Repurposing antiviral drugs against the human monkeypox virus DNA-dependent RNA polymerase; in silico perspectiveComment Published on 2022-12-012023-07-10 Journal: The Journal of Infection [Category] COVID19(2023년), [키워드] DdRp Drug repurposing homology modeling Human monkeypox virus (HMV) Molecular dynamics simulation [DOI] 10.1016/j.jinf.2022.09.002 PMC 바로가기 [Article Type] Comment
Computational Repurposing of Mitoxantrone-Related Structures against Monkeypox Virus: A Molecular Docking and 3D Pharmacophore StudyArticle Published on 2022-11-182023-06-09 Journal: International Journal of Molecular Sciences [Category] 원숭이두창, [키워드] Drug repurposing Epidemic in silico mitoxantrone molecular docking Monkeypox pharmacophore poxviruses zoonotic [DOI] 10.3390/ijms232214287 PMC 바로가기
Structural Homology-Based Drug Repurposing Approach for Targeting NSP12 SARS-CoV-2Article Published on 2022-11-102023-08-30 Journal: Molecules [Category] E형 간염, [키워드] Drug repurposing FDA-approved antivirals NSP-12 RdRp domain SARS-CoV-2 [DOI] 10.3390/molecules27227732 PMC 바로가기
The 2022 Monkeypox outbreak: How the medicinal chemistry could help us?Article Published on 2022-11-012023-06-09 Journal: Bioorganic & Medicinal Chemistry [Category] Fulltext, 원숭이두창, [키워드] antivirals Drug repurposing in silico Medicinal chemistry Monkeypox [DOI] 10.1016/j.bmc.2022.117036 PMC 바로가기
Chemical-induced degradation of PreS2 mutant surface antigen via the induction of microautophagyArticle Published on 2022-11-012023-06-13 Journal: Antiviral Research [Category] B형 간염, [키워드] Chronic Hepatitis B Drug repurposing Drugging the undruggable target Hepatocarcinogenesis Protein degradation. [DOI] 10.1016/j.antiviral.2022.105417
Computational pharmacology: New avenues for COVID-19 therapeutics search and better preparedness for future pandemic crisesArticle Published on 2022-11-012022-11-16 Journal: Biophysical chemistry [Category] 신약개발, [키워드] affected Analysis approach Cheminformatics clinical clinical study clinical trials complex compounds COVID-19 COVID-19 pandemic COVID-19 therapeutics deep learning develop Disease progression drug Drug repurposing drugs effort global healthcare Health help identify in silico Infectious disease information Intervention lack limitation machine machine learning miRNA MONITOR New pandemic pharmacological strategy Regulatory Research robust Side-effects System Systems biology targets therapeutic therapeutic target Treatment strategies [DOI] 10.1016/j.bpc.2022.106891 PMC 바로가기
Use of Human Lung Tissue Models for Screening of Drugs against SARS-CoV-2 InfectionArticle Published on 2022-10-312023-07-10 Journal: Viruses [Category] COVID19(2023년), [키워드] 3D tissue models COVID-19 CoviRx.org Drug repurposing Therapeutics [DOI] 10.3390/v14112417 PMC 바로가기
A comprehensive update on CIDO: the community-based coronavirus infectious disease ontologyArticle Published on 2022-10-212022-11-16 Journal: Journal of Biomedical Semantics [Category] COVID19(2023년), SARS, 변종, 신약개발, [키워드] aligned Amino acid amino acid substitution Analysis applied basic Clinical data clinical trial coronavirus coronavirus disease COVID-19 COVID-19 pandemic Delta Diagnosis diagnostic disease domain drug Drug repurposing drug-target effective Epidemiology evaluated example Formal global public health heterogeneous Human Infectious disease initiated knowledge Metadata omicron ontologies Ontology outbreak phenotype PPI protein-protein interaction Safe SARS-CoV-2 SARS-CoV-2 protein Standardization Support supported target protein Treatment Vaccine variant variants variants of SARS-CoV-2 virus [DOI] 10.1186/s13326-022-00279-z PMC 바로가기
Griseofulvin: An Updated Overview of Old and Current KnowledgeArticle Published on 2022-10-182022-11-16 Journal: Molecules [Category] COVID19(2023년), SARS, 신약개발, 유전자 메커니즘, [키워드] ACE2 addition ascomycetes binding cancer cell capillary blood flow Cell contribute current derivative dermatophytic fungi disrupt domain Drug repurposing ENhance explain FDA-approved drug filament protein griseofulvin griseofulvin derivatives gsf gene cluster Hepatitis hepatitis C virus hepatocyte IMPROVE infections information inhibitory effect Inhibitory effects Interaction introduced K18 Liver injury Mallory mechanism metabolite metabolites mitosis molecular docking analysis multifunctional polyketide compound produced RBD RdRP Replication responsible RNA-dependent RNA polymerase rodent SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 main protease severity Spike protein spindle microtubule. therapeutic interventions treated Vascular viral replication [DOI] 10.3390/molecules27207034 PMC 바로가기
A lipid nanoparticle platform for mRNA delivery through repurposing of cationic amphiphilic drugsResearch article Published on 2022-10-012022-10-05 Journal: Journal of controlled release : official journal o [Category] 신약개발, [키워드] addition approach approval bovine CAD cancer cell cationic Cationic amphiphilic drugs Cationic lipid Cell Cellular delivery component Corneal COVID-19 mRNA vaccines drug drug combination Drug repurposing Efficiency encapsulation epithelial cell epithelial cells eyes functional healthcare HeLa cell in vitro in vivo Lipid lipid component Lipid nanoparticles Liposome LNP maintain Messenger RNA mRNA nanomedicine Patient pharmacological platform primary cell RNA RNA therapeutics selected small molecule drug subsequent Therapies Vesicle was obtained [DOI] 10.1016/j.jconrel.2022.08.009 [Article Type] Research article