Potentially effective drugs for the treatment of COVID-19 or MIS-C in children: a systematic review소아에서 COVID-19 또는 MIS-C 치료를 위한 잠재적으로 효과적인 약물: 체계적인 검토Original Article Published on 2022-02-222022-09-12 Journal: European journal of pediatrics [Category] MERS, 진단, [키워드] 95%CI adverse events association case sery children Clinical efficacy Clinical symptoms clinical trial cohort study control group COVID-19 died drug effective drug Effectiveness Efficacy and safety evaluate Evidence extracorporeal membrane oxygenation glucocorticoid Glucocorticoids Google Intravenous immunoglobulin Invasive mechanical ventilation mechanical ventilation Meta-analysis Methylprednisolone MIS-C Mortality nine Odds ratio Patient platform Randomized controlled trial Remdesivir searched Seven shown single-arm supplementary material systematic review Treatment were used with COVID-19 [DOI] 10.1007/s00431-022-04388-w PMC 바로가기 [Article Type] Original Article
Impact of Glucocorticoid Cumulative Doses in a Real-Life Cohort of Patients Affected by Giant Cell ArteritisArticle Published on 2022-02-162024-09-02 Journal: Journal of Clinical Medicine [Category] 대상포진, [키워드] adverse events cumulative doses giant cell arteritis Glucocorticoids Tolerance [DOI] 10.3390/jcm11041034 PMC 바로가기 [Article Type] Article
Intranasal dexamethasone: a new clinical trial for the control of inflammation and neuroinflammation in COVID-19 patientsRandomized Controlled Trial Published on 2022-02-142022-10-04 Journal: Trials [Category] COVID19(2023년), SARS, 임상, [키워드] 1:1 Abstract Administered administration affected approved caused Central nervous system Clinical improvement clinical trial CNS concentrations conducted COVID-19 COVID-19 patient Critical death defined Dexamethasone dose doses dysregulated Effectiveness Efficacy FIVE Glucocorticoids group health institution Hospitalization IMPROVE individual Inflammation intranasal intranasal administration intranasally intravenous intravenously low dose Mexico City moderate multi-organ dysfunction multicenter Neuroinflammation Open-label Patient patients Primary outcome protocol Randomized Randomized controlled trial recruited reduce reduce mortality reduction in mortality regimen respiratory tract secondary outcome severe COVID-19 severe COVID-19 patients statistically significant reduction systemic inflammation therapeutic therapeutic dose treated triggering two group [DOI] 10.1186/s13063-022-06075-5 PMC 바로가기 [Article Type] Randomized Controlled Trial
Review of Anti-inflammatory and Antiviral Therapeutics for Hospitalized Patients Infected with Severe Acute Respiratory Syndrome Coronavirus 2Review Published on 2022-02-142023-06-15 Journal: Critical Care Clinics [Category] COVID19(2023년), MERS, SARS, [키워드] Anti-inflammatory antibody Antiviral COVID-19 Cytokines Glucocorticoids Interleukins SARS-CoV-2 [DOI] 10.1016/j.ccc.2022.02.002 PMC 바로가기 [Article Type] Review
Risk Factors for Infection and Health Impacts of the Coronavirus Disease 2019 (COVID-19) Pandemic in People With Autoimmune DiseasesArticle Published on 2022-02-112023-07-06 Journal: Clinical Infectious Diseases: An Official Publicat [Category] COVID19(2023년), [키워드] Autoimmune disease COVID-19 Glucocorticoids immune-modulating medications. [DOI] 10.1093/cid/ciab407 PMC 바로가기
Graves’ disease overlapping with chronic hepatitis B and methimazole-induced liver injury and autoimmune hepatitis: a case reportCase Report Published on 2022-02-102023-05-23 Journal: BMC Gastroenterology [Category] B형 간염, Fulltext, [키워드] Case report Glucocorticoids Graves’ disease Hepatitis B virus Methimazole [DOI] 10.1186/s12876-022-02133-z PMC 바로가기 [Article Type] Case Report
An Acute Exacerbation of Idiopathic Pulmonary Fibrosis After BNT162b2 mRNA COVID-19 Vaccination: A Case ReportCase report Published on 2022-02-042022-10-05 Journal: Chest [Category] COVID19(2023년), SARS, 바이오마커, [키워드] acute exacerbation adverse event association BNT162b2 mRNA BNT162b2 mRNA COVID-19 vaccine Case report characterized clinically Course COVID-19 COVID-19 vaccination disease Exacerbation Glucocorticoids idiopathic Idiopathic pulmonary fibrosis immunization Infection Interstitial lung disease IPF Lung disease morbidity and mortality proportion pulmonary raise report scar tissue Toxicity treated vulnerable patient while [DOI] 10.1016/j.chest.2021.07.2160 [Article Type] Case report
Systemic administration of glucocorticoids, cardiovascular complications and mortality in patients hospitalised with COVID-19, SARS, MERS or influenza: A systematic review and meta-analysis of randomised trialsCOVID-19, SARS, MER 또는 인플루엔자로 입원 한 환자의 글루코 코르티코이드, 심혈관 합병증 및 사망률의 전신 투여 : 무작위 시험의 체계적인 검토 및 메타 분석Meta-Analysis Published on 2022-02-012022-09-10 Journal: Pharmacological research [Category] COVID19(2023년), MERS, SARS, 임상, [키워드] 95% CI administration all-cause mortality benefit cardiometabolic cardiovascular complication cardiovascular complications Confidence intervals COVID-19 Dexamethasone Effects estimate Follow-up glucocorticoid Glucocorticoids hospitalised in-hospital mortality Influenza lower mortality Mantel-Haenszel mechanical ventilation MERS Meta-analysis Mortality objective outcomes oxygen Patient patients Placebo random effect randomisation Randomised trial randomised trials receiving reduce reduce mortality reduced reduction renal function reported respiratory Respiratory Support respiratory viral infections Result risk severe COVID-19 significantly standard care Steroids subgroup subgroups systematic review systemic systemic glucocorticoid systemic glucocorticoids Treatment trials Viral was reduced were used with COVID-19 worsening [DOI] 10.1016/j.phrs.2021.106053 PMC 바로가기 [Article Type] Meta-Analysis
An in silico analysis identifies drugs potentially modulating the cytokine storm triggered by SARS-CoV-2 infection실리코 분석은 SARS-CoV-2 감염에 의해 유발된 사이토카인 폭풍을 잠재적으로 조절하는 약물을 식별합니다Article Published on 2022-01-312022-09-10 Journal: Scientific Reports [Category] 신약개발, 유전자 메커니즘, 치료제, [키워드] “cytokine storm” addition Analysis anti-inflammatory properties anti-inflammatory property approach BALF Bronchoalveolar lavage fluid cause causes Computational biology and bioinformatics connectivity COVID-19 COVID-19 mortality COVID-19 pandemic COVID-19 patient Cytokines Data mining dataset drug Effect expected female hormone glucocorticoid Glucocorticoids Health help human cell lines identify immune response immune responses in silico analysis in vitro data Inflammatory Map MEK inhibitor modulating molecules Mortality negative regulation pathology pathway Pathways PKC predicted reveal SARS-CoV-2 SARS-COV-2 infection small molecule Small molecules supported the cytokine storm these compounds Transcription Transcriptome transcriptomic data Treatment triggered [DOI] 10.1038/s41598-022-05597-x PMC 바로가기 [Article Type] Article
Cytokine Storm in COVID-19: Immunopathogenesis and TherapyCOVID-19의 사이토카인 폭풍: 면역 병인 및 치료Review Published on 2022-01-182022-09-12 Journal: Medicina [Category] SARS, 진단, [키워드] administration affected Allogeneic allogeneic hematopoietic stem cell transplantation Anakinra antibody autoinflammatory disease CAR Care clinically Coagulopathy conditions coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients Critically ill critically ill patients cytokine cytokine inhibitors Cytokine storm Cytokines death deregulated disease disease severity effective effort excessive production of cytokines glucocorticoid Glucocorticoids GM-CSF Graft Graft-versus-host disease Hematopoietic stem cell hemophagocytic lymphohistiocytosis Hope hyperinflammatory state IFN-γ IL-1 IL-10 IL-2 IL-6 immune cells immune system IP-10 jak inhibitors leading MCP-1 Methylene blue mitigate multi-organ failure Novel coronavirus novel coronavirus disease overcome pandemic Pathogenesis Patient Plasmapheresis pro-inflammatory cytokines reducing mortality secondary hemophagocytic lymphohistiocytosis secondary to Sepsis severe cases stem cell Stem cell transplantation storm syndrome T-cell tested the cytokine storm the disease therapeutic strategy therapy TNF-α to define Tocilizumab [DOI] 10.3390/medicina58020144 PMC 바로가기 [Article Type] Review