Cardiac dysfunction and mortality in critically ill patients with COVID-19: A Swedish multicentre observational studyObservational Study Published on 2022-05-012022-10-05 Journal: Acta Anaesthesiologica Scandinavica [Category] 임상, [키워드] Admission cardiac Cardiac biomarkers cardiac dysfunction changed COVID-19 Critically ill patient death defined dysfunction echocardiography Ejection fraction elevated examined FIVE ICU ICUs increased risk intensive care intensive care unit Intubated LV dysfunction Mortality Most patient multicentre occur Patient patients patients with COVID-19 performed Prevalence pulmonary artery pressure RV dysfunction Swedish TAPSE ventricular with COVID-19 [DOI] 10.1111/aas.14039 PMC 바로가기 [Article Type] Observational Study
Efficacy and safety of HD-tDCS and respiratory rehabilitation for critically ill patients with COVID-19 The HD-RECOVERY randomized clinical trialRandomized Controlled Trial Published on 2022-05-012022-10-05 Journal: Brain stimulation [Category] COVID19(2023년), SARS, 임상, [키워드] 1:1 acute respiratory distress syndrome addition Adverse adverse effect attenuate Brain clinical response conducted coronavirus disease corticospinal COVID-19 Critically ill patient current defined delirium Direct Direct Current distress dysfunction Efficacy Efficacy and safety evaluate event fatigue feasible groups High-definition transcranial direct current stimulation hospital impairment increase in intensive care Intervention investigated mechanical ventilation moderate Mortality no significant difference Noninvasive brain stimulation organ dysfunction Organ failure pathway patients patients with COVID-19 patients with moderate positive Primary outcome Randomized randomized clinical trial rehabilitation respiratory respiratory rehabilitation Safe secondary outcome severe ARDS severe hypoxemia statistically significant Stimulation therapy Trial unit discharge ventilator-free day with COVID-19 [DOI] 10.1016/j.brs.2022.05.006 PMC 바로가기 [Article Type] Randomized Controlled Trial
Low phase angle is associated with 60-day mortality in critically ill patients with COVID-19낮은 위상각은 COVID-19 중환자의 60일 사망률과 관련이 있습니다.Article Published on 2022-05-012022-09-11 Journal: JPEN. Journal of parenteral and enteral nutrition [Category] COVID19(2023년), SARS, 치료기술, [키워드] 95% CI acute respiratory syndrome acute respiratory syndrome coronavirus Admission Analysis association bioelectrical impedance Bioelectrical Impedance Analysis biological marker body composition body water clinical outcomes coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Critically ill Critically ill patient critically ill patients Cutoff death Extracellular female hazard ratio Hospital stay increased risk intensive care intensive care unit admission Kaplan-Meier curves Linear regression model male Malnutrition mechanical ventilation mechanically ventilated patient mechanically ventilated patients Mortality mortality risk nutrition risk nutrition status Odds ratio on mechanical ventilation parameter Pathologies Patient Phase angle predictor prospective cohort risk Risk assessment SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significantly increased survival analysis variable was performed water were used with COVID-19 [DOI] 10.1002/jpen.2236 PMC 바로가기 [Article Type] Article
The role of Monocyte Distribution Width (MDW) in the prognosis and monitoring of COVID-19 patientsCOVID-19 환자의 예후 및 모니터링에서 단핵구 분포 폭(MDW)의 역할Article Published on 2022-05-012022-09-11 Journal: Clinical biochemistry [Category] COVID19(2023년), MERS, SARS, 바이오마커, 진단, [키워드] age AUC Beckman Coulter blood count blood sample calculated complete blood count correlated COVID-19 COVID-19 patient COVID-19 patients Critically ill Critically ill patient critically ill patients cut-off diagnostic distribution Efficacy enrolled form hospitalisation ICU less monocyte Monocyte Distribution Width (MDW) non-survivor not significant outcome parameter Patient patients procalcitonin Prognosis prognostic reported SARS-CoV-2-positive patient Sensitivity and specificity severe forms of COVID-19 shown significantly Standard deviation Support Surveillance Survivors the mean unfavourable prognosis was used width [DOI] 10.1016/j.clinbiochem.2022.02.007 PMC 바로가기 [Article Type] Article
Prognostic Impact of Bronchoalveolar Lavage Fluid Galactomannan and Aspergillus Culture Results on Survival in COVID-19 Intensive Care Unit Patients: a Post Hoc Analysis from the European Confederation of Medical Mycology (ECMM) COVID-19-Associated Pulmonary Aspergillosis StudyObservational Study Published on 2022-04-202022-10-05 Journal: Journal of Clinical Microbiology [Category] 임상, [키워드] 95% CI adjusted Analysis aspergillosis Aspergillus association BALF Biomarker Bronchoalveolar lavage fluid can be used CAPA Combination conducted confidence interval coronavirus disease COVID-19 Critically ill patient Culture develop diagnosed enrolled European final multivariable model galactomannan galactomannan. GM hazard ratio heterogeneity Impact increasing age independent independent predictor intensive care unit lavage malignant disease Mortality MOST multicenter mycology optical Patient positive prognostic Prognostic value pulmonary Result survival with COVID-19 [DOI] 10.1128/jcm.02298-21 PMC 바로가기 [Article Type] Observational Study
Closed-loop oxygen control improves oxygen therapy in acute hypoxemic respiratory failure patients under high flow nasal oxygen: a randomized cross-over study (the HILOOP study)Randomized Controlled Trial Published on 2022-04-142022-10-04 Journal: Critical Care [Category] 임상, [키워드] 95% confidence interval Acute respiratory failure AHRF assigned Automatic Automatic oxygen titration Closed-loop oxygen control COVID-19 pandemic Critically ill patient cross-over cut-off Efficacy event groups healthcare personnel HFNO High flow nasal cannula High-flow nasal oxygen hypoxemic IMPROVE less moderate nasal Nasal high-flow. nasal oxygen not significantly different oxygen Oxygen administration oxygen supply Oxygen therapy Oxygenation Patient patients with moderate Primary outcome Randomized Randomly Registered Respiratory failure therapy treated [DOI] 10.1186/s13054-022-03970-w PMC 바로가기 [Article Type] Randomized Controlled Trial
Platelet-monocyte interaction amplifies thromboinflammation through tissue factor signaling in COVID-19Research article Published on 2022-04-142022-10-05 Journal: Blood advances [Category] SARS, 바이오마커, 비임상, [키워드] activated Activation aggregate amplification amplify amplifying Analysis approach assays binding CD16 Coagulation Combination COVID-19 Critically ill patient driving Evidence Ex vivo exhibited expression fibrinogen function functional high risk highlight HLA-DR hypercoagulability hyperinflammation identify in vitro indicated Inflammation Inflammatory Inflammatory cytokine Inflammatory mediators inflammatory monocyte Interaction interleukin-1β life-threatening mechanism mechanisms monocyte P-selectin pathogenesis of COVID-19 Patient pharmacological Platelet platelet activation Platelets presenting proinflammatory cytokines receptor response RNA-sequencing SARS-COV-2 infection secretion severe COVID-19 Signaling single-cell subset thromboembolic complications Thromboinflammation tissue tumor necrosis factor-α with COVID-19 [DOI] 10.1182/bloodadvances.2021006680 [Article Type] Research article
Voices from the Pandemic: A Qualitative Study of Family Experiences and Suggestions regarding the Care of Critically Ill PatientsObservational Study Published on 2022-04-012022-10-05 Journal: Annals of the American Thoracic Society [Category] 임상, [키워드] age analyzed approach Care clinician Clinicians communication Contact contributed coronavirus coronavirus disease COVID-19 COVID-19 pandemic Critical Critical care Critically ill patient critically ill patients described early phase experience family family member female hospital ICU ICU patient Ill IMPROVE interview nine Observational cohort study offer offered pandemic participant Patient physical distancing physically postintensive care syndrome-family. Psychological Qualitative recommendation reduced Satisfaction Stress suggestion Support the mean thematic analysis therapeutic relationship transcribed understanding United State voice weakened with COVID-19 [DOI] 10.1513/AnnalsATS.202105-629OC PMC 바로가기 [Article Type] Observational Study
Steroid therapy and antiviral treatment in SARS-CoV-2 pneumonia: clinical contexts and indicationsSARS-CoV-2 폐렴에서 스테로이드 요법 및 항바이러스 치료: 임상적 맥락 및 적응증Review Published on 2022-04-012022-09-11 Journal: Revista española de quimioterapia : publicación [Category] COVID19(2023년), SARS, 치료제, [키워드] 28-day mortality Antiviral treatment benefit Clinical improvement clinical trial complications Corticosteroids Critically ill Critically ill patient critically ill patients decrease Dexamethasone Disease progression drug Effectiveness Fluid management group Health Organization higher risk include indication measure mechanical ventilation Meta-analysis Mortality oxygen Oxygen therapy Patient patients with COVID-19 per day performed Placebo RECOVERY trial reduction in Remdesivir requiring supplemental oxygen routine care SARS-CoV-2 Standard of care steroid therapy subgroup analysis supplemental oxygen supportive care systemic corticosteroid systemic corticosteroids Trial WHO with COVID-19 World Health Organization [DOI] 10.37201/req/s01.13.2022 PMC 바로가기 [Article Type] Review
Therapeutic potential of induced iron depletion using iron chelators in Covid-19Review article Published on 2022-04-012022-10-05 Journal: Saudi Journal of Biological Sciences [Category] 유전자 메커니즘, 치료제, [키워드] Administered antioxidants Antiviral approved benefit cascade Clinical use Corticosteroids COVID 19 COVID-19 Critically ill patient effective FDA ferritin ferritin levels Genomics heavy chain Hyperferritinemia immunomodulators include Inflammation inflammatory markers intravenous iron Iron Chelator lactoferrin men metabolism monoclonal antibodies Pathogenesis poor prognosis proportion Proteomic interaction responsible signaling molecules the patient therapy tissue tissues treat Treatment women [DOI] 10.1016/j.sjbs.2021.11.061 [Article Type] Review article