Current knowledge about the antivirals remdesivir (GS-5734) and GS-441524 as therapeutic options for coronavirusesReview article Published on 2020-06-012022-10-05 Journal: One Health [Category] 치료제, [키워드] accumulate Antiviral antiviral drug Antiviral effect approved clinical trial clinical trials Community compassionate use coronavirus coronavirus disease Coronaviruses COVID-19 current demonstrated Epidemics Evidence GS-441524 GS-5734 illness imperative in vitro in vivo information International knowledge mitigate one health pandemic pandemic progresses Potential treatment Practitioner public health recent Regulatory Remdesivir SARS-CoV-2 tested therapeutic option Therapies Treatment Vaccine development [DOI] 10.1016/j.onehlt.2020.100128 [Article Type] Review article
Drug repurposing against COVID-19: focus on anticancer agentsReview Published on 2020-05-122022-10-29 Journal: Journal of Experimental & Clinical Cancer Research : CR [Category] COVID-19, MERS, SARS, [키워드] anticancer anticancer drugs BCG Body boost Cancer cancer cell Cancer cells Cancer therapy cancer treatment clinical trials Clinical use compassionate use comprehensive analysis COVID-19 COVID-19 outbreak COVID-19 pandemic dosage drug Drug repurposing effective energy metabolism ENhance feature health emergencies Human immune response information knowledge medication MOST nucleic acids pathway phase III trial preclinical study Protein SARS-COV-2 infection therapeutic approaches therapy time-consuming Toxicity Treatment Viral pneumonia viral replication virus-infected cell [DOI] 10.1186/s13046-020-01590-2 PMC 바로가기 [Article Type] Review
Successful COVID-19 rescue therapy by extra-corporeal membrane oxygenation (ECMO) for respiratory failure: a case reportCase Report Published on 2020-05-082022-10-28 Journal: Patient Safety in Surgery [Category] COVID-19, [키워드] acute respiratory syndrome Antiviral treatment bilateral pneumonia Care Case report cohort of patients compassionate use coronavirus Course COVID-19 Critical care decannulated deteriorate discharged ECMO Extra-corporeal membrane oxygenation extracorporeal membrane oxygenation female Future healthy high mortality rate hospital initiated Lung injury nitric oxide novel coronavirus disease outcome Patient patient with COVID-19 positive prone positioning rehabilitation Remdesivir Remdesivir treatment Respiratory failure SARS-CoV-2 severe COVID-19 disease significantly therapy transferred treated Treatment Ventilation Wuhan, China [DOI] 10.1186/s13037-020-00245-7 PMC 바로가기 [Article Type] Case Report
Role of adjunctive treatment strategies in COVID-19 and a review of international and national clinical guidelinesReview Published on 2020-05-052022-10-31 Journal: Military Medical Research [Category] COVID-19, MERS, SARS, [키워드] adjunctive treatment affected candidate Chloroquine clinical evidence clinical guideline clinical trials Combination compassionate use convalescent plasma coronavirus disease Corticosteroids COVID-19 COVID-19 patient Critically ill disease drug healthcare identify IMPROVE intensive care International investigated Lopinavir-ritonavir National off-label organization outbreak outcome pandemic public health measure recommendation Remdesivir role Support supportive care Treatment treatment strategy turn umifenovir urgency while [DOI] 10.1186/s40779-020-00251-x PMC 바로가기 [Article Type] Review
Pharmacological Therapeutics Targeting RNA-Dependent RNA Polymerase, Proteinase and Spike Protein: From Mechanistic Studies to Clinical Trials for COVID-19Review Published on 2020-04-152022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] ACE2 acute respiratory syndrome addition angiotensin-converting enzyme 2 approach Calu-3 Camostat mesylate Chloroquine clinical clinically compassionate use Coronavirus infection Coronavirus-2 country COVID-19 demonstrated develop enzyme human lung cells in vitro Infection infection with SARS-CoV-2 inhibit Interaction management Novel coronavirus novel coronavirus SARS-CoV-2 outbreak patients with COVID-19 pharmacological Pneumonia Prevent Protease inhibitor Protein proteinase RdRP Remdesivir Replication RNA RNA-dependent RNA polymerase S protein SARS-CoV-2 SARS-COV-2 infection shown spike spike glycoproteins Spread systemically targeting the S protein The United States Therapeutic approach Therapeutics Transmission treated Treatment viability [DOI] 10.3390/jcm9041131 PMC 바로가기 [Article Type] Review
Lung Involvement Found on Chest CT Scan in a Pre-Symptomatic Person with SARS-CoV-2 Infection: A Case ReportCase Report Published on 2020-04-072022-10-29 Journal: Tropical Medicine and Infectious Disease [Category] COVID-19, [키워드] acute respiratory distress antimalarial Antiviral Asymptomatic caused compassionate use COVID-19 CT-scan Emerging infectious diseases health-care Infection Involvement lung field lung involvement novel coronavirus SARS-CoV-2 performed Person Pneumonia report reported SARS-CoV-2 Supportive treatment syndrome the SARS-CoV-2 virus with COVID-19 [DOI] 10.3390/tropicalmed5020056 PMC 바로가기 [Article Type] Case Report
Therapeutic strategies in an outbreak scenario to treat the novel coronavirus originating in Wuhan, ChinaOpinion Article Published on 2020-02-072022-10-31 Journal: F1000Research [Category] COVID-19, MERS, SARS, [키워드] 2019-nCoV 2019-nCoV infection ACE2 ACE2-Fc acute respiratory distress angiotensin-converting enzyme 2 approaches biologic block breath build clinical trial compassionate use coronavirus current death develop domain effective therapy effort fused help helping immune system Immunity Immunoglobulin infected individuals infected patient Infection investigators lung mechanism of action monoclonal antibody Mutation Neutralizing neutralizing antibody Novel coronavirus outbreak pandemic pathophysiology Patient patients Prevent producing Protective Protein protein expression provided quarantine receptor recruit Research respiratory viral sequence therapy treat Treatment Vaccine viral escape viral RNA genome virus while Wuhan Wuhan, China [DOI] 10.12688/f1000research.22211.2 PMC 바로가기 [Article Type] Opinion Article
Hydroxychloroquine is no miracle cure for covid-19 infection -imaging and clinical course in an elderly femaleCase Reports Published on 2020-01-012023-07-05 Journal: Wiadomości lekarskie (Warsaw, Poland : 1960) [Category] SARS, [키워드] Chest CT Chloroquine compassionate use COVID-19 Hydroxychloroquine repurposed agent. SARS-CoV-2 [Article Type] Case Reports