COVID-19 containment on a college campus via wastewater-based epidemiology, targeted clinical testing and an intervention폐수 기반 역학, 표적 임상 테스트 및 개입을 통한 대학 캠퍼스의 COVID-19 억제Article Published on 2021-07-202022-09-11 Journal: The Science of the total environment [Category] SARS, 유전자 메커니즘, 치료기술, 치료제, [키워드] activities Asymptomatic case study clinical test clinical testing Clinical tests Community conducted Course COVID-19 defined demonstrated diagnostic disease transmission Dormitory effective Epidemiology Evidence increase Increases infected individual Infection Intervention Isolation MONITOR Negative predictive value outbreak Outbreak prevention positive Positive predictive value Predictive value provide provided Public health intervention Public health interventions reducing reported resource SARS-CoV-2 SARS-CoV-2 RNA selected sewer Sewer manhole Surveillance symptomatic table university University campus virus RNA wastewater wastewater surveillance [DOI] 10.1016/j.scitotenv.2021.146408 PMC 바로가기 [Article Type] Article
Attitudes toward the SARS-CoV-2 Vaccine: Results from the Saudi Residents’ Intention to Get Vaccinated against COVID-19 (SRIGVAC) StudyArticle Published on 2021-07-182022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] adverse event asked Attitude clinical testing COVID-19 cross-sectional demographic data demographic factor determinant Effectiveness effort female Health Hesitancy individual Influenza information Intention less likelihood multinomial logistic regression participant Perceived risk responses Result risk Saudi Arabia significantly higher the SARS-CoV-2 vaccinated against COVID-19 vaccination Vaccine Vaccine hesitancy widespread [DOI] 10.3390/vaccines9070798 PMC 바로가기 [Article Type] Article
Early treatment with a combination of two potent neutralizing antibodies improves clinical outcomes and reduces virus replication and lung inflammation in SARS-CoV-2 infected macaques2개의 강력한 중화 항체 조합을 통한 조기 치료는 SARS-CoV-2에 감염된 원숭이에서 임상 결과를 개선하고 바이러스 복제 및 폐 염증을 감소시킵니다.Research Article Published on 2021-07-062022-09-10 Journal: PLoS Pathogens [Category] SARS, 변종, 진단, [키워드] 24 hour 24 hours animal animals anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody antibodies antibody antibody combination clinic clinical development Clinical outcome Clinical signs Clinical studies clinical testing Combination combinations controls COVID-19 COVID-19 disease develop dose early infection effective extension group half-lives High dose high risk histology Human IMPROVE infected individual Infection inoculated interstitial pneumonia intra-tracheally intranasally intravenously investigated less Lower respiratory tract lung Lung inflammation macaque maintain monoclonal antibodies monoclonal antibody mutations neutralize neutralizing antibody neutralizing monoclonal antibodies Placebo progression promise Prophylactic provide reduce reduced respiratory respiratory tract rhesus rhesus macaque SARS-CoV-2 SARS-COV-2 infection severe COVID-19 disease shown significantly Support tested therapeutic efficacy therapeutic intervention Therapeutic strategies three groups treated Treatment upper and lower respiratory tract variant Viral Viral variants virus replication [DOI] 10.1371/journal.ppat.1009688 PMC 바로가기 [Article Type] Research Article
Operation Warp Speed: implications for global vaccine securityOperation Warp Speed: 글로벌 백신 보안에 미치는 영향Review Published on 2021-07-012022-09-11 Journal: The Lancet. Global health [Category] 신약개발, 임상, [키워드] AstraZeneca clinical testing COVID-19 COVID-19 vaccines develop Efficacy effort Emergency use equity Expanded access funding global effort group Health implication Informed consent Interim analyses interim analysis Johnson & Johnson Johnson & Johnson Justice mechanism Microbiology Moderna nine Novavax operation Pfizer Phase 3 populations provided question Sinopharm Sinovac speed transition Vaccine [DOI] 10.1016/S2214-109X(21)00140-6 PMC 바로가기 [Article Type] Review
Noncoding RNA therapeutics — challenges and potential solutions Reviews Published on 2021-06-182022-10-05 Journal: Nature Reviews Drug Discovery [Category] 바이오마커, 치료제, [키워드] Antisense oligonucleotide approach boost cancers clinical testing demonstrated Effect Efficacy effort FDA approval long noncoding RNA microRNA miRNAs ncRNA ncRNAs noncoding RNA other diseases over RNA therapeutics RNAs specificity Tolerability Toxicity Treatment Trial [DOI] 10.1038/s41573-021-00219-z [Article Type] Reviews
Early Returns on Small Molecule Therapeutics for SARS-CoV-2SARS-CoV-2에 대한 저분자 치료제의 조기 수익Article Published on 2021-06-112022-09-11 Journal: ACS Infectious Diseases [Category] SARS, 신약개발, 치료제, [키워드] approach breadth clinical testing Computational approaches COVID-19 pandemic determine effort Extraordinary identify molecule Pandemics Potential treatment potential treatments preparation progression return SARS-CoV-2 SARS-COV-2 infection Scientific community small molecule Therapeutics treat [DOI] 10.1021/acsinfecdis.0c00874 PMC 바로가기 [Article Type] Article
Validation of a multiplex flow immunoassay for detection of IgG antibodies against SARS-CoV-2 in dried blood spots건조된 혈반에서 SARS-CoV-2에 대한 IgG 항체 검출을 위한 다중 흐름 면역분석의 검증Research Article Published on 2021-05-282022-09-10 Journal: PLoS ONE [Category] SARS, 진단, 치료기술, 치료법, [키워드] analyzed anti-SARS-CoV-2 anti-SARS-CoV-2 IgG Anti-viral antibodies antibody Antibody detection attribute authorization Blood clinical testing Community comparable complementary Concordance detect dried blood spot drug Elecsy Elecsys ELISA Emergency Emergency use authorization EUA expansion FDA food Food and Drug Administration IgG antibody immunoassay Interpretation magnetic bead Magnetic beads multiplex nucleocapsid overall concordance Pattern recognition plasma provide provided Receptor binding domain reference method Result Roche Diagnostics S1 subunit SARS-CoV-2 SARS-CoV-2 antibody sera serologic testing serum serum and plasma specimen storage tested thresholds validation Viral Viral antigen viral antigens [DOI] 10.1371/journal.pone.0252621 PMC 바로가기 [Article Type] Research Article
Recovery of SARS-CoV-2 from Wastewater Using Centrifugal UltrafiltrationProtocol Published on 2021-05-122022-10-30 Journal: Methods and Protocols [Category] COVID-19, [키워드] ACE-2 angiotensin-converting enzyme 2 Castle cause Centrifugal clinical clinical testing collected Community Concentration costly COVID-19 COVID-19 pandemic COVID-19 surveillance disease enteric virus evaluate fluctuation gastrointestinal tract genomic genomic RNA Human infected individual monitoring New populations processed protocol provide receptor replicate Research RT-qPCR SARS-CoV-2 Spread spreads Surveillance target the disease Ultrafiltration Urine virus wastewater [DOI] 10.3390/mps4020032 PMC 바로가기 [Article Type] Protocol
The neutralizing antibody, LY-CoV555, protects against SARS-CoV-2 infection in nonhuman primates중화 항체 LY-CoV555는 비인간 영장류에서 SARS-CoV-2 감염을 예방합니다Research Article Published on 2021-05-122022-09-12 Journal: Science Translational Medicine [Category] MERS, SARS, 비임상, 진단, [키워드] acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus airway airways angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Anti-spike antibody Antigen antigen-specific B cell Antigen-specific B cells B cells bamlanivimab binding characterized clearance clinical testing Clinical use collected conducted convalescent patient coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 demonstrated evaluated functional high-affinity binding Hospitalized in vitro in vivo indications individual infected with SARS-CoV-2 Infection Interaction Jone Jones less Lower respiratory tract LY-CoV555 mAb mAbs monoclonal monoclonal antibodies monoclonal antibody neutralize Neutralizing activity Neutralizing antibodies neutralizing antibody offer patients with COVID-19 pharmacokinetic Population prevented prophylactic dose prophylactic doses prophylactic treatment PROTECT public health threat Receptor-binding domain reduced respiratory distress Respiratory distress syndrome rhesus rhesus macaque SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike severe acute respiratory distress syndrome Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 Spectrum Spike protein Support syndrome tested the receptor-binding domain therapeutic therapeutic agent therapeutic option Therapeutics These data Treatment upper and lower respiratory tract upper and lower respiratory tracts vaccination viral replication widespread [DOI] 10.1126/scitranslmed.abf1906 PMC 바로가기 [Article Type] Research Article
Process development and scale-up optimization of the SARS-CoV-2 receptor binding domain–based vaccine candidate, RBD219-N1C1Biotechnological Products and Process Engineering Published on 2021-05-072022-10-28 Journal: Applied Microbiology and Biotechnology [Category] COVID-19, SARS, [키워드] Abstract ACE2 receptor binding addition Antigen clinical testing condition COVID-19 COVID-19 vaccine downstream elicit fermentation generate good manufacturing practice include mice Neutralizing antibody response performed Pichia pastoris Process produced Protein protocol purification purified Receptor binding recombinant COVID-19 vaccine robust SARS-CoV-2 SARS-CoV-2 pseudovirus SEC-HPLC shown Spike protein supplementary material the SARS-CoV-2 upstream vaccine candidate yeast [DOI] 10.1007/s00253-021-11281-3 PMC 바로가기 [Article Type] Biotechnological Products and Process Engineering