Bioinformatics and in-silico findings reveal medical features and pharmacological targets of biochanin A against colorectal cancer and COVID-19Research Article Published on 2021-12-232022-10-27 Journal: Bioengineered [Category] Coronavirus, COVID-19, Fulltext, SARS, [키워드] addition Analysis applied approach biochanin a bioinformatics biological function Cancer patients CCND1 cell proliferation Chronic diseases Clinical use Cluster Colorectal cancer combination therapy COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 vaccine demonstrated Effect effective EGFR feature functional gene cluster IL1A IL2 IL6R immune response in-silico Interaction interleukin-6 involved JAK-STAT signaling pathway lack Mortality network pharmacology pathology Pathway analysis Patient patients pharmaceutical target pharmacological target PPARG receptor Side effect therapeutic option Treatment [DOI] 10.1080/21655979.2021.2005876 PMC 바로가기 [Article Type] Research Article
Hydrogen, a Novel Therapeutic Molecule, Regulates Oxidative Stress, Inflammation, and ApoptosisPhysiology Published on 2021-12-202022-10-31 Journal: Frontiers in Physiology [Category] COVID-19, [키워드] Administered Anti-inflammatory antiapoptotic antioxidant Antioxidative Apoptosis Autoimmunity autophagy cell death cell membrane China chronic inflammatory diseases clinical trials Clinical use coronavirus COVID-19 Diseases Effect Effects Efficacy energy metabolism help hydrogen immune system injection Ischemia mechanism mitochondrial modulating molecular Molecular hydrogen molecular hydrogen (H2) molecule novel Novel coronavirus nuclear penetrate Pneumonia pyroptosis reactive oxygen species reactive oxygen specy Regulation reperfusion injury Respiratory disease Sepsis shown Spread therapeutic effect transcription factor Treatment treatment guideline variety [DOI] 10.3389/fphys.2021.789507 PMC 바로가기 [Article Type] Physiology
What Is the Role of Pharmacists in Treating COVID-19 Patients? The Experiences and Expectations of Front Line Medical StaffPublic Health Published on 2021-12-202022-10-31 Journal: Frontiers in Public Health [Category] Coronavirus, MERS, SARS, [키워드] activity Adverse drug reactions analyzed Care Chinese Clinical use complex contraindications COVID-19 Drug interactions drugs expectation experience growth help information Isolation LINE medical staff medication Nurse patients Perspective Pharmacist pharmacists physician play a role positive provided qualitative research role therapy treating treating COVID-19 patient was used [DOI] 10.3389/fpubh.2021.778863 PMC 바로가기 [Article Type] Public Health
Secretome of Mesenchymal Bone Marrow Stem Cells: Is It Immunosuppressive or Proinflammatory?Article Published on 2021-12-012022-11-16 Journal: Bulletin of experimental biology and medicine [Category] SARS, 치료기술, [키워드] Allogeneic Anti-inflammatory approved Autoimmune disease bone Bone marrow cause Cell cell transplantation characterized chemokine Clinical use condition conditions COVID-19 patient Culture cytokine profile Cytokine storm Cytokines disease functions Graft-versus-host disease GVHD hematopoietic stem cell transplantation IL-10 IL-4 IL-6 IL-8 IMPROVE Intensive Marrow MCP-1 mesenchymal stem cell Mesenchymal stem cells MSC Pathogenesis proinflammatory protocols reaction reduce required risk STEM stem cells therapeutic therapy tolerogenic Treatment [DOI] 10.1007/s10517-021-05371-5 PMC 바로가기
Blockchain applications in health care for COVID-19 and beyond: a systematic reviewReview article Published on 2021-12-012022-10-05 Journal: International Journal of Environmental Research an [Category] SARS, 유전자 메커니즘, [키워드] accelerated Analysis article Blockchain Care Characteristics Clinical use conducted Contact tracing COVID-19 COVID-19 pandemic domain electronic medical record electronic medical records Electronics Engineer Ethereum evaluated Final full length Google Scholar Health highlighting Hyperledger Immunity management Mobile health MOST nine pandemic platform remote monitoring reported Research Surveillance systematic review translate unique Vaccine [DOI] 10.1016/S2589-7500(21)00210-7 [Article Type] Review article
Evaluation of Abbott ID NOW COVID-19 POC test performance characteristics and integration in the regional health network workflows to improve health care deliveryResearch article Published on 2021-12-012022-10-05 Journal: Clinical biochemistry [Category] 진단, [키워드] 95% CI Abbott aligned Black patient Black patients Care Characteristics Clinical use clinics Community COVID-19 delta variant diagnostic diagnostic testing Health health system healthcare hospital hospitals ID NOW IMPROVE Patient performance performed POC POC test positive presenting Prevalence Regional health network SARS-CoV-2 specimen tested variety white White patient [DOI] 10.1016/j.clinbiochem.2021.12.003 [Article Type] Research article
Repurposed pharmacological agents for the potential treatment of COVID-19: a literature reviewCOVID-19의 잠재적 치료를위한 용도 기반 약리학 적제 : 문헌 검토Review Published on 2021-11-272022-08-31 Journal: Respiratory Research [Category] MERS, SARS, 신약개발, 치료제, [키워드] “cytokine storm” affected analysed anticoagulation article articles Azithromycin benefit Chloroquine clinical benefit clinical benefits clinical trial clinical trials Clinical use Coagulopathy cohorts collected confirmation Corticosteroids Course COVID-19 COVID-19 pandemic COVID-19 patients COVID-19 pneumonia Cytokine storm death Dexamethasone disease Disease progression drug drug names Efficacy Efficacy and safety elicited examined Google Scholar Hydroxychloroquine IL-6 IL-6 receptor literature review Lopinavir Lopinavir/ritonavir mechanically ventilated mechanically ventilated COVID-19 patients monoclonal antibodies monoclonal antibody Mortality multiple organ failure Organ failure Other oxygen Oxygen therapy Pathogenesis pathophysiologic patients with COVID-19 pharmacological pharmacological agent pharmacological agents pharmacological treatment Pneumonia Potential treatment prevent disease progression professional Randomised controlled trials Randomised trial receptor antagonist Remdesivir Research Respiratory complications Result Ritonavir SARS-CoV-2 severe COVID-19 shown significantly Stage Supplemental oxygen therapy tested the disease Tocilizumab treat Treatment treatment of COVID-19 utilised were used [DOI] 10.1186/s12931-021-01885-8 PMC 바로가기 [Article Type] Review
An open-label, randomized, single intravenous dosing study to investigate the effect of fixed-dose combinations of tenofovir/lamivudine or atazanavir/ritonavir on the pharmacokinetics of remdesivir in Ugandan healthy volunteers (RemTLAR)Study Protocol Published on 2021-11-232022-10-29 Journal: Trials [Category] COVID-19, [키워드] Administered African anticipated Antiretroviral therapy Antiviral approach Atazanavir Blood blood sample Clinical use Combination Concentration COVID-19 criteria dataset demographic characteristics Diseases dose drug concentration Drug-drug interactions Ebola enrolled fixed healthy volunteer HIV Interaction intravenous lamivudine Open-label participant Patient performed pharmacokinetic plasma Randomized receive Remdesivir Ritonavir sequence Support tenofovir therapeutic treatment regimen virus Volunteer [DOI] 10.1186/s13063-021-05752-1 PMC 바로가기 [Article Type] Study Protocol
Overview of Neutralizing Antibodies and Their Potential in COVID-19Review Published on 2021-11-232022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] antibody Antibody Response Clinical use Convalescent plasma therapy COVID-19 COVID-19 research criteria Donor Efficacy humoral Immunity manuscript mechanism monoclonal antibodies NAbs neutralization assays Neutralizing antibodies Potential presenting Protective respiratory syndrome coronavirus SARS-CoV-2 therapeutic Vaccine [DOI] 10.3390/vaccines9121376 PMC 바로가기 [Article Type] Review
Screening of a Small Molecule Compound Library Identifies Toosendanin as an Inhibitor Against Bunyavirus and SARS-CoV-2Pharmacology Published on 2021-11-112022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] activity Against Anti-viral anti-viral drug anti-viral drug screening antiviral activity approved bunyavirus changes in Clinical use Compound compounds displaying effective Efficacy Fever highest histopathological indicated Infection Infectious disease inhibited library molecule performed reduced SARS-CoV-2 Screening severe cases SFTSV significantly syndrome toosendanin Treatment Viral load virus [DOI] 10.3389/fphar.2021.735223 PMC 바로가기 [Article Type] Pharmacology