Viral mapping in COVID-19 deceased in the Augsburg autopsy series of the first wave: A multiorgan and multimethodological approachAugsburg 부검 시리즈의 첫 번째 웨이브에서 사망 한 COVID-19의 바이러스 매핑 : 다층 및 다중 방법 학적 접근Research Article Published on 2021-07-192022-09-10 Journal: PLoS ONE [Category] MERS, 진단, 치료기술, [키워드] affected alterations alveolar damage analyzed approach Autopsies Autopsy Central nervous system Chain Reaction CNS correlation COVID-19 Deceased died diffuse Diffuse alveolar damage disease distribution early phase Epidemiology Evidence exhibited fat First wave focus frequencies Germany gross examination histological change histological changes histology immunohistochemistry information internal organ internal organs inverse correlation lung Lungs mediastinal lymph node mediastinal lymph nodes Multiorgan organ organs Other other organ other organs outcome pandemic pathophysiology Patient performed polymerase polymerase chain polymerase chain reaction positive positive sample Result SARS-CoV-2 SARS-CoV-2 detection Stage the disease the stage therapy upper airway upper airways Viral viral infection Viral load virus [DOI] 10.1371/journal.pone.0254872 PMC 바로가기 [Article Type] Research Article
Efruxifermin in non-alcoholic steatohepatitis: a randomized, double-blind, placebo-controlled, phase 2a trial Research Published on 2021-07-082022-10-05 Journal: Nature Medicine [Category] 바이오마커, 임상, [키워드] Administered Algorithm Analysis baseline change Clinical data conducted confidence interval double-blind Efficacy fat FGF21 fibroblast fibrosis FIVE fraction fusion protein group groups growth factor hepatic fat IMPROVE majority NASH Patient patients Placebo placebo-controlled placebo-controlled study Preclinical Randomized receive reduced reported safety profile significantly statistically significant difference steatohepatitis stratified study drug subcutaneous injection TEAE the placebo group the United State treat Treatment treatment-emergent adverse event Trial [DOI] 10.1038/s41591-021-01425-3 [Article Type] Research
Increasing adiposity and the presence of cardiometabolic morbidity is associated with increased Covid-19-related mortality: results from the UK Biobank지방 증가 및 심장 대사 이환율의 존재는 Covid-19 관련 사망률 증가와 관련이 있습니다 : 영국 Biobank의 결과Research Article Published on 2021-07-032022-09-01 Journal: BMC Endocrine Disorders [Category] SARS, 진단, [키워드] 95% CI adipose Adiposity adjusted age angina Anthropometric data Atrial fibrillation BMI body fat body mass body mass index cardiometabolic Chi-squared test Cohort contribute Course COVID-19 COVID-19-related death death defined diabetes died distribution dyslipidaemia fat healthcare higher odd higher odds higher risk hospitalisation hypertension increase in increased mortality Increasing Infection Logistic regression male morbidity Mortality normal weight obesity outcome participant performed positive positive patient positive patients Public Health England Repository Research question Result Sex significantly higher tested translate UK biobank Volume waist WHR [DOI] 10.1186/s12902-021-00805-7 PMC 바로가기 [Article Type] Research Article
Evaluation of the chest computed tomography and hemogram data in patients with COVID-19: the importance of thymusCOVID-19 환자의 흉부 컴퓨터 단층 촬영 및 혈색소 측정 데이터 평가: 흉선의 중요성Article Published on 2021-06-282022-09-12 Journal: Turkish Journal of Medical Sciences [Category] MERS, 진단, [키워드] age blood cell calculated Chest Chest computed tomography Computed tomography COVID-19 COVID-19 patient COVID-19 patients evaluated fat imaging increase in involution laboratory data lung lung involvement lymphocyte Lymphocyte count material neutrophil NLR observer Patient patients patients with COVID-19 Peripheral blood peripheral blood cell Platelet platelet counts Pneumonia positive Radiologists Result RT-PCR testing scored severity significantly significantly lower statistical significance statistically thymus tissue tomography Viral pneumonia was determined were recorded [DOI] 10.3906/sag-2007-306 PMC 바로가기 [Article Type] Article
Liver fat storage is controlled by HNF4α through induction of lipophagy and is reversed by a potent HNF4α agonistArticle Published on 2021-06-112022-10-04 Journal: Cell Death & Disease [Category] 신약개발, [키워드] Administered agonist benfluorex cells clearance Control CYP26A1 downstream downstream genes drug expression fat highest dose increased expression Lipid signalling liver mice NAFLD nontoxic occurred pathway reduction reversed secretion SPNS2 steatosis Target validation therapeutic [DOI] 10.1038/s41419-021-03862-x PMC 바로가기 [Article Type] Article
Nutritional, Cardiovascular Health and Lifestyle Status of ‘Health Conscious’ Adult Vegans and Non-Vegans from Slovenia: A Cross-Sectional Self-Reported SurveyArticle Published on 2021-06-022022-10-29 Journal: International Journal of Environmental Research an [Category] Coronavirus, MERS, SARS, [키워드] age blood lipids blood pressure body composition body mass index both group cardiovascular Cardiovascular health cardiovascular health status comparable Concentration COVID-19 COVID-19 pandemic cross-sectional diet dietary intake Energy intake explained fat fatty Fatty acid females fiber Frequency High-density lipoprotein cholesterol initial LDL cholesterol lifestyle Linear regression model Low-Density Lipoprotein cholesterol non-vegan nutrition performed Polyunsaturated questionnaire Questionnaires recommendations remained saturated significant difference significantly lower Sociodemographic sodium status subject subjects sugar survey vegan was used were assessed [DOI] 10.3390/ijerph18115968 PMC 바로가기 [Article Type] Article
Health behaviours of young adults during the outbreak of the Covid-19 pandemic – a longitudinal studyResearch Article Published on 2021-06-022022-10-28 Journal: BMC Public Health [Category] COVID-19, MERS, SARS, [키워드] activity Adults affected alcohol Anxiety assessment changed changes in COVID-19 diet eating habits fat food GAD-7 Generalized Health Health-related behaviours index lockdown MET obligatory outbreak pandemic physical activity Pittsburgh preference Quality reduced Result Sedentary behaviours significantly Sleep sleep quality supplementary material sweet worsened young adults [DOI] 10.1186/s12889-021-11140-w PMC 바로가기 [Article Type] Research Article
Mediterranean Diet and SARS-COV-2 Infection: Is There Any Association? A Proof-of-Concept Study지중해식 식단과 SARS-COV-2 감염: 연관성이 있습니까? 개념 증명 연구Clinical Trial Published on 2021-05-192022-08-13 Journal: Nutrients [Category] SARS, 임상, [키워드] 95% CI age analyzed Asymptomatic Asymptomatic individuals cereals collected Consumption correlation diet dietary habit dietary habits fat fruit hcp Healthcare professional healthcare professionals Hospitalization individual Infection infection rate Italy logistic regression model Mediterranean diet observational study Older olive oil Piedmont questionnaire reported risk of infection SARS-COV-2 infection saturated saturated fat saturated fats severity significantly significantly lower symptomatic individual symptomatic individuals [DOI] 10.3390/nu13051721 PMC 바로가기 [Article Type] Clinical Trial
Leveraging Genomic Associations in Precision Digital Care for Weight Loss: Cohort StudyOriginal Paper Published on 2021-05-192022-10-30 Journal: Journal of Medical Internet Research [Category] Coronavirus, SARS, [키워드] accompanied Accuracy alleles analyzed average BMI Care cholesterol clinical factors Cohort contributing to COVID-19 pandemic demonstrated described Digital digital therapeutics Efficacy enrolled Epidemic fat Genetic genetic data genetic risk genomic genomic data genomic information greater gut microbiota Health health coaching illnesses IMPROVE Including Inclusion indicated Inflammatory insulin resistance Interaction Intervention involved LASSO lifestyle medicine Linear regression model Logistic logistic regression model lost weight machine learning machine learning analysis metabolic pathway metabolism mHealth mobile apps mobile phone Model Modification nutrigenomics obesity objective outcome outcomes participant Personalized nutrition polymorphism Precision precision nutrition predictor previous study protocol R 2 recommendation Research Result risk serum calcium significantly single-nucleotide SNP SNPs Support the mean Transport urgency variable variables Waist circumference weight weight loss [DOI] 10.2196/25401 PMC 바로가기 [Article Type] Original Paper
Phenome-wide and expression quantitative trait locus associations of coronavirus disease 2019 genetic risk lociArticle Published on 2021-05-182022-10-30 Journal: iScience [Category] COVID-19, [키워드] Abstract addition affecting Analysis association associations contribute coronavirus disease COVID-19 disease eQTL etiology Express expression fat Genes Genetic genetic risk Genetic variant Genetic variation Genome-wide association study genome-wide significance Genomics GWAS higher risk Host host immune responses immune immune gene interstitial pneumonia loci locus metabolism monocyte omics parameter Patient performed Pleiotropy Quantitative Respiratory failure risk factor several gene severe coronavirus disease severe COVID-19 severe disease single-cell transcriptomes threshold tissue traits Virology while with COVID-19 [DOI] 10.1016/j.isci.2021.102550 PMC 바로가기 [Article Type] Article