viruses [Category] SARS, 바이오마커, [키워드] 2019 coronavirus disease antiviral cytokine antiviral cytokines antiviral immunity Autoimmunity breadth compromise coronavirus coronavirus disease COVID-19 cytokine Cytokines DCs dendritic cell dendritic cells Exhaustion family favor finding focus HBV HCV HIV-1 IFN-I immunopathology induce induction Infection Influenza innate response interferons isoform LCMV less mechanism opportunistic Infections pandemic pDC pDCs plasmacytoid dendritic cells producing reduced referred to SARS-CoV-2 secrete Stimulation susceptibility sustained Type type I interferons Viral viral infection viral persistence viral replication while [DOI] 10.3390/v13091839 PMC 바로가기 [Article Type] Review
COVID-19 vaccines: Current evidence and considerationsArticles from the Vaccines, Immune Response, Therapeutic Interventions and COVID-19 Special Issue Published on 2021-09-112022-10-04 Journal: Metabolism Open [Category] 변종, [키워드] 2019-nCoV vaccines adverse effects age Allergic reactions anaphylaxis antiviral immunity approved blood clot children coronavirus disease COVID-19 COVID-19 vaccination COVID-19 vaccine COVID-19 vaccines current Delta distribution dosage dose effective Efficacy elicited Emergency use Evidence Gender Health impacts Inflammation Lambda less limitation pandemic pregnant women risk Safe SARS-CoV-2 vaccine shown Side effects Transport vaccination Vaccine variant variants [DOI] 10.1016/j.metop.2021.100124 PMC 바로가기 [Article Type] Articles from the Vaccines, Immune Response, Therapeutic Interventions and COVID-19 Special Issue
Metabolic requirements of NK cells during the acute response against retroviral infectionArticle Published on 2021-09-102022-10-29 Journal: Nature Communications [Category] Coronavirus, SARS, [키워드] acute response acute viral infection alteration Amino acid amino acid transporter Antimicrobial responses Antiviral antiviral activity antiviral immunity Cancer Cell change deficiency dysfunction Effect Friend functions Glycolysis HIV Immune cell implication Infection infections Innate lymphoid cells metabolic metabolism mitochondrial metabolism natural NK cell NK cell response NK cell responses NK cells obesity Responder Retroviral infection retrovirus SARS-CoV-2 Signal transduction Specific Transport viral infection viral infections viral loads [DOI] 10.1038/s41467-021-25715-z PMC 바로가기 [Article Type] Article
Resveratrol as an Adjunctive Therapy for Excessive Oxidative Stress in Aging COVID-19 PatientsReview Published on 2021-09-092022-10-28 Journal: The Cochrane database of systematic reviews [Category] COVID-19, [키워드] accelerate accompanied Adaptive immune response Adaptive immunity age aging antioxidant antioxidants antiviral activity antiviral immunity Asymptomatic Comorbidities coronavirus disease COVID-19 COVID-19 symptom Cytokine storm deficiency dendritic cell determinant disease distress dysregulation Elderly patient Healthcare system heterogeneous Illness severity immune function Immunosuppression Infection Inflammation Inflammatory inflammatory immune response inhibiting viral replication Innate immunity interferon Macrophage Mild molecular mechanism outcomes oxidative oxidative stress pandemic pathophysiological progression response resulting resveratrol risk SARS-CoV-2 SARS-COV-2 infection Sex Symptoms the patient Treatment viral infections [DOI] 10.3390/antiox10091440 PMC 바로가기 [Article Type] Review
Role of neutrophils in acute viral infectionReview Article Published on 2021-09-022022-10-30 Journal: Immunity, Inflammation and Disease [Category] COVID-19, [키워드] activate acute viral infection acute viral infections Adaptive immune response Antiviral antiviral immunity Cell Characteristics COVID‐19 Cytokines degranulation diffusion eliminating function neutrophil Neutrophil extracellular trap Neutrophil extracellular traps Neutrophils outcomes pathological role phagocytosis Protective provide restrict viral replication role secretion tissue damage viruses [DOI] 10.1002/iid3.500 PMC 바로가기 [Article Type] Review Article
Pathogenesis and treatment of cytokine storm in COVID-19Article Published on 2021-08-302022-10-29 Journal: Turkish Journal of Biology [Category] COVID-19, [키워드] acute respiratory distress syndrome acute respiratory syndrome Anakinra antiviral agent antiviral immunity blocker caused Clinical course Clinical findings Clinical symptoms Complication coronavirus Corticosteroids COVID-19 cytokine response Cytokine storm death Diagnosis diagnosis of COVID-19 distress hyperinflammatory state IL-1 IL-6 blockers immunomodulatory drug immunosuppressive inhibit SARS-CoV-2 Insufficient Laboratory tests main mechanism Measures mechanism organ damage Pathogenesis pathogenesis of COVID-19 Patient persistence reduce Replication resulting SARS-CoV-2 suggested syndrome systemic inflammation the cytokine storm Tocilizumab treated Treatment viral clearance viral infection [DOI] 10.3906/biy-2105-37 PMC 바로가기 [Article Type] Article
AHR signaling is induced by infection with coronavirusesArticle Published on 2021-08-262022-10-04 Journal: Nature Communications [Category] MERS, SARS, 치료제, [키워드] activate activated Activation AhR Analysis antagonist antiviral immunity antiviral response antiviral therapy Aryl hydrocarbon receptor association boost common cold contribute coronavirus Coronaviruses COVID-19 pandemic COVID-19 patients decrease Dengue epithelial cell evade evaluate expression Future HCoV-229E Host Human illnesses immune response in vitro in vivo increased expression Infection Infectious diseases life-threatening limit Lung epithelial cells Lung pathology lung tissue Medical research Mild pathology pharmacological promote Replication Respiratory failure respiratory tract restrict RNA viruses SARS-CoV-2 SARS-CoV-2 infected patients SARS-CoV-2 replication severity Signaling single-cell RNA-seq suppressed targets transcriptional Viral load viral replication viral titer Zika [DOI] 10.1038/s41467-021-25412-x PMC 바로가기 [Article Type] Article
Lacticaseibacillus paracasei DG enhances the lactoferrin anti-SARS-CoV-2 response in Caco-2 cellsLacticaseibacillus paracasei DG는 Caco-2 세포에서 락토페린 항-SARS-CoV-2 반응을 향상시킵니다Brief Report Published on 2021-08-072022-09-11 Journal: Gut Microbes [Category] 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected anti-SARS-CoV-2 Anti-SARS-CoV-2 Activity Antiviral antiviral immunity Caco-2 Caco-2 cell cell line Combination coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 distress ENhance epithelial epithelial cells exhibit expression expression of gene gastrointestinal tract global pandemic immune immunomodulatory effect immunomodulatory effects in vitro inhibited intestinal intestinal epithelial cells investigated involved lactobacilli lactoferrin lead microorganism microorganisms prevented Probiotics proinflammatory gene proinflammatory genes Prophylactic Protective respiratory respiratory distress SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infection in vitro shown significantly Strains Symptom triggered [DOI] 10.1080/19490976.2021.1961970 PMC 바로가기 [Article Type] Brief Report
Multipotent Stromal Cells and Viral Interaction: Current Implications for TherapyArticle Published on 2021-08-042022-10-28 Journal: Stem cell reviews and reports [Category] COVID-19, [키워드] animal model antiviral immunity antiviral property clearance conditions current Effect human clinical trial immune response immunomodulatory properties implementation less maintain mesenchymal stem cell MSC MSC therapy MSCs Multipotent stromal cells pathogen clearance recent stromal cell susceptibility therapy viral disease Viral diseases viral replication virus infection Virus interaction [DOI] 10.1007/s12015-021-10224-9 PMC 바로가기 [Article Type] Article
Rapid and Flexible Platform To Assess Anti-SARS-CoV-2 Antibody Neutralization and Spike Protein-Specific AntiviralsAnti-SARS-CoV-2 항체 중화 및 스파이크 단백질 특이적 항바이러스제를 평가하기 위한 신속하고 유연한 플랫폼Research Article Published on 2021-07-282022-09-10 Journal: mSphere [Category] MERS, SARS, 변종, 진단, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus addition antibody Antiviral antiviral immunity approach Assessing binding biosafety biosafety level BSL2 BSL3 caused cDNA Cell Community complement condition conditions coronavirus COVID-19 pandemic evaluated flexible genetic information glycoprotein human sera human serum Immunity Infection level 2 MONITOR natural infection neutralization Neutralizing pandemic platform population immunity positive sample protocol pseudotyped Rapid respiratory Safe SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 spike protein screened sera shown spike Spike protein vaccination Vaccines variants variants of concern Viral viral envelope virus Virus neutralization virus-neutralizing viruses [DOI] 10.1128/mSphere.00571-21 PMC 바로가기 [Article Type] Research Article