inhibitory – Page 7 – Communicable Diseases Research

Drug Repurposing for the Identification of Compounds with Anti-SARS-CoV-2 Capability via Multiple Targets

Article

Published on 2022-01-122022-10-28
Journal: Pharmaceutics [Category] COVID-19,

[키워드] 3C-like protease (3CL^pro/M^pro) 3CL pro accelerate acute respiratory syndrome addition anti-SARS-CoV-2 antiviral potency approved assays bioinformatics Compound coronavirus coronavirus disease COVID-19 docking simulation domain drug Drug screening enzyme activity evaluated feasible food identification infections inhibitory inhibitory effect Multiple other diseases Papain-like protease papain-like protease (PL^pro) protease RBD reduction repurposing SARS-CoV-2 serine 2 severe acute respiratory syndrome coronavirus 2 Tamoxifen target therapeutic potential these compound TMPRSS2 transmembrane transmembrane protease serine 2 (TMPRSS2) Treatment Vaccines
[DOI] 10.3390/pharmaceutics14010176 PMC 바로가기 [Article Type] Article

High-Throughput Virtual Screening and Validation of a SARS-CoV-2 Main Protease Noncovalent Inhibitor

SARS-CoV-2 주요 프로테아제 비공유 억제제의 고성능 가상 스크리닝 및 검증

Article

Published on 2022-01-102022-09-11
Journal: Journal of Chemical Information and Modeling [Category] SARS, 변종, 치료제,

Hydroxychloroquine and azithromycin used alone or combined are not effective against SARS-CoV-2 ex vivo and in a hamster model

Article

Published on 2022-01-012022-10-04
Journal: Antiviral Research [Category] SARS, 신약개발,

Characterization of the non-covalent interaction between the PF-07321332 inhibitor and the SARS-CoV-2 main protease

PF-07321332 억제제와 SARS-CoV-2 주요 프로테아제 간의 비공유 상호작용의 특성화

Article

Published on 2022-01-012022-09-11
Journal: Journal of molecular graphics & modelling [Category] SARS, 치료제,

[키워드] 3CL-Pro 3CL-PRO inhibitor addition Anti-SARS-CoV-2 Activity Antiviral approach atomic level binding binding pocket catalytic catalytic dyad characterization characterized Chemical structure clinical trial clinical trials Combination coronavirus Coronavirus main protease COVID-19 Cys145 cysteine drug dyad electrophilic explicit solvent in vitro inhibitor inhibitory Interaction Ligand mechanism molecular dynamics Molecular dynamics simulation molecular dynamics simulations Neutral nitrile PF-07321332 Pfizer protease Protein protonation state residue residues Ritonavir SARS-CoV-2 SARS-CoV-2 main protease Support the SARS-CoV-2 water water molecule water molecules
[DOI] 10.1016/j.jmgm.2021.108042 PMC 바로가기 [Article Type] Article

Discovery of Highly Potent Fusion Inhibitors with Potential Pan-Coronavirus Activity That Effectively Inhibit Major COVID-19 Variants of Concern (VOCs) in Pseudovirus-Based Assays

Article

Published on 2021-12-312022-10-28
Journal: Viruses [Category] COVID-19, SARS,

[키워드] activities activity acute respiratory syndrome ADME African Analysis B.1.1.7 B.1.351 B.1.617.2 bind Candidates Compound concern coronavirus COVID-19 Cytopathic effect delta variant demonstrated distribution facilitate fusion fusion inhibitor half-maximal inhibitory concentration in vivo India inhibited inhibitor inhibitors inhibitory lowest Major MERS-CoV metabolism Middle East Middle East respiratory syndrome (MERS) oral bioavailability pan-coronavirus potent Potential prefusion prevented respiratory syndrome coronavirus SARS-CoV SARS-CoV-2 SARS-CoV-2 spike protein Severe acute respiratory syndrome (SARS) small molecule South SPR surface plasmon resonance trimer variant variants of concern VOCs
[DOI] 10.3390/v14010069 PMC 바로가기 [Article Type] Article

Expansion of CD56 dim CD16 neg NK Cell Subset and Increased Inhibitory KIRs in Hospitalized COVID-19 Patients

CD56 DIM CD16 Neg NK 세포 서브 세트의 확장 및 입원 COVID-19 환자에서 증가 된 억제 KIR.

Article

Published on 2021-12-282022-09-10
Journal: Viruses [Category] SARS, 바이오마커,

[키워드] acute respiratory syndrome coronavirus alteration CD16 CD56 coronavirus COVID-19 COVID-19 infection COVID-19 patients Cytokines cytotoxicity Defense deficiency Depletion distribution elevated ENhance expansion Frequency hospitalized COVID-19 patient hospitalized COVID-19 patients IFN-γ impairment Increased induce Infection Inflammatory cytokines inhibitory innate response KIR KIR receptor KIR receptors NK cell NK cell subsets NK cells no difference no differences phenotype produced respiratory SARS-CoV-2 SARS-COV-2 infection Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus subset virus
[DOI] 10.3390/v14010046 PMC 바로가기 [Article Type] Article

A Review of the Current Landscape of SARS-CoV-2 Main Protease Inhibitors: Have We Hit the Bullseye Yet?

Review

Published on 2021-12-272022-10-29
Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS,

Multi-Targeted Approaches and Drug Repurposing Reveal Possible SARS-CoV-2 Inhibitors

Article

Published on 2021-12-262022-10-28
Journal: Vaccines [Category] COVID-19,

Atazanavir Is a Competitive Inhibitor of SARS-CoV-2 M pro , Impairing Variants Replication In Vitro and In Vivo

Article

Published on 2021-12-242022-10-28
Journal: Pharmaceuticals [Category] COVID-19,

Complement Inhibitors Vitronectin and Clusterin Are Recruited from Human Serum to the Surface of Coronavirus OC43-Infected Lung Cells through Antibody-Dependent Mechanisms

Article

Published on 2021-12-242022-10-28
Journal: Viruses [Category] Coronavirus,