Extracellular – Page 7 – Communicable Diseases Research

Extracellular vimentin is an attachment factor that facilitates SARS-CoV-2 entry into human endothelial cells

423

Published on 2022-01-252022-10-29
Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, COVID19(2023년), SARS,

Thiol-based chemical probes exhibit antiviral activity against SARS-CoV-2 via allosteric disulfide disruption in the spike glycoprotein

423

Published on 2022-01-242022-10-29
Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, COVID19(2023년), MERS, SARS,

[키워드] ACE2 ACE2 binding Analysis angiotensin-converting enzyme 2 antiviral activity binding binding pocket change complement component Compound consequence conserved coronavirus COVID-19 pandemic cysteine decrease disrupt distal disulfide bond disulfide bonds Extracellular host cells human coronavirus human coronaviruses hydrophobic Infection inhibit mechanism mechanism of action membrane permeability nontoxic occur probe RBD reactive reactivity receptor Receptor binding domain receptor binding motif redox biology reducing reduction SARS-CoV-2 shifting Significance significantly spike glycoprotein the RBD the SARS-CoV-2 these compound thiol-based chemical probes Treatment vaccination
[DOI] 10.1073/pnas.2120419119 PMC 바로가기 [Article Type] 423

Exosomes Recovered From the Plasma of COVID-19 Patients Expose SARS-CoV-2 Spike-Derived Fragments and Contribute to the Adaptive Immune Response

COVID-19 환자의 혈장에서 회수된 엑소좀은 SARS-CoV-2 스파이크 유래 단편을 노출시키고 적응 면역 반응에 기여합니다

Immunology

Published on 2022-01-172022-09-12
Journal: Frontiers in Immunology [Category] SARS, 진단,

Direct comparison of different therapeutic cell types susceptibility to inflammatory cytokines associated with COVID-19 acute lung injury

COVID-19 급성 폐 손상과 관련된 염증성 사이토카인에 대한 다양한 치료 세포 유형 감수성의 직접 비교

Research

Published on 2022-01-152022-09-10
Journal: Stem Cell Research & Therapy [Category] SARS, 유전자 메커니즘, 진단,

[키워드] acute lung injury acute respiratory distress acute respiratory distress syndrome Alter Analysis ARDS ARDS patients Bone marrow Cell Cell therapy cell type cell viability cells characterized clinical evaluation clinical trial clinically Combination conditioned media COVID-19 COVID-19 ARDS patient cytokine Cytokine storm Cytokines Cytometry deleterious effect determine Direct Disease progression dose doses dysregulated immune response evaluate the effect excluded expression Extracellular Extracellular vesicles Flow flow cytometry greater high risk IL-6 immunomodulatory implicated Infection Inflammatory cytokine Inflammatory cytokines inflammatory mediator Inflammatory mediators mediators Mesenchymal stromal cells Mild Mortality not altered Novel coronavirus paracrine pathology Patient pro-inflammatory mediator pro-inflammatory mediators progression proteomic receptor receptors respiratory distress Respiratory distress syndrome Result severe ARDS severe COVID-19 stem cell stem cells stromal cells supplementary material survival susceptibility syndrome the cell therapeutic therapeutic efficacy therapy Treatment umbilical Vesicle viability were assessed widespread with COVID-19
[DOI] 10.1186/s13287-021-02699-7 PMC 바로가기 [Article Type] Research

eNAMPT neutralization reduces preclinical ARDS severity via rectified NFkB and Akt/mTORC2 signaling

Article

Published on 2022-01-132022-10-29
Journal: Scientific Reports [Category] Coronavirus,

Treatment with soluble CD24 attenuates COVID-19-associated systemic immunopathology

가용성 CD24를 사용한 치료는 COVID-19 관련 전신 면역병리를 약화시킵니다

Clinical Trial

Published on 2022-01-102022-09-12
Journal: Journal of Hematology & Oncology [Category] 임상, 진단,

[키워드] acute respiratory syndrome coronavirus Analysis anti-inflammatory agent anti-inflammatory agents Anti-viral Antibody Response approach attenuate binding blunt cause CD24 CD24Fc CD4 CD56 CD8 cellular compartments chemokine chemokines Clinical characteristics Clinical efficacy coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 severity cytokine Cytokine score Cytokines damage damage-associated molecular pattern Damage-associated molecular patterns demonstrated downstream enrolled epithelial cells Extracellular flow cytometry heat shock proteins homeostasis homology Immune homeostasis immunopathology Immunophenotyping induce infected individuals Inflammatory response Lung epithelial cells Natural killer cells Pathogenesis pathway Patient patients with COVID-19 performed Peripheral blood peripheral blood samples phosphatase placebo group pro-inflammatory cytokine Protein Randomized Release respiratory Result return SARS-CoV-2 SARS-CoV-2-infected individuals severe acute respiratory syndrome coronavirus 2 severe COVID-19 severity shown Siglec10 significantly Soluble CD24 supplementary material systemic cytokine response systemic inflammation T cell T cells therapeutic therapeutic efficacy Treatment Trial with COVID-19
[DOI] 10.1186/s13045-021-01222-y PMC 바로가기 [Article Type] Clinical Trial

Meso -Dihydroguaiaretic Acid Ameliorates Acute Respiratory Distress Syndrome through Inhibiting Neutrophilic Inflammation and Scavenging Free Radical

Article

Published on 2022-01-062022-10-28
Journal: The Cochrane database of systematic reviews [Category] COVID-19,

[키워드] meso-dihydroguaiaretic acid acid activated Activation acute respiratory distress acute respiratory distress syndrome Alter anti-inflammatory effect ARDS assays CD11b cellular complex Critical expression Extracellular Factor Free G-protein high mortality human neutrophil human neutrophils inflammatory effect Inflammatory response inhibit inhibited lung lung damage mice neutrophil Neutrophil extracellular trap neutrophil infiltration Pathogenesis pathogenic Phosphorylation PKC Protein Radical reactive oxygen species reactive oxygen specy receptor reduced respiratory ROS scavenging superoxide anion suppressed syndrome treat Treatment
[DOI] 10.3390/antiox11010123 PMC 바로가기 [Article Type] Article

USP10 regulates B cell response to SARS-CoV-2 or HIV-1 nanoparticle vaccines through deubiquitinating AID

Article

Published on 2022-01-042022-10-29
Journal: Signal Transduction and Targeted Therapy [Category] COVID-19,

MRI and CT coronary angiography in survivors of COVID-19

Observational Study

Published on 2022-01-012022-10-05
Journal: Heart (British Cardiac Society) [Category] 임상,

Engineered small extracellular vesicles displaying ACE2 variants on the surface protect against SARS-CoV-2 infection

표면에 ACE2 변이체를 표시하는 조작된 작은 세포외 소포는 SARS-CoV-2 감염으로부터 보호합니다

Article

Published on 2022-01-012022-09-11
Journal: Journal of Extracellular Vesicles [Category] 변종, 비임상,

[키워드] ACE2 ACE2 variant acute respiratory syndrome acute respiratory syndrome coronavirus angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antiviral efficacy antiviral therapeutics Beta Beta variant binding interaction breath carriers CD9 Characteristics clinical trial coronavirus COVID-19 D614G variant Delta delta variant displaying dominant effective delivery Efficacy ENhance enzyme Extracellular extracellular vesicle Extracellular vesicles hACE2 host cell host cell surface Infection inhibit Interaction K18-hACE2 mice L452R molecular PROTECT Protein receptor S protein sACE2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pseudovirus severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 soluble ACE2 spike the S protein therapeutic efficacy variant variants viral spike wild-type
[DOI] 10.1002/jev2.12179 PMC 바로가기 [Article Type] Article