Community‐based differentiated service delivery models incorporating multi‐month dispensing of antiretroviral treatment for newly stable people living with HIV receiving single annual clinical visits: a pooled analysis of two cluster‐randomized trials in southern Africa매년 단일 임상 방문을 받는 HIV에 감염된 새로 안정된 사람들을 위한 항레트로바이러스 치료의 수개월 분배를 통합하는 지역 사회 기반의 차별화된 서비스 제공 모델: 남아프리카의 2건의 클러스터 무작위 시험에 대한 통합 분석Meta-Analysis Published on 2021-10-282022-09-10 Journal: Journal of the International AIDS Society [Category] MERS, SARS, 임상, 치료제, [키워드] 95% CI acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adjusted Analysis antiretroviral antiretroviral treatment ARMS ART CAG Care Clinic visits clinical cluster‐randomized trial Clustering Community conducted coronavirus country COVID‐19 decrease differentiated service delivery Effectiveness enrolled enrolment Evidence exposure to Frequency group Health healthcare healthcare facility HIV treatment incidence rate include Intervention intervention arms limit margin multi‐month dispensing not increased operational research participant Primary outcome provided rate ratio receiving regression analysis respiratory Result retained retention risk risk difference risk ratio secondary outcome Secondary outcomes severe acute respiratory syndrome Coronavirus SOC Treatment Trial Viral visit frequency with HIV Zimbabwe [DOI] 10.1002/jia2.25819 PMC 바로가기 [Article Type] Meta-Analysis
Changes in HIV treatment differentiated care uptake during the COVID‐19 pandemic in Zambia: interrupted time series analysis잠비아 COVID-19 대유행 기간 동안 HIV 치료 차별화된 치료 수용의 변화: 중단된 시계열 분석Supplement: Short Report Published on 2021-10-282022-09-10 Journal: Journal of the International AIDS Society [Category] MERS, SARS, 치료제, [키워드] accelerated acceleration advent Analysis antiretroviral antiretroviral treatment ART benefit Care change changed Contact contact with Coverage COVID‐19 COVID‐19 determine diagnosed differentiated service delivery distribution effort enrolled enrolment expected Health health facilities healthcare facility HIV service delivery HIV treatment Human immunodeficiency virus immunodeficiency virus IMPROVE increase in interval intervals Linear regression management medical record MMD multi‐month dispensing Older outbreak pandemic Participation reduce reduction in representing Result resulting risk study period Supply chain Treatment was used Zambia [DOI] 10.1002/jia2.25808 PMC 바로가기 [Article Type] Supplement: Short Report
SARS-CoV-2 antibodies in Ontario health care workers during and after the first wave of the pandemic: a cohort study전염병의 첫 번째 물결 동안과 이후에 온타리오 의료 종사자의 SARS-CoV-2 항체: 코호트 연구Multicenter Study Published on 2021-10-122022-09-11 Journal: CMAJ open [Category] MERS, SARS, 진단, 치료기술, [키워드] 95% confidence interval adjusted adjusted odds ratio age antibody blood sample Blood samples Canada Care Chain Reaction Clustering cohort study Community community hospital conducted COVID-19 COVID-19 outbreak Critical detect enrolled enrolment evaluated exposure to female First wave Health Health care Health care worker health care workers highlighting hospital household IgG IgG antibodies IgG antibody Immunoglobulin Immunoglobulin G increased risk Infection median age multicentre multivariable logistic regression pandemic participant patient with COVID-19 patients with COVID-19 pediatric polymerase chain polymerase chain reaction Polymerase chain reaction testing Providing public health public health measure public health measures questionnaire risk factor SARS-CoV-2 SARS-CoV-2 antibody seropositive Seropositivity Seroprevalence symptomatic contact symptomatic contacts the median the strongest unit were excluded [DOI] 10.9778/cmajo.20210044 PMC 바로가기 [Article Type] Multicenter Study
A prospective, randomized, single-blinded, crossover trial to investigate the effect of a wearable device in addition to a daily symptom diary for the Remote Early Detection of SARS-CoV-2 infections (COVID-RED): a structured summary of a study protocol for a randomized controlled trialSARS-COV-2 감염 (COVID-RED)의 원격 조기 발견을위한 일일 증상 일기 외에 웨어러블 장치의 효과를 조사하기위한 전향 적, 무작위, 단일 맹장, 크로스 오버 시험 : 연구의 구조적 요약.무작위 제어 시험을위한 프로토콜Update Published on 2021-10-112022-09-01 Journal: Trials [Category] MERS, SARS, 임상, 진단, 치료기술, 치료제, [키워드] 1:1 addition adhere Algorithm Algorithms all subject all subjects among others analysed antibody Antibody testing antibody tests Antigen antigen tests approach asked assigned Asymptomatic asymptomatic individual asymptomatic infection average baseline blinded Blinding can not capillary blood Chain Reaction changes in Characteristics cholinergic urticaria Cohort collected Complete conditions conducted consent form contribute control condition COVID-19 COVID-19 infection COVID-19 vaccination current Daily defined demographics described detect detection determine develop deviation diary dissemination Early detection element eligibility criteria eligible End enrolled enrolment evaluate exclusion exploratory feedback Follow-up followed by gold gold standard Health health resource heart rate incidence rates Inclusion inclusion criteria individual individuals infected individual infected individuals infected with SARS-CoV-2 Infection information Informed consent informed consent form initial involved Laboratory laboratory-confirmed SARS-CoV-2 infection machine learning management maximum media medical history Mobile application must nasal swab National natural infection Negative predictive value Netherland Netherlands notification NPV number objective occur outcome pacemaker parameter participant PCR PCR test PCR tests physiological physiological parameters polymerase chain polymerase chain reaction populations portal positive Positive predictive value PPV pre-symptomatic Predictive value primary analysis profession proportion Prospective protocol provided public health Pulse rate questionnaire randomization randomization sequence Randomized Randomized controlled trial Randomly receive recommendation recruited recruitment reduce remote reported resident resource responsible resulting risk RIVM Sample size SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 test SARS-CoV-2 virus sensitivity sequence sequence 1 Sequence 2 sequences serology serology test serology tests significantly skin temperature Smartphone social media specificity staff stratified stratified block randomization study participation Study protocol subject suffering supplementary material Symptom Symptom diary Symptoms target temperature test result tested the SARS-CoV-2 thought Transmission transmissions Trial Trial registration undergo urticaria used to evaluate vaccinated against COVID-19 vaccination Vaccine Variability wearable device website Well-being [DOI] 10.1186/s13063-021-05643-5 PMC 바로가기 [Article Type] Update
A Web-Based Intervention (Germ Defence) to Increase Handwashing During a Pandemic: Process Evaluations of a Randomized Controlled Trial and Public Dissemination팬데믹 기간 동안 손 씻기를 늘리기 위한 웹 기반 개입(세균 방어): 무작위 대조 시험 및 공개 배포의 프로세스 평가Randomized Controlled Trial Published on 2021-10-052022-09-10 Journal: Journal of Medical Internet Research [Category] MERS, SARS, 비임상, 임상, [키워드] 95% CI adaptation affected attrition automated Behavior breath Cold colds Controlled coughing COVID-19 digital intervention dissemination dropped Effect Engagement Enrollment enrolment evaluation studies flu framework general practices Germ Guidance hands handwashing health emergency help increase Increases increases in Infection Influenza Intention Internet Intervention ISRCTN registry mean difference Medical Research Council objective Open Access outbreak pandemic participant Prevent prevention Process Public Randomized controlled trial RCT reached Registration replicated reported Research respiratory respiratory tract infection Respiratory tract infections respiratory viruses Result selected sneezing Spread swine flu Transmission Trial Usage user virus washing website [DOI] 10.2196/26104 PMC 바로가기 [Article Type] Randomized Controlled Trial
When Covid-19 first struck: Analysis of the influence of structural characteristics of countries – technocracy is strengthened by open democracyResearch Article Published on 2021-10-042022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] absence age Analysis approach Characteristics Cluster Context correlation country death Depth Desk Effects enrolment Evidence facilitate facilitated Factor Factors feature Features finding Government had no Health Health services health system identify implication influence Interpretation majority measure moderate Multiple regression National nine notable outcome pandemic Population positive profiles resources respond responses seeking strength structures therapeutic Volume [DOI] 10.1371/journal.pone.0257757 PMC 바로가기 [Article Type] Research Article
IgG antibody response against nucleocapsid and spike protein post-SARS-CoV-2 infectionSARS-CoV-2 감염 후 뉴클레오캡시드 및 스파이크 단백질에 대한 IgG 항체 반응Observational Study Published on 2021-10-012022-09-11 Journal: Infection [Category] MERS, SARS, 임상, 진단, 치료법, [키워드] Abbott antibody Architect Chain Reaction changes in collected Complete Concentration coronavirus coronavirus disease Coronavirus disease-19 COVID-19 enrolment epidemiological Follow-up Frequency growth help IgG IgG antibody individual Infection magnitude neutralising nucleocapsid nucleocapsid antigen nucleocapsid protein Observational cohort study pandemic persistence platform polymerase chain reaction positive Protein public health quantitative assay real-time reverse transcriptase-polymerase chain reaction recorded remained reverse transcriptase reverse transcriptase-polymerase chain reaction Roche RT-qPCR SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-COV-2 infection sera seronegative seropositive serum sample serum samples spike Spike protein tested titre virus [DOI] 10.1007/s15010-021-01651-4 PMC 바로가기 [Article Type] Observational Study
Radiological and functional evidence of the bronchial spread of tuberculosis: an observational analysis결핵의 기관지 스프레드의 방사선 및 기능적 증거 : 관찰 분석Articles Published on 2021-10-012022-09-06 Journal: The Lancet. Microbe [Category] Communicable Disease, [키워드] 2-Fluoro-2-deoxy-D-glucose Abstract active tuberculosis analysed Analysis animal model animal models baseline bronchial cavitary change China Chinese clinical clinical trial consolidations criteria CT scans cured described Developing diabetes Direct disease enrolled enrolment European Evidence examined explain extrapulmonary tuberculosis FDG finding foundation functional funding GeneXpert MTB/RIF granuloma HIV infection Inflammation Laboratory lesion lesions location Lungs material Melinda Gate Melinda Gates Mycobacterium tuberculosis natural participant partnership pathology Patient PET-CT positive pulmonary tuberculosis randomised rifampicin Science South Africa Spread sputum culture technology translation treated treated patient treated patients Treatment Treatment outcome Tuberculosis tuberculosis treatment viability were assessed were excluded [DOI] 10.1016/S2666-5247(21)00058-6 PMC 바로가기 [Article Type] Articles
PRO B: evaluating the effect of an alarm-based patient-reported outcome monitoring compared with usual care in metastatic breast cancer patients—study protocol for a randomised controlled trialPRO B: 전이성 유방암 환자에서 일반 치료와 비교하여 경보 기반 환자 보고 결과 모니터링의 효과 평가 - 무작위 대조 시험을 위한 연구 프로토콜Study Protocol Published on 2021-09-282022-09-10 Journal: Trials [Category] SARS, 임상, [키워드] 1:1 acute disease alarm among others approach ARMS Breast cancer breast cancer patient clinical Clinical practice Complete Contact control arm Controlled trial controls determined by develop disease domain elongation emergency room Endpoint enrolment ePROs fatigue female form Health apps hospitalisation hospitalisations identify include independent intervene Intervention intervention arm intervention group less life Metastatic breast cancer metastatic disease mobile devices outcome Patient Patient-reported outcomes Personalised medicine positive Primary outcome pros protocol Quality of life randomisation randomised randomised controlled trial receive recruited reported symptom reported symptoms required Research secondary Secondary endpoints selected Society supplementary material survival the patient transfer Treatment Trial Trigger usual care Value-based health care [DOI] 10.1186/s13063-021-05642-6 PMC 바로가기 [Article Type] Study Protocol
ACTION-1: study protocol for a randomised controlled trial on ACT-guided heparinization during open abdominal aortic aneurysm repairACTION-1: 개방 복부 대동맥류 수리 중 ACT 유도 헤파린 처리에 대한 무작위 대조 시험 연구 프로토콜Study Protocol Published on 2021-09-192022-09-10 Journal: Trials [Category] SARS, 임상, [키워드] 30-Day mortality A significant reduction Abdominal aortic aneurysm Activated clotting time Admission Aneurysm Aneurysmal anticoagulation aortic aneurysm applied benefit bleeding blind Blood blood loss caused Clotting time Complication complications contrary data set Date decrease development disease dose eligible Endpoint enrolment EudraCT Europe evaluate exclusion criteria expected Germany GRADE Grade 1 healthy healthy volunteers heparin Hospital stay in-hospital mortality incidence Inclusion increase International less major bleeding Mesenteric artery Mortality Netherland Netherlands open Open repair operation Patient patients phase primary efficacy endpoint protocol Public randomised randomised controlled trial Randomized RCT re-operation reached recruitment reduce Registration repair report research and development Sample size secondary secondary outcome Sponsor Standard Standard of care Study protocol superior mesenteric artery supplementary material Support target TEC the patient Treatment Trial Trial registration undergo Vascular surgery [DOI] 10.1186/s13063-021-05552-7 PMC 바로가기 [Article Type] Study Protocol