A Bispecific Antibody Targeting RBD and S2 Potently Neutralizes SARS-CoV-2 Omicron and Other Variants of ConcernRBD 및 S2를 표적으로 하는 이중특이성 항체는 SARS-CoV-2 오미크론 및 우려되는 기타 변이체를 잠재적으로 중화합니다Article Published on 2022-08-242022-09-11 Journal: Journal of Virology [Category] SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Alpha antibodies antibody B.1.1.7 B.1.351 B.1.617.1 B.1.617.2 Beta binding bispecific antibodies breadth Breakthrough infection caused concern contagious coronavirus country COVID-19 COVID-19 vaccines Delta demonstrated domain dominant effective Efficacy epitope Epitopes feasible highlighting IMPROVE mAbs monoclonal antibody Mutation neutralization neutralize Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody omicron Omicron variant Omicron variants Other other variant other variants parental Prevent Pseudotyped virus RBD Receptor-binding domain reduced respiratory retained SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 variants SARS-CoV-2 WT specificity Spike protein target targeting tested the spike protein therapeutic treat Vaccine variant variants variants of concern VoC VOCs wild-type [DOI] 10.1128/jvi.00775-22 PMC 바로가기 [Article Type] Article
Duration of Severe Acute Respiratory Syndrome Coronavirus 2 Natural Immunity and Protection Against the Delta Variant: A Retrospective Cohort Study중증 급성 호흡기 증후군 코로나 바이러스 2의 지속 기간 및 델타 변이에 대한 자연 면역 및 보호: 후향적 코호트 연구Article Published on 2022-08-242022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 변종, [키워드] 95% CI 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus Against Analysis Chain Reaction coronavirus coronavirus 2 COVID-19 defined Delta delta variant dominant Duration Effectiveness infected patient Infection initial natural natural immunity Patient PCR polymerase chain polymerase chain reaction positive positive PCR test Positive test Primary outcome protection Protective protective effectiveness Reinfection respiratory retrospective cohort study SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shown subsequent symptomatic disease tested vaccination Vaccinations Vaccine [DOI] 10.1093/cid/ciab999 PMC 바로가기 [Article Type] Article
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Naturally Acquired Immunity versus Vaccine-induced Immunity, Reinfections versus Breakthrough Infections: A Retrospective Cohort Study중증 급성 호흡기 증후군 코로나바이러스 2(SARS-CoV-2) 자연 획득 면역 대 백신 유도 면역, 재감염 대 돌발 감염: 후향적 코호트 연구Observational Study Published on 2022-08-242022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 변종, 임상, [키워드] 95% CI 95% confidence interval Acquired acquired immunity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 applied BNT162b2 BNT162b2 vaccine Breakthrough infection caused coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 delta variant demonstrated dominant dose Evidence evidence of examined Hospitalization Immunity increased risk individual individuals induced immunity infected individual infected individuals Infection inoculation mRNA BNT162b2 vaccine multivariate logistic regression Naturally naturally acquired immunity observational study occur occurred regimen Reinfection respiratory retrospective SARS-CoV-2 severe acute respiratory syndrome Coronavirus symptomatic disease vaccination Vaccine Vaccine-induced immunity vaccinee [DOI] 10.1093/cid/ciac262 PMC 바로가기 [Article Type] Observational Study
Omicron spike function and neutralizing activity elicited by a comprehensive panel of vaccines포괄적인 백신 패널에 의해 유도된 오미크론 스파이크 기능 및 중화 활성Article Published on 2022-08-192022-09-11 Journal: Science (New York, N.y.) [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin angiotensin-converting enzyme 2 Antibody titers binding booster breadth coronavirus dominant elicited evade evaluated homologous or heterologous Infection leads Neutralizing activity Neutralizing antibody response Neutralizing antibody titer neutralizing antibody titers omicron plasma polyclonal Prevalence reduced replaced respiratory SARS-CoV-2 sequence Seven severe acute respiratory syndrome Coronavirus severe disease spike mutation Vaccine variant virus Wuhan-Hu-1 [DOI] 10.1126/science.abq0203 PMC 바로가기 [Article Type] Article
Infections with the SARS-CoV-2 Delta variant exhibit fourfold increased viral loads in the upper airways compared to Alpha or non-variants of concernSARS-CoV-2 Delta 변이체 감염은 우려되는 알파 또는 비 변이체에 비해 상기도에서 4배 증가된 바이러스 부하를 나타냅니다.Article Published on 2022-08-172022-09-11 Journal: Scientific Reports [Category] SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age all age group all age groups Alpha Alpha variant B.1.1.7 B.1.617.2 coronavirus Delta delta variant dominant Evidence evidenced genomic Genomic surveillance group groups in viral no difference Older age other variants reported respiratory sample Respiratory samples Sample size SARS-CoV-2 severe acute respiratory syndrome Coronavirus Sex significantly lower suggested Surveillance the SARS-CoV-2 Transmissibility upper airway vaccination variant variants Viral load viral loads Wuhan strain [DOI] 10.1038/s41598-022-18279-5 PMC 바로가기 [Article Type] Article
Host and microbiome features of secondary infections in lethal covid-19Research article Published on 2022-08-132022-10-05 Journal: iScience [Category] 바이오마커, 변종, 유전자 메커니즘, 진단, 치료기술, [키워드] alteration Bacterial C1q cause cellular complement contribute Control DAD death Defense Diffuse alveolar damage dominant driving Factor feature fungal pathogen highlight Immunity immunology inhibitory lethal lung lung tissue Macrophage microbial Microbiome Mortality myeloid cells organ pandemic pathology pathophysiological reduced RNA-Seq SARS-COV-2 infection Secondary infection secondary infections significantly stratified subgroup Virology [DOI] 10.1016/j.isci.2022.104926 [Article Type] Research article
Skin-patch delivered subunit vaccine induces broadly neutralising antibodies against SARS-CoV-2 variants of concern피부 패치 전달 소단위 백신은 우려되는 SARS-CoV-2 변이체에 대한 광범위 중화 항체 유도Article Published on 2022-08-122022-09-11 Journal: Vaccine [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] booster circulation COVID-19 Delta demonstrated dominant Efficacy Health high-density highlight Immunity immunized induce mice Microarray Microarray patch Mutation neutralisation Neutralising Antibodies neutralising antibody omicron Omicron variant resulting robust SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 variant serum Spike protein subunit Subunit vaccine tested the spike protein Vaccine variant variants variants of concern Viral viral strain Viral variants [DOI] 10.1016/j.vaccine.2022.07.013 PMC 바로가기 [Article Type] Article
Heterogeneous impact of Covid-19 response on tuberculosis burden by age group Research Published on 2022-08-122022-10-05 Journal: Scientific Reports [Category] 치료법, [키워드] affected age baseline Care caused COVID-19 COVID-19 pandemic death deaths decrease disease dominant Health Service incidence influence Korean MONITOR Mortality nine occur other diseases predicted progression reduced reduction significantly social distancing South Korea Transmission Tuberculosis would increase [DOI] 10.1038/s41598-022-18135-6 [Article Type] Research
Transmissibility, hospitalization, and intensive care admissions due to omicron compared to delta variants of SARS-CoV-2 in Catalonia: A cohort study and ecological analysisArticle Published on 2022-08-122022-11-15 Journal: Frontiers in Public Health [Category] SARS, 변종, 치료기술, [키워드] 95% CI 95% confidence interval addition Admission admitted to ICU age Analysis average calculate calculated cohort study cohorts COVID-19 decrease delta variant dominant dropped ecological Ecological study groups hospital Hospital admissions Hospitalization Hospitalized ICU ICU admission ICU admissions increase in independent intensive care intrinsic Local omicron Omicron variant performed population-based cohort positive primary care proportion rate ratio reduced reduction reduction in required risk SARS-CoV-2 severity severity and vaccination status Severity of infection stratified substitution model. System Transmissibility vaccination variant [DOI] 10.3389/fpubh.2022.961030 PMC 바로가기
Persistent Fever and Positive PCR 90 Days Post-SARS-CoV-2 Infection in a Rituximab-Treated Patient: A Case of Late Antiviral Treatment리툭시맙 치료 환자에서 SARS-CoV-2 감염 후 90일 동안 지속되는 발열 및 PCR 양성: 후기 항바이러스 치료 1례Case Reports Published on 2022-08-112022-09-11 Journal: Viruses [Category] SARS, 진단, 치료제, [키워드] Antiviral treatment antivirals B cell B cell immune responses benefit Day defined diagnostic dominant Dyspnea early treatment feasible Fever full recovery high fever Hospitalized human long-term infection hyperinflammation Hypoxemia immune immune responses Immunocompromised Immunocompromised patients immunosuppressive immunosuppressive therapy infusion interval low-grade viral replication lower airway lower airways lung infiltrate lung infiltrates Mild mild to moderate moderate monoclonal monoclonal antibodies monoclonal antibody multiple sclerosis Patient patients PCR persistent persistent fever positive PCR test post infection Prophylactic receiving reduced reported Respiratory failure rituximab SARS-CoV-2 SARS-COV-2 infection sensitivity serum severe respiratory failure Symptom therapy Treatment treatment approach treatment approaches Viral viral replication [DOI] 10.3390/v14081757 PMC 바로가기 [Article Type] Case Reports