Computational methods for inferring location and genealogy of overlapping genes in virus genomes: approaches and applications바이러스 게놈에서 겹치는 유전자의 위치 및 계보를 추론하는 전산 방법: 접근 방식 및 응용Review Published on 2022-02-012022-09-11 Journal: Current opinion in virology [Category] COVID19(2023년), SARS, 치료기술, [키워드] accessory proteins applied approach Atypical Computational methods COVID-19 pandemic detect etiological agent facilitate feature Genes genetic information Genome genomes in viral limitations Metrics nine overlap overlapping pathogenicity Recognition SARS-CoV-2 Spread statistically significant reduction synonymous Variability viral pathogenicity virus [DOI] 10.1016/j.coviro.2021.10.009 PMC 바로가기 [Article Type] Review
Occurrence of a substitution or deletion of SARS-CoV-2 spike amino acid 677 in various lineages in Marseille, France프랑스 마르세유의 다양한 계통에서 SARS-CoV-2 스파이크 아미노산 677의 치환 또는 결실의 발생Article Published on 2022-02-012022-09-11 Journal: Virus Genes [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] Amino acid amino acids change collected convergent evolution COVID-19 database Deletion described E484K eight emergence Evolution example FIVE France Genome genomes incidence independent lineages involved L18F L452R Lineage lineages Marseille MOST N501Y pangolin Patient Q677 Q677H raised respiratory sample Respiratory samples SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 spike SARS-CoV-2 variant SARS-CoV-2 variants searched sequence Seven Substitution USA variant [DOI] 10.1007/s11262-021-01877-2 PMC 바로가기 [Article Type] Article
A Structurally Conserved RNA Element within SARS-CoV-2 ORF1a RNA and S mRNA Regulates Translation in Response to Viral S Protein-Induced Signaling in Human Lung CellsSARS-CoV-2 ORF1a RNA 및 S mRNA 내의 구조적으로 보존된 RNA 요소는 인간 폐 세포에서 바이러스성 S 단백질 유도 신호에 대한 반응으로 번역을 조절합니다Article Published on 2022-01-262022-09-11 Journal: Journal of Virology [Category] SARS, 유전자 메커니즘, [키워드] ACE2 ACE2 receptor activated Analysis bind Cell Cell signaling cis -acting element cis -acting elements Cohort complex conservation conserved control mechanism Critical dependent on effective element elements experiment Extracellular facilitate form functional Gait Genome genomes hairpin structure highlighting Host host cell Human human lung cell human lung cells IFN-γ in vitro inhibitor Interaction Intervention lentivirus mechanism mRNA mRNA vaccines myeloid cell myeloid cells NMR ORF1a Pathways Phosphorylation positive-sense pseudotyped regulate response ribosomal loading ribosomal protein ribosomal proteins ribosomal subunit RNA RNA genome RNA virus RNA viruses S protein S1 subunit SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 RNA Sequence alignment signal signaling pathway single-stranded small molecule Specific Spike protein target translation translational translational control Treatment Trigger triggered viral entry viral gene expression Viral protein Viral RNA viral RNA element virus Virus-host interactions Virus-like particle [DOI] 10.1128/JVI.01678-21 PMC 바로가기 [Article Type] Article
Absolute quantitation of individual SARS-CoV-2 RNA molecules provides a new paradigm for infection dynamics and variant differences개별 SARS-CoV-2 RNA 분자의 절대 정량은 감염 역학 및 변이체 차이에 대한 새로운 패러다임을 제공합니다Research Article Published on 2022-01-202022-09-10 Journal: eLife [Category] SARS, 변종, 유전자 메커니즘, 치료기술, [키워드] B.1.1.7 B.1.1.7 variant cell population cells cellular clinical implications contributing to COVID-19 Degradation detection efficiency displaying early replication early stage early stages effort event exhibit genomes genomic RNA Human Infection mechanism nucleases positive provide quantification quantitation Replication replication kinetics Research RNA genome SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 RNA molecule significantly single-molecule fluorescence in situ hybridisation smFISH subgenomic RNAs Transcription Transmissibility Transmission variant variant of concern Victoria Viral Viral proteins viral replication Viral RNA viral RNAs viral variant viruses [DOI] 10.7554/eLife.74153 PMC 바로가기 [Article Type] Research Article
Cross-sectional genomic perspective of epidemic waves of SARS-CoV-2: A pan India studySARS-CoV-2 전염병 파동의 단면 게놈 관점: 범인도 연구Article Published on 2022-01-152022-09-11 Journal: Virus research [Category] SARS, 변종, 유전자 메커니즘, [키워드] affecting Analysis average coding COVID-19 cross-sectional D614G Deadly variants downloaded elevated Epidemic epidemic wave event Evolution extragenic First wave Genome Genome-wide genomes genomic inception incidence India investigated isolate management Mutation mutation rate Mutation rates NC_045512.2 Non-synonymous NSP pandemic Perspective Phylogeny RdRP reported representing RNA RNA dependent RNA polymerase SARS-CoV-2 second wave Seven silent Silent mutation SNP spike the epidemic UTR VoC VOCs VOI VOI. VOIs was obtained was performed Wuhan [DOI] 10.1016/j.virusres.2021.198642 PMC 바로가기 [Article Type] Article
Interrelationship between 2019-nCov receptor DPP4 and diabetes mellitus targets based on protein interaction network단백질 상호 작용 네트워크를 기반으로 2019-NCOV 수용체 DPP4와 당뇨병 대상 간의 상호 관계Article Published on 2022-01-072022-08-31 Journal: Scientific Reports [Category] 바이오마커, [키워드] added Affect ALB Analysis analyzed antagonists ApoB carried Cluster cluster analysis coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infection cross database diabete diabetes Diabetes Mellitus Dipeptidyl peptidase-4 DPP4 Drug development Epidemiology Final final analysis functional GeneCard Genome genomes glucagon glucagon signaling pathway high mortality highest human coronavirus IL-6 IL-6 antagonist IL6 inhibitor initial INS insulin Interaction involved KEGG Kyoto LEP management module Ontology Outcomes research Pathway analysis patients patients with diabete patients with diabetes Protein receptor Receptor binding reduce risk of death secretion selected Signaling significantly higher STRING target targets was obtained with COVID-19 [DOI] 10.1038/s41598-021-03912-6 PMC 바로가기 [Article Type] Article
VarEPS: an evaluation and prewarning system of known and virtual variations of SARS-CoV-2 genomesVarEPS: SARS-CoV-2 게놈의 알려진 가상 변이에 대한 평가 및 사전 경고 시스템AcademicSubjects/SCI00010 Published on 2022-01-072022-09-10 Journal: Nucleic Acids Research [Category] 변종, 진단, [키워드] ACE2 affinity Algorithm binding characteristic Classifier database drugs Effect Effectiveness Efficiency evaluate genomes genomic variation genomic variations Genomics MONITOR mutant strain Mutant strains Mutation Neutralizing antibodies Perspective Physicochemical properties provided reduced Research research and development resource risk SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 variation secondary structure Spread structural biology translation Transmissibility unique Vaccine Vaccines Variation viral strain viral strains virulence was used [DOI] 10.1093/nar/gkab921 PMC 바로가기 [Article Type] AcademicSubjects/SCI00010
Developing an Amplification Refractory Mutation System-Quantitative Reverse Transcription-PCR Assay for Rapid and Sensitive Screening of SARS-CoV-2 Variants of ConcernSARS-CoV-2 변이체의 신속하고 민감한 스크리닝을 위한 증폭 불응 돌연변이 시스템-정량적 역전사-PCR 분석법 개발Research Article Published on 2022-01-052022-09-10 Journal: Microbiology Spectrum [Category] COVID19(2023년), MERS, SARS, 변종, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alpha alpha and delta variants amplification analyzed application ARMS ARMS-RT-qPCR B.1.617.2 clinical sample clinical samples concern concerning conserved conserved unique mutation coronavirus Delta delta variant Delta variants demonstrated detect develop Developing fluorescent Genome genomes Genomic analysis GISAID hospital Laboratory Lineage lineages Molecular assay Molecular diagnosis Mutation network organizations pandemic PCR position Quantitative quantitative reverse transcription-PCR Rapid reagent reagents refractory respiratory reverse transcription-PCR SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 genomic sequence SARS-CoV-2 genomic sequences SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 variants of concern Screening sensitive sequencing-based methods severe acute respiratory syndrome Coronavirus Spread target Transmission unique variant variants of concern VoC VOCs whole-genome sequencing [DOI] 10.1128/spectrum.01438-21 PMC 바로가기 [Article Type] Research Article
Emergence of B.1.1.318 SARS-CoV-2 viral lineage and high incidence of alpha B.1.1.7 variant of concern in the Republic of GabonB.1.1.318 SARS-CoV-2 바이러스 계통의 출현 및 가봉 공화국에서 우려되는 알파 B.1.1.7 변이체의 높은 발생률Article Published on 2022-01-012022-09-11 Journal: International Journal of Infectious Diseases [Category] SARS, 변종, 치료기술, [키워드] addition Alpha Alpha VOC Analysis B.1.1.318 B.1.1.7 B.1.1.7 variant Central Africa distribution Efficacy emergence Gabon Genome genomes Guidance highlight imperative implication incidence Lineage lineages MinION Nanopore Oxford Oxford Nanopore Phylogenetic analysis SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 viral second wave sequenced study period Surveillance the SARS-CoV-2 genome Transmissibility Transmission Vaccine vaccine efficacy variant variant of concern variants VoC VOCs was performed [DOI] 10.1016/j.ijid.2021.10.057 PMC 바로가기 [Article Type] Article
SARS-CoV-2 variants with T135I nucleocapsid mutations may affect antigen test performanceT135I 뉴클레오캡시드 돌연변이가 있는 SARS-CoV-2 변이체가 항원 테스트 성능에 영향을 미칠 수 있음Article Published on 2022-01-012022-09-11 Journal: International Journal of Infectious Diseases [Category] MERS, SARS, 변종, 진단, 치료기술, 치료법, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Affect Amino acid amino acid substitutions Antigen antigen tests B.1.1.7 B.1.1.7 variant caused coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 detect determine diagnostic Diagnostic method diagnostic testing Direct exhibiting false-negative False-negative result false-negative results Genome genomes GISAID isolate molecular Mutation mutations N protein negative and positive nucleocapsid Outbreaks PanBio pandemic Patient performed Prevent proliferation Protein Rapid rapid antigen test Rapid antigen tests respiratory reverse transcription PCR risk RT-PCR RT-PCR test SARS-CoV-2 SARS-CoV-2 variant Sequencing several variant several variants severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 the N protein variant variants variations Viral virus strain was performed whole genome Whole genome sequencing [DOI] 10.1016/j.ijid.2021.11.006 PMC 바로가기 [Article Type] Article