Cellular heterogeneity in disease severity and clinical outcome: Granular understanding of immune response is keyArticle Published on 2022-08-222022-11-16 Journal: Frontiers in Immunology [Category] 유전자 메커니즘, [키워드] age cellular cellular heterogeneity Clinical outcome clinical outcomes Comorbidities complex correlation COVID-19 COVID-19 disease COVID-19 disease severity disease severity dysregulation functional Gender genetics granular heterogeneity heterogeneous heterogeneous population highlight Host host response identify immune immune cells Immune profile immune response immunological mechanism impairment Infectious disease information pandemic Patient progression regulated RNA-Seq severity single-cell genomics single-cell genomics. subset the disease with COVID-19 [DOI] 10.3389/fimmu.2022.973070 PMC 바로가기
The effect of influenza vaccine in reducing the severity of clinical outcomes in patients with COVID-19: a systematic review and meta-analysis Research Published on 2022-08-222022-10-05 Journal: Scientific Reports [Category] 치료법, [키워드] 95% CI 95% confidence interval Admission Analysis CIs Clinical outcome clinical outcomes COVID-19 COVID-19 pandemic COVID-19 patient database Evidence favor FIVE fixed group heterogeneity Hospital admission indicated Infection Influenza intensive care limitations mean difference mechanical ventilation Meta-analysis mortality rate no significant difference observational study outcomes Patient random effect recent reduce reducing reported Research risk searched severity severity of COVID-19 significantly lower statistically significant difference systematic review vaccination Vaccine [DOI] 10.1038/s41598-022-18618-6 [Article Type] Research
The Associations of Iron Related Biomarkers with Risk, Clinical Severity and Mortality in SARS-CoV-2 Patients: A Meta-AnalysisSARS-CoV-2 환자의 위험, 임상 중증도 및 사망률과 철분 관련 바이오마커의 연관성: 메타 분석Review Published on 2022-08-192022-09-11 Journal: Nutrients [Category] SARS, 바이오마커, 치료기술, [키워드] 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition article Biomarker calculation caused clinical coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 progression deaths disease Diseases eligible evaluate Evidence ferritin ferritin level ferritin levels hemoglobin heterogeneity indicate Infection iron Iron metabolism magnitude mean difference Meta-analysis metabolism Mortality non-survivor Non-survivors Occurrence opposite Patient peer-reviewed Previous studies previous study progression random effect respiratory risk SARS-CoV-2 searched serum severe acute respiratory syndrome Coronavirus severity significantly lower SMD Survivors the disease TIBC was used Web of Science with COVID-19 [DOI] 10.3390/nu14163406 PMC 바로가기 [Article Type] Review
Artificial intelligence model on chest imaging to diagnose COVID-19 and other pneumonias: A systematic review and meta-analysisReview article Published on 2022-08-182022-10-05 Journal: European Journal of Radiology Open [Category] 진단, [키워드] 2Dtwo-dimensional 3Dthree-dimensional 95 % CI Accuracy AIartificial intelligence area under the curve article artificial intelligence AUC AUCarea under the curve average C-reactive protein calculate Characteristics chest imaging chest X-ray CNNConvolutional neural network Cochrane Library Computed tomography Convolutional neural network Coronavirus disease 2019 COVID-19 COVID-19coronavirus disease 2019 COVID‐19 CRPC-reactive protein CTComputed Tomography CXRChest X-Ray Deep Learning Method diagnose diagnosing diagnostic disease for inclusion Future Generalizability GGOground-glass opacities Ground-glass opacities heterogeneity IMPROVE K-nearest neighbor KNNK-nearest neighbor LASSOleast absolute shrinkage and selection operator least absolute shrinkage and selection operator less machine learning MEERS-COVMiddle East respiratory syndrome coronavirus Meta-analysis Methodological quality methodology Middle East respiratory syndrome Coronavirus MLmachine learning negative likelihood ratio objective participant performed PLRnegative likelihood ratio PLRpositive likelihood ratio Pneumonia positive likelihood ratio predictive models QUADAS-2 Quality radiologist random-effects model regions of interest Research researcher Result retrieved Reverse transcriptase polymerase chain reaction ROIregions of interest RT-PCRReverse transcriptase polymerase chain reaction SARS-CoV-2severe acute respiratory syndrome coronavirus 2 SARSSevere Acute Respiratory Syndrome score screened searched sensitivity Sensitivity and specificity Severe acute respiratory syndrome severe acute respiratory syndrome coronavirus 2 specificity SROCsummary receiver operating characteristic summary receiver operating characteristic support vector machine SVMSupport vector machine systematic review three-dimensional total score two-dimensional Web of Science were used [DOI] 10.1016/j.ejro.2022.100438 [Article Type] Review article
Heterogenous humoral and cellular immune responses with distinct trajectories post-SARS-CoV-2 infection in a population-based cohort인구 기반 코호트에서 SARS-CoV-2 감염 후 뚜렷한 궤적을 가진 이종 체액성 및 세포성 면역 반응Article Published on 2022-08-182022-09-11 Journal: Nature Communications [Category] SARS, 변종, 진단, 치료기술, 치료법, [키워드] Analysis anti-N IgG anti-S responses antibody Antibody responses Cellular immune response cellular immunity cellular response characterized clinical factors Cluster analyses Delta detectable develop Diagnosis FIVE heterogeneity humoral humoral and cellular immunity Humoral and cellular responses identify IgA IgG immune Immunity individual infected individuals Infection maintain membrane Neutralizing activity neutralizing antibody omicron Omicron variants Participants population-based cohort required responses S proteins SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-infected individual T cell T cell response T cell responses T cells trajectory variant [DOI] 10.1038/s41467-022-32573-w PMC 바로가기 [Article Type] Article
Platform for Active Vaccine Formulation Using a Two-Mode Enhancement Mechanism of Epitope Presentation by Pickering Emulsion피커링 에멀젼에 의한 에피토프 제시의 2-모드 향상 메커니즘을 사용한 활성 백신 제형을 위한 플랫폼Article Published on 2022-08-152022-09-12 Journal: ACS applied bio materials [Category] SARS, 진단, [키워드] Administered ambient antigenic Antisera applied approach Concentration conditions conjugate correlated determinants Efficacy Efficiency Emulsion enhancement epitope epitope-based vaccination Formulation heterogeneity IgG IgG titer Immunoglobulin include magnitude Pathogens peptide Pickering emulsion plant virus platform presentation subsequent subunit subunit vaccines vaccination Vaccine development Virus-like-particles. vivo assay VLPs [DOI] 10.1021/acsabm.2c00410 PMC 바로가기 [Article Type] Article
Defining resistance and tolerance traits in Covid-19: towards a stratified medicine approachCovid-19의 내성 및 내성 특성 정의: 계층화된 의학 접근 방식Article Published on 2022-08-132022-09-11 Journal: QJM: An International Journal of Medicine [Category] SARS, 변종, [키워드] activated anti-Spike IgG approach Auto-antibodies CCR2 component coronavirus disease Coronavirus disease 2019 COVID-19 pathogenesis Deleterious failure Genetic Genetic variant genotypic GM-CSF heterogeneity highlight Highlights Host Host-directed therapies Human IFN-I IFN-α IFNA10 IFNAR2 IL-6 infection with SARS-CoV-2 Infectious disease inflammasomes inflammatory lung injury integration Inter-individual variation life-threatening coronavirus disease lung Lung injury M-CSF macrophages MCP-1 Monocyte-derived macrophages Monocytes neutralizing auto-antibodies neutralizing auto-antibody NLRP1 pathogen Pathogenesis periphery PLSCR1 pro-inflammatory pro-inflammatory response progression recruited reduce regulate response responses resulting reticuloendothelial system SARS-COV-2 infection stratified the disease therapeutic tissue damage Tolerance treatable TYK2 type 1 interferon virus-independent immunopathology [DOI] 10.1093/qjmed/hcac143 PMC 바로가기 [Article Type] Article
Context-specific emergence and growth of the SARS-CoV-2 Delta variant Research Published on 2022-08-112022-10-05 Journal: Nature [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] Analysis Contact Contact tracing COVID-19 Delta delta variant Delta wave dissemination England faster genomic data global genome growth heterogeneity heterogeneous Immunity Increasing India Intervention introduced Invasion Lineage Local occurred omicron onward transmission quarantine receiving reduce reduced relative growth SARS-CoV-2 Spread the SARS-CoV-2 Transmission Travel variant virus virus genome [DOI] 10.1038/s41586-022-05200-3 [Article Type] Research
Investigating Linkages Between Spatiotemporal Patterns of the COVID-19 Delta Variant and Public Health Interventions in Southeast Asia: Prospective Space-Time Scan Statistical Analysis MethodCOVID-19 델타 변이의 시공간 패턴과 동남아시아의 공중 보건 개입 간의 연관성 조사: 전향적 시공간 스캔 통계 분석 방법Article Published on 2022-08-092022-09-11 Journal: JMIR Public Health and Surveillance [Category] SARS, 변종, 치료기술, [키워드] adopted aligned Analysis analyzed Asia assistance benefit Cluster Clusters collected Continuous continuous surveillance country COVID-19 COVID-19 transmission cumulative Delta delta variant effective Effectiveness Epidemic exacerbate heterogeneity identify increase in Indonesia infection risk Intervention linkage Malaysia measure NPI outbreak pattern progression Propagation Prospective Public public health authorities public health authority Public health intervention reducing Relative risk risk risk of COVID-19 SEA shown Singapore Southeast Asia space-time scan. spatiotemporal Surveillance Transmission Variation variations [DOI] 10.2196/35840 PMC 바로가기 [Article Type] Article
Seroconversion following the first, second, and third dose of SARS-CoV-2 vaccines in immunocompromised population: a systematic review and meta-analysis면역저하 집단에서 SARS-CoV-2 백신의 1차, 2차, 3차 접종 후 혈청전환: 체계적인 검토 및 메타분석Review Published on 2022-08-082022-09-12 Journal: Virology Journal [Category] SARS, 진단, [키워드] 95% CI administration Analysis article Autoimmune Autoimmune disease booster dose conditions conducted COVID-19 COVID-19 vaccine database develop dose dose administration Efficacy etiology evaluate first dose General population heterogeneity high-risk population higher risk Immunity Immunocompromised Immunocompromised patient investigated item less lowest malignancy material Meta-analysis mRNA mRNA vaccine observational study Patient patients Prevalence R software Reporting review rising SARS-CoV-2 SARS-CoV-2 vaccine searched second dose sensitivity analysis Seroconversion Severe COVID-19 Infection subgroup analysis systematic review the vaccine transplantation vaccination Vaccine was performed Web of Science [DOI] 10.1186/s12985-022-01858-3 PMC 바로가기 [Article Type] Review