The development and validation of a novel LC-MS/MS method for the simultaneous quantification of Molnupiravir and its metabolite ß-d-N4-hydroxycytidine in human plasma and saliva인간 혈장 및 타액에서 Molnupiravir 및 대사 산물 β-d-N4-hydroxycytidine의 동시 정량을 위한 새로운 LC-MS/MS 방법의 개발 및 검증Article Published on 2021-09-102022-09-10 Journal: Journal of pharmaceutical and biomedical analysis [Category] MERS, SARS, 비임상, 치료기술, [키워드] Accuracy Acetate acetonitrile Ammonium Ammonium acetate analyte antiviral therapy caused clinical column concentrations conducted coronavirus Coronaviruses COVID-19 COVID-19 infection EIDD-2801 followed by global pandemic highly pathogenic Human plasma Infection Influenza LC-MS/MS linear m/z metabolite molnupiravir MPV N4-hydroxycytidine NHC Patient patients with COVID-19 pharmacokinetic plasma polar Precision protein precipitation quantification Saliva SRM Treatment validation was performed water [DOI] 10.1016/j.jpba.2021.114356 PMC 바로가기 [Article Type] Article
Genetic and antigenic diversity of H7N9 highly pathogenic avian influenza virus in ChinaArticle Published on 2021-09-012023-06-22 Journal: Infection, genetics and evolution : journal of mol [Category] 조류인플루엔자, [키워드] Avian influenza virus Evolution H7N9 highly pathogenic vaccination [DOI] 10.1016/j.meegid.2021.104993
Differential host circRNA expression profiles in human lung epithelial cells infected with SARS-CoV-2SARS-CoV-2에 감염된 인간 폐 상피 세포의 차등 숙주 circRNA 발현 프로필Article Published on 2021-09-012022-09-11 Journal: Infection, genetics and evolution : journal of mol [Category] 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Analysis binding cause cell death Circular circular RNA coronavirus coronavirus disease COVID-19 death down-regulated dysregulated enrichment analysis epithelial epithelial cell epithelial cells expression pattern expression profile function functions Gene Expression Gene ontology genomic highly pathogenic Host host immune responses human lung human lung epithelial cells immune immune responses Immunity implicated in viral indicated infected with SARS-CoV-2 Infection Inflammatory responses involved KEGG Lung epithelial cells miRNAs mRNA stability network analysis Ontology parental Pathogenesis performed Proteins regulate regulated RNA RNA binding protein RNA-Seq RNAs SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significantly up-regulated viral pathogenesis Virus-host interactions [DOI] 10.1016/j.meegid.2021.104923 PMC 바로가기 [Article Type] Article
Risk Factors Associated with the Clinical Outcomes of COVID-19 and Its Variants in the Context of Cytokine Storm and Therapeutics/Vaccine Development ChallengesReview Published on 2021-08-232022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] added Analysis approved Asthma Blood challenge clinical comparison Context contribute Coronaviridae coronavirus disease COVID-19 COVID-19 patients COVID-19 vaccines Cytokine storm deficiency development Disease progression disease severity Factor genotypes groups higher risk highly pathogenic HLA IL-6 IL-6 pathway immune response Immunological response imperative India Inflammatory information limit MERS MERS-CoV Mortality obesity opportunistic infection outcomes pandemic Pandemics pathophysiology Patient Perspective predict Prevent profile progression provide public health Research responsible risk factor RNA SARS-CoV-1 SARS-CoV-2 Sex single-stranded positive-sense smoking storm Therapeutic approach variant virulence virus viruses WHO [DOI] 10.3390/vaccines9080938 PMC 바로가기 [Article Type] Review
Putative Role of Vitamin D for COVID-19 VaccinationCOVID-19 예방 접종을 위한 비타민 D의 추정 역할Review Published on 2021-08-202022-09-10 Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 변종, 임상, [키워드] 2019 coronavirus disease ACE2 expression acute respiratory syndrome acute respiratory syndrome coronavirus adaptive Adaptive immunity airways Analysis angiotensin applied caused characterized Clinical use complementary complex component coronavirus coronavirus disease correlated COVID-19 COVID-19 vaccines Cytokines defend delayed response demonstrated develop DNA effective Effectiveness Efficacy effort elicited Evidence Extensive Factor global pandemic highly pathogenic IFN-III Immune cell infiltration immune dysfunction immune reactions immune signaling pathways Immunity inactivated incidence innate immune response Innate immunity innate response Interaction interferon interferons involved knowledge mechanism modulation molecular mechanism mRNA observational studies observational study pathophysiological progression Proinflammatory cytokine proinflammatory cytokines Protein subunit vaccines pulmonary disease RAS reduce Renin renin-angiotensin system respiratory role SARS-CoV-2 Serum level serum levels severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe COVID-19 patient severe COVID-19 patients severity severity of COVID-19 shown Significant Strategy subunit vaccines synthesis Treatment Vaccine vaccine efficacy Vaccines variant virus viruses Vitamin D Vitamin D supplementation [DOI] 10.3390/ijms22168988 PMC 바로가기 [Article Type] Review
A computational analysis of molecular evolution for virulence genes of zoonotic novel coronavirus (COVID-19)Research article Published on 2021-08-012022-10-05 Journal: Computational biology and chemistry [Category] SARS, 변종, 유전자 메커니즘, [키워드] Adaptive molecular evolution Affect Amino acid Analysis coated computational analysis Coronaviridae family coronavirus disease COVID COVID-19 Diagnosis distribution Evolution genomic RNA hemagglutinin highly pathogenic homology Host Hypothesis Likelihood ratio test LRT Markov model Maximum likelihood MERS-CoV molecular motif Mutation Non-synonymous novel Novel coronavirus nucleocapsid protein nucleotide substitutions null hypothesis pandemic disease positive Positive selection Radiation Ratio RdRP reported respiratory tract selected silent single-stranded synonymous Test virulence gene virulence genes virus were used zoonotic [DOI] 10.1016/j.compbiolchem.2021.107532 [Article Type] Research article
Highly pathogenic avian influenza virus H5N2 (clade 2.3.4.4) challenge of mallards age appropriate to the 2015 midwestern poultry outbreakOriginal Article Published on 2021-07-292023-05-31 Journal: Influenza and Other Respiratory Viruses [Category] Fulltext, 조류인플루엔자, [키워드] Adult highly pathogenic Influenza mallards outbreak poultry [DOI] 10.1111/irv.12886 PMC 바로가기 [Article Type] Original Article
A Review on the Development of Gold and Silver Nanoparticles-Based Biosensor as a Detection Strategy of Emerging and Pathogenic RNA Virus신흥 및 병원성 RNA 바이러스의 탐지 전략으로 금 및은 나노 입자 기반 바이오 센서의 개발에 대한 검토Review Published on 2021-07-282022-09-10 Journal: Sensors (Basel, Switzerland) [Category] SARS, 치료기술, 치료제, [키워드] Accuracy addition analytical methods antibody Antigen biological activity biosensor Characteristics clinical samples Containment contribute death detection detection system development disease Diseases DNA early diagnosis effective electrochemical biosensing enhancer gold higher risk highly pathogenic human coronaviruses immunological involved knowledge MERS-CoV Nanoparticles nanotechnologies Nanotechnology nucleic acid optical pathogenic plasmonic POC point-of-care probe Protein provide required review RNA RNA viruses robust SARS-CoV SARS-CoV-2 Sensitivity and specificity severe cases silver single-stranded DNA ssDNA Strategy Treatment unique Viral viral disease Viral diseases viral infection viral nucleic acid virtue viruses [DOI] 10.3390/s21155114 PMC 바로가기 [Article Type] Review
Single-Particle Characterization of SARS-CoV-2 Isoelectric Point and Comparison to Variants of InterestCommunication Published on 2021-07-282022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] adhesion Adsorption aligning Amino acid amino acid sequence approach biochemical Biophysics characterization coronavirus COVID-19 demonstrated dipole distal emerging viruses encoded proteins estimate Evidence functional Genetic global pandemic highly pathogenic highly pathogenic specy homology hydrophobicity interest nucleic acid Organisms Point Prevent proliferation Protein recent SARS-CoV-2 sequence surface characterization variants of interest Viral protein Viral RNA Viral transmission virus viruses VOIs [DOI] 10.3390/microorganisms9081606 PMC 바로가기 [Article Type] Communication
Design and proof of concept for targeted phage-based COVID-19 vaccination strategies with a streamlined cold-free supply chain423 Published on 2021-07-272022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, [키워드] AAVP Administered aerosolization Antibody Response Antigen approach attributes Bacteria circulation CMV promoter coronavirus disease COVID-19 COVID-19 pandemic COVID-19 vaccination COVID-19 vaccine COVID-19 vaccine development development displaying effective vaccine elicit Emergency use authorization epitope experiments expression gene delivery Genetic highly pathogenic humans humoral immune response immunization imperative infect inherent initial injected Ligand lung lung epithelium mice Particle Particles peptide performed phage phage display plasticity platform Protein Rapid Research robust S protein S protein-specific antibody safety profile SARS-CoV-2 SARS-CoV-2 S protein Significance stability subcutaneous vaccination sustained temperature the SARS-CoV-2 transgene translational Transport unique vaccination Vaccine Vaccine development virus widespread [DOI] 10.1073/pnas.2105739118 PMC 바로가기 [Article Type] 423