Characterization of the Role of Hexamer AGUAAA and Poly(A) Tail in Coronavirus PolyadenylationResearch Article Published on 2016-10-192022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, [키워드] Analysis characterization Coronaviral coronavirus demonstrated element eukaryotic Evidence Factor Genetic Genome Infection initial length involved mRNA Mutagenesis nucleotides Polyadenylation regulated Regulation responsible role tail Variation [DOI] 10.1371/journal.pone.0165077 PMC 바로가기 [Article Type] Research Article
X-Ray Structure and Inhibition of 3C-like Protease from Porcine Epidemic Diarrhea VirusArticle Published on 2016-05-132022-10-29 Journal: Scientific Reports [Category] Coronavirus, [키워드] 3CL pro acute respiratory syndrome alpha-coronavirus binding conserved contribute Coronaviral coronavirus epidemic diarrhea expression infect inhibition inhibitor involved knowledge majority mortality rate PEDV Phylogeny protease purification residue reveal SARS-CoV sequence identity sequence variation Structure virus X-ray [DOI] 10.1038/srep25961 PMC 바로가기 [Article Type] Article
Critical Assessment of the Important Residues Involved in the Dimerization and Catalysis of MERS Coronavirus Main ProteaseResearch Article Published on 2015-12-142022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] Analysis Asian assessment catalysis catalytic activity Coronaviral coronavirus correlation country CoV Critical demonstrated domain domain III enzyme European Fatality rate FIVE highly pathogenic indicate investigated Jeddah M pro MERS MERS-CoV Middle East monomer Mutagenesis Mutation peptide protease Protein proteolytic activity provide required residue respiratory syndrome coronavirus Result Saudi Arabia spread to ultracentrifugation virus wild-type [DOI] 10.1371/journal.pone.0144865 PMC 바로가기 [Article Type] Research Article
Host Tissue and Glycan Binding Specificities of Avian Viral Attachment Proteins Using Novel Avian Tissue MicroarraysResearch Article Published on 2015-06-022022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] attachment attachment protein binding binding pattern Coronaviral coronavirus CoV Critical dependent on glycan Host host cell hosts Infectious disease influenza virus H5N1 initial Interaction lung M41 Microarray novel organ organ system pathogen Pathogens platform predominant profile Protein reported respiratory tissue S1 protein selected sialic acid specificity susceptibility susceptible tissue tissues type I Validity virus [DOI] 10.1371/journal.pone.0128893 PMC 바로가기 [Article Type] Research Article
The Nucleocapsid Protein of Human Coronavirus NL63Research Article Published on 2015-02-202022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] Analysis binding C-terminal domain Cell cell cycle progression cellular processes Characteristics Coronaviral coronavirus described disease expressing feature Genetic genomes HCoV-229E HCoV-NL63 homologous Human human coronavirus human coronavirus 229E infected cells involved N-terminal domain NL63 nucleic acid nucleocapsid protein nucleus oligomerization other coronaviruses pathogen Protein respiratory tract responsible reveal SARS-CoV severity subcellular localization the N protein transfected cells unique viral replication [DOI] 10.1371/journal.pone.0117833 PMC 바로가기 [Article Type] Research Article
On the biased nucleotide composition of the human coronavirus RNA genomeArticle Published on 2015-02-022022-11-01 Journal: Virus research [Category] Coronavirus, [키워드] Atypical characteristic Characteristics codon usage Coronaviral coronavirus coronavirus RNA Coronaviruses domains event Evolution Genome human coronaviruses human pathogen investigated less MERS MOST nucleotide Nucleotide signature opposite proportion Region RNA RNA genome SARS sequence single-stranded vessels viral genome viral RNA genome virus virus isolate viruses zoonotic [DOI] 10.1016/j.virusres.2014.11.031 PMC 바로가기 [Article Type] Article
Structural and functional characterization of MERS coronavirus papain-like proteaseResearch Published on 2014-06-042022-10-29 Journal: Journal of Biomedical Science [Category] Coronavirus, [키워드] Analysis antiviral drug antiviral target Circular Coronaviral coronavirus Coronaviruses CoV demonstrated Deubiquitination develop European country exhibit expressed Fatality rate functional functional consequence highly pathogenic indicated inhibiting Jeddah kinetic MERS coronavirus MERS-CoV Middle East monomer natural mutation organized Papain-like protease proteolytic proteolytic activity respiratory syndrome coronavirus Result SARS-CoV Saudi Arabia spread to therapy ultracentrifugation virus [DOI] 10.1186/1423-0127-21-54 PMC 바로가기 [Article Type] Research
Targeting Membrane-Bound Viral RNA Synthesis Reveals Potent Inhibition of Diverse Coronaviruses Including the Middle East Respiratory Syndrome VirusResearch Article Published on 2014-05-292022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] accompanied accumulating antiviral activity antiviral drug antiviral intervention cellular membrane complex component Compound concerning conserved Coronaviral coronavirus coronavirus 229E Coronavirus infection Coronavirus replication Coronaviruses Culture early phase epithelia genome replication hallmark highly pathogenic Host host cell cytoplasm implicated Including infections inhibit inhibition inhibitor knowledge membrane membrane vesicle membrane-bound membranes MERS-CoV MERS–CoV Middle East mutant Mutation non-structural protein not affected positive potent raise recruitment reduced replicate Replication representing respiratory respiratory syndrome coronavirus RNA RNA synthesis RNA virus RNA viruses SARS-CoV screened Substitution synthesis target targeting Transcription Treatment viral life cycle viral replication viral RNA synthesis virus virus entry zoonotic [DOI] 10.1371/journal.ppat.1004166 PMC 바로가기 [Article Type] Research Article
The 3′-Terminal 55 Nucleotides of Bovine Coronavirus Defective Interfering RNA Harbor Cis -Acting Elements Required for Both Negative- and Positive-Strand RNA SynthesisResearch Article Published on 2014-05-222022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] Bovine coronavirus cis -acting element complement Coronaviral Coronavirus replication Coronaviruses Critical defined detect element Genome genome replication Harbor identify knowledge mechanism negative Northern blot nucleotide polymerase chain qRT-PCR Quantitative required responsible reverse transcription RNA RNA synthesis synthesis [DOI] 10.1371/journal.pone.0098422 PMC 바로가기 [Article Type] Research Article
Lack of Innate Interferon Responses during SARS Coronavirus Infection in a Vaccination and Reinfection Ferret ModelResearch Article Published on 2012-09-242022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] acute infection against SARS-CoV Antiviral antiviral therapeutics approach Coronaviral CoV develop expression ferret ferrets functional gene expression signature help highly pathogenic identify IFN response immune immune protection immune response Immunity immunized Immunopathogenesis inactivated Infected Infection infections Innate innate immune response inoculated IRG lung Lungs Model molecular Pathogenesis pathology prevalent protective immunity provide resource response SARS virus SARS-coronavirus SARS-CoV SARS-CoV infection SARS-like-CoV Vaccine vaccine candidate Vaccines virus [DOI] 10.1371/journal.pone.0045842 PMC 바로가기 [Article Type] Research Article