Malnutrition is associated with hyperinflammation and immunosuppression in COVID-19 patients: A prospective observational studyObservational Study Published on 2021-08-012022-10-05 Journal: Nutrition in clinical practice : official publicat [Category] SARS, 임상, [키워드] Admission Analysis of covariance caused CD8+ T cell Concentration contribute coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients cytokine Cytokines deaths Disease progression Effect elevated highest Hospitalization hyperinflammation IL-10 IL-4 immune response immune responses Immunosuppression incidence Inflammation Inflammatory investigated Malnutrition nutrition status Patient patients proportion prospective observational study Prospective Study recruited risk severe disease significantly lower subpopulation T-cell the patient were measured were used Whole blood [DOI] 10.1002/ncp.10679 PMC 바로가기 [Article Type] Observational Study
SARS-CoV-2 specific T cell responses are lower in children and increase with age and time after infectionSARS-CoV-2 특이적 T 세포 반응은 소아에서 더 낮고 감염 후 나이와 시간이 지남에 따라 증가합니다Article Published on 2021-07-292022-09-12 Journal: Nature Communications [Category] SARS, 진단, [키워드] adaptive Adults age antibodies B cell response baseline CD4 CD4+ CD8 CD8+ T cell CD8+ T cell response cellular immunity children comparable COVID-19 COVID-19 pathogenesis cytokine Cytokines effector memory examined follicular immune cell response immune cell responses Immunity immunological infected children Infection Inflammation less levels of antibody memory mild illness monocyte ordination ORF1ab Post-infection Protein reduced response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 protein susceptible T and B cell responses T cell T cell activation T cell response T cell responses Total viral infection β-coronavirus β-Coronaviruses [DOI] 10.1038/s41467-021-24938-4 PMC 바로가기 [Article Type] Article
Impaired humoral and cellular immunity after SARS-CoV-2 BNT162b2 (tozinameran) prime-boost vaccination in kidney transplant recipients신장 이식 환자에서 SARS-CoV-2 BNT162b2(토지나메란) 프라임-부스트 백신 접종 후 체액 및 세포 면역 손상Article Published on 2021-07-152022-09-12 Journal: The Journal of Clinical Investigation [Category] SARS, 진단, [키워드] accompanied Adaptive immunity Affect age analyzed antibody approach BNT162b2 booster caused CD4+ CD8+ T cell cellular immunity cellular response change combating Control COVID-19 cytokine production dialysis dose Frequency global pandemic healthy healthy control Hemodialysis humoral IgA IgG immune immunization immunology immunosuppressed patients Immunosuppressive medication Impaired impairment individual kidney transplant recipient less majority memory mounted mRNA-based vaccine novel organ transplantation Patient patients powerful tool promotion reduced rejection renal response responses risk SARS-CoV-2 SARS-CoV-2 BNT162b2 second vaccination Seroconversion severe COVID-19 significantly Still T cells T helper cell transplantation undetectable vaccination Vaccine-induced immunity vaccinee [DOI] 10.1172/JCI150175 PMC 바로가기 [Article Type] Article
A yeast expressed RBD-based SARS-CoV-2 vaccine formulated with 3M-052-alum adjuvant promotes protective efficacy in non-human primates3M-052-명반 보조제로 제형화된 효모 발현 RBD 기반 SARS-CoV-2 백신은 인간이 아닌 영장류에서 보호 효능을 촉진합니다Article Published on 2021-07-152022-09-12 Journal: Science Immunology [Category] Fulltext, SARS, 진단, 치료법, [키워드] accompanied accumulated adjuvants antibodies Antibody Response BAL blocked blood monocytes Bone marrow candidate CD8+ T cell Cell contrary controls correlated Decreased domain draining lymph node Efficacy expressed Frequency immune response increase in Lung inflammation MCP-1 monocyte nasal Neutralizing antibodies non-human primate plasma Plasma cell promote promoted Protective provide RBD RBD binding Reactions reduced reduction respiratory tract response rhesus macaques robust SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 virus secretion Th1 the RBD These data TLR-7/8 TRAIL Vaccine vaccine candidate Viral load viral loads yeast [DOI] 10.1126/sciimmunol.abh3634 PMC 바로가기 [Article Type] Article
Modulation of Host Immune Response Is an Alternative Strategy to Combat SARS-CoV-2 PathogenesisImmunology Published on 2021-07-082022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] ACE-2 receptor acting activated alveolar alveolar macrophage caused CD8+ T cell chemokines chemotactic combat complex COVID-19 cytokine Cytokines fusion help high mortality Host host cell Host immune response host immune system infected cells inflammatory mediator kill Local macrophages membrane Modifying Monocytes Neutrophils NK cells pandemic phagocytosis pneumocyte Pneumocytes Protein receptor reduce replicate response RTC SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2virus secreting Spike protein Strategy the disease therapeutic targets TMPRSS2 translated type-2 pneumocyte viral life cycle viral membrane Viral RNA virus [DOI] 10.3389/fimmu.2021.660632 PMC 바로가기 [Article Type] Immunology
SARS-CoV-2-specific immune response in COVID-19 convalescent individualsCOVID-19 회복기 개인의 SARS-CoV-2 특이 면역 반응Article Published on 2021-07-072022-09-12 Journal: Signal Transduction and Targeted Therapy [Category] 진단, 치료기술, [키워드] Activation affected Analysis Antigen Blood CD8+ T cell cell count cell counts cellular immunity Cohort collected convalescent individual convalescent individuals coronavirus disease Coronavirus disease 2019 correlated COVID-19 discharged patients disease severity effective Follow-up analysis healthy donors humoral IgG antibodies immune response Immunological disorders implication Infectious diseases investigated natural killer neutralizing antibody NK cells Pathogenesis pathogenesis of COVID-19 Patient peptide positive protective immunity provide SARS-CoV-2 SARS-CoV-2 antigen SARS-COV-2 infection significantly specimen suggested survival T cell T cells tested Vaccine [DOI] 10.1038/s41392-021-00686-1 PMC 바로가기 [Article Type] Article
A tale of two diseases: Sarcoidosis, COVID-19 and new therapeutic options with dual RAS inhibition and tetanus-diphtheria vaccineResearch article Published on 2021-07-012022-10-05 Journal: Medical Hypotheses [Category] SARS, 치료제, [키워드] ACE2 ACE2 binding Anergy angiotensin antibodies antigenic Antiviral agents ARDS beta coronavirus CD4+ CD4+ T cell CD8+ T cell Cell Combination COVID-19 described dysfunction Hydroxychloroquine immune dysregulation immune response lung Mortality natural killer overcome pathogen problem RAS RAS inhibition Re-infections receptor renin-angiotensin system response responsible sarcoidosis SARS CoV-2 similarity target Tetanus-diphtheria vaccine the disease the patient therapeutic option therapeutic strategy turn Vaccine [DOI] 10.1016/j.mehy.2021.110619 [Article Type] Research article
Dose-Related Aberrant Inhibition of Intracellular Perforin Expression by S1 Subunit of Spike Glycoprotein That Contains Receptor-Binding Domain from SARS-CoV-2Article Published on 2021-06-152022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] Antigen presentation CD8+ T cell Cell correlation COVID-19 cytokine Cytokine storm syndrome cytotoxic activity cytotoxicity decrease dendritic cell dose dose-dependent explain explained expression feature functional help High dose Hypothesis immune response impairment in vitro Influenza inhibit inhibition interferon-γ Intracellular kill linear low dose Lymphocytes lymphoproliferation manifestation perforin persistence proinflammatory cytokines replicated response SARS-CoV-2 Seven Severe case shown significantly higher spike spike glycoprotein strain subsequent suppress suppressed the S1 subunit tumor necrosis factor-α Viral load virus [DOI] 10.3390/microorganisms9061303 PMC 바로가기 [Article Type] Article
Thymosin Alpha-1 Has no Beneficial Effect on Restoring CD4+ and CD8+ T Lymphocyte Counts in COVID-19 PatientsImmunology Published on 2021-06-032022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] age baseline CD4 benefit cancers CD4 CD4 counts CD4+ CD8 CD8+ CD8+ T cell Clinical Center conducted count COVID-19 COVID-19 patient COVID-19 patients Critically ill Effect Efficacy evaluate homeostasis hypertension immune response immune system Infection investigated laboratory characteristics Linear regression analysis longitudinal change males management multivariate no significant difference no statistical difference observé Older Patient patients phenotype public health reduction Restoring Retrospective study severity Shanghai significantly subset T lymphocyte the median the patient therapy thymosin alpha 1 thymosin alpha-1 treated two group upper respiratory tract virus virus clearance [DOI] 10.3389/fimmu.2021.568789 PMC 바로가기 [Article Type] Immunology
Association of Clinical and Immunological Characteristics With Disease Severity and Outcomes in 211 Patients With COVID-19 in Wuhan, ChinaCellular and Infection Microbiology Published on 2021-05-282022-10-31 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID-19, MERS, SARS, [키워드] Admission age Analysis B cells body temperature CD4+ T cells CD8+ T cell changes in clinical Clinical characteristics Clinical outcome clinician Comorbidities Comorbidity Coronavirus disease 2019 COVID-19 COVID-19 patients CREA creatinine Critical disease deterioration Disease progression disease severity duration of fever effective intervention expression feature functions global public health higher risk Hospital stay identify IL-6 immunological immunological characteristics indicated information Laboratory liver Logistic lymphocyte lymphocyte counts lymphopenia Male sex median age non-severe cases non-severe patient non-severe patients Older age Patient patients with COVID-19 peripheral lymphocyte predominant presenting progression recruited renal Result risk risk factor selective serum Serum level Severe case severe cases Severe patient severe patients significantly subpopulations subset sustained fever Symptom university WBC White blood cell with COVID-19 Wuhan Wuhan, China [DOI] 10.3389/fcimb.2021.667487 PMC 바로가기 [Article Type] Cellular and Infection Microbiology