Cardiac and Renal SARS-CoV-2 Viral Entry Protein Regulation by Androgens and Diet: Implications for Polycystic Ovary Syndrome and COVID-19Article Published on 2021-09-092022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] ACE2 acute respiratory syndrome ADAM17 analyzed androgen androgens angiotensin converting enzyme 2 cardiac cardiometabolic cathepsin L caused complications conditions coronavirus coronavirus disease COVID-19 Deleterious Dihydrotestosterone disorder Endocrine exacerbated expression fat Fat mass female furin high risk increase in kidney LFD mice mitigate Modification modulated mRNA expression obesity outcome Ovary Polycystic polycystic ovary Polycystic ovary syndrome positively correlated Protein protein expression receptor renal SARS-CoV-2 SARS-CoV-2 viral serum severity susceptibility syndrome TMPRSS2 TMPRSS4 treated Treatment upregulated weight loss women [DOI] 10.3390/ijms22189746 PMC 바로가기 [Article Type] Article
Cyclosporin A: A Repurposable Drug in the Treatment of COVID-19?Medicine Published on 2021-09-062022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] acting Angiotensin converting enzyme-2 anti-inflammatory effect anti-SARS-CoV-2 antiviral activity Antiviral effect attrition rates clinical trial complex Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients creating cyclophilin cyclosporin cyclosporin A death Deleterious drug Drug discovery Health highlight incidence increasingly investigated management molecular mechanism performed proinflammatory cytokines reducing Safe SARS-CoV-2 shown target therapeutic Therapeutic strategies therapy thrombosis tissue damage viral RNA synthesis [DOI] 10.3389/fmed.2021.663708 PMC 바로가기 [Article Type] Medicine
7-Ketocholesterol: Effects on viral infections and hypothetical contribution in COVID-197-케토콜레스테롤: 바이러스 감염에 미치는 영향 및 COVID-19에 대한 가설적 기여Review Published on 2021-09-012022-09-11 Journal: The Journal of steroid biochemistry and molecular [Category] MERS, 바이오마커, 치료제, [키워드] 7-Ketocholesterol activate activities activity acute respiratory distress acute respiratory distress syndrome adjuvant adjuvant therapies adjuvant therapy affected Age-related macular degeneration alveolar cells Alzheimer's disease Anti-viral antiviral activity Apoptosis appear assumed auto-oxidation autophagy Biomarker cancers cardiovascular diseases cell death cholesterol chronic inflammatory bowel diseases concentrations contribute contributing to COVID-19 COVID-19 patients Deleterious density disease Diseases Effect food hypothetical Inflammatory bowel disease inflammatory bowel diseases involved macular degeneration outcome Oxidation oxidized oxysterol Oxysterols pathophysiology pro-inflammatory produced promote provided recent respiratory distress Respiratory distress syndrome resulting SARS-CoV-2 serum shown side chain significantly suggested syndrome toxic effect toxic effects Viral Viral diseases viral infection [DOI] 10.1016/j.jsbmb.2021.105939 PMC 바로가기 [Article Type] Review
Mechanisms underlying genetic susceptibility to multisystem inflammatory syndrome in children (MIS-C)어린이의 다기관 염증 증후군(MIS-C)에 대한 유전적 감수성의 기본 메커니즘Article Published on 2021-09-012022-09-11 Journal: The Journal of Allergy and Clinical Immunology [Category] SARS, 바이오마커, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Apoptosis Beta cardiovascular dysfunction characterized children cohort of patient condition coronavirus COVID-19 CYBB cytokine cytokine signaling Deleterious develop Diagnosis differentially expressed gene Differentially expressed genes downstream enrichment enrolled Exome General population Genetic genetic mechanism genetic risk factor genetic susceptibility had no haploinsufficiency healthy children identify IL-18 Immune cell Including Infection Inflammation Inflammatory inflammatory disorder inflammatory disorders inhibitor interferons interquartile range median age Mild MIS-C Multiorgan multisystem inflammatory syndrome in children Next-generation sequencing nuclear obesity occur pathway Pathways Patient PBMC PBMCs pediatric prospective cohort study reported respiratory SARS-CoV-2 Sequencing severe acute respiratory syndrome Coronavirus single-center SOCS1 subunit Support suppressor susceptibility syndrome Transcriptome type I variant was performed was tested whole exome sequencing X-linked XIAP [DOI] 10.1016/j.jaci.2021.06.024 PMC 바로가기 [Article Type] Article
Awareness and Mental Health of Male Drug Addicts With Tuberculosis During the COVID-19 PandemicPsychiatry Published on 2021-08-182022-10-31 Journal: Frontiers in Psychiatry [Category] COVID-19, [키워드] Accuracy Addict addition albumin Awareness be worn blood tests BMI changed Chinese cohorts collected Combination complementary Compliance consequence COVID-19 COVID-19 epidemic COVID-19 in patient COVID-19 pandemic COVID-19 symptoms Deleterious demographics dimension disease Diseases drug drug addicts effort emotional Epidemic Epidemics evaluate flu Health help hemoglobin immunomodulation infection rate knowledge Laboratory male mandatory measure mental health performed populations positive preventive measure Psychological psychological health question questionnaire Reactions rehabilitation response responses Risk perception selected serum significant difference significantly lower statistical analysis subject susceptible total serum protein Transmission Tuberculosis [DOI] 10.3389/fpsyt.2021.697508 PMC 바로가기 [Article Type] Psychiatry
Antibodies against type I interferon: detection and association with severe clinical outcome in COVID‐19 patientsShort Communication Published on 2021-08-172022-10-31 Journal: Clinical & Translational Immunology [Category] COVID-19, [키워드] addition admitted to ICU antibody antiviral immune response association autoantibodies autoantibody circulating Clinical characteristics Clinical course Clinical outcome Cohort Concentration COVID‐19 COVID‐19 patient COVID‐19 patients COVID‐19 Critical Critically ill critically ill patients Deleterious evaluate explained France higher risk hospice ICU IFN Immunity impairment IMPROVE intensive care unit majority Mild neutralising Neutralising activity neutralize no significant difference objective outcome pandemic progresses Patient positive Prevalence quantification reported Result SARS‐CoV‐2 virus sera serum subset subtype the disease Thermo Fisher type I Type I IFN type I interferon viral infection was determined [DOI] 10.1002/cti2.1327 PMC 바로가기 [Article Type] Short Communication
Acceptability of COVID-19 Certificates: A Qualitative Study in Geneva, Switzerland, in 2020Public Health Published on 2021-08-172022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, MERS, SARS, [키워드] acceptability activities acute respiratory syndrome age anti-SARS-CoV-2 serology coded conducted consequence Coronavirus-2 COVID-19 COVID-19 immunity COVID-19 vaccine debate Deleterious discrimination favor General population group identify Immunity immunity certificates implementation interview Invasion knowledge lockdown Major outcomes pandemic participant public health measure public health policy Qualitative qualitative study Re-infection reliability SARS-CoV-2 Serological testing social acceptability Switzerland took place transcript vaccination Vaccine [DOI] 10.3389/fpubh.2021.682365 PMC 바로가기 [Article Type] Public Health
Sleep quality deterioration in middle-aged and older adults living in a rural Ecuadorian village severely struck by the SARS-CoV-2 pandemic. A population-based longitudinal prospective studyClinical Trial Published on 2021-08-132022-10-05 Journal: Sleep [Category] SARS, 임상, [키워드] adjusted age Atahualpa baseline changes in Community Coronavirus-19 covariates COVID-19 Deleterious demonstrated Deterioration disrupting eligible enrolled Follow-up independent index individual Logistic logistic regression model Longitudinal data Odds ratio Older pandemic participant pathway Pittsburgh Pittsburgh Sleep Quality Index progression proportion Prospective Study Quality Registered SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-COV-2 infection seronegative seropositive individual seropositive individuals seropositive subject significant increase Sleep sleep quality the SARS-CoV-2 [DOI] 10.1093/sleep/zsab041 PMC 바로가기 [Article Type] Clinical Trial
Intranasal type I interferon treatment is beneficial only when administered before clinical signs onset in the SARS-CoV-2 hamster model비강 내 I형 인터페론 치료는 SARS-CoV-2 햄스터 모델에서 임상 징후가 발병하기 전에 투여할 때만 유익합니다.Research Article Published on 2021-08-092022-09-10 Journal: PLoS Pathogens [Category] SARS, 치료제, [키워드] Administered administration Antiviral caused Clinical course Clinical sign clinical trial clinical trials COVID-19 patients days post-infection Deleterious deleterious effects demonstrated disease Effect effector Efficacy and safety Evidence had no Host IFN-α IFNs immunopathology Impaired Infection information interferon interferons Intervention intranasal lung titers MERS MERS-CoV mice modulate observation onset of symptom onset of symptoms patients Post-infection preclinical study produced provide provided SARS-CoV SARS-CoV-2 SARS-COV-2 infection severe COVID-19 shown Signaling Stage the SARS-CoV-2 the timing Therapeutics Treatment Type Type I IFN type I IFNs type I interferon type I interferons Viral viral infections weight loss [DOI] 10.1371/journal.ppat.1009427 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 and the Brain: What Do We Know about the Causality of ‘Cognitive COVID?Review Published on 2021-08-022022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] approach Brain Causality caused changes in cognitive Cognitive impairment consequence coronavirus disease correlations COVID-19 COVID-19 case Deleterious delirium Diagnosis domains encephalopathy-like symptoms event Evidence exhibiting Healthcare system hematogenous highlight identify Immune cell Infection Inflammation intubation management mechanism mechanisms memory MERS-CoV mitigate mRNA neuronal neurotropism olfactory outbreak pandemic pathway Patient Prevalence prevention pro-inflammatory state proportion psychosocial stressor Quality of life raised rehabilitation risk SARS-CoV SARS-CoV-2 SARS-COV-2 infection spike glycoprotein Spread Symptom Symptoms syndrome Transmission unique Vaccine vectors virus [DOI] 10.3390/jcm10153441 PMC 바로가기 [Article Type] Review