More Than Just Gene Therapy Vectors: Lentiviral Vector Pseudotypes for Serological Investigation유전자 치료 벡터 그 이상: 혈청학적 조사를 위한 Lentiviral Vector PseudotypesReview Published on 2021-01-312022-09-01 Journal: Viruses [Category] MERS, 진단, 치료기술, 치료제, [키워드] Above Analysis Anti-viral Cell culture cell entry characterization COVID-19 pandemic culture system envelope envelope protein evaluate flexibility handling immune response immune responses Infection investigation landscape lentiviral lentiviral vectors lentivirus Neutralising Antibodies neutralising antibody Outbreaks Protein pseudotype pseudotyped sequence serological Serological assay serological assays serology shown speed Surrogates target vaccination Vaccines vector Viral viral surface virus viruses [DOI] 10.3390/v13020217 PMC 바로가기 [Article Type] Review
Reaction of Human Monoclonal Antibodies to SARS-CoV-2 Proteins With Tissue Antigens: Implications for Autoimmune DiseasesSARS-CoV-2 단백질에 대한 인간 단일클론 항체와 조직 항원의 반응: 자가면역 질환에 대한 시사점Immunology Published on 2021-01-192022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, 치료법, [키워드] (spike protein Actin anti-SARS-CoV-2 antibodies antibody Antigen applied approved Autoimmune diseases Autoimmunity BLAST COVID-19 cross-reactivity determine disease disorder Diversity envelope protein epitope epitope mapping exacerbate F-actin Gastrointestinal group homology Human human monoclonal antibodies Human monoclonal antibody human tissue human tissues immune immune reactivity membrane protein Mitochondria molecular molecular mimicry monoclonal nucleoprotein occur patients with COVID-19 polyclonal potential risk Protein Proteins reaction Reactions reactivity representing Safe SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 protein SARS-CoV-2 proteins selective severity similarities similarity Spike protein subgroups subject susceptible the disease Thyroid tissue tissue antigen tissue antigens tissues TPO Treatment Vaccine Viral protein Viral proteins virus with COVID-19 [DOI] 10.3389/fimmu.2020.617089 PMC 바로가기 [Article Type] Immunology
The Fatty Acid Lipid Metabolism Nexus in COVID-19COVID-19의 지방산 지질 대사 넥서스Review Published on 2021-01-112022-09-10 Journal: Viruses [Category] 치료제, [키워드] acid Activation acute respiratory syndrome Affect AMPK Antiviral assembly Clinical data complex coronavirus coronavirus protein Coronavirus replication COVID-19 COVID-19 immune response disease severity drugs endoplasmic reticulum stress response enteric envelope protein Evidence evidence of FASN fatty Fatty acid Formation Gut Immune homeostasis increase individual inhibit inhibition inhibitor Intervention intestine Lipid lipid metabolism liver mechanism membrane membrane protein metformin morbidly obese mTORC1 nexus nonstructural protein obese observation orlistat palmitoylation pancreas Protein protein kinase reduce Replication replicative organelle respiratory restoration Spike protein SREBP-1 systemic inflammation the disease therapeutic target unfolded protein response Viral viral replication virus replication [DOI] 10.3390/v13010090 PMC 바로가기 [Article Type] Review
Identification and molecular characterization of mutations in nucleocapsid phosphoprotein of SARS-CoV-2Biochemistry Published on 2021-01-042022-10-28 Journal: PeerJ [Category] COVID-19, [키워드] alterations America analysed conducted country COVID-19 domain ENCODE envelope protein events function genomic RNA help hotspot identification identify include Infectious disease interact Interaction interfere intrinsically membrane protein molecular multiple mutation Mutation mutations N-protein nucleocapsid Nucleocapsid Phosphoprotein (N protein) oligomerization Protein RBD Region reported residue residues reveal RNA RNA genome SARS-CoV-2 SARS-CoV-2 genome sequence spike glycoprotein spread to stability structural protein United State USA Variation Wuhan, China [DOI] 10.7717/peerj.10666 PMC 바로가기 [Article Type] Biochemistry
Phase 1 Human Immunodeficiency Virus (HIV) Vaccine Trial to Evaluate the Safety and Immunogenicity of HIV Subtype C DNA and MF59-Adjuvanted Subtype C Envelope ProteinHIV 서브타입 C DNA 및 MF59-보강 서브타입 C 엔벨로프 단백질의 안전성 및 면역원성을 평가하기 위한 1상 인간 면역결핍 바이러스(HIV) 백신 시험Articles and Commentaries Published on 2021-01-012022-09-06 Journal: Clinical Infectious Diseases: An Official Publicat [Category] Communicable Disease, [키워드] adjuvant administration advancement African Antibody Response antibody response rate Biojector boost CD4 cellular clinical Department DNA DNA prime/protein boost Efficacy elicited enrolled envelope envelope protein evaluate followed by glycoprotein greater healthy HIV HIV vaccine HIV-1 HIV-1 infection Human Human immunodeficiency virus Humoral response immunogenicity injected injection intramuscularly network partnership Phase 1 Placebo priming Protein Randomized regimen Registration registry response rate Result risk Safe Safety significantly significantly higher South South Africa subtype subtype C T-cell Response T-cell responses Trial vaccination Vaccine [DOI] 10.1093/cid/ciz1239 PMC 바로가기 [Article Type] Articles and Commentaries
Rapid lateral flow immunoassay for the fluorescence detection of SARS-CoV-2 RNA Research Published on 2020-12-032022-10-05 Journal: Nature biomedical engineering [Category] SARS, 임상, 진단, 치료기술, 치료제, [키워드] acute respiratory syndrome bind conserved coronavirus coronavirus disease COVID-19 diagnosis of COVID-19 DNA double-blind trial double-stranded envelope protein facilitate fluorescence detection Frame immunoassay individuals lateral flow immunoassay lateral flow strip less monoclonal antibody nucleic acid Nucleic acid detection nucleocapsid ORF1ab pandemic point of care probe provided quantitative PCR Randomized Rapid Region reverse transcription RNA SARS-CoV-2 SARS-CoV-2 RNA sensitivity specificity sputum the SARS-CoV-2 genome throat swab was determined [DOI] 10.1038/s41551-020-00655-z [Article Type] Research
An Immunoinformatics Study to Predict Epitopes in the Envelope Protein of SARS-CoV-2Research Article Published on 2020-11-252022-10-31 Journal: The Canadian Journal of Infectious Diseases & Medical Microbiology = Journal Canadien des Maladies Infectieuses et de la Microbiologie Médicale [Category] COVID-19, [키워드] affected Analysis analyzed B-cell epitope binding energy Bioinformatics analysis carried caused Cell-mediated immune responses complementary computational method coronavirus Coverage COVID-19 CTL CTL epitope disease docked elicit envelope envelope protein epitope evaluated HLA allele HTL humoral IEDB Immune Epitope Database immune system in vitro in vivo NCBI database overlapped peptide peptide-based vaccine predict predicted retrieved SARS-CoV-2 sequence suggested Support T-cell epitopes Vaccine vaccine for COVID-19 virus was determined was performed [DOI] 10.1155/2020/7079356 PMC 바로가기 [Article Type] Research Article
The COVID-19 pandemic: a global health crisisCOVID-19 팬데믹: 글로벌 보건 위기Review Published on 2020-11-012022-09-10 Journal: Physiological Genomics [Category] SARS, 유전자 메커니즘, 치료제, [키워드] ACE2 ACE2 receptors acute respiratory distress acute respiratory distress syndrome age amplify angiotensin angiotensin converting enzyme Angiotensin converting enzyme-2 ARDS Atypical cardiovascular disease causative agent cause Comorbidities Comorbidity Complication COVID-19 COVID-19 infection crown Cytokine storm degrade destruction diabetes disease Disease progression envelope protein epithelial cells Ethnicity event Extracellular fibrosis genetics geographic location GTPases Health Health Organization Host Hypercoagulation hypertension include induce Infection inflammatory immune response lead Lung epithelial cells mechanism membrane morbidity Novel coronavirus novel coronavirus SARS-CoV-2 pandemic Pathogenesis pathophysiology patients positive-sense prevalent Prevent pulmonary fibrosis receptor reduce respiratory Respiratory disease respiratory diseases respiratory distress Respiratory distress syndrome risk factor RNA genome route SARS-CoV-2 Sepsis severe cases Severity of infection single-stranded spike glycoprotein spike glycoproteins subsequent Symptom syndrome The United States Therapeutic approach thrombosis Transmission understanding United States upregulation Vaccine Vascular Viral viral envelope proteins World Health Organization Wuhan Wuhan, China [DOI] 10.1152/physiolgenomics.00089.2020 PMC 바로가기 [Article Type] Review
Improved binding of SARS-CoV-2 Envelope protein to tight junction-associated PALS1 could play a key role in COVID-19 pathogenesisSARS-CoV-2 Envelope 단백질과 밀착 연접 관련 PALS1의 향상된 결합은 COVID-19 발병에 중요한 역할을 할 수 있습니다Article Published on 2020-11-012022-09-11 Journal: Microbes and infection [Category] SARS, 유전자 메커니즘, [키워드] Amino acid amino acid sequence amplifying Analysis bat bats binding C-terminal COVID-19 COVID-19 pathogenesis docking E protein envelope envelope protein epithelial Evidence GenBank Genome genomic sequence GISAID Improved in silico Inflammatory interfere junctions key factor knowledge mechanism MOST open PALS1 pangolin pangolins pathogenic Protein raise route SARS-CoV SARS-CoV-2 sequence significant difference tight junction tight junctions tissue remodelling [DOI] 10.1016/j.micinf.2020.08.006 PMC 바로가기 [Article Type] Article
SARS-CoV2 envelope protein: non-synonymous mutations and its consequencesSARS-CoV2 외피 단백질: 동의어가 아닌 돌연변이와 그 결과Article Published on 2020-11-012022-09-11 Journal: Genomics [Category] SARS, 변종, [키워드] Affect analyzed Asia binding C-terminus Complete consequence COVID-19 domain envelope envelope protein Europe Genome genome sequence Genome sequences Guangzhou host protein Missense mutation Missense mutations motif NCBI database Non-synonymous mutation Non-synonymous mutations Oceania PALS1 Protein SARS-CoV2 SARS-CoV2 genomes transmembrane USA Victoria [DOI] 10.1016/j.ygeno.2020.07.001 PMC 바로가기 [Article Type] Article