Complement Genetic Variants and FH Desialylation in S. pneumoniae -Haemolytic Uraemic Syndrome보완 유전 변이 및 S. pneumoniae - 용혈성 요독 증후군의 FH 탈시알화Original Research Published on 2021-03-112024-07-30 Journal: Frontiers in immunology [Category] 폐렴구균 감염증, [키워드] complement system Factor H Genetic variant Haemolytic uraemic syndrome Streptococcus pneumoniae (pneumococcus) [DOI] 10.3389/fimmu.2021.641656 PMC 바로가기 [Article Type] Original Research
Acquisition of human plasminogen facilitates complement evasion by the malaria parasite Plasmodium falciparumarticle Published on 2021-02-282024-09-01 Journal: Neurogastroenterology and motility : the official [Category] 말라리아, [키워드] complement system immune evasion malaria plasminogen Plasmodium falciparum [Article Type] article
The Outcome of Critically Ill COVID-19 Patients Is Linked to Thromboinflammation Dominated by the Kallikrein/Kinin System중환자 COVID-19 환자의 결과는 칼리크레인/키닌 시스템이 지배하는 혈소판 염증과 관련이 있습니다Observational Study Published on 2021-02-222022-09-11 Journal: Frontiers in Immunology [Category] MERS, 바이오마커, 임상, 진단, [키워드] activated Activation Analysis Angiogenesis ARDS association biochemical parameter Biomarkers Blood C3a C4d cascade Clinical outcome Coagulation Coagulation system complement complement system components Contact COVID-19 COVID-19 patient Critically ill critically ill COVID-19 patients Critically ill patient critically ill patients D-dimer death debris demonstrated driving drug eliminating Evidence fibrinolysis system ICU Ill Illness severity Inflammation inhibitor innate immune system involved kallikrein/kinin system kidneys lung Lung injury microorganism molecular weight organ damage outcome Pathogenesis pathogenesis of COVID-19 Patient patients with COVID-19 prekallikrein Prognosis Prognostic marker Prospective Study recognizing reflected SC5b-9 severe COVID-19 Strong survival System TAT the patient Thromboinflammation thrombosis Treatment Uppsala University Vascular with COVID-19 [DOI] 10.3389/fimmu.2021.627579 PMC 바로가기 [Article Type] Observational Study
A double edged-sword – The Complement System during SARS-CoV-2 infectionReview Article Published on 2021-02-172023-06-16 Journal: Life sciences [Category] MERS, SARS, [키워드] complement inhibitors complement system COVID-19 Inflammation SARS-CoV-2 [DOI] 10.1016/j.lfs.2021.119245 PMC 바로가기 [Article Type] Review Article
Complement Activation in Kidneys of Patients With COVID-19COVID-19 환자의 신장에서 보체 활성화Immunology Published on 2021-01-292022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, 치료기술, [키워드] activated Activation acute kidney failure acute respiratory syndrome affected Alternative pathway analyzed Antigen arteries Arterioles Artery Autopsy basement membrane biopsies biopsy C1q C3c C4d C5b-9 Capillaries capillary Cell classical pathway cleavage clinical setting Coagulation collateral tissue collectin complement Complement activation Complement pathway complement system complement—immunological term complex controls COVID-19 COVID-19 patients Critically ill Critically ill patient critically ill patients CTRL deregulated develop Disseminated intravascular coagulation dominant Endothelial cell endothelial injury Factor Frequency glomerular hemolytic uremic syndrome highest immune cell responses immune response immunohistochemistry In situ hybridization in some infection with COVID-19 Injury innate immune system intravascular coagulation investigated involved kidney Kidney failure kidneys lectin lectin pathway lectin pathway activation lung marker MASP-2 membrane Most patient Most patients nuclear occur opsonization organ pathway Patient patients with COVID-19 PCNA peritubular peritubular capillaries peritubular capillary plasma Platelet Platelets positive platelets Prevent proliferation Protein protocol renal renal arteries renal tissue respiratory SARS-CoV-2 Severe acute respiratory syndrome specimen specimens subsequent therapy Thrombus thrombus formation tissue tissue injury Transplant Treatment triggering uremic syndrome virus viruses with COVID-19 worsening [DOI] 10.3389/fimmu.2020.594849 PMC 바로가기 [Article Type] Immunology
Anti-phospholipids antibodies and immune complexes in COVID-19 patients: a putative role in disease course for anti-annexin-V antibodiesCOVID-19 환자의 항인지질 항체 및 면역 복합체: 항-아넥신-V 항체의 질병 경과에서의 추정 역할Original Article Published on 2021-01-192022-09-11 Journal: Clinical Rheumatology [Category] MERS, SARS, 진단, 치료기술, [키워드] “COVID-19 Analysis Anti-phospholipid Anti-phospholipid antibodies antibodies antibody APL cause characterized CIC circulating circulating immune complexes Coagulopathy complement system complement system activation conditions control group COVID-19 COVID-19 patient Critical Critical illness Diagnosis digestive disease course distribution dysregulation early infection Endothelial cell endothelial cell damage evaluate glycoprotein group hypercoagulable Hypercoagulable state hypercoagulable states IgG immune complex immune dysregulation in some increases in Infection Inflammatory response Inflammatory responses inflammatory status knowledge lead negative control Pathogenesis Patient patients performed Point positive Prevalence pro-inflammatory prothrombin reported respiratory Result SARS-COV-2 infection significantly suggested syndrome thrombocytopenia thrombosis thrombotic Thrombotic complications Thrombotic events Trigger uniformity Viral viral infection viral infections worsening [DOI] 10.1007/s10067-021-05580-3 PMC 바로가기 [Article Type] Original Article
Recombinant human C1 esterase inhibitor (conestat alfa) in the prevention of severe SARS-CoV-2 infection in hospitalized patients with COVID-19: A structured summary of a study protocol for a randomized, parallel-group, open-label, multi-center pilot trial (PROTECT-COVID-19)입원한 COVID-19 환자의 중증 SARS-CoV-2 감염 예방을 위한 재조합 인간 C1 에스테라제 억제제(conestat alfa): 무작위, 병렬 그룹, 공개 라벨, 다중 센터에 대한 연구 프로토콜의 구조화된 요약 파일럿 시험(PROTECT-COVID-19)Letter Published on 2021-01-042022-09-10 Journal: Trials [Category] 임상, [키워드] 24 hour 24 hours Activation activities acute lung injury addition adjusted Administered administration allergy Antibiotics anticipated anticoagulation arterial Arterial hypertension Basel Blinding BMI Brazil Breast Breast feeding breathing ambient air C-reactive protein C1 esterase inhibitor cardiovascular disease Caregivers changes in Chest Child-Pugh score chronic chronic pulmonary disease chronic renal disease cirrhosis class clinical Clinical improvement clinical trial comparator comparator Patients complement complement system completion conducted Conestat alfa Contact contact activation system contraindication control group Corticosteroids COVID-19 COVID-19 patient CT scan death defined discharge disease disease severity dissemination drug Duration Efficacy and safety element eligibility enrolment evidence of experimental arm family members FIVE followed by history hospital Hospitalization hospitalized patient hypertension ICU IL-6 inhibitor IL-6R improvement Incapacity include inclusion criteria individual Infection inflammatory cascade inflammatory cascades inflammatory proteins inhibitor Interactive Web Response System interim analysis Intravenous injection invasive invasive or non-invasive ventilation investigator-initiated investigators kallikrein kinin system laboratory parameter Liver cirrhosis Local Lung injury mechanical ventilation non-invasive ventilation not blinded number obesity objective Open-label open-label trial Ordinal Scale outcome outcome assessor outcome assessors oxygen oxygen saturation pandemic PaO parallel-group participant Participants Participation Patient performed Pregnancy primary endpoint progression proportion protocol pulmonary disease pulmonary involvement randomised randomization Randomized randomized trial receive recombinant recruited recruitment Registered Remdesivir renal renal disease required risk factor Sample size SARS-COV-2 infection SARS-CoV-2 pandemic scale screened secondary Secondary outcomes severe COVID-19 severe SARS-CoV-2 Standard of care status Study protocol subject supplemental oxygen supplementary material suspicion Switzerland Symptom the SARS-CoV-2 the WHO their family members Tocilizumab Treatment treatment arm Trial Two interim analyses Two interim analysis virological clearance website WHO WHO ordinal scale with COVID-19 X-ray [DOI] 10.1186/s13063-020-04976-x PMC 바로가기 [Article Type] Letter
Complement activation and endothelial perturbation parallel COVID-19 severity and activity보완 활성화 및 내피 교란은 COVID-19 심각도 및 활동과 병행합니다.Article Published on 2021-01-012022-08-31 Journal: Journal of autoimmunity [Category] MERS, SARS, 바이오마커, [키워드] Activation animal animal models association Biomarker Biomarkers C5a cohort study complement Complement activation complement system contribute coronavirus coronavirus disease coronavirus disease-2019 correlated COVID-19 COVID-19 patients COVID-19 severity disease severity endothelial endothelial damage endotheliopathy Endothelium evaluate evaluated high plasma level high plasma levels Hospital admission hypercoagulability manifestation Mild moderate pathophysiology Patient patients with COVID-19 plasma progression Remission SC5b-9 selectin severe disease severity significantly significantly increased target the disease the patient therapy tissue injury von Willebrand factor were measured [DOI] 10.1016/j.jaut.2020.102560 PMC 바로가기 [Article Type] Article
Common Genetic Variants in the Complement System and their Potential Link with Disease Susceptibility and Outcome of Invasive Bacterial Infectionarticle Published on 2020-12-312024-09-01 Journal: Journal of Innate Immunity [Category] 폐렴구균 감염증, [키워드] Common genetic variants complement system disease susceptibility Inflammation single nucleotide polymorphisms Streptococcus pneumoniae [Article Type] article
Transcriptional Differences for COVID-19 Disease Map Genes between Males and Females Indicate a Different Basal Immunophenotype Relevant to the Disease남성과 여성 간의 COVID-19 질병 지도 유전자의 전사적 차이는 질병과 관련된 다른 기초 면역표현형을 나타냅니다Article Published on 2020-12-012022-09-10 Journal: Genes [Category] MERS, SARS, 유전자 메커니즘, [키워드] Adults affected age age and sex basal basal immunophenotype complement complement system contribute COVID-19 COVID-19 progression Cytokines death DeCovid app demographic group demographic groups difference Differential gene expression disease incidence disease severity effective Epidemiology Female patients Gender Gene Expression Genes groups healthy immunophenotype individuals interferon maintain male Map matrix metalloprotease matrix metalloproteases men Older Older adults older population pathway Patient proinflammatory cytokines risk Sex significantly more tissue tissues virus women [DOI] 10.3390/genes11121447 PMC 바로가기 [Article Type] Article