Impact of the COVID-19 Pandemic on Cancer Diagnoses in General and Specialized Practices in GermanyArticle Published on 2021-01-222022-10-31 Journal: Cancers [Category] COVID-19, [키워드] addition age Cancer cancer diagnosis coronavirus disease Coronavirus disease 2019 country COVID-19 COVID-19 pandemic COVID-19 patients database decrease Dermatology diagnose diagnosed Evidence general practices Germany global healthcare group Healthcare system highlighting Impact incidence management New organs other disease outcomes pandemic Patient Practice proportion provide public health measure Retrospective study Sex significant decrease significantly simple specialized practices These data unlikely [DOI] 10.3390/cancers13030408 PMC 바로가기 [Article Type] Article
COVID-19 and healthcare system in China: challenges and progression for a sustainable futureReview Published on 2021-01-212022-11-01 Journal: Globalization and Health [Category] COVID-19, MERS, [키워드] adopted approach China Chinese COVID-19 COVID-19 outbreak Data analysis demonstrated detect early stage Epidemic: healthcare system global healthcare Government healthcare Healthcare system High-tech hospitals infected case Infection Internet Internet hospitals: post-epidemic era intrinsic limit Personal protective equipment problems progression Public Hospital resource Spread the disease the epidemic virus widespread [DOI] 10.1186/s12992-021-00665-9 PMC 바로가기 [Article Type] Review
Impact of a pandemic on surgical neuro-oncology—maintaining functionality in the early phase of crisisResearch Article Published on 2021-01-182022-10-28 Journal: BMC Surgery [Category] COVID-19, MERS, [키워드] activity administer Asian change Chinese Coronavirus disease 2019 country COVID-19 COVID-19 negative COVID-19 pandemic early phase Elective surgery feature global healthcare highlight hospital Impact impacted initiated measure median Modification MOST Neuro-oncological surgery Neuro-oncology neurosurgery pandemic Patient patient triage performed questionnaire raise recommendation reduced reduction in reported Research response Result Society Stage surgical therapy Volume WHO widespread [DOI] 10.1186/s12893-021-01055-z PMC 바로가기 [Article Type] Research Article
Laboratory-Based Resources for COVID-19 Diagnostics: Traditional Tools and Novel Technologies. A Perspective of Personalized MedicineReview Published on 2021-01-132022-10-30 Journal: Journal of Personalized Medicine [Category] COVID-19, [키워드] Accuracy antibody Asymptomatic carried category cause caused Clinical use Combination contagious Coronavirus infection COVID-19 COVID-19 in patients COVID-19 pandemic dependent on Diagnosis diagnostic diagnostics Efficiency Enzyme-linked immunosorbent assay (ELISA) Factors Final global healthcare healthcare Healthcare system identify increase increase in infected patient Infection isothermal amplification Laboratory lateral flow immunoassay Lateral flow immunoassay (LFIA) LFIA limitations Loop mediated isothermal amplification (LAMP) Medicine Mild novel pandemic patients patients with COVID-19 Personalized medicine platform polymerase chain population immunity promising biomarkers repeated Research resources retrospective reverse transcription Reverse transcription polymerase chain reaction (RT-PCR) RT-PCR SARS-CoV-2 SARS-CoV-2 virus Sensitivity and specificity serological severity Spread spread of COVID-19 susceptibility the disease the SARS-CoV-2 the timing Traditional Treatment Variation widespread with COVID-19 [DOI] 10.3390/jpm11010042 PMC 바로가기 [Article Type] Review
SARS-CoV-2 Causes a Systemically Multiple Organs Damages and Dissemination in HamstersMicrobiology Published on 2021-01-122022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] accompanied acute respiratory syndrome adrenal gland Affect alimentary system alimentary tract animal model Antigen antigen expression cause Coronavirus-2 corpus COVID-19 damage Diffuse alveolar damage disease distribution effective extrapulmonary organs focal lesion Gallbladder global healthcare hamster histological Human immunohistochemistry impacted induce Inflammation kidney lesion liver Lymph node lymph nodes Multiple Myocardium observation organ pathological changes pathophysiologic patients post inoculation Prostate pulmonary lesion qRT-PCR SARS-CoV-2 spleen Spread Syrian hamsters systemic damages Treatment strategies Viral RNA with COVID-19 [DOI] 10.3389/fmicb.2020.618891 PMC 바로가기 [Article Type] Microbiology
Study protocol for CO vid-19 V ascular s ER vice (COVER) study: The impact of the COVID-19 pandemic on the provision, practice and outcomes of vascular surgeryRegistered Report Protocol Published on 2020-12-302022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] Analysis Care complications COVID-19 COVID-19 pandemic determine deviation form global healthcare increased risk independent intensive care International longitudinal change management multiple comorbidity National network occur operating theatre outcome pandemic Patient performed presenting protocol reduction in Research resource Statistical analysis plan submission Support surgical undergo Vascular vascular surgeon [DOI] 10.1371/journal.pone.0243299 PMC 바로가기 [Article Type] Registered Report Protocol
COVID-19: additive manufacturing response in the UKPerspective Published on 2020-12-072022-10-31 Journal: Journal of 3d Printing in Medicine [Category] COVID-19, [키워드] acute respiratory syndrome Additive manufacturing agile manufacturing bypassing caused Community coronavirus COVID-19 equipment global healthcare healthcare Increased linear Medical devices medical equipment Novel coronavirus Personal protective equipment Regulatory regulatory approval risk shown [DOI] 10.2217/3dp-2020-0013 PMC 바로가기 [Article Type] Perspective
Infection of human Nasal Epithelial Cells with SARS-CoV-2 and a 382-nt deletion isolate lacking ORF8 reveals similar viral kinetics and host transcriptional profilesSARS-CoV-2 및 ORF8이 결여된 382-nt 결실 분리주에 의한 인간 비강 상피 세포의 감염은 유사한 바이러스 동역학 및 숙주 전사 프로필을 나타냅니다Research Article Published on 2020-12-072022-08-13 Journal: PLoS Pathogens [Category] Biochemistry, MERS, SARS, 유전자 메커니즘, 치료기술, [키워드] absence airway airway epithelial cells anti-viral gene up-regulation anti-viral signaling pathway anti-viral signaling pathways apical side basolateral secretion causative agent cell type cell types comparable conserved expression coronavirus disease Coronavirus disease 2019 CoV COVID-19 COVID-19 patients CXCL10 CXCL10 production cytokine cytokine production Cytokines differentiated NEC differentiated NECs distinct gene subset distinct gene subsets Duration of infection early response elevated elicited epithelial epithelial cell epithelial cells examined genomes global healthcare greater magnitude H3N2 healthy nasal-tissue highlight Host host gene expression Host immune response Host transcriptional response host-response hours post-infection hpi IL-6 Immune cell infiltration immune cells immune response impair in vitro In-vitro infancy infected cells infected NEC infected NECs Infection Infection of NEC Infection of NECs Infection with Δ382 infiltrating immune cell infiltrating immune cells Inflammatory response Influenza influenza strain late time-point late time-points less modulating Nasal Epithelial cells NECs Novel coronavirus novel coronavirus SARS-CoV-2 ORF8 other SARS-CoV-2 genes Pathogenesis patient sera patients plasticity post-infection time-point pro-inflammatory cytokine pro-inflammatory cytokines released reported reveal SARS-CoV-2 SARS-CoV-2 and Δ382 infection SARS-CoV-2 genes SARS-COV-2 infection Screening severe disease significantly similar replication kinetics similarities similarity Singapore stem cell stem cells subsequent cytokine production temporal up-regulation therapeutic node TNFα transcriptional transcriptional profile Transcriptome transcriptome analysis transcripts transcripts mapping understanding Viral viral clearance viral kinetics virus particle virus particles wild-type and Δ382 wild-type SARS-CoV-2 Δ382 Δ382 infected cell Δ382 infected cells Δ382 infection [DOI] 10.1371/journal.ppat.1009130 PMC 바로가기 [Article Type] Research Article
Recent Progress in the Drug Development Targeting SARS-CoV-2 Main Protease as Treatment for COVID-19Molecular Biosciences Published on 2020-12-042022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] ab initio drug design 2019 novel coronavirus 2019-nCoV accelerate affected anti-SARS-CoV-2 antiviral target approach candidate Compound coronavirus coronavirus disease CoV COVID-19 Developing development dominant drug drugs targeting effort feasible global healthcare Healthcare system in viral M pro main protease Occurrence outbreak overcome pandemic polyprotein Progress protease Protein recent Repurposed drug Repurposed drugs SARS-CoV-2 Scientific community targeting therapeutic therapeutic option treatment for COVID-19 [DOI] 10.3389/fmolb.2020.616341 PMC 바로가기 [Article Type] Molecular Biosciences
Evaluation on the use of Nanopore sequencing for direct characterization of coronaviruses from respiratory specimens, and a study on emerging missense mutations in partial RdRP gene of SARS-CoV-2호흡기 표본에서 코로나바이러스의 직접적 특성 규명을 위한 나노포어 염기서열 분석의 사용에 대한 평가 및 SARS-CoV-2의 부분 RdRP 유전자에서 출현하는 미스센스 돌연변이에 대한 연구Short Report Published on 2020-11-232022-09-10 Journal: Virology Journal [Category] SARS, 변종, [키워드] Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affecting Amplicon amplicons amplified antiviral drug antiviral drugs catastrophic collected component Consensus conserved coronavirus coronavirus disease Coronavirus disease 2019 Coronaviruses COVID-19 COVID-19 outbreak database Decision making diagnostic domains Efficacy etiologic agent Europe evaluated feasibility Flongle Frequency genetic marker Genome GISAID global healthcare high mutation rate highest highlight Hong Kong human coronaviruses identify knowledge MinION Missense mutation Missense mutations mutation rate mutations Nanopore nanopore sequencing nucleotide pandemic Partial platform positive provided public health RdRP RdRp gene RdRp sequences respiratory respiratory specimens RNA polymerase RNA viruses SARS-CoV-2 sequence sequenced Sequencing severe acute respiratory syndrome Coronavirus Single nucleotide variant SNV SNVs specimen specimens Spread Surveillance Vaccines variant virus [DOI] 10.1186/s12985-020-01454-3 PMC 바로가기 [Article Type] Short Report