Single Parameter Estimation Approach for Robust Estimation of SIR Model With Limited and Noisy Data: The Case for COVID-19제한적이고 잡음이 많은 데이터가 있는 SIR 모델의 강력한 추정을 위한 단일 매개변수 추정 접근 방식: COVID-19의 경우Original Research Published on 2020-06-252022-09-10 Journal: Disaster Medicine and Public Health Preparedness [Category] MERS, SARS, 변종, [키워드] Algorithm Analysis approach Characteristics choice circumvent Cluster cluster analysis coronavirus coronavirus disease Coronavirus disease 2019 country COVID-19 COVID-19 cases Critical epidemic models estimate estimation highest incompatibility initial Limited Model observé pandemic parameter predict problem Research question robust robust estimation robustness significant difference SIR variant Variation [DOI] 10.1017/dmp.2020.220 PMC 바로가기 [Article Type] Original Research
Common-path interferometric label-free protein sensing with resonant dielectric nanostructuresArticle Published on 2020-06-022022-10-04 Journal: Light, Science & Applications [Category] 바이오마커, [키워드] antibiotic approach bacterial co-infection benefit binding Biomarker biomarker for bacterial Biophotonics bloodstream caused change circumvent clinically Concentration COVID-19 patients demonstrated detect driven by example Guidance Imaging and sensing indicate Infection infections inherent intrinsically Isabel lack limits Nanophotonics and plasmonics nanostructure offer Optical sensors Personalized medicine Photonic crystals point-of-care procalcitonin Protein required researcher robust sensitivity small molecule stability Structure Tolerance turn United Kingdom university utility York [DOI] 10.1038/s41377-020-0336-6 PMC 바로가기 [Article Type] Article
Trends and Innovations in Biosensors for COVID‐19 Mass TestingMinireview Published on 2020-05-272022-10-31 Journal: Chembiochem [Category] COVID-19, MERS, SARS, [키워드] accelerate antibody assays benefit Biomarker biosensor Blood circumvent COVID-19 COVID‐19 CRISPR CRISPR Diagnostics Diagnosis diagnostic diagnostics DNA amplification DNA sequencing ENhance equipment immunoassay immunoassays Infectious disease Innovation isothermal isothermal amplification mass molecular molecular diagnostics outbreak pandemic point‐of‐care test polymerase chain Quantitative Rapid test respond reverse transcription sensitivity Sensitivity and specificity serological specificity Swab Testing trend Viral protein Viral RNA virus widespread [DOI] 10.1002/cbic.202000250 PMC 바로가기 [Article Type] Minireview
Development of a recombinant Newcastle disease virus-vectored vaccine for infectious bronchitis virus variant strains circulating in EgyptResearch Article Published on 2019-02-112022-10-28 Journal: Veterinary Research [Category] Coronavirus, [키워드] analyses avirulent bronchitis cause chick circulating circumvent clinical disease Clinical sign comparable Complete develop development disease Express expressing growth IBV immunofluorescence in vitro Infectious Bronchitis Virus Lineage live-attenuated vaccine Middle East mutate newcastle disease virus parental prevalent provided recombine reduced reduction in resulting S glycoprotein S protein S protein expression significantly Single-dose SPF strain supplementary material tracheal vaccination Vaccine vaccine candidate variant viral shedding virulent virus viruses were expressed white wild type [DOI] 10.1186/s13567-019-0631-5 PMC 바로가기 [Article Type] Research Article
The nucleocapsid proteins of mouse hepatitis virus and severe acute respiratory syndrome coronavirus share the same IFN-β antagonizing mechanism: attenuation of PACT-mediated RIG-I/MDA5 activationResearch Paper Published on 2017-07-252022-10-28 Journal: Oncotarget [Category] Coronavirus, [키워드] activate Activation acute respiratory syndrome antiviral response association cellular circumvent coronavirus CoV CoV-infected cells CoVs epidemic diarrhea Human IFN IFN-β IFNs inhibited Innate immunity innate immunity evasion Interaction interferon MDA5 mechanism Melanoma MHV molecular mouse hepatitis virus N protein N proteins Nidovirale nucleocapsid protein PACT PEDV Protein reproductive RIG-I RIG-I/MDA5 SARS-CoV N protein Sendai virus syndrome the N protein turn type I interferon upstream Viral protein virus [DOI] 10.18632/oncotarget.17912 PMC 바로가기 [Article Type] Research Paper
Exploiting Genetic Interference for Antiviral Therapy항바이러스 치료를 위한 유전자 간섭 활용Review Published on 2016-05-052022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, 신종인플루엔자, [키워드] Antiviral strategies Cell circumvent competing de novo dominant drug resistance Ebola virus Evolution generate Genetic genetic diversity Genome genome replication Health heterogeneity heterogeneous highly pathogenic HIV Influenza Influenza virus inherent interfere Interference Particles Population power replicate therapeutic therapeutic intervention therapy Treatment Viral viral fitness viral variant virus viruses [DOI] 10.1371/journal.pgen.1005986 PMC 바로가기 [Article Type] Review
SARS Coronavirus nsp1 Protein Induces Template-Dependent Endonucleolytic Cleavage of mRNAs: Viral mRNAs Are Resistant to nsp1-Induced RNA CleavageResearch Article Published on 2011-12-082022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] 40S accelerated accompany acute respiratory syndrome Antiviral Author bind binding block cells characterized circumvent classical cleavage cleavage sites coronavirus cricket paralysis viruses Degradation demonstrated different element elements events exhibited facilitate Fever found function Hepatitis Host host gene expression host genes host mRNA host protein in vitro induce infected cells Infection inhibitor leader sequence Modification mRNA mRNAs nucleotide nucleotide sequence Protein protein synthesis recognize reporter Resistant ribosome RNA RNA modification SARS Coronavirus SARS infection severe severe symptom subunit suppress the expression susceptible translation type I type I interferon unique viral mRNA Viral protein virus virus replication [DOI] 10.1371/journal.ppat.1002433 PMC 바로가기 [Article Type] Research Article
Distinct Patterns of IFITM-Mediated Restriction of Filoviruses, SARS Coronavirus, and Influenza A VirusResearch Article Published on 2011-01-062022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] Acidic Author bypasse bypassed cathepsin L Cell cellular cellular tropism circumvent compared Control cytoplasm described did not reduce Ebola Ebola virus Endocytic pathway ENhance example Express expression Factors Filovirus glycoprotein highly pathogenic IAV IFITM IFITM1 IFITM3 indicate Infection infectious influenza A virus inhibit inhibited innate immune system interfere late stage less limit lysosomal modulate murine observation pathogenic viruses pattern plasma membrane Protein Proteins pseudovirions receptor Replication restrict restriction restriction factor SARS Coronavirus SARS-CoV transmembrane transmembrane protein Treatment viral replication virion virus viruses [DOI] 10.1371/journal.ppat.1001258 PMC 바로가기 [Article Type] Research Article
Functional Genomics Highlights Differential Induction of Antiviral Pathways in the Lungs of SARS-CoV–Infected MacaquesResearch Article Published on 2007-08-102022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] activate activated acute phase acute respiratory distress acute respiratory syndrome Admission Adult against SARS-CoV analyzed Antiviral antiviral signaling Atypical Author cause Cell cells characterized chemokine genes chemokines circumvent Complication coronavirus Critical cynomolgus macaque cytokine demonstrated early IFN signaling Effect event examined functional gene expression profile gene signature Genomics highlight Host host response IFNs IL-8 immune response immunohistochemistry in vitro experiments individuals induction Infection innate immune response Innate immunity intensive care involved IP-10 lung Lung pathology macaque macaques nuclear translocation Pathogenesis pathogenic pathway phosphorylated Pneumonia protective immune response regulated required SARS patient SARS-CoV SARS-CoV infection SARS-CoV–infected cells severe shown Stat1 subset syndrome Transcription transcription factor type I interferon viral infection virus virus replication [DOI] 10.1371/journal.ppat.0030112 PMC 바로가기 [Article Type] Research Article