expression pattern – Page 7 – Communicable Diseases Research

Competing endogenous RNA network profiling reveals novel host dependency factors required for MERS-CoV propagation

Article

Published on 2020-03-302022-10-31
Journal: Emerging Microbes & Infections
[Category] Coronavirus,

[키워드] Analysis Antiviral antiviral strategy biological pathways biological processe Calu-3 Cell cells cellular change characterized circRNA Circular competing endogenous RNA demonstrated epithelial expression expression pattern Factor function group highly pathogenic Host host genes human lung in viral Infection investigated involved KEYWORDS: MERS-CoV knockdown MAPK MERS-CoV MERS-CoV infection metabolic processes Middle East miRNA modulate mRNA noncoding RNA Pathways perturbations predicted proportion Protein provided reaction recent reduced Regulatory required respiratory syndrome coronavirus reveal RNA selected significantly siRNA Specific Structure target mRNA targets unique Variation viral infections
[DOI] 10.1080/22221751.2020.1738277 PMC 바로가기 [Article Type] Article

Evidence of SARS-CoV2 Entry Protein ACE2 in the Human Nose and Olfactory Bulb

인간의 코와 후각구에서 SARS-CoV2 진입 단백질 ACE2의 증거

Article

Published on 2020-01-012022-09-11
Journal: Cells, tissues, organs
[Category] SARS, 치료기술,

[키워드] ACE2 anatomical angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Anosmia Basal cell basal cells Bulb caused Cell cell type cells Central nervous system clinical cough COVID-19 disease defined dissemination enzyme epithelial cell epithelial cells Evidence evidence of expressed expression expression pattern Fever Human immature Meningitis mild respiratory symptom mild respiratory symptoms nasal Nasal septum Neurological symptoms nose olfactory olfactory bulb Olfactory epithelium olfactory receptor olfactory receptor neuron olfactory receptor neurons organ pandemic paranasal Paranasal sinuses pathway positive Region respiratory respiratory epithelium respiratory symptoms Sagittal section SARS-CoV2 SARS-CoV2. Serine severe symptom severe symptoms sustentacular cells Symptom tissue TMPRSS2 TMPRSS2 protein transmembrane serine protease transmembrane serine protease 2 vice Viral viral meningitis viral tropism
[DOI] 10.1159/000513040 PMC 바로가기 [Article Type] Article

Therapeutic effect and autophagy regulation of myriocin in nonalcoholic steatohepatitis

비알코올성 지방간염에서 미리오신의 치료 효과 및 자가포식 조절

Research

Published on 2019-10-212022-09-06
Journal: Lipids in Health and Disease
[Category] B형 간염, Communicable Disease,

[키워드] Acox-2 active CHB administration Adults alternate days analyzed animal model autophagy autophagy function autophagy marker autophagy markers ballooning blockade body weight ceramide ceramide signaling Ceramides change CHB chronic hepatitis Chronic Hepatitis B Control Cpt-1α de novo synthesis disease dyslipidemia elevated expression pattern Fabp1 fatty Fatty acid fatty acid metabolism Fatty liver fatty liver disease healthy hepatic autophagy function HepG2 cell HepG2 cells HFD-induced NASH High fat diet incubated Lipid accumulation liver Liver Biopsy liver biopsy-proven patient liver biopsy-proven patients Liver histology liver pathology lobular inflammation mechanisms metabolism myriocin NAFLD NASH NASH patient NASH patients Non-alcoholic fatty liver disease non-NASH patients nonalcoholic fatty liver Nonalcoholic Fatty Liver Disease oral administration Pathogenesis pathogenic Patient PPARα profiles qPCR qPCR analysis randomly divided RATs Registered Registration Regulation Regulatory restored Result reversed screened serum transaminase serum transaminases significantly significantly increased sphingolipid steatohepatitis steatosis subject three groups Treatment were measured
[DOI] 10.1186/s12944-019-1118-0 PMC 바로가기 [Article Type] Research

Integrative “Omics”-Approach Discovers Dynamic and Regulatory Features of Bacterial Stress Responses

통합 "Omics" 접근 방식으로 세균 스트레스 반응의 동적 및 조절 기능 발견

Research Article

Published on 2013-06-202022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] (transcriptome adaptation adaptive mechanism adaptive mechanisms addition alternative approach approach assigned Author Bacteria cellular stress responses change choice complex conditions determine different dynamic Effect elevated temperature event events example exhibited expression expression level expression pattern expressome Factor Factors feature found fraction Frequency Gene Genes Genome help in addition to include initiated integration maintain mass spectrometry Microarrays mRNA mRNA level mRNA levels mRNAs Occurrence open reading frames operon organism oxygen phototrophic polar polysome Population post-transcriptional level Protein Proteins proteome provided quantification quorum regulated Regulation Regulatory reported required response RNA-Seq RpoE singlet oxygen Stress stress condition stress conditions stress response stress responses survival transcriptional activation transcriptional level transcriptional regulator transcriptional regulators Transcriptome translation translational was used
[DOI] 10.1371/journal.pgen.1003576 PMC 바로가기 [Article Type] Research Article

The Regulatory Network of Natural Competence and Transformation of Vibrio cholerae

Vibrio cholerae의 자연적 능력 및 변형의 규제 네트워크

Research Article

Published on 2012-06-212022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] a major Analysis aquatic bacterium aquatic environment assays Author autoinducers Bacteria Bacterial bacterium CAMP carbon Carbon catabolite repression catabolite repression Cell chitin chitinous chitinous exoskeleton colonization Combination competence condition conditions consequence contribute Degradation degradation products dependent on determine developmental different DNA ecological environmental niche environmental reservoirs Evidence Evolution Express expression pattern Extracellular Factor found Gene Gene Expression gene transfer Genes Genetic genetic transformation genomes growth heterogeneity heterogeneous homogeneous horizontal gene Horizontal gene transfer human pathogen immunological detection initiate intracellular signaling investigated involved lead maintenance majority metabolism mode natural Natural competence natural transformation network organism pathogenic phenotype protein level protein levels quantitative RT–PCR quorum-sensing pathways regions regulated regulatory circuit released reporter fusions required signaling cascade signaling pathway single cell level tested TfoX the cells transcriptional transfer transformation V. cholerae Vibrio cholerae western blot Western blot analysis zooplankton
[DOI] 10.1371/journal.pgen.1002778 PMC 바로가기 [Article Type] Research Article