Immunoinformatics Analysis of SARS-CoV-2 ORF1ab Polyproteins to Identify Promiscuous and Highly Conserved T-Cell Epitopes to Formulate Vaccine for Indonesia and the World PopulationArticle Published on 2021-12-092022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] Algorithms allele Antigen caused class conserved contribute Coverage COVID-19 pandemic criteria CTL cytotoxic T-cells docking epitope epitope mapping FIVE helper T-cells HLA HLA-A*24:07 HTL human leukocyte antigen IFNγ immunoinformatics in vitro study Indonesia Infection leukocyte linkers Microbiome multi-epitope peptide-based vaccine ORF1ab peptide peptides physicochemical characteristics Population predominant Protective reducing reflected Region responses SARS-CoV-2 shown stimulate Symptom T-cell T-cell epitopes T-cell Response the vaccine TLR4 toll-like receptor 4 vaccine construct Vaccine design variant β-defensin [DOI] 10.3390/vaccines9121459 PMC 바로가기 [Article Type] Article
Potential Use of CRISPR/Cas13 Machinery in Understanding Virus–Host InteractionMicrobiology Published on 2021-11-262022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] acquisition approaches Cas13 Cas9 class component CRISPR-Cas Degradation degrade diagnostics DNA effector elements Features Genetic identify immune system Interaction modulate Nuclease nucleases nucleic acid offer Palindromic phage plasmids Potential Prokaryote Protein Proteins recognizing Repeat Research RNA RNA interference RNA-labeling sequence spacer subsequent understanding variant Viral RNA Virological virus diagnosis virus interference virus resistance [DOI] 10.3389/fmicb.2021.743580 PMC 바로가기 [Article Type] Microbiology
Single-Cell Immunogenomic Approach Identified SARS-CoV-2 Protective Immune Signatures in Asymptomatic Direct Contacts of COVID-19 CasesCOVID-19 사례의 무증상 직접 접촉에서 SARS-CoV-2 보호 면역 서명을 식별한 단일 세포 면역유전체학적 접근 방식Immunology Published on 2021-11-252022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adaptive immune response amplitude antibody Antibody titer Asymptomatic B-cell BCR CD4 CD8 Cell characterized class close contact colony stimulating factor concomitant increase Contact controls coronavirus coronavirus disease Coronavirus disease 2019 CoV COVID-19 cytokine cytokine levels Cytokines direct contact Direct Contacts Eotaxin G-CSF granulocyte granulocyte-colony stimulating factor host immunity Identified IL-7 impacted infected cases infected patients Inflammatory inhibitory interleukin Macrophage memory memory B cell memory B cells MIF Migration MIP-1α naïve T cells Neutralizing Patient patients Profiling proportion receptor reported respiratory RNA SARS-CoV-2 scBCR-seq scRNA-seq scTCR-seq Sequencing severe acute respiratory syndrome Coronavirus shown signature significant increase single-cell status T cell T cells T-cell receptor TCR Temra cells virus Virus neutralization [DOI] 10.3389/fimmu.2021.733539 PMC 바로가기 [Article Type] Immunology
Transparent Polymeric Formulations Effective against SARS-CoV-2 InfectionSARS-CoV-2 감염에 효과적인 투명한 고분자 제제Article Published on 2021-11-242022-09-11 Journal: ACS applied materials & interfaces [Category] SARS, 치료제, [키워드] 229E alternative Antibacterial antibacterial activity antimicrobial agent antimicrobial agents Antiviral antiviral activity antiviral property approaches backbone Bacteria benzalkonium Candida albican Candida albicans candidate Cell CFU class Compound compounds Contact contaminated surface contaminated surfaces coronavirus decrease droplet droplets EMA European Medicines Agency evaluated Formulation fungal gram Gram-negative bacteria Gram-positive bacteria growth increasingly inhibit Ion Particle Polymer polymers polystyrene sulfonate Postinfection product reduction SARS-CoV-2 SARS-CoV-2 coronavirus SARS-COV-2 infection SARS-CoV-2 virus silver Spread sulfonate target cell tested the SARS-CoV-2 virus Transmission transmitted variety virucidal virus [DOI] 10.1021/acsami.1c10404 PMC 바로가기 [Article Type] Article
ENNAVIA is a novel method which employs neural networks for antiviral and anti-coronavirus activity prediction for therapeutic peptidesEnnavia는 치료 펩티드에 대한 항 바이러스 및 항 코로나 바이러스 활성 예측에 대한 신경망을 사용하는 새로운 방법입니다.Problem Solving Protocol Published on 2021-11-232022-09-10 Journal: Briefings in Bioinformatics [Category] MERS, SARS, 치료제, [키워드] Accuracy activities an area anti-coronavirus activity Antiviral antiviral activities antiviral activity antiviral drug antiviral drugs Area biological activity Candidates Cheminformatics class Classifier Community correlation coefficient Curve dataset deep learning Health in silico in silico screening machine learning Neural network novel antiviral drugs novel sequence outperform peptide peptides quantity Research sequencing data therapeutic threat Toxicity viruses web server [DOI] 10.1093/bib/bbab258 PMC 바로가기 [Article Type] Problem Solving Protocol
Comparative genomic analysis reveals varying levels of mammalian adaptation to coronavirus infections비교 게놈 분석은 코로나 바이러스 감염에 대한 다양한 수준의 포유류 적응을 보여줍니다.Comparative Study Published on 2021-11-182022-09-10 Journal: PLoS Computational Biology [Category] MERS, SARS, 바이오마커, 유전자 메커니즘, [키워드] 229E ACE2 ACE2 protein ACE2 proteins acting adaptation adaptive Affect Amino acid amino acid substitution amino acid substitutions aminopeptidase aminopeptidase N Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Animal host APN bats binding causative agent cause caused cellular receptor Chinese Chinese Horseshoe bats clade class common cold Comparative coronavirus Coronavirus infection Coronaviruses COVID-19 Evidence evidence of Evolution genomic Genomic analysis HCoV HCoV-229E Health horseshoe horseshoe bats Host host receptor host susceptibility hosts human coronavirus human coronavirus 229E Interaction Lineage lineages mammal mammalian pathogen Pathogens pattern Phylogeny primates Protein receptor Research reservoir resistance to infection resistance to infections respiratory Respiratory Coronavirus reveal rodent rodents SARS-CoV SARS-CoV-2 SARS-CoV-2 spike protein SARS-like coronaviruses SARS-like virus SARS-like viruses severe acute respiratory coronavirus severe acute respiratory coronavirus 2 severity of symptom shown species Spike protein susceptible symptomatic disease the SARS-CoV-2 these viruses Tolerance Variation Viral viral entry viral infection viral infections Viral vector virus viruses zoonotic origin [DOI] 10.1371/journal.pcbi.1009560 PMC 바로가기 [Article Type] Comparative Study
A Highly Sensitive and Specific SARS-CoV-2 Spike- and Nucleoprotein-Based Fluorescent Multiplex Immunoassay (FMIA) to Measure IgG, IgA, and IgM Class AntibodiesResearch Article Published on 2021-11-172022-10-30 Journal: Microbiology Spectrum [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome analyses antibody antibody concentration assays Biosafety Level 3 BSL-3 calibrated calibration class collected comparability Concentration Concordance coronavirus coronavirus disease correlated strongly correlation COVID-19 enzyme fluorescent gold standard identify IgA IgG IgM Immunity immunoassay IMPROVE Infection International measure microneutralization Microneutralization test MNT moderate multiplex NAb titer NAb titers NAbs neutralization test Neutralizing antibodies neutralizing antibody neutralizing antibody titers nucleoprotein pandemic persistence population immunity quantification Receptor-binding domain SARS-CoV-2 SARS-CoV-2 antibody sensitive sensitivity Serological assay serological assays Specific specificity spike spike glycoprotein Standard Standardization Surveillance Symptom the WHO vaccination validation WHO WHO International Standard World Health Organization [DOI] 10.1128/Spectrum.01131-21 PMC 바로가기 [Article Type] Research Article
Support through Social Media and Online Class Participation to Enhance Psychological ResilienceArticle Published on 2021-11-142022-10-29 Journal: International Journal of Environmental Research an [Category] Coronavirus, MERS, SARS, [키워드] applied build class conducted COVID-19 lockdown COVID-19 pandemic develop Effect enrolled Future help lockdown media online class participation Partial Participation Psychological psychological resilience Research Resilience Result social isolation social media social media platform Social support Support Teacher education [DOI] 10.3390/ijerph182211962 PMC 바로가기 [Article Type] Article
Molecular strategies for antibody binding and escape of SARS-CoV-2 and its mutationsSARS-COV-2의 항체 결합 및 탈출을위한 분자 전략 및 그 돌연변이Article Published on 2021-11-052022-09-01 Journal: Scientific Reports [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] ACE2 affecting antibodies antibody Antibody binding binding binding affinity binding energy binding mechanism caused class Combination Computational models COVID19 E484K effective Effectiveness Efficiency ENhance higher efficiency host cells Human investigated K417N L452R less molecular simulations Multiple multiple mutations Mutation N501Y N501Y mutation neutralizing antibody new strain pandemic produced raised S-protein SARS-CoV-2 sequence Strains T478K the binding affinity Treatment Vaccine variants Viral viral infection Viral proteins while wild type [DOI] 10.1038/s41598-021-01081-0 PMC 바로가기 [Article Type] Article
Crocetin and related oxygen diffusion-enhancing compounds: Review of chemical synthesis, pharmacology, clinical development, and novel therapeutic applications크로세틴 및 관련 산소 확산 강화 화합물: 화학 합성, 약리학, 임상 개발 및 새로운 치료 응용 프로그램 검토Review Published on 2021-11-012022-09-11 Journal: Drug development research [Category] 임상, [키워드] among others being Blood Cancer cancers class clinical development clinical investigation clinical trial Complete Compound conditions COVID-19 Crocetin crocin diffusion disease disorders Glioblastoma glioblastoma multiforme Hemorrhagic hemorrhagic shock investigated macromolecular medical need name oxygen oxygen diffusion-enhancing compounds pandemic pharmacological phase potential therapeutic agents radiosensitizer review Shock stroke subject therapeutic therapeutic agent Therapeutic benefit these compound these compounds tissue trans-sodium crocetinate trans-sodium crocetinate. TSC unique [DOI] 10.1002/ddr.21814 PMC 바로가기 [Article Type] Review