Transcriptional Profiling and Machine Learning Unveil a Concordant Biosignature of Type I Interferon-Inducible Host Response Across Nasal Swab and Pulmonary Tissue for COVID-19 Diagnosis전사 프로파일링 및 기계 학습, COVID-19 진단을 위한 비강 면봉 및 폐 조직 전반에 걸쳐 I형 인터페론 유도성 숙주 반응의 일치하는 생체특징 공개Immunology Published on 2021-11-222022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘, 진단, 치료기술, [키워드] adjusted adopted Analysis approach biosignature BST2 caused complementary computational analysis concordant conserved COVID-19 COVID-19 diagnosis data interpretation dataset Diagnosis Diagnostic method embedding Factor false-negative Genes geometric global pandemic GSE147507 heterogeneous high mortality homological Host host response IFIT1 IFIT2 IFIT3 IFITM1 IFN-I IFN-I signaling infection control Interferome interferon involved ISG15 Limited lung tissue machine learning morbidity MX1 MX2 nasal swab NCBI-GEO network OAS1 OAS2 OAS3 OASL objective other respiratory infections outcome Profiling pulmonary respiratory respiratory infections response Result retrieved RNA-seq data RNA-sequencing RSAD2 RT-PCR SARS-CoV-2 SARS-CoV-2 virus sequencing data severity of COVID-19 similarity Stat1 stochastic stratified transcriptional transcriptional level transcriptomics Type type I interferon virus was used WGCNA [DOI] 10.3389/fimmu.2021.733171 PMC 바로가기 [Article Type] Immunology
A Markerless 2D Video, Facial Feature Recognition–Based, Artificial Intelligence Model to Assist With Screening for Parkinson Disease: Development and Usability Study마커가 없는 2D 비디오, 얼굴 특징 인식 기반, 파킨슨병 스크리닝을 지원하는 인공 지능 모델: 개발 및 사용성 연구Original Paper Published on 2021-11-192022-09-10 Journal: Journal of Medical Internet Research [Category] MERS, SARS, 치료기술, [키워드] Accuracy acquisition Algorithm artificial artificial intelligence assist characteristic clinical manifestation clinician collected Control COVID-19 pandemic develop development Diagnosis diagnostic effective experimental results expression facial facial expressions facial features feasible feature Features geometric help hospital IMPROVE intelligence lack Masked face matched controls Model objective Parkinson disease Patient random Random forest reached remote monitoring Result Screening Support Symptom tested Usability video camera were used [DOI] 10.2196/29554 PMC 바로가기 [Article Type] Original Paper
Modeling in the Time of COVID-19: Statistical and Rule-based Mesoscale ModelsArticle Published on 2021-11-182022-10-29 Journal: IEEE transactions on visualization and computer graphics [Category] COVID-19, MERS, [키워드] 3D model applicability approach Characteristics defined determine distribution effort element Evidence geometric information Interaction knowledge macromolecular macromolecules membrane mesoscale modeling Microscopy Model modeling molecular visualization outer membrane Research resulting Spread statistical structures the SARS-CoV-2 time ultrastructure virion virus [DOI] 10.1109/TVCG.2020.3030415 PMC 바로가기 [Article Type] Article
Persistence of Neutralizing Antibodies to SARS-CoV-2 in First Wave Infected Individuals at Ten Months Post-Infection: The UnIRSA Cohort Study감염 후 10 개월에 첫 파동 감염된 개체에서 SARS-COV-2에 대한 항체 중화 항체의 지속성 : UNIRSA 코호트 연구Brief Report Published on 2021-11-122022-09-01 Journal: Viruses [Category] MERS, SARS, 진단, [키워드] Anti-spike antibody binding domain Bio-Techne Cohort collected COVID-19 Critical elicited first positive First wave fraction geometric geometric mean humoral IgG antibody IgG titers immune response individual Infection Italy longitudinal longitudinal analysis Mild Mild disease Month natural infection neutralization titer Neutralizing activity neutralizing antibody neutralizing humoral response pandemic PCR test performed pseudotype public health R&D Systems RBD Re-infection SARS-CoV-2 SARS-CoV-2 IgG SARS-CoV-2 immunity seroconverted seronegative Seropositivity serum sample subject subjects USA Vaccine development was tested Wave were infected [DOI] 10.3390/v13112270 PMC 바로가기 [Article Type] Brief Report
SARS-CoV-2 Variants, RBD Mutations, Binding Affinity, and Antibody EscapeArticle Published on 2021-11-092022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS, [키워드] ACE2 acute respiratory syndrome affinity amino-acid Analysis antibodies antibody binding binding affinity binding energy Breakthrough infection changes in complex complexes Contagion coronavirus coronavirus disease country COVID-19 delta variant detrimental docking driving ENhance enzyme escape geometric Gibbs free energy highest hydrophilic hydrophobic Immune profile L452R mechanism Missense mutation Mutation mutations notable pandemic physical prevalent preventive measures producing RBD receptor reduction residue responsible risk SARS-CoV-2 SARS-CoV-2 variant Structure the binding affinity the epidemic the RBD the receptor-binding domain the spike protein therapeutic Transmissibility understanding vaccination rates Vaccine-induced immunity Vaccines variant variants virus were used [DOI] 10.3390/ijms222212114 PMC 바로가기 [Article Type] Article
1089. Use of a Whole-Body Quantitative System Pharmacology Physiologically-Based Pharmacokinetic (QSP/PBPK) Model to Support Dose Selection of ADG20: an Extended Half-Life Monoclonal Antibody Being Developed for the Prevention of Coronavirus Disease (COVID-19)Poster Abstracts Published on 2021-11-042022-10-29 Journal: Open Forum Infectious Diseases [Category] COVID-19, [키워드] acute respiratory syndrome Administered administration Adults Ambrose anticipated being Bioavailability CDC center Concentration Control coronavirus COVID-19 COVID-19 vaccine Developed distribution dose employee evaluated exceeded Extended figure geometric human IgG1 in vitro Inc Inc. include inhibitory concentration inter-individual intramuscularly linear material median Model monoclonal antibody Neonatal neutralization neutralization potency neutralization titer neutralizing antibody non-human primate Other pandemic Pharmacology phase plaque reduction neutralization predicted prevention prevention of COVID-19 profile recipients regimen regression equation reported representing required Result SARS-CoV-2 SARS-COV-2 infection SARS-like CoV Selection serum shown submitted Support System Therapeutics threshold transfer Trial Van Variation virus Walker Wart were used [DOI] 10.1093/ofid/ofab466.1283 PMC 바로가기 [Article Type] Poster Abstracts
633. Preliminary Results from a Phase 1 Single Ascending-Dose Study Assessing Safety, Serum Viral Neutralizing Antibody Titers (sVNA), and Pharmacokinetic (PK) Profile of ADG20: an Extended Half-Life Monoclonal Antibody Being Developed for the Treatment and Prevention of Coronavirus Disease (COVID-19)Poster Abstracts Published on 2021-11-042022-10-29 Journal: Open Forum Infectious Diseases [Category] COVID-19, [키워드] acute respiratory syndrome Administered adverse event AEs Ambrose ambulatory patient Assessing being binding BSN clinical development Cohort Concentration conserved consultant coronavirus COVID-19 COVID-19 mRNA vaccines Developed dose Ellie employee epitope Evidence Extended Fc region Frank geometric healthy human IgG1 hypersensitivity reaction Inc injection intramuscularly intravenously Ligand Mild Moderate COVID-19 monoclonal antibody neutralization pandemic participant phase Phase 1 PK modeling Placebo plaque reduction neutralization predicted prevention prevention of COVID-19 profile Randomized RBD Reactions reported Result Safety SARS-CoV-2 SARS-COV-2 infection SARS-like CoV serious AEs Serum neutralizing antibody single dose Support the receptor-binding domain the spike protein Therapeutics titer Tolerability translational Treatment Trial Variation were assessed were measured [DOI] 10.1093/ofid/ofab466.831 PMC 바로가기 [Article Type] Poster Abstracts
Contamination of Air and Surfaces in Workplaces with SARS-CoV-2 Virus: A Systematic ReviewSARS-CoV-2 바이러스가 있는 작업장의 공기 및 표면 오염: 체계적인 검토Article Published on 2021-10-092022-09-11 Journal: Annals of work exposures and health [Category] SARS, 치료기술, [키워드] aerosol article collected Concentration Contamination detectable Detection limit evaluate Evidence facilitate fomite geometric geometric mean Google Scholar healthcare help hospital identify IMPROVE Interpretation limit of detection lowest majority methodology other respiratory virus Other respiratory viruses reliability reported review RNA RNA copy SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 virus searched surface swabs systematic review transportation unit variety virus Web of Science Workplace [DOI] 10.1093/annweh/wxab026 PMC 바로가기 [Article Type] Article
Does reactogenicity after a second injection of the BNT162b2 vaccine predict spike IgG antibody levels in healthy Japanese subjects?Research Article Published on 2021-09-202022-10-28 Journal: PLoS ONE [Category] COVID-19, SARS, [키워드] 95% confidence interval adjusted adverse event Adverse reaction age antibody antibody production antibody unit blood sample BNT162b2 BNT162b2 vaccine calculated correlated geometric healthcare worker healthy IgG level injection Japanese log-transformed magnitude median Messenger RNA positively correlated predict Questionnaires reactogenicity reflect Sample size SARS CoV-2 severity Sex significantly spike spike IgG Vaccine virus spike protein [DOI] 10.1371/journal.pone.0257668 PMC 바로가기 [Article Type] Research Article
Evaluation of Capillary Blood Gases in Medical Personnel Caring for Patients Isolated Due to SARS-CoV-2 in Intensive Care Units before and after Using Enhanced Filtration Masks: A Prospective Cohort StudyArticle Published on 2021-09-072022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, SARS, [키워드] age Analysis Blood blood pressure capillary capillary blood caused Dizziness eligible enhanced epidemiological situation fatigue geometric hospital human hydration ICU intensive care unit Isolated Isolation Laboratory lack malaise Mask Masks nine no significant difference Nurse oxygen Oxygenation parameter participant Patient performed Prospective pulmonary ventilation reported risk SARS-CoV-2 somnolence subject sweating Symptom the SARS-CoV-2 virus zone [DOI] 10.3390/ijerph18189425 PMC 바로가기 [Article Type] Article