“What should be computed” for supporting post-pandemic recovery policymaking? A life-oriented perspectiveReview Published on 2021-11-192022-10-31 Journal: Computational Urban Science [Category] COVID-19, [키워드] affecting approach big data catch caused changes in complex COVID-19 COVID-19 pandemic Daily life described domains Effect Evidence Factor Impact Interaction Life-oriented approach pandemic Perspective Policymaking Post-pandemic recovery questionnaire data Science selected shown Spread spread of COVID-19 suggested Support the SARS-CoV-2 virus understanding urban variety [DOI] 10.1007/s43762-021-00025-8 PMC 바로가기 [Article Type] Review
Disability and self-care living strategies among adults living with HIV during the COVID-19 pandemicResearch Published on 2021-11-192022-10-27 Journal: AIDS Research and Therapy [Category] [키워드] adopted antiretroviral Canada Chronic illness Community COVID-19 pandemic cross-sectional defined dimensions disability domain domains employment greater Health help HIV HIV/AIDS median age men MOST pandemic participant Perspective physical distancing positive attitude proportion question reported Result resulting self-care severity Severity Score significantly social isolation supplementary material Toronto web-based survey with HIV worsening [DOI] 10.1186/s12981-021-00413-4 PMC 바로가기 [Article Type] Research
Disability and self-care living strategies among adults living with HIV during the COVID-19 pandemicResearch Published on 2021-11-192022-10-27 Journal: AIDS Research and Therapy [Category] COVID-19, MERS, SARS, [키워드] adopted antiretroviral Canada Chronic illness Community COVID-19 pandemic cross-sectional defined dimensions disability domain domains employment greater Health help HIV HIV/AIDS median age men MOST pandemic participant Perspective physical distancing positive attitude proportion question reported Result resulting self-care severity Severity Score significantly social isolation supplementary material Toronto web-based survey with HIV worsening [DOI] 10.1186/s12981-021-00413-4 PMC 바로가기 [Article Type] Research
SARS-CoV-2 Variants and Their Relevant Mutational Profiles: Update Summer 2021SARS-CoV-2 변이체 및 관련 돌연변이 프로필: 2021년 여름 업데이트Research Article Published on 2021-11-172022-09-10 Journal: Microbiology Spectrum [Category] MERS, SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 animals antigenicity antivirals assist caused circulating variant circulating variants coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 database diagnostic domains Efficacy emerging variants event Evolution full-length Genetic GISAID highlighting Human human-to-human transmission impacts mapped modulate monoclonal antibodies Mutation mutations Nextstrain pandemic profile Protein provide reported respiratory retrieved SAR-CoV-2 SARS-CoV-2 SARS-CoV-2 genome sequence SARS-CoV-2 spike protein SARS-CoV-2 variant SARS-CoV-2 variants sera severe acute respiratory syndrome Coronavirus spike mutation spike mutations Spike protein Stanford summer the SARS-CoV-2 the spike protein Therapeutics three-dimensional structure Vaccine variant variants variants of concern Viral viral infectivity VOCs VOIs website [DOI] 10.1128/Spectrum.01096-21 PMC 바로가기 [Article Type] Research Article
Persistent symptoms and decreased health-related quality of life after symptomatic pediatric COVID-19: A prospective study in a Latin American tertiary hospitalObservational Study Published on 2021-11-172022-10-04 Journal: Clinics [Category] MERS, SARS, 유전자 메커니즘, 임상, [키워드] abnormality Adolescent age alteration Anemia approach baseline body mass index C-reactive protein characteristic Child children chronic condition Concentration Control controls coronavirus disease COVID-19 COVID-19 diagnosis D-dimer level domains Dyspnea Echocardiogram evaluate Follow-up Frequency headache highlight hospital inventory laboratory-confirmed Latin Long Coronavirus Disease 2019 lymphopenia Male sex median multisystem inflammatory syndrome in children parameters Patient patients patients with COVID-19 pediatric Pediatric patient persistent physical score post-COVID-19 patient proportion Prospective Study Quality Quality of life reduced reported reported symptom Sequelae significantly significantly lower subject Symptom symptomatic tiredness was performed with COVID-19 X-ray [DOI] 10.6061/clinics/2021/e3511 PMC 바로가기 [Article Type] Observational Study
Thermostable designed ankyrin repeat proteins (DARPins) as building blocks for innovative drugsResearch Article Published on 2021-11-152022-10-30 Journal: The Journal of Biological Chemistry [Category] Coronavirus, MERS, SARS, [키워드] abicipar pegol Ala antibody block clinical development clinically DARPin DARPins, designed ankyrin repeat proteins designed ankyrin repeat protein domain domains drug Drug development drug engineering electrostatic repulsion endothelial ensovibep FIVE flexible growth HER2, human epidermal growth factor receptor 2 hGABP, human guanine-adenine-binding protein HSA, human serum albumin Ile IMPROVE improvement in silico analysis inhibitor IR, internal repeat less molecular dynamics Molecular dynamics simulation Mutation N-terminal N-terminal capping repeat Protein reduce replaced responsible SARS-CoV-2 entry temperature thermostability thermostable Thr transferred Val Vascular VEGF, Vascular endothelial growth factor was increased [DOI] 10.1016/j.jbc.2021.101403 PMC 바로가기 [Article Type] Research Article
A Smartphone Intervention for People With Serious Mental Illness: Fully Remote Randomized Controlled Trial of CORERandomized Controlled Trial Published on 2021-11-122022-10-04 Journal: Journal of Medical Internet Research [Category] MERS, SARS, 임상, [키워드] alleviate Analysis assessment baseline Beck Bipolar disorder clinical trial control group control groups Controlled COVID-19 pandemic Depression depressive development disability disorder dissemination domains Effect effect size effective Facebook feasible Friendship GAD-7 Generalized Google green group individual Interaction Intervention measure mental health mental illness Mobile health mobile health intervention mobile phone moderate objective outcome measure participant participated Program promote Psychiatric public health Randomized Rapid RAS recruited reducing Registration remote Result retained scale Schizophrenia screened SDS severe symptom severity Similar change Smartphone Symptom treated Trial [DOI] 10.2196/29201 PMC 바로가기 [Article Type] Randomized Controlled Trial
Design of functionalised circular tandem repeat proteins with longer repeat topologies and enhanced subunit contact surfacesArticle Published on 2021-10-292022-10-31 Journal: Communications Biology [Category] COVID-19, MERS, SARS, [키워드] binding affinity Circular Contact de novo demonstrated domain domains inefficient Interaction motif Nanobiotechnology Particle Protein protein sequence Proteins Receptor binding domain repeated SARS CoV-2 significantly stability structures subunit subunits Topology trimeric viral neutralization X-ray crystallography [DOI] 10.1038/s42003-021-02766-y PMC 바로가기 [Article Type] Article
Unravelling the Immunomodulatory Effects of Viral Ion Channels, towards the Treatment of DiseaseReview Published on 2021-10-272022-10-28 Journal: Viruses [Category] COVID-19, [키워드] Anti-viral antiviral therapy cellular membranes Community conserved contribute COVID-19 pandemic creating develop domain domains Effect Endoplasmic reticulum Express facilitate feature HCV hepatitis C highlight highlighting HIV Host host membrane HPV Human hydrophilic hydrophobic IAV immune evasion immune modulation immunomodulatory effect Infection Influenza Ion ion channels ion homeostasis knowledge mechanisms papillomavirus Polyomavirus Protein Proteins reading regulate replicative Research respiratory SARS-CoV Structure target Transport Treatment Vaccine Viral immune evasion viral infection virion assembly viroporins virus viruses [DOI] 10.3390/v13112165 PMC 바로가기 [Article Type] Review
Burnout Among Surgeons in the UK During the COVID-19 Pandemic: A Cohort StudyOriginal Scientific Report Published on 2021-10-262022-10-28 Journal: World Journal of Surgery [Category] Coronavirus, MERS, SARS, [키워드] addition arising Burnout core COVID-19 COVID-19 pandemic cross-sectional degree domain domains Emotional exhaustion greater highlight implication inventory involved MBI-HSS measure mental health National Health Service participant patient safety Prevalence questionnaire reported Result self-care service supplementary material Support surgeon survey trainee [DOI] 10.1007/s00268-021-06351-6 PMC 바로가기 [Article Type] Original Scientific Report