Deep mutational scanning identifies SARS-CoV-2 Nucleocapsid escape mutations of currently available rapid antigen testsArticle Published on 2022-09-152022-11-15 Journal: Cell [Category] SARS, 변종, 진단, 치료기술, [키워드] antibodies antibody Antibody binding Antigen Complete COVID-19 patient deep deep mutational scanning diagnostic Effect Emergency use authorization epitope epitope mapping escape mutation evaluate identify mammalian mammalian surface-display Mutation platform Point mutation predict profile public health rapid antigen test Rapid antigen tests Rapid diagnostic tests SARS-CoV-2 SARS-CoV-2 nucleocapsid protein susceptibility the antibody utility valuable resource variants variants of concern variants of SARS-CoV-2 [DOI] 10.1016/j.cell.2022.08.010 PMC 바로가기
Cross-Reactivity of SARS-CoV-2 Nucleocapsid-Binding Antibodies and Its Implication for COVID-19 Serology TestsArticle Published on 2022-09-142022-11-15 Journal: Viruses [Category] SARS, 변종, 진단, 치료기술, [키워드] Adequate Analysis analyzed antibody antibody tests B.1 can be used caused characterized conserved convalescent sera COVID-19 COVID-19 patient cross-reactive cross-reactivity diagnostic domain ELISA test epitope global pandemic Humoral immunity immunogenic Infection magnitude new coronavirus SARS-CoV-2 nucleocapsid Nucleocapsid phosphoprotein patients positive correlation Protein raised RBD Recombinant protein reduced SARS-CoV-2 SARS-CoV-2 strain selective sensitivity sera serology test serology tests spike Spread Test the SARS-CoV-2 Vaccine variants of concern virus VoC VOCs [DOI] 10.3390/v14092041 PMC 바로가기
A Glycosylated RBD Protein Induces Enhanced Neutralizing Antibodies against Omicron and Other Variants with Improved Protection against SARS-CoV-2 InfectionArticle Published on 2022-09-142022-11-15 Journal: Journal of Virology [Category] SARS, 변종, 진단, [키워드] Affect antibody production B.1.1.529 B.1.1.7 lineage B.1.351 B.1.427 B.1.429 B.1.617.2 Beta coronavirus COVID-19 COVID-19 vaccine Delta delta variant demonstrated develop disease severity domain effective effective vaccine Effectiveness Efficacy elicited enhanced enhanced protection epitope Epsilon Gamma global public health highlight human ACE2 immunized immunized mice immunodominant IMPROVE Improved improved neutralizing activity induce Lineage mice mutant mutated Mutation Neutralizing Neutralizing activity neutralizing antibody Neutralizing antibody titer Numerous omicron Omicron and other variants Other P.1 pandemic Prevent probe protection Protective Protein pseudotyped pseudovirus RBD RBD protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 strain SARS-CoV-2 variant SARS-CoV-2 variants shown significantly Strains subunit Subunit vaccine the receptor-binding domain threat Transmissibility Vaccine variant variants weight loss [DOI] 10.1128/jvi.00118-22 PMC 바로가기
Preclinical characterization of amubarvimab and romlusevimab, a pair of non-competing neutralizing monoclonal antibody cocktail, against SARS-CoV-2Article Published on 2022-09-142022-11-15 Journal: Frontiers in Immunology [Category] SARS, 변종, 진단, [키워드] acute respiratory syndrome amino acid substitution amubarvimab (BRII-196) antibody antibody cocktail Clinical efficacy Combination controls coronavirus coronavirus disease COVID-19 demonstrated Emergency use authorization epitope EUA Evolution half-maximal inhibitory concentration half-maximal inhibitory concentration (IC50) in vitro introduced less Lung pathology Lungs M252Y/S254T/T256E (YTE) mAb mAbs Modification monoclonal antibody monoclonal antibody (mAb) Mutation neutralize neutralized Neutralizing Post-infection Preclinical RBD receiving Receptor binding domain receptor binding domain (RBD) reduce reduced regions regulatory authority resulting retained romlusevimab (BRII-198) SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variants serum severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) significantly Spike protein Support susceptibility therapeutic option variant variant of concern (VOC) variants variants of concern Viral load virus VoC weight loss [DOI] 10.3389/fimmu.2022.980435 PMC 바로가기
Correlates with Vaccine Protective Capacity and COVID-19 Disease Symptoms Identified by Serum Proteomics in Vaccinated IndividualsArticle Published on 2022-09-132022-11-15 Journal: Molecules [Category] SARS, 변종, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome Algorithm allergy Analysis Asymptomatic autoantibodies autoantibody biological processes Biomarker Capacity caused characterized circulating Cohort coronavirus coronavirus disease correlated COVID-19 disease disease severity disease-associated effective intervention Efficacy epitope Evidence Genetic HBV Identified Immunoglobulin immunology implementation individual individuals mechanism non-severe cases pandemic PCR-negative PCR-positive PCR-positive individual profile Protective Protein Proteins proteomic proteomics purpura Quantitative RBD reducing response to vaccination risk SARS-CoV-2 severe disease severe symptom spike receptor-binding domain Symptom thrombosis understanding uninfected vaccinated individual Vaccine Vaccine development virus transmission virus variant viruses with COVID-19 [DOI] 10.3390/molecules27185933 PMC 바로가기
Mucosal nanobody IgA as inhalable and affordable prophylactic and therapeutic treatment against SARS-CoV-2 and emerging variantsArticle Published on 2022-09-122022-11-15 Journal: Frontiers in Immunology [Category] SARS, 변종, 진단, [키워드] administration antibodies Antibody therapeutics Antiviral antiviral prophylaxis and therapeutics Biological sciences comparable conserved effective epitope fusion protein IgA IgG Fc Immunity infected with SARS-CoV-2 Infection intranasal invasive K18-ACE2 less Lineage mammalian Microbiology mucosal nanobody neutralization neutralize omicron Pichia pastoris produced Prophylactic Prophylaxis provide RBD recognize SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 variant severe respiratory disease Therapeutic treatment transgenic mice variant variants VoC [DOI] 10.3389/fimmu.2022.995412 PMC 바로가기
Arsenal of nanobodies shows broad-spectrum neutralization against SARS-CoV-2 variants of concern in vitro and in vivo in hamster modelsArticle Published on 2022-09-092022-11-15 Journal: Communications Biology [Category] SARS, 변종, 진단, 치료기술, [키워드] anti-RBD anti-S2 anti-SARS-CoV-2 antibody fragment arsenal candidate characterized conserved cross-reactivity demonstrated detectable Efficacy epitope feasibility IgG in vitro in vivo intrinsic mAb magnitude nanobodies nanobody neutralization offer provide reducing SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants shown specificity spike glycoprotein therapeutic thermodynamic viral burden [DOI] 10.1038/s42003-022-03866-z PMC 바로가기
IMM-BCP-01, a patient-derived anti-SARS-CoV-2 antibody cocktail, is active across variants of concern including Omicron BA.1 and BA.2Article Published on 2022-09-092022-11-15 Journal: Science Immunology [Category] SARS, 변종, 진단, [키워드] ACE2 receptor Activation acute respiratory syndrome ADCC anti-SARS-CoV-2 antibody antibodies antibody antibody cocktail Antiviral antiviral activity binding blocked Cell Complement pathway convalescent coronavirus COVID-19 Delta demonstrated Efficacy epitope in vitro in vivo Infection lung memory B Neutralizing neutralizing antibody omicron Patient phagocytosis preclinical data Protein RBD SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant spike susceptible individuals Syrian golden hamster tested the SARS-CoV-2 the Spike Therapies therapy variants of concern Viral mutagenesis [DOI] 10.1126/sciimmunol.abl9943 PMC 바로가기
Long-term memory CD8+ T cells specific for SARS-CoV-2 in individuals who received the BNT162b2 mRNA vaccineArticle Published on 2022-09-062022-11-16 Journal: Nature Communications [Category] SARS, 변종, 치료기술, [키워드] Analysis analyzed BNT162b2 mRNA vaccine CD8 CD8+ T cell conserved COVID-19 vaccine detectable Efficacy epitope Epitopes evaluate help high affinity high stability HLA-A*24:02 immunized immunodominant epitope individual induce infection with SARS-CoV-2 long-term memory memory T cell peptide populations Prevent recognize SARS-CoV-2 SARS-CoV-2 variants second vaccination T cell T cell receptor the vaccine Vaccine variants [DOI] 10.1038/s41467-022-32989-4 PMC 바로가기
Immunology to Immunotherapeutics of SARS-CoV-2: Identification of Immunogenic Epitopes for Vaccine DevelopmentArticle Published on 2022-09-052022-11-16 Journal: Current microbiology [Category] SARS, 유전자 메커니즘, [키워드] adaptive Antigen approach candidate caused Coverage COVID19 cytokine development epitope global public health homology identification immune in silico mechanism pandemic Pathogenesis pathway peptide Protein retrieved SARS-CoV-2 SARS-CoV-2 virus Signaling spike Stage T cell Trial Vaccine vaccine candidates Vaccine development virus [DOI] 10.1007/s00284-022-03003-3 PMC 바로가기