Presence of hyaluronan in lung alveoli in severe Covid-19: An opening for new treatment options?Research article Published on 2020-09-252022-10-05 Journal: The Journal of Biological Chemistry [Category] 치료법, [키워드] acute respiratory distress alveolar ARDS Autopsy caused characterized coronavirus coronavirus disease COVID-19 Deceased Extracellular matrix glycosaminoglycan Hyaluronan Inflammation involved lung Lung alveoli Lungs normal lung tissue Patient perivascular plugs Presence processed reducing respiratory impairment SARS-CoV-2 staining syndrome tissue Treatment virus [DOI] 10.1074/jbc.AC120.015967 [Article Type] Research article
“Small” Intestinal Immunopathology Plays a “Big” Role in Lethal Cytokine Release Syndrome, and Its Modulation by Interferon-γ, IL-17A, and a Janus Kinase InhibitorImmunology Published on 2020-06-262022-10-31 Journal: Frontiers in Immunology [Category] COVID-19, MERS, [키워드] accompanied administration affected antibodies Antigen blood pressure bowel caused characterized contribute contributed coronavirus disease COVID-19 CRS cytokine cytokine production Cytokine release syndrome deficiency Degradation down-regulated expression Extracellular matrix HLA class II transgenic mice HLA-DR3 IFN-γ IL-17A immune Immunopathogenesis immunopathology indicated inflammatory pathway inhibitor inhibitors intestinal intestinal tissue JAK inhibitor janus kinase lethal maintain mice Mortality multiple organ multiple organ dysfucntion multiple organ dysfunction organ organ function pathogenic pathology pathway pro-apoptotic receptor Release RNA sequencing role SARS-CoV-2 selective severity signaling pathway significantly significantly increased specific treatment staphylococcal superantigens Support systemic level T cell T cell activation therapy Toxic shock syndrome transgenic mice Treatment TSS [DOI] 10.3389/fimmu.2020.01311 PMC 바로가기 [Article Type] Immunology
E-cigarette-induced pulmonary inflammation and dysregulated repair are mediated by nAChR α7 receptor: role of nAChR α7 in SARS-CoV-2 Covid-19 ACE2 receptor regulationResearch Published on 2020-06-182022-10-28 Journal: Respiratory Research [Category] COVID-19, [키워드] ACE2 receptor affected BALF cellular collagen collected conducted determine dysregulated Dysregulated repair E-cig exposure ECM Effect Electronic cigarette Extracellular matrix female glycol Health induce Inflammation Inflammatory Inflammatory response less lung epithelial Lung inflammation lung tissue Macrophage male matrix metalloproteinase mechanism mice MMP12 MMP2 Mmp8 MMP9 mRNA transcript nAChRα7 occur phenotype pro-inflammatory cytokine Protein Proteins pulmonary inflammation receptor reduced Regulation Research SARS-CoV-2 significantly T-lymphocyte The United States Toxicity was increased wild-type [DOI] 10.1186/s12931-020-01396-y PMC 바로가기 [Article Type] Research
Role of Extracellular Matrix in Gastrointestinal Cancer-Associated AngiogenesisReview Published on 2020-05-232023-08-30 Journal: International Journal of Molecular Sciences [Category] E형 간염, [키워드] Angiogenesis endothelial cells Extracellular matrix tumor microenvironment [DOI] 10.3390/ijms21103686 PMC 바로가기 [Article Type] Review
Pathological study of the 2019 novel coronavirus disease (COVID-19) through postmortem core biopsies Research Published on 2020-04-012022-10-05 Journal: Modern pathology : an official journal of the Unit [Category] 진단, 치료기술, 치료법, [키워드] 2019 novel coronavirus age alveolar epithelial cells Bacterial biopsy bronchopneumonia change cirrhosis Cluster component condition consolidation contribute COVID-19 death diabetes died Diffuse alveolar damage disease disease onset Disease progression elevated exhibit Extracellular matrix fatality female fibrosis hyaline membrane formation hypertension immunocompromised status infiltration Injury intra-alveolar knowledge leukemia liver lobular lung Lungs Lymphocytes lymphocytopenia male Mild Myocardial Necrosis neutrophilic pathologic pathological pathology Patient patients performed Pneumonia postmortem examination proliferation ranged renal the patient time type II pneumocytes underlying conditions underlying disease underlying diseases White blood cell [DOI] 10.1038/s41379-020-0536-x [Article Type] Research
Infectious Diseases and the Lymphoid Extracellular Matrix Remodeling: A Focus on Conduit SystemReview Published on 2020-03-162023-08-30 Journal: Cells [Category] E형 간염, [키워드] conduit system Extracellular matrix Infectious diseases Lymph node remodeling spleen [DOI] 10.3390/cells9030725 PMC 바로가기 [Article Type] Review
Extracellular Vesicles From Hepatocytes Are Therapeutic for Toxin-Mediated Fibrosis and Gene Expression in the LiverOriginal Research Published on 2020-01-102023-08-30 Journal: Frontiers in Cell and Developmental Biology [Category] E형 간염, [키워드] cell cycle Exosome Extracellular matrix extracellular vesicle hepatic fibrosis hepatic stellate cell hepatocyte Inflammation [DOI] 10.3389/fcell.2019.00368 PMC 바로가기 [Article Type] Original Research
Fibroblastic Reticular Cells Control Conduit Matrix Deposition during Lymph Node ExpansionArticle Published on 2019-11-262023-08-30 Journal: Cell Reports [Category] E형 간염, [키워드] CLEC-2 conduit Extracellular matrix Fibroblastic reticular cells Lymph node microtubules pleckstrin homology-like domain family B member 2 podoplanin Polarity [DOI] 10.1016/j.celrep.2019.10.103 PMC 바로가기 [Article Type] Article
Establishment of porcine enterocyte/myofibroblast co-cultures for the growth of porcine rota- and coronavirusesArticle Published on 2018-10-122022-10-29 Journal: Scientific Reports [Category] Coronavirus, [키워드] bovine can be used Cell Characteristics co-culture co-cultured contributing to coronavirus Culture demonstrated enteric virus Enterocyte epithelial cells evaluated Extracellular matrix fecal fetal Genotype growth growth factor infect Last Miller PEDV proliferation Replication rotavirus strain secrete serum strain subepithelial susceptibility susceptible TGEV Vero viruses [DOI] 10.1038/s41598-018-33305-1 PMC 바로가기 [Article Type] Article
[Study on diagnostic value of extracellular volume imaging by magnetic resonance imaging for liver fibrosis of hepatitis B]Article Published on 2018-09-202023-06-16 Journal: Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese [Category] B형 간염, [키워드] Extracellular matrix Extracellular volume Liver fibrosis magnetic resonance imaging [DOI] 10.3760/cma.j.issn.1007-3418.2018.09.003