Automated detection of COVID-19 cases from chest X-ray images using deep neural network and XGBoost심층 신경망 및 XGBoost를 사용하여 흉부 X선 이미지에서 코로나19 사례 자동 감지Article Published on 2022-08-012022-09-11 Journal: Radiography (London, England : 1995) [Category] SARS, 치료기술, [키워드] Accuracy Activation Algorithm approach approaches assist can be used Chest chest X-ray Chest X-ray image Chest X-ray images chests coronavirus disease COVID-19 COVID-19 case COVID-19 cases COVID-19 diagnosis COVID-19 pandemic deep Deep neural network (DNN) DenseNet169 detect diagnosing evaluate experiment faster feature Gradient heatmap implementation initial input network Neural patients with COVID-19 people with COVID-19 problems radiologist Radiologists researcher sensitivity specificity the disease the patient was used X-ray XGBoost [DOI] 10.1016/j.radi.2022.03.011 PMC 바로가기 [Article Type] Article
Reverse vaccinology approach for multi-epitope centered vaccine design against delta variant of the SARS-CoV-2Article Published on 2022-08-012022-11-16 Journal: Environmental science and pollution research inter [Category] COVID19(2023년), SARS, 변종, [키워드] addition adverse effect Alpha applied approach Asia B-cell chimeric Chimeric vaccine conserved contagious COVID-19 COVID-19 infection COVID-19 outbreak CTL epitope Delta delta variant docking Efficacy effort elicit Epitopes expression faster globe highly antigenic HLA HTL humoral immune response Immune simulation impacted in silico India induce infective Multi-epitope vaccine Mutation non-allergenic other variant Protein reported reverse vaccinology SARS-CoV-2 South spike Spike protein the SARS-CoV-2 the spike protein TLR4 transmission rate USA Vaccine vaccine construct Vaccine design Vaccines variant variants of concern variants of SARS-CoV-2 was performed Wuhan, China [DOI] 10.1007/s11356-022-19979-1 PMC 바로가기
Serial Intervals for SARS-CoV-2 Omicron and Delta Variants, Belgium, November 19-December 31, 2021SARS-CoV-2 Omicron 및 Delta 변종에 대한 일련 간격, 벨기에, 2021년 11월 19일-12월 31일Article Published on 2022-08-012022-09-11 Journal: Emerging Infectious Diseases [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Belgium cause causes coronavirus coronavirus disease COVID-19 Delta delta variant Delta variants faster interval investigated omicron respiratory infections Result SARS-CoV-2 Serial interval severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Transmission vaccination Vaccination Status vaccine-preventable diseases variant variants variants of concern viruses zoonoses [DOI] 10.3201/eid2808.220220 PMC 바로가기 [Article Type] Article
In vitro high-content tissue models to address precision medicine challengesReview article Published on 2022-08-012022-10-05 Journal: Molecular aspects of medicine [Category] SARS, 비임상, [키워드] Accuracy arising bioprinting Combination coronavirus disease COVID-19 demonstrated Diagnosis diagnostic diagnostics disease Efficacy Efficiency faster highlight IMPROVE in vitro in vitro model individual lack Mutation Organ-on-a-chip pandemic Pandemics Patient Precision precision medicine reduce Reinfection SARS-CoV-2 Side effect tissue Toxicity Treatment vaccinated individuals vaccination Vaccine virus [DOI] 10.1016/j.mam.2022.101108 [Article Type] Review article
Whole blood samples for faster real-time PCR analysis of thrombophilic mutations in SARS-CoV-2 virus positive patientsArticle Published on 2022-07-292022-11-16 Journal: Physiological research [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] Analysis Blood blood sample carried carrier carriers Complete Concordance COVID-19 COVID-19 positive patients cycle threshold demonstrated DNA DNA extraction DNA molecule evaluated faster genotyping healthy heterozygote heterozygous homozygote homozygous incidence Laboratory Leiden median Modification Mutation mutations outpatients patients with COVID-19 PCR performed positive positive patient protocol provided real time Real-time PCR reported SARS-CoV-2 virus significant difference significantly subject thawing thrombosis Venous Thromboembolism Whole blood whole blood sample [DOI] 10.33549/physiolres.934883 PMC 바로가기
Automatic scoring of COVID-19 severity in X-ray imaging based on a novel deep learning workflow Research Published on 2022-07-282022-10-05 Journal: Scientific Reports [Category] 임상, 치료기술, [키워드] Algorithm approach Automatic Clinicians Combination COVID-19 COVID-19 patient COVID-19 severity dataset deep learning disease disorders faster lung Lung disease Lung diseases MAE mean absolute error Patient Pneumonia Pulmonary pathology quantification radiologist reduced severity significantly Stage tested Tuberculosis X-ray [DOI] 10.1038/s41598-022-15013-z [Article Type] Research
BSL2-compliant lethal mouse model of SARS-CoV-2 and variants of concern to evaluate therapeutics targeting the Spike proteinSARS-CoV-2의 BSL2 호환 치명적인 마우스 모델 및 Spike 단백질을 표적으로 하는 치료제 평가를 위한 우려 변종Article Published on 2022-07-282022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 transgenic mice acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 animal model antibody both virus both viruses brains BSL-2 BSL-2 mouse model BSL2 BSL3 BST2 can be used CCL5 change competent concern conditions coronavirus COVID-19 COVID19 CXCL10 disease Disease progression drugs Encephalitis evaluate experimental therapeutics facilitate faster generate GFP glycoprotein hACE2 host-pathogen interactions in vivo increased expression Infection interferon IRF7 K18-hACE2 K18-hACE2 transgenic mice lethal infection LILRB4 lung Lungs mass vaccination mice modulate mouse model mutations Neonatal neuronal infection neurotropism pathogenicity prophylactic treatment Protein pseudotyped Pseudotyped virus Receptor binding domain replaced REPLACED BY Replication reported SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 variants SARS-CoV-2 viruses SARS2 severe acute respiratory syndrome Coronavirus Spike protein stomatitis successive wave successive waves the SARS-CoV-2 the Spike the spike protein therapeutic Therapeutics transgenic transgenic mice Transmission vaccination Vaccine development variant variants of concern vesicular vesicular stomatitis vesicular stomatitis virus virulence virus VoC VSV VSV (vesicular stomatitis virus) [DOI] 10.3389/fimmu.2022.919815 PMC 바로가기 [Article Type] Article
An in silico approach to study the role of epitope order in the multi-epitope-based peptide (MEBP) vaccine design다중 에피토프 기반 펩타이드(MEBP) 백신 설계에서 에피토프 순서의 역할을 연구하기 위한 in silico 접근법Article Published on 2022-07-222022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, [키워드] Accessibility approaches bioinformatics candidate Candidates cellular response country COVID-19 pandemic death rates develop epitope Epitopes experimental protocols experimental validation faster highest humoral immunization immunoinformatics in silico in silico Approach introduced less likelihood limitation methodology MOST MVP overcome pandemic peptide positive predicted predictors Quantitative ranking reported SARS-CoV-2 SARS-CoV-2 variant shown Vaccine vaccine candidate vaccine candidates Vaccine design Vaccine development variant virulent [DOI] 10.1038/s41598-022-16445-3 PMC 바로가기 [Article Type] Article
COVID-19 Variant Detection with a High-Fidelity CRISPR-Cas12 Enzyme고충실도 CRISPR-Cas12 효소를 사용한 COVID-19 변이체 탐지Article Published on 2022-07-202022-09-11 Journal: Journal of Clinical Microbiology [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] Analysis Assay validation circulating variant clinical sample clinical samples Concordance COVID-19 COVID-19 patient COVID-19 patients CRISPR CRISPR-Cas12 detection DETECTR Diagnostic method enzyme Enzymes faster followed by Genome sequencing guide RNAs identify infection control isothermal amplification L452R Laboratory test Laboratory tests LAMP Loop-mediated isothermal amplification Mutation mutations N501Y nucleotide omicron Patient polymorphism public health real-time RT-PCR RNAs SARS Coronavirus SARS coronavirus 2 SARS-CoV-2 SARS-CoV-2 lineage SARS-CoV-2 variant SARS-CoV-2 variants Sequencing single nucleotide Single nucleotide polymorphism SNP Surveillance target the SARS-CoV-2 Treatment treatment of COVID-19 patients utility variant variants Viral mutations viral mutations. whole-genome sequencing [DOI] 10.1128/jcm.00261-22 PMC 바로가기 [Article Type] Article
Development of a Rapid Live SARS-CoV-2 Neutralization Assay Based on a qPCR ReadoutqPCR 판독을 기반으로 한 Rapid Live SARS-CoV-2 중화 분석의 개발Article Published on 2022-07-202022-09-11 Journal: Journal of Clinical Microbiology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] antibody Antibody-mediated immunity antiviral activity calculate can be used characteristic controls correlation COVID-19 COVID-19 pandemic cross-neutralization demonstrated detect determine determined by development domain ELISA experiments faster generate gold gold standard Immunity Live virus natural infection neutralization Neutralization assay neutralization assays Neutralizing Neutralizing antibodies neutralizing antibody patient sera priority qPCR qRT-PCR Rapid Receptor-binding domain reduce reduction SARS-CoV-2 SARS-CoV-2 neutralizing antibodies SARS-CoV-2 neutralizing antibody SARS-CoV-2 qRT-PCR Sensitivity and specificity sera significantly standard curve surrogate neutralization assay tested vaccination variants Vero E6 Vero E6 cell VERO E6 cells Viral Viral load Viral RNA virus virus isolate Virus neutralization [DOI] 10.1128/jcm.00376-22 PMC 바로가기 [Article Type] Article