Considerations for bioanalytical characterization and batch release of COVID-19 vaccinesPerspective Published on 2021-04-132022-10-04 Journal: NPJ Vaccines [Category] 임상, [키워드] addition Antigen approval assays attribute authorization biological activity Biotechnology Chemistry clinical trials CMC Control country COVID-19 pandemic COVID-19 vaccine Critical develop dose Efficacy elicited Emergency EUA gene sequence hallmark immunogenic immunology IMPROVE Laboratory less predicted Regulatory robust Safe SARS-CoV-2 transfer Vaccine Vaccine development Vaccines while [DOI] 10.1038/s41541-021-00317-4 PMC 바로가기 [Article Type] Perspective
Practical laboratory considerations amidst the COVID-19 outbreak: early experience from SingaporeArticle Published on 2021-04-012023-07-13 Journal: Journal of Clinical Pathology [Category] SARS, [키워드] chemical pathology Chemistry infection control laboratory management [DOI] 10.1136/jclinpath-2020-206563
Biosyntheses characterization of alkaloids and flavonoids in Sophora flavescens by combining metabolome and transcriptomeArticle Published on 2021-04-012022-10-04 Journal: Scientific Reports [Category] 바이오마커, [키워드] Analysis analyzed Biomarker Biosynthesis Chemistry components contribute distribution Effects expression level expression profile Genetic highest include involved metabolic pathways metabolite metabolome metabolomics Molecular biology molecular mechanism oxymatrine pharmacological positively correlated profile provided Quantitative Sophora flavescen specificity tissue tissues transcript Transcriptome [DOI] 10.1038/s41598-021-86970-0 PMC 바로가기 [Article Type] Article
App Use and Usability of a Barcode-Based Digital Platform to Augment COVID-19 Contact Tracing: Postpilot Survey and Paradata AnalysisOriginal Paper Published on 2021-03-262022-10-31 Journal: JMIR Public Health and Surveillance [Category] COVID-19, [키워드] Analysis analyzed app asked assist changed Chemistry collected conducted Contact tracing country Course COVID-19 COVID-19 case COVID-19 pandemic Critical death Department Digital effective effort enrolled Enrollment examined feature Improvements increasingly initial less margin Mobile health mobile health intervention monitoring MOST objective offers participant performed pilot provided recorded recruitment replacing researchers Result Study participants study period suggested Surveillance survey System Usability Scale The United States threshold time tracking Transmission university Usability Usage Vaccine widespread [DOI] 10.2196/25859 PMC 바로가기 [Article Type] Original Paper
Computational evidence for nitro derivatives of quinoline and quinoline N-oxide as low-cost alternative for the treatment of SARS-CoV-2 infectionArticle Published on 2021-03-182022-10-29 Journal: Scientific Reports [Category] COVID-19, SARS, [키워드] Chemistry Compound compounds Computational biology and bioinformatics contagious coronavirus deaths derivative docking drugs Evidence help Infection isomer Medical research molecular molecular function Molecular medicine pandemic physicochemical property SARS-CoV-2 SARS-COV-2 infection Spread Symptoms the WHO therapeutic option transmission rate Treatment [DOI] 10.1038/s41598-021-85280-9 PMC 바로가기 [Article Type] Article
Phase-wise analysis of the COVID-19 lockdown impact on aerosol, radiation and trace gases and associated chemistry in a tropical rural environmentArticle Published on 2021-03-012023-07-13 Journal: Environmental research [Category] SARS, [키워드] aerosol Air quality Chemistry COVID-19 lockdown Radiation Trace gases. [DOI] 10.1016/j.envres.2020.110665 PMC 바로가기
The electrochemical detection of bioterrorism agents: a review of the detection, diagnostics, and implementation of sensors in biosafety programs for Class A bioweaponsReview Article Published on 2021-02-102022-10-04 Journal: Microsystems & Nanoengineering [Category] 진단, [키워드] biosafety biosensors Chemistry class diagnostics disease Electronic properties and materials Government Health implementation instance limit of detection platform shown [DOI] 10.1038/s41378-021-00242-5 PMC 바로가기 [Article Type] Review Article
An efficient chemical screening method for structure-based inhibitors to nucleic acid enzymes targeting the DNA repair-replication interface and SARS CoV-2DNA 복구-복제 인터페이스 및 SARS CoV-2를 표적으로 하는 핵산 효소에 대한 구조 기반 억제제에 대한 효율적인 화학적 스크리닝 방법Article Published on 2021-01-012022-09-11 Journal: Molecules [Category] Coronavirus, 유전자 메커니즘, [키워드] Absorption ADME ADP-ribose affinity approach approved Cancer cancer cell Cancer cells Cassandra CASSIE Cell Chemical Chemical library Chemistry classical Compound defined distribution DNA DNA replication DNA replication and repair docking drug drug design Drug discovery effective effort enzyme excretion facilitate human protein human proteins increasingly inhibitor inhibitors iterative Mac1 macrodomain mechanism metabolism molecular nonstructural protein 3 Nsp3 nucleic acid optimization PARG Pathogenesis pathway predicted problem profiles protein 3 Proteins provide repair ribose RNA SARS CoV SARS CoV-2 SARS-CoV2 Screen screening method specific inhibitor specific inhibitors Structure structures target to define [DOI] 10.1016/bs.mie.2021.09.003 PMC 바로가기 [Article Type] Article
On the Challenges for the Diagnosis of SARS-CoV-2 Based on a Review of Current Methodologies현재의 방법론 검토를 기반으로 한 SARS-CoV-2 진단의 과제Review Published on 2020-12-242022-09-11 Journal: ACS Sensors [Category] SARS, 치료기술, [키워드] Accuracy antibodies artificial intelligence biosensors bottleneck bottlenecks Chain Reaction challenge Chemistry Combination COVID-19 COVID-19 diagnosis current detection diagnosing diagnosis of COVID-19 genetic material high accuracy immunoassays infected individual infected individuals Infection lateral flow lateral flow devices less limitation methodology Nanoparticles POC point-of-care polymerase chain polymerase chain reaction prevented protocol real-time polymerase chain reaction required review RT-PCR SARS-CoV-2 Stage surface plasmon surface plasmon resonance time-consuming [DOI] 10.1021/acssensors.0c01382 PMC 바로가기 [Article Type] Review
Molecular docking, molecular dynamics, and in vitro studies reveal the potential of angiotensin II receptor blockers to inhibit the COVID-19 main proteaseResearch Article Published on 2020-12-032022-10-04 Journal: Heliyon [Category] 신약개발, [키워드] Anti-SARS-CoV-2 Activity ARB ARBs Azilsartan binding affinity binding free energy Biological Biological sciences blocker Blood coagulation carried Chemistry clinical study Combination Compound compounds computer Computer science COVID-19 COVID-19 pandemic COVID-19 virus disease docked docking drug Drug repurposing drugs targeting effective drug Effectiveness eprosartan fibrosis in vitro In vitro studies Inflammation inhibit Irbesartan material Materials science MD MM-GBSA molecular N3 inhibitor nine olmesartan pandemic coronavirus Patient patients worldwide Physics Prevent profiles Prophylactic protease pulmonary fibrosis receptor reduce required SAR SARS-CoV-2 SARS-CoV-2 protease Science telmisartan tested Treatment valsartan vasodilatation VERO E6 cells Virtual screening was performed [DOI] 10.1016/j.heliyon.2020.e05641 PMC 바로가기 [Article Type] Research Article