Disseminated Kaposi sarcoma following COVID-19 in a 61-year-old Albanian immunocompetent man: a case report and review of the literatureCase Report Published on 2021-12-202022-10-31 Journal: European Journal of Medical Research [Category] COVID-19, SARS, [키워드] Abstract anti-inflammatory treatment article articles Bacterial Brescia Case report Combination COVID-19 COVID-19 patient database described explained Factors genetic susceptibility healthy individual HHV-8 Hospitalization IL-6 immunodeficiency immunomodulators incidence of COVID-19 induce Infection infections Italy Kaposi sarcoma knowledge latent infection literature review observation Prevalence provided Reactivation reported Research Result SARS-COV-2 infection screened selected Steroids syndrome title Topic Treatment university viral infections were excluded with COVID-19 [DOI] 10.1186/s40001-021-00620-9 PMC 바로가기 [Article Type] Case Report
Microarray-Based Detection of Antibodies against SARS-CoV-2 Proteins, Common Respiratory Viruses and Type I InterferonsArticle Published on 2021-12-202022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] absence analyzed anti-SARS-CoV-2 antibody antibody cross-reactivity Antibody Response applied autoantibodies to interferons autoantibody Autoimmune Betacoronavirus Cohort common Contact convalescent plasma Coronaviruses COVID-19 COVID-19 patient cross-reactivity detect detection disorders donors ELISA Endocrine healthy individual heterogeneous HKU1 ICU ICU Patients identify IFN-I IFN-Is IgG IgG and IgM IgM antibody ill patient intensive care marker MERS Microarray Multiplex analysis Multiplex assay nucleocapsid OC43 other respiratory virus pandemic Patient positive protein microarray RBD recipients respiratory respiratory viruses resulting SARS-CoV-2 serum sample severe COVID-19 Spike protein the SARS-CoV-2 Type type I interferon Vaccine virus viruses [DOI] 10.3390/v13122553 PMC 바로가기 [Article Type] Article
Correlation of the Commercial Anti-SARS-CoV-2 Receptor Binding Domain Antibody Test with the Chemiluminescent Reduction Neutralizing Test and Possible Detection of Antibodies to Emerging Variants상업용 Anti-SARS-CoV-2 수용체 결합 도메인 항체 테스트와 화학발광 환원 중화 테스트의 상관관계 및 항체의 새로운 변이체 검출 가능Research Article Published on 2021-12-012022-09-10 Journal: Microbiology Spectrum [Category] SARS, 변종, 진단, 치료기술, [키워드] 95% confidence interval Accuracy acquisition acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 anti-RBD anti-receptor-binding domain Antibody test antibody test result antibody tests B.1.1.7 B.1.351 B.1.351 variant B.1.351 variants biohazard clinical laboratory close contact comparable convalescent convalescent COVID-19 patients convalescent phase Coronavirus-2 correlated correlation COVID-19 COVID-19 patient COVID-19 patients Critical defined detection diagnostic disease onset displaying Efficacy episode episode of Evidence evidence of functional healthy individual high throughput identify immune response Immunity indicate Laboratory lead neutralization Neutralizing Neutralizing activity Neutralizing antibodies Neutralizing titer neutralizing titers optimization Patient PCR-negative positive result proof protective immunity provide Pseudotyped virus Pseudotyped viruses Quantitative RBD Receptor-binding domain recognizing reduction respiratory SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants Seroconversion serological test Serological tests serology serum sample serum samples Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus Spike protein Strong symptomatic Test test validity Vaccine vaccine efficacy Validity variant variants virus viruses wild-type [DOI] 10.1128/Spectrum.00560-21 PMC 바로가기 [Article Type] Research Article
Humoral protection to SARS-CoV2 declines faster in patients on TNF alpha blocking therapiesSARS-CoV2에 대한 체액 보호는 TNF 알파 차단 요법을 받는 환자에서 더 빨리 감소합니다Article Published on 2021-12-012022-09-11 Journal: RMD Open [Category] 변종, 진단, [키워드] Anti-spike anti-Spike IgG anti-TNF Antigen appearance Arthritis blockade booster booster vaccination booster vaccinations CD4+ T cell CD4+ T-cell chronic inflammatory disease chronic inflammatory diseases clinically Cohort controls COVID-19 Critical Decline declined Efficacy faster Frequency greater groups healthy controls healthy individual humoral immune response Humoral response humoral responses IgA level IgA levels IgG immune responses Inflammatory diseases lack mRNA vaccination Necrosis neutralization Neutralizing antibodies no differences pandemic Patient patients persistence receiving regimens response SARS-CoV2 second vaccination significantly T cell therapy TNF TNF alpha Treatment Tumor tumor necrosis tumor necrosis factor tumor necrosis factor inhibitors vaccination vaccine response vaccine responses variants while [DOI] 10.1136/rmdopen-2021-002008 PMC 바로가기 [Article Type] Article
Emerging SARS‐CoV‐2 variants can potentially break set epidemiological barriers in COVID‐19Review Published on 2021-11-292022-10-04 Journal: Journal of medical virology [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, [키워드] absence accumulating ACE2 acute respiratory syndrome age antibodies antigenic sites binding causing changes in Comorbidities coronavirus coronavirus disease COVID‐19 COVID‐19 demographic disease severity driven by ENhance enzyme epidemiological Epidemiology Evidence expression female glycosylation greater Harbor Health healthy individual healthy individuals induce Infection interactions mechanisms Mutation mutations neutralization other proteases outcome pandemic prolonged viral shedding Proteases proteolytic cleavage RBD recent receptor receptor‐binding domain reduced repeated Replication resulting SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 variants sequence severe disease severe inflammation Sex show significant changes in Spike protein symptomatic the disease the RBD the spike protein tissue injury Transmissibility vaccination Vaccine vaccine breakthrough infection variant variants Viral load viral loads viral spike protein virus virus–host interaction Waves widespread women [DOI] 10.1002/jmv.27467 PMC 바로가기 [Article Type] Review
Neutrophil-mediated oxidative stress and albumin structural damage predict COVID-19-associated mortality호중구 매개 산화 스트레스와 알부민 구조적 손상은 COVID-19 관련 사망률을 예측합니다Research Article Published on 2021-11-252022-09-12 Journal: eLife [Category] MERS, 진단, [키워드] accumulated albumin analyzed Anti-inflammatory anticoagulation antioxidant Blood blood sample candidate COVID-19 mortality COVID-19 treatment critically ill COVID-19 patients critically ill patients died Evidence faster Fatty acid functions healthy individual Human human serum albumin damage hydrogen peroxide in-hospital mortality indicated Kaplan–Meier survival analysis marker means median Mortality neutrophil Neutrophils non-survivor Non-survivors outcome oxidative stress parameter Patient plasma predict predicted Protein recruited reduced risk serum albumin severe patients significantly subject survivor the mean Transport Whole blood [DOI] 10.7554/eLife.69417 PMC 바로가기 [Article Type] Research Article
Clonal Hematopoiesis of Indeterminate Potential Is Associated with Increased Age-Independent Morbidity and Mortality in Patients with COVID-19- the Beyond DNA COVID-19 ProjectConference abstract Published on 2021-11-242022-10-05 Journal: Blood [Category] 변종, [키워드] accounted affected age age and sex allele approved assays association ASXL1 ATAC-seq baseline Blood blueprint carried ChIP clinically collected common Comorbidities comparable Coverage COVID-19 COVID-19 diagnosis COVID-19 disease severity COVID-19 patient CRP CRS cytokine cytokine levels Cytokine release syndrome Cytokines database death defined described Detection limit DNA download elevated ELISA assay entire cohort figure Fisher Follow-up funding Genes grade 3 group had more hazard healthy individual Hematopoiesis Hospitalization hypoxemic hypoxic respiratory failure identify IL6 Increased increased mortality indeterminate indicated individuals Infection Inflammation Inflammatory inflammatory cascade Inflammatory marker IRB male Mayo Clinic MCP-1 median median age mononuclear cell morbidity Mortality MPL Mutation mutations neutropenia no difference observé Older pathophysiology Patient patients patients with COVID-19 PBMC Peripheral blood Potential proteomic study reached regression models remained Research resolved Respiratory failure RNA scale Sequencing severe disease severity Sex SF3B1 Single Cell ssDNA subsequent survival survival analysis TET2 the Kaplan-Meier method the WHO TNF-a TP53 two groups variables variant was performed WHO Wilcoxon rank sum with COVID-19 [DOI] 10.1182/blood-2021-151548 [Article Type] Conference abstract
Correlates of neutralizing/SARS-CoV-2-S1-binding antibody response with adverse effects and immune kinetics in BNT162b2-vaccinated individualsBNT162B2- 암시 처리 된 개체에서 부작용 및 면역 동역학과의 중화/SARS-COV-2-S1- 결합 항체 반응의 상관 관계Article Published on 2021-11-242022-09-01 Journal: Scientific Reports [Category] MERS, SARS, 변종, 진단, 치료기술, [키워드] adverse effect adverse effects Antibody Response average B.1.351 blocked BNT162b2 determinant dose doses effective enrolled examined feature greater healthy individual IgG levels immune immune response Immunity individual individuals inverse correlation Japan measure men moderate mRNA vaccine mRNA vaccines neutralization Neutralizing activity no correlation Pain Participants potency Prospective Study Protective RNA vaccines SARS-CoV-2 sera Significant symptomatic infection Vaccine variants variants of concern viral infection virions was determined while women [DOI] 10.1038/s41598-021-01930-y PMC 바로가기 [Article Type] Article
Indications of Persistent Glycocalyx Damage in Convalescent COVID-19 Patients: A Prospective Multicenter Study and HypothesisObservational Study Published on 2021-11-212022-10-04 Journal: Viruses [Category] MERS, 임상, 치료기술, [키워드] analyzed caused controls convalescent COVID-19 patient convalescent COVID-19 patients convalescent patient Course COVID-19 COVID-19 infection COVID-19 pandemic Critical disease cross-sectional damage Degradation demonstrated disease disease course Disease progression elevated Endothelial cell endothelial damage Evidence glycocalyx healthy controls healthy individual Hospitalization hospitalized COVID-19 patient hospitalized patient hyperinflammation indication infected with SARS-CoV-2 Injury long-COVID-19 lung damage median Mild multicenter multicenter study no difference parameter persistent progression Prospective SARS CoV-2 SARS-CoV-2 significantly symptom onset Syndecan-1 virus with mild disease [DOI] 10.3390/v13112324 PMC 바로가기 [Article Type] Observational Study
Rapid and Effective Vitamin D Supplementation May Present Better Clinical Outcomes in COVID-19 (SARS-CoV-2) Patients by Altering Serum INOS1, IL1B, IFNg, Cathelicidin-LL37, and ICAM1신속하고 효과적인 비타민 D 보충은 혈청 INOS1, IL1B, IFNg, Cathelicidin-LL37 및 ICAM1을 변경하여 COVID-19(SARS-CoV-2) 환자에서 더 나은 임상 결과를 제시할 수 있습니다Article Published on 2021-11-122022-09-10 Journal: Nutrients [Category] MERS, SARS, 유전자 메커니즘, [키워드] 25OHD 25OHD level Acute respiratory failure Altering analyzed Better Biomarkers Blood Cathelicidin cathelicidin-LL37 clinical clinical outcomes Comorbidities Comorbidity conducted Correlation analysis COVID-19 COVID-19 case COVID-19 cases COVID-19 treatment cytokine decreased mortality effective Effectiveness evaluate evaluated healthy individual Hospital stay Hospitalization ICAM1 IFNg IL1B increased risk indicated metabolism mortality rate outcomes parameter potential mechanism potential mechanisms present Prospective Study Rapid Regulation SARS-CoV-2 serum serum biomarker Serum level serum levels serum vitamin D significantly specific serum Treatment Treatment protocol Vitamin D Vitamin D Metabolism Vitamin D supplementation Vitamin D3 [DOI] 10.3390/nu13114047 PMC 바로가기 [Article Type] Article