Immune responses to mRNA vaccines against SARS-CoV-2 in patients with immune-mediated inflammatory rheumatic diseases면역 매개 염증성 류마티스 질환 환자에서 SARS-CoV-2에 대한 mRNA 백신에 대한 면역 반응Article Published on 2022-01-012022-09-12 Journal: RMD Open [Category] SARS, 진단, [키워드] abatacept age Autoimmune Autoimmune diseases B-cell CD4 CD8 Cellular immune response cellular response Cellular responses correlated COVID-19 cumulative deleterious effects demonstrated depleting dose drug Effect Efficacy elicited Gender glucocorticoid healthy controls humoral humoral responses identify immune response immune system immune system diseases Immune-mediated Immunosuppression immunotherapies infections Inflammatory introduced investigated leflunomide methotrexate mRNA mRNA vaccine mRNA vaccines naïve Patient patients with SARS-CoV-2 phase III trial preserved receiving reduce reduced responders response rheumatic disease rituximab SARS-CoV-2 SARS-CoV-2 vaccine selected Seroconversion seroconversion rate T-cell immune response T-lymphocyte subsets the vaccine Therapies therapy titre treated two-dose regimen vaccination Vaccine were excluded [DOI] 10.1136/rmdopen-2021-001898 PMC 바로가기 [Article Type] Article
Longitudinal humoral response after SARS-CoV-2 vaccination in ocrelizumab treated MS patients: To wait and repopulate?ocrelizumab 치료 MS 환자에서 SARS-CoV-2 백신 접종 후 세로 체액 반응: 기다렸다가 다시 채우려면?Article Published on 2022-01-012022-09-11 Journal: Multiple sclerosis and related disorders [Category] MERS, SARS, 진단, 치료기술, [키워드] antibodies B-cell B-cells baseline booster vaccination COVID-19 cut-off detectable disease first vaccination humoral Humoral response humoral responses infusion longitudinal Moderna mRNA mRNA-1273 Multiple multiple sclerosis occurred Ocrelizumab Patient patients patients treated SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 vaccination Seroconversion therapy treated treated patient vaccination were measured [DOI] 10.1016/j.msard.2021.103416 PMC 바로가기 [Article Type] Article
SARS-CoV-2 serology among people with multiple sclerosis on disease-modifying therapies after BBIBP-CorV (Sinopharm) inactivated virus vaccination: Same story, different vaccineBBIBP-CorV(Sinopharm) 비활성화 바이러스 백신 접종 후 질병 조절 요법을 받는 다발성 경화증 환자의 SARS-CoV-2 혈청학: 같은 이야기, 다른 백신Article Published on 2022-01-012022-09-11 Journal: Multiple sclerosis and related disorders [Category] SARS, 치료기술, [키워드] Analysis anti-CD20 therapy anti-SARS-CoV-2 association BBIBP-CorV booster carried Cohort cohort study cohorts contribute COVID-19 COVID-19 vaccines detect Disease-modifying therapies dose Efficiency Evidence fingolimod first vaccination healthy humoral Humoral response humoral responses IgG inactivated indicated investigated Iran less Linear regression mode mRNA Multiple multiple sclerosis multivariable analysis multivariable logistic regression multivariable logistic regression model participant Participants phlebotomy Previous studies previous study receive receptor SARS-CoV-2 seroconverted serology serology testing serostatus Sinopharm sphingosine spike Statistical power Statistical tests t-test therapy vaccination Vaccination strategies Vaccination strategy Vaccine vaccine dose Viral vector Viral vector vaccine Viral vector vaccines virus was used [DOI] 10.1016/j.msard.2021.103417 PMC 바로가기 [Article Type] Article
Longitudinal SARS-CoV-2 mRNA Vaccine-Induced Humoral Immune Responses in Patients with Cancer암 환자의 세로 SARS-CoV-2 mRNA 백신 유도 체액 면역 반응Article Published on 2021-12-152022-09-11 Journal: Cancer research [Category] MERS, SARS, 진단, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Anti-spike antibody antibody levels Antibody Response B-cell BNT162b2 booster booster vaccination booster vaccinations Breakthrough infection breakthrough infections Cancer clinical care coronavirus COVID-19 illness dose elicit evaluated Follow-up Frequency hematologic humoral responses Immune checkpoint inhibitor Immune checkpoint inhibitors immune responses immunogenicity Immunoglobulin implication longitudinal Longitudinal studies malignancies median mRNA mRNA-1273 Patient patient selection patients Patients with cancer peak levels Population prospective cohort study receiving reduced remained respiratory response SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 vaccines sequence severe acute respiratory syndrome Coronavirus severe COVID-19 illness Solid solid tumor solid tumors sustained therapeutic trajectory Treatment Tumor tumors vaccination Vaccinations Vaccine vaccine-induced immune response Variation [DOI] 10.1158/0008-5472.CAN-21-3554 PMC 바로가기 [Article Type] Article
Reduced magnitude and durability of humoral immune responses to COVID-19 mRNA vaccines among older adults노인에서 COVID-19 mRNA 백신에 대한 체액성 면역 반응의 크기 및 내구성 감소Major Article Published on 2021-12-092022-09-10 Journal: The Journal of Infectious Diseases [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] ACE2 activity Adults age All participants antibodies antibody binding antibodies binding antibody characterized correction COVID-19 COVID-19 mRNA vaccine COVID-19 mRNA vaccines declined delta variant elevated evaluated except for exhibited health condition healthcare worker humoral humoral immune response Humoral response humoral responses immune response immune responses magnitude measure mRNA vaccine mRNA vaccines Neutralizing activity Older older adult Older adults Older age Participants plasma RBD reduced remained response Result risk of infection second dose significantly significantly lower sociodemographic factors tested vaccination vaccine dose variables viral neutralization virus were assessed [DOI] 10.1093/infdis/jiab592 PMC 바로가기 [Article Type] Major Article
Phosphate-mediated coanchoring of RBD immunogens and molecular adjuvants to alum potentiates humoral immunity against SARS-CoV-2Research Article Published on 2021-12-082022-10-28 Journal: Science Advances [Category] COVID-19, [키워드] acute respiratory syndrome Adding adjuvant aluminum hydroxide amplify Antigen binding clearance component coronavirus CpG description effective Efficacy elicit ENhance Humoral immunity humoral responses immunization immunogen increases in lymph nodes mice molecular Neutralizing antibody titer neutralizing response notable Particle peptide RBD Receptor binding domain response rhesus macaques Saponin SARS-CoV-2 SARS-CoV-2 variants subunit vaccines vaccination Vaccine vaccine immunogenicity [DOI] 10.1126/sciadv.abj6538 PMC 바로가기 [Article Type] Research Article
Widely heterogeneous humoral and cellular immunity after mild SARS-CoV-2 infection in a homogeneous population of healthy young men균질한 건강한 젊은 남성 집단에서 가벼운 SARS-CoV-2 감염 후 광범위하게 이질적인 체액성 및 세포성 면역Article Published on 2021-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] SARS, 진단, 치료기술, 치료법, [키워드] adaptive Adaptive immunity anti-nucleoprotein antibodies antibody Antibody detection cellular immunity cellular response Cellular responses Cohort conducted COVID-19 cross-sectional survey detect detectable Diagnosis Frequency healthy heterogeneity heterogeneous homogeneous humoral humoral and cellular immunity Humoral and cellular responses Humoral response humoral responses implication individual Infection magnitude median median age men Mild Mild disease mild SARS-CoV-2 infection Neutralizing antibodies nine observation Patient persistence recruited reduction SARS-CoV-2 SARS-CoV-2 protein serological test Serological tests South Asian spike study population Surveillance T cell T cell response T cells Vaccination strategies was tested were used with mild disease [DOI] 10.1080/22221751.2021.1999777 PMC 바로가기 [Article Type] Article
Humoral protection to SARS-CoV2 declines faster in patients on TNF alpha blocking therapiesSARS-CoV2에 대한 체액 보호는 TNF 알파 차단 요법을 받는 환자에서 더 빨리 감소합니다Article Published on 2021-12-012022-09-11 Journal: RMD Open [Category] 변종, 진단, [키워드] Anti-spike anti-Spike IgG anti-TNF Antigen appearance Arthritis blockade booster booster vaccination booster vaccinations CD4+ T cell CD4+ T-cell chronic inflammatory disease chronic inflammatory diseases clinically Cohort controls COVID-19 Critical Decline declined Efficacy faster Frequency greater groups healthy controls healthy individual humoral immune response Humoral response humoral responses IgA level IgA levels IgG immune responses Inflammatory diseases lack mRNA vaccination Necrosis neutralization Neutralizing antibodies no differences pandemic Patient patients persistence receiving regimens response SARS-CoV2 second vaccination significantly T cell therapy TNF TNF alpha Treatment Tumor tumor necrosis tumor necrosis factor tumor necrosis factor inhibitors vaccination vaccine response vaccine responses variants while [DOI] 10.1136/rmdopen-2021-002008 PMC 바로가기 [Article Type] Article
Functional convalescent plasma antibodies and pre-infusion titers shape the early severe COVID-19 immune response기능적 회복기 혈장 항체 및 주입 전 역가는 초기 중증 COVID-19 면역 반응을 형성합니다Article Published on 2021-11-252022-09-10 Journal: Nature Communications [Category] MERS, SARS, 유전자 메커니즘, 임상, 진단, 치료기술, 치료법, [키워드] administration Anti-nucleocapsid antibodies anti-nucleocapsid antibody Anti-spike anti-Spike IgG antibodies antibody Antibody titer binding convalescent plasma Evolution function functional heterogeneous nature heterogenous hospitalized COVID-19 patient hospitalized COVID-19 patients humoral humoral immune responses Humoral immunity Humoral response humoral responses immune immune response immune responses modulation nucleocapsid-specific antibody outcomes pandemic Patient plasma profile Receptor binding recipient SARS-CoV-2 SARS-CoV-2 nucleocapsid SARS-CoV-2 pandemic severe COVID-19 Severe infection Symptoms the SARS-CoV-2 therapy transfer Translational immunology Trial viral infection [DOI] 10.1038/s41467-021-27201-y PMC 바로가기 [Article Type] Article
Evaluation of Humoral Immune Response after SARS-CoV-2 Vaccination Using Two Binding Antibody Assays and a Neutralizing Antibody Assay2개의 결합 항체 분석 및 중화 항체 분석을 사용한 SARS-CoV-2 백신 접종 후 체액 면역 반응의 평가Research Article Published on 2021-11-242022-09-12 Journal: Microbiology Spectrum [Category] MERS, SARS, 진단, 치료기술, [키워드] Abbott Abbott Laboratories Abbott SARS-CoV-2 IgG acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Administered antibody Antibody assays Antibody detection automated BNT162b2 ChAdOx1 ChAdOx1 nCoV-19 ChAdOx1 nCoV-19 vaccine collected concordance rate coronavirus coronavirus disease Coronavirus disease 2019 correlation COVID-19 Cutoff demonstrated elicited evaluate first vaccination Genscript Healthcare Diagnostics humoral humoral immune response Humoral response humoral responses IgG Inc. indicated Ireland mitigate Multiple nCoV neutralization test Neutralizing antibodies neutralizing antibody of BNT162b2 pandemic predict Quantitative quantitative value quantitative values response robust SARS-CoV-2 SARS-CoV-2 IgG SARS-CoV-2 neutralization second vaccination seropositive serum sample serum samples severe acute respiratory syndrome Coronavirus Siemen Siemens Sligo suggested U/mL USA Vaccinations Vaccine Vaccines venous blood virus neutralization test was obtained [DOI] 10.1128/Spectrum.01202-21 PMC 바로가기 [Article Type] Research Article