CETSA MS Profiling for a Comparative Assessment of FDA-Approved Antivirals Repurposed for COVID-19 Therapy Identifies TRIP13 as a Remdesivir Off-TargetArticle Published on 2020-11-182022-10-04 Journal: SLAS discovery : advancing life sciences R & D [Category] 신약개발, 치료제, [키워드] Antiviral compound antiviral drug antivirals assessment binding cells cellular CETSA MS changes in Clinical effect Comparative complex Compound contribute coronavirus disease COVID-19 COVID-19 therapy Effect Efficacy emerging disease example Host host cell induce Interaction molecular target physiological Profiling Protein Protein target proteome Remdesivir reuse small molecule target target engagement targets Therapies thermal stability TRIP13 turn Viral protein virus [DOI] 10.1177/2472555220973597 PMC 바로가기 [Article Type] Article
SARS-CoV-2 RNA shedding in recovered COVID-19 cases and the presence of antibodies against SARS-CoV-2 in recovered COVID-19 cases and close contacts, Thailand, April-June 2020회복된 COVID-19 사례에서 SARS-CoV-2 RNA 방출 및 회복된 COVID-19 사례 및 밀접 접촉에서 SARS-CoV-2에 대한 항체 존재, 태국, 2020년 4월-6월Research Article Published on 2020-10-292022-08-13 Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS, SARS, [키워드] absence acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibody Antibody Response Antibody responses antivirals approved blood sample Blood samples caused clearance close contact combating Contact coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 case COVID-19 cases Defense detectable disease onset Disease surveillance effective emerging disease evaluated examined Hospitalized Host host defenses IgA antibodies IgA antibody IgG IgG antibodies IgM infected individual infected individuals information levels of antibody natural history Patient pattern positive presence of antibody provide recovered COVID-19 patient Recovered COVID-19 patients recovered patient recovered patients remained respiratory SARS-CoV-2 SARS-CoV-2 RNA severe acute respiratory syndrome Coronavirus spread of COVID-19 tested Vaccine Viral viral clearance Viral RNA Viral RNA shedding [DOI] 10.1371/journal.pone.0236905 PMC 바로가기 [Article Type] Research Article
2019 Novel Coronavirus-Infected Pneumonia on CT: A Feasibility Study of Few-Shot Learning for Computerized Diagnosis of Emergency DiseasesComputational and artificial intelligence Published on 2020-10-222022-10-30 Journal: Ieee Access [Category] COVID-19, [키워드] 2019 novel coronavirus-infected pneumonia approach approval AUC automated Chest Chest CT clinically collected COVID-19 COVID-19 patient develop Diagnosis diagnostic decision Digital effective Emergency emerging disease Endemic few-shot learning help IRB learning lesion Lung disease mortality rate novel pandemic Patient physician Pneumonia Probability Radiography reference standard reported serious complication severity therapeutic drug Transmissibility Vaccine [DOI] 10.1109/ACCESS.2020.3033069 PMC 바로가기 [Article Type] Computational and artificial intelligence
The Role of the Dental Surgeon in Controlling the Dissemination of COVID-19: A Literature ReviewReview Article Published on 2020-10-012022-10-29 Journal: The Scientific World Journal [Category] COVID-19, MERS, [키워드] biosafety China concerning Contamination Control controlling coronavirus coughing COVID-19 COVID-19 pandemic CoVs dental dentist diarrhea Dyspnea emerging disease etiology Fever Guidance high risk imperative implication Infection prevention literature literature review malaise Measures Nidovirale occurred Orthocoronavirinae Patient patients with pneumonia professional raising review role salivary SARS-CoV-2 sore throat sputum Symptom the Coronaviridae transmitted treat virus [DOI] 10.1155/2020/7945309 PMC 바로가기 [Article Type] Review Article
Hospital and Population-Based Evidence for COVID-19 Early Circulation in the East of FranceArticle Published on 2020-09-302022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, SARS, [키워드] Analysis Care circulating Cluster COVID-19 creating dissemination East emerging disease Emerging infectious disease epidemic surveillance epidemic threshold Evidence France French Good help hospital independent information laboratory data Local lockdown medical record outbreak participant retrospective SARS-CoV-2 SARS-CoV-2 dynamics the epidemic Transmission understanding virus propagation [DOI] 10.3390/ijerph17197175 PMC 바로가기 [Article Type] Article
COVID-19 Screening for Healthcare Workers in a Tertiary Infectious Diseases Referral Hospital in Manila, the PhilippinesArticles Published on 2020-09-292022-10-28 Journal: The American Journal of Tropical Medicine and Hygi [Category] COVID-19, SARS, [키워드] COVID-19 COVID-19 patients eight emerging disease HCW HCWs healthcare worker hospital Hospital staff Infectious disease initial Patient performed PROTECT Referral routine Screening Seven Tertiary tested the patient worker [DOI] 10.4269/ajtmh.20-0715 PMC 바로가기 [Article Type] Articles
Implications of human activities for (re)emerging infectious diseases, including COVID-19Review Published on 2020-09-252022-10-30 Journal: Journal of Physiological Anthropology [Category] COVID-19, SARS, [키워드] (Re)emerging infectious disease activity coronavirus COVID-19 diagnostics disease Diseases effective emerging disease Epidemics Factor Factors Health humans Impact Infectious disease Occurrence pandemic pathogen reduce respond risk Spread Surveillance threat Transmission Vaccines [DOI] 10.1186/s40101-020-00239-5 PMC 바로가기 [Article Type] Review
Evaluation of pooled sample analysis strategy in expediting case detection in areas with emerging outbreaks of COVID-19: A pilot study신종 코로나바이러스 감염증(COVID-19) 발병 지역에서 사례 발견을 촉진하기 위한 통합 샘플 분석 전략 평가: 파일럿 연구Research Article Published on 2020-09-222022-08-13 Journal: PLoS ONE [Category] MERS, SARS, 유전자 메커니즘, [키워드] adoption Analysis applicability blinded Characteristics choice consecutive sample COVID-19 Ct value Diagnosis diagnosis of COVID-19 diagnostic diagnostics disease outbreak effective emerging disease evaluated impair infected individual infected individuals Isolation Laboratory lead nasopharyngeal Negative predictive value Oropharyngeal outbreak pilot study point prevalence pool positive positive sample Predictive value Presence Prevalence qRT-PCR Quantitative reduced reported reverse transcriptase reverse transcriptase PCR technique tested time-consuming transmission of SARS-CoV-2 while [DOI] 10.1371/journal.pone.0239492 PMC 바로가기 [Article Type] Research Article
Application of Artificial Intelligence in COVID-19 drug repurposingReview article Published on 2020-09-012022-10-05 Journal: Diabetes & metabolic syndrome [Category] SARS, 신약개발, 치료제, [키워드] active against analyzed application applied approach artificial artificial intelligence coronavirus COVID-19 COVID-19 outbreak COVID-19 patient COVID-19 patients deep learning detect drug Drug discovery drug repositioning Drug repurposing drugs Efficiency emerging disease feasible Google Scholar IMPROVE intelligence machine learning outcome pandemic Patient patients reported Result SARS-CoV-2 shown significantly the disease therapeutic treat Treatment Virtual screening [DOI] 10.1016/j.dsx.2020.06.068 [Article Type] Review article
Real-world evaluation of a novel technology for quantitative simultaneous antibody detection against multiple SARS-CoV-2 antigens in a cohort of patients presenting with COVID-19 syndrome † †Electronic supplementary information (ESI) available. See DOI: 10.1039/d0an01066aChemistry Published on 2020-08-212022-10-28 Journal: The Analyst [Category] COVID-19, MERS, SARS, [키워드] 95% CI 95%CI Accuracy Admission Antibody detection Antigen clinical setting cohort of patient Concentration conducted Control control patient control patients COVID-19 diagnostic emerging disease ESI highlight hospital IgA IgG antibody information inherent nucleocapsid Patient patients presenting provide Quantitative robust SARS-CoV-2 antigen SARS-CoV-2 IgM SARS-CoV-2 RNA sensitivity serological profile serological test serum serum sample specificity Support syndrome tested was obtained with COVID-19 [DOI] 10.1039/d0an01066a PMC 바로가기 [Article Type] Chemistry