Synthetic SARS-CoV-2 Spike-Based DNA Vaccine Elicits Robust and Long-Lasting Th1 Humoral and Cellular Immunity in Mice
Microbiology
[키워드] BALB/c
BALB/c mice
binding
candidate vaccine
CD4
CD8
Cell
cellular immunity
clinical testing
coding sequence
Consensus
coronavirus disease
COVID-19
cytokine production
demonstrated
DNA
DNA vaccine
dose
effective
elicit
elicited
ENhance
full-length S
global pandemic
glycoprotein
humoral
IFN-γ
IgG
IgG antibodies
IgG antibody
IL-2
immune response
immune responses
immunization
immunogenic
in viral
induce
injection
intramuscular
long-lasting
Measures
memory
memory T
mice
mouse model
NAb
neutralizing antibody
Pathogenesis
plasmid DNA
preclinical (in vivo ) studies
Prophylactic
Protective
protective immunity
Protein
response
robust
Safe
SARS-CoV-2
significant level
significantly
spike (S) glycoprotein
synthetic
T cell
Th1
the vaccine
therapeutic
TNF
Vaccine
was tested
[DOI] 10.3389/fmicb.2021.727455 PMC 바로가기 [Article Type] Microbiology
[DOI] 10.3389/fmicb.2021.727455 PMC 바로가기 [Article Type] Microbiology