Bronchoalveolar lavage in suspected COVID-19 cases with a negative nasopharyngeal swab: a retrospective cross-sectional study in a high-impact Northern Italy areaArticle Published on 2021-10-012023-06-19 Journal: Internal and Emergency Medicine [Category] MERS, [키워드] Bronchoalveolar lavage bronchoscopy Chest computed tomography Coronavirus infections interstitial pneumonia Pandemics [DOI] 10.1007/s11739-021-02714-y PMC 바로가기
mRNA-1273 protects against SARS-CoV-2 beta infection in nonhuman primatesmRNA-1273은 비인간 영장류의 SARS-CoV-2 베타 감염으로부터 보호합니다Article Published on 2021-10-012022-09-11 Journal: Nature Immunology [Category] MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 airway Antibody neutralization Antibody titers B.1.351 B.1.617.2 Bronchoalveolar lavage coronavirus Critical dose groups immunization Infection inhibitory live SARS-CoV-2 Moderna mRNA mRNA-1273 mRNA-1273 vaccine nasal swab nasal swabs neutralization Neutralizing antibody titer neutralizing response PROTECT reduction reduction in Replication respiratory RNA SARS-CoV-2 serum dilution severe acute respiratory syndrome Coronavirus single dose These data two-dose regimen undetectable Vaccine variant variants of concern Viral [DOI] 10.1038/s41590-021-01021-0 PMC 바로가기 [Article Type] Article
Understanding the burden of interstitial lung disease post-COVID-19: the UK Interstitial Lung Disease-Long COVID Study (UKILD-Long COVID)Interstitial Lung Disease Published on 2021-09-232022-10-28 Journal: BMJ Open Respiratory Research [Category] COVID-19, [키워드] alveolar Analysis approvals assessment biochemical breathlessness Bronchoalveolar lavage bronchoscopy clinically Community consequence COVID COVID-19 COVID-19 pandemic deaths determine dissemination dysfunction Epigenetic Ethics exploratory Factor fatigue Gene Expression Genetic Hospital admission hospitalised ILD include indicated Infection interstitial Interstitial Fibrosis Interstitial lung disease lung mitigate MRI observational study Patient patients with COVID-19 peer-reviewed platform Prevalence progression Result RNA Secondary objective Severe infection severity Single Cell Symptoms trajectory transfer understanding Whole blood xenon [DOI] 10.1136/bmjresp-2021-001049 PMC 바로가기 [Article Type] Interstitial Lung Disease
Impact of Viral Decontamination Method on Cytokine Profile of COVID-19 PatientsArticle Published on 2021-09-222022-10-28 Journal: Biomedicines [Category] COVID-19, [키워드] Affect BAL BAL fluid Bronchoalveolar lavage change chemokine chemokines Clinical practice Complete COVID-19 cytokine cytokine profile Cytokines decontamination equipment exaggerated immune response help Illness severity Impact IMPROVE inactivation Inflammation Laboratory lack live viruses morbidity and mortality occurred Patient performed precautions preserved profile progression Quantitative RT-qPCR Safety assessment Sample SARS-CoV2 specimen tested the disease Treatment ultrafiltration device UVC Vero E6 cell Viral load viral replication [DOI] 10.3390/biomedicines9101287 PMC 바로가기 [Article Type] Article
LOX-1-Expressing Immature Neutrophils Identify Critically-Ill COVID-19 Patients at Risk of Thrombotic ComplicationsImmunology Published on 2021-09-202022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, SARS, [키워드] acute respiratory distress Alpha ARDS association BAL Blood Bronchoalveolar lavage CD10 CD123 CD64 Clinical characteristics Clinical severity Complication complications COVID-19 COVID-19 patient COVID-19 severity Critical Cytokine storm Cytometry death develop disease severity expressing Factors function functions help high risk ICU ICU patient IL-1β IL-6 IL-8 immature neutrophil independent Infectious diseases Innate immunity intensive care unit invasive ventilation investigated marker neutrophil Neutrophils non-ICU patients objective oxidized pandemic Patient patients patients with ARDS PD-L1 plasma positively correlated Prognostic value proportion receptor remained Result severe COVID-19 patients severity subset syndrome thrombosis TNFα validation study [DOI] 10.3389/fimmu.2021.752612 PMC 바로가기 [Article Type] Immunology
Immune correlates of protection by mRNA-1273 vaccine against SARS-CoV-2 in nonhuman primates비인간 영장류에서 SARS-CoV-2에 대한 mRNA-1273 백신 보호의 면역 상관 관계Article Published on 2021-09-172022-09-12 Journal: Science (New York, N.y.) [Category] Fulltext, SARS, 비임상, 진단, [키워드] acute respiratory syndrome airway antibody Antibody Response Bronchoalveolar lavage can be used circulating coronavirus correlated dose dose-dependent manner Efficacy elicited Endpoint hamster humoral immune response Immunoglobulin Lower mRNA-1273 mRNA-1273 vaccine mucosal naïve nasal swab Neutralizing activity NHPs passive transfer reduced reduction Replication SARS-CoV-2 significantly vaccination Vaccine viral replication [DOI] 10.1126/science.abj0299 PMC 바로가기 [Article Type] Article
Rapid diagnosis of SARS-CoV-2 pneumonia on lower respiratory tract specimensResearch Article Published on 2021-09-082022-10-28 Journal: BMC Infectious Diseases [Category] COVID-19, SARS, [키워드] accelerate Accuracy BAL BAS Bronchoalveolar lavage Bronchoalveolar lavage (BAL) Bronchoaspirates (BAS) can be used Characteristics clinical setting collected cycle threshold Cycle threshold value demographic diagnosis of SARS-CoV-2 diagnostic diagnostic tests distribution E gene evaluate expected feasible Germany Inc. intensive care unit intensive care units IQR Italy Lower respiratory tract LRT median molecular negative NPV PCR PCR assay Pneumonia positive PPV Predictive proportion Rapid Rapid PCR Result RT-PCR RT-PCR testing Sample size SARS-CoV-2 SARS-CoV-2 pandemic sensitivity solution South Korea specificity specimen specimens table tested threshold variables Viral load viral loads was used were expressed [DOI] 10.1186/s12879-021-06591-w PMC 바로가기 [Article Type] Research Article
Longitudinal Characterization of Cytokine Overproduction: A Case Report in Critically Ill COVID-19 Patients With Hyperinflammation in Bronchoalveolar LavageMedicine Published on 2021-09-072022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] acute respiratory syndrome addition BALF biochemical parameter Blood Bronchoalveolar lavage Bronchoalveolar lavage fluid Case report Characteristics characterization clinical Clinical characteristics clinical trials collected Comorbidity coronavirus coronavirus disease COVID-19 COVID-19 case Critical Critical case critical COVID-19 patient critical COVID-19 patients Critically ill patient cytokine cytokine overproduction death demonstrated diagnosed enrolled high risk Hospitalization hyperinflammation Hyperinflammatory IL-6 Ill immunological Infection Inflammation Intervention laboratory result lavage liver longitudinal lung Nasopharyngeal swab outcome outcomes parameter pathogen Patient poor outcomes populations positive reduced report risk RT-PCR SARS-CoV-2 symptoms of COVID-19 T cell tested Therapies therapy Treatment Two patient was related [DOI] 10.3389/fmed.2021.690523 PMC 바로가기 [Article Type] Medicine
Metoprolol in Critically Ill Patients With COVID-19Randomized Controlled Trial Published on 2021-09-072022-10-05 Journal: Journal of the American College of Cardiology [Category] SARS, 신약개발, 임상, [키워드] Activated neutrophils acute care acute respiratory distress administration alleviate alveolar alveolar inflammation appear ARDS BAL baseline Bronchoalveolar lavage control group control groups control subjects coronavirus COVID COVID-19 COVID-19 pandemic COVID-19 patient COVID-19-associated ARDS evaluate the effect evaluated exacerbated groups hemodynamic Ill infiltration Inflammation intravenous invasive Invasive mechanical ventilation Lung inflammation marker metoprolol metoprolol. Myocardial infarction neutrophil Neutrophil extracellular trap not differ Oxygenation PaO Patient patients randomized Randomized reduced remained repurposing Respiratory function Safe shown Side effects significantly syndrome Treatment Trial [DOI] 10.1016/j.jacc.2021.07.003 PMC 바로가기 [Article Type] Randomized Controlled Trial
Laryngotracheal aspiration test reduce the false negative rate in patients with suspected SARS-COV-2 pneumonia despite a negative nasopharyngeal swabObservational Study Published on 2021-09-012022-10-05 Journal: European journal of internal medicine [Category] SARS, 임상, [키워드] Accuracy adverse events BAL Bronchoalveolar lavage consecutive patient COVID-19 cross-sectional definitive diagnosis diagnose diagnosed Diagnosis Emergency emergency department enrolled evaluate False negative rate false negative results feasible final diagnosis hospital hospitals Laryngotracheal aspiration limitations LTA majority Nasopharyngeal swab Negative predictive value not be collected NPs Patient patients performed Pharyngeal swab Pneumonia positive pulmonary diseases reduce reduced Safe SARS-CoV-2 specimen sputum Strategy time-consuming was performed [DOI] 10.1016/j.ejim.2021.06.019 PMC 바로가기 [Article Type] Observational Study