Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine: a pooled analysis of four randomised trials
단회 투여 및 ChAdOx1 nCoV-19(AZD1222) 백신의 면역원성 및 효능에 대한 추가 투여 시간의 영향: 4건의 무작위 시험에 대한 통합 분석
Meta-Analysis
[키워드] 1:1
95% CI
addition
administration
Ageusia
All participants
Analysis
Anosmia
antibody
antibody levels
Antibody Response
Antibody responses
approved
assigned
AstraZeneca
AZD1222
baseline
binding antibody
booster dose
booster doses
Brazil
category
ChAdOx1
ChAdOx1 nCoV-19
Clinical research
Coalition
control group
control vaccine
cough
COV005
COVID-19
COVID-19 disease
COVID-19-related death
Cutoff
death
defined
described
dose
doses
double-blind
Efficacy
Emergency use
Endpoint
Evidence
evidence of
exclusion
exploratory
Exploratory analyses
Exploratory analysis
Fever
finding
first dose
FIVE
Follow-up
for inclusion
foundation
funding
geometric mean
geometric mean ratio
GMR
had no
Hospital admission
immunoassay
immunogenicity
immunogenicity data
independent
indicated
individual
Infection
initial
Innovation
interim analysis
ISRCTN89951424
less
lower dose
Medicine
Medicines
Medicines and Healthcare products Regulatory Agency
Melinda Gate
Melinda Gates
N protein
NAAT
NAAT-positive swab
network
neutralisation
NIHR
no evidence of
nucleic acid
nucleic acid amplification
nucleic acid amplification test
observation
offered
Older
outcomes
Oxford
pandemic
participant
phase 2/3
phase 3 study
positive swab
primary analysis
primary endpoint
Primary outcome
prime-boost interval
priming
PROTECT
pseudovirus
randomised controlled
Randomised trial
Randomly
receive
receiving
recruited
regimen
Registered
regulatory authority
response
Safety
saline placebo
SARS-COV-2 infection
SARS-CoV-2 N protein
second dose
secondary
Serious Adverse Events
seronegative
Seven
Shortness of breath
single-blind
Single-dose
South
South Africa
Standard dose
subset
supported
Swab
swabs
Symptom
symptomatic COVID-19 disease
symptomatic infection
Telle
the primary endpoint
the timing
the vaccine
Trial
vaccination
Vaccine
vaccine efficacy
Valley
Viral
Viral particles
[DOI] 10.1016/S0140-6736(21)00432-3 PMC 바로가기 [Article Type] Meta-Analysis
[DOI] 10.1016/S0140-6736(21)00432-3 PMC 바로가기 [Article Type] Meta-Analysis