NETosis: Molecular Mechanisms, Role in Physiology and PathologyNETosis: 분자 기전, 생리학 및 병리학에서의 역할Review Published on 2020-10-012022-09-12 Journal: Biochemistry. Biokhimiia [Category] MERS, SARS, 진단, [키워드] antibody chromatin chromatin decondensation component Concentration COVID-19 Cytokines cytoplasm cytosol disease Granule histone Immune complexes include increase in induction mechanism Modification NADPH oxidase NETosis NETs Neutrophil extracellular trap nuclear envelope Pathogenesis Pathogens physiological Physiology plasma membrane Protein reactive oxygen specy role ROS [DOI] 10.1134/S0006297920100065 PMC 바로가기 [Article Type] Review
Low Humoral Immune Response and Ineffective Clearance of SARS-Cov-2 in a COVID-19 Patient With CLL During a 69-Day Follow-UpOncology Published on 2020-07-032022-10-31 Journal: Frontiers in Oncology [Category] COVID-19, [키워드] accumulate acute respiratory syndrome antiviral therapy B cell B cells B-cell Blood Cell chronic lymphocytic leukemia circulating clearance Clinical characteristics CLL CLL patients clone Cluster combination regimen coronavirus coronavirus disease-2019 COVID COVID-19 criteria cytoplasm deficiency demonstrated diagnosed with COVID-19 distribution early stage effective etiology female flow cytometry Follow-up help Hematological malignancy High-dose highest home quarantine hospital human-to-human transmission humoral immune response Humoral immunity IgG antibody IgM and IgG immune Ineffective ineffective clearance infected with COVID-19 Infection Intravenous immunoglobulin Isolation laboratory result leukemia Lung injury lymphocyte lymphocytosis outbreak Patient plasma prevent disease progression progeny progression reported response severe disease severe pneumonia suffered T lymphocytes therapy Viral load virus infection Wuhan, China [DOI] 10.3389/fonc.2020.01272 PMC 바로가기 [Article Type] Oncology
Novel COVID-19: A Comprehensive Review of Transmission, Manifestation, and PathogenesisInfectious Disease Published on 2020-05-182022-10-31 Journal: Cureus [Category] COVID-19, [키워드] ACE2 ACE2 receptor acute respiratory syndrome affecting alveolar alveolar cell angiotensin converting enzyme 2 angiotensin-converting enzyme 2 Asymptomatic carrier binding Cell China Comprehensive coronavirus Coronavirus disease 2019 country COVID-19 cytoplasm District elderly endocytosed epithelial global pandemic greater highlight immune response increase individual Infection initial stage International Intervention majority manifestation medical condition membrane MERS Mild moderate new strain novel other coronaviruses outbreak presenting receptor replicate replicated resulting review risk of infection S glycoprotein SARS SARS-CoV2 Seafood self-isolate susceptibility Symptom type II pneumocytes Viral load Viral RNA virus weakened immune system West WHO World Health Organization wuhan-hu-1-cov [DOI] 10.7759/cureus.8184 PMC 바로가기 [Article Type] Infectious Disease
Is the use of RAS inhibitors safe in the current era of COVID-19 pandemic?Review Published on 2020-05-072022-10-31 Journal: Clinical Hypertension [Category] COVID-19, [키워드] 2019 novel coronavirus ACE inhibitor ACE2 ACE2 expression angiotensin receptor blocker Antihypertensive drug antihypertensive drugs blockade cell membrane COVID-19 COVID-19 infection cytoplasm death enzyme Evidence exacerbated facilitate homeostasis hypertension Infection maintain mechanism nervous system pandemic Protein RAS RAS inhibitor respiratory Safe SARS SARS-CoV-2 Sepsis shown sodium balance subject subjects therapy viral entry viral surface virus [DOI] 10.1186/s40885-020-00144-0 PMC 바로가기 [Article Type] Review
Coronavirus endoribonuclease targets viral polyuridine sequences to evade activating host sensors530 Published on 2020-04-072022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, MERS, [키워드] activate activating Activation approach caused Cell cells cleave conserved coronavirus Coronaviruses CoV CoVs cytoplasm dampen detect disease Endemic endoribonuclease EndoU evade Express extension facilitate Factor Host immune immune sensing infect infections information inhibiting inhibitor interfere interferon interferon response limit MDA5 mechanism morbidity and mortality Mutation Nsp15 pathogen-associated molecular Pathways pattern recognition receptor positive-sense Prevent previous study reservoir RNA RNA synthesis RNA virus robust sequence Significance stimulate target therapeutic intervention transfecting Viral RNA virus viruses [DOI] 10.1073/pnas.1921485117 PMC 바로가기 [Article Type] 530
Swine acute diarrhea syndrome coronavirus-induced apoptosis is caspase- and cyclophilin D- dependentArticle Published on 2020-02-242022-10-31 Journal: Emerging Microbes & Infections [Category] COVID-19, MERS, [키워드] activated acute diarrhea Apoptosis apoptosis-inducing factor Apoptotic cell death apoptotic pathway association Bax caspase caspase-8 cause Cell characterized cleavage coronavirus cyclosporin A cytochrome cytoplasm diarrhea Evidence extrinsic facilitate host cells IMPROVE in vitro in vivo induce Infection inhibitor intestinal pathological damage intrinsic mechanism mitochondrial MPTP Pathogenesis pathway Pathways Protein reduction in Replication SADS-CoV syndrome treated upregulated Vero E6 viral replication [DOI] 10.1080/22221751.2020.1722758 PMC 바로가기 [Article Type] Article
Lessening of porcine epidemic diarrhoea virus susceptibility in piglets after editing of the CMP-N-glycolylneuraminic acid hydroxylase gene with CRISPR/Cas9 to nullify N-glycolylneuraminic acid expressionResearch Article Published on 2019-05-292022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, [키워드] age biallelic Cas9 clinical manifestation clinical symptom colostrum cytoplasm Deceased detectable diarrhoea died Epidemic epithelial cell euthanized exhibited experiments expression Glucose Health homozygous hpi Hypothesis immune immunofluorescence infect Infection inoculated intestine moderate mRNA mutated occurred Occurrence offered offspring PEDV replaced severity single-guide RNA staining susceptibility TCID two group vacuolization villus virus was tested wild-type [DOI] 10.1371/journal.pone.0217236 PMC 바로가기 [Article Type] Research Article
Characteristics of the Life Cycle of Porcine Deltacoronavirus (PDCoV) In Vitro: Replication Kinetics, Cellular Ultrastructure and Virion Morphology, and Evidence of Inducing AutophagyArticle Published on 2019-05-182022-10-28 Journal: Viruses [Category] Coronavirus, MERS, [키워드] affected Alpha Analysis autophagy beta-coronavirus cause cells cellular Characteristics cycle cytoplasm described diarrhea electron microscopy evidence of genomic RNA help in vitro indicated Inducing Infection infectious titer Kinetics life membrane molecular mechanism morphology p62 porcine deltacoronavirus (PDCoV) Replication replication kinetics Structure ultrastructure Vesicle virion vomiting [DOI] 10.3390/v11050455 PMC 바로가기 [Article Type] Article
Real-time analysis of quantum dot labeled single porcine epidemic diarrhea virus moving along the microtubules using single particle trackingArticle Published on 2019-02-042022-10-29 Journal: Scientific Reports [Category] Coronavirus, [키워드] addition Analysis cause Cell cell membrane Characteristics contagious cytoplasm disease epidemic diarrhea host cells infection mechanism live cells mechanism microtubule organizing center PEDV performed provided Real-time analysis Transport Vero cells virus [DOI] 10.1038/s41598-018-37789-9 PMC 바로가기 [Article Type] Article
Determination of host proteins composing the microenvironment of coronavirus replicase complexes by proximity-labelingResearch Article Published on 2019-01-112022-10-31 Journal: eLife [Category] Coronavirus, MERS, [키워드] assist Biotin breadth build caused Cell common cold Complete complex complexes comprehensive analysis Contact Coronaviral coronavirus Coronaviruses Critical cytoplasm demonstrated Determination disease enzyme Factor Factors genetic code help Host host cell host cells host protein host proteins Human infect Infection infections Interaction involved kill knowledge membrane MERS microenvironment Mild molecular mouse nose and throat Other Pathways platform positive-sense RNA virus Protein proximal proximity labeling question replicase complex replication complex researcher RNA virus RTC scientist severe disease short-lived starting point Symptom target therapeutic intervention These viruses translation translation initiation Transport turn Vesicular Transport Viral proteins viral RNA synthesis virus virus infection virus particles Virus-host interaction waste disposal [DOI] 10.7554/eLife.42037 PMC 바로가기 [Article Type] Research Article