Types and Applications of Nicking Enzyme-Combined Isothermal AmplificationNicking 효소 결합 등온 증폭의 유형 및 응용Review Published on 2022-04-212022-09-11 Journal: International Journal of Molecular Sciences [Category] 진단, 치료제, [키워드] amplification amplify application biochemical cleavage clinics Community complexity COVID-19 diagnostic diagnostics Disadvantages Efficiency enzyme Enzymes hospitals Immunodiagnosis IMPROVE Intensive isothermal isothermal amplification limitations molecular molecular detection Molecular diagnosis Nicking nicking enzyme. nucleic acid nucleic acids outbreak overcome platform POCT point-of-care Research shown subject target targets temperature Type [DOI] 10.3390/ijms23094620 PMC 바로가기 [Article Type] Review
Abnormal global alternative RNA splicing in COVID-19 patientsCOVID-19 환자의 비정상적인 글로벌 대체 RNA 스플라이싱Article Published on 2022-04-142022-09-11 Journal: PLoS Genetics [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] affecting Alter Analysis antiviral immunity Blood coagulation CD74 changes in Clinical severity contribute correlated COVID-19 COVID-19 diagnosis COVID-19 patient COVID-19 patients cytokine production disrupt domain down-regulated dysregulation ExoN expression functional highlight Host host transcriptome induce Infection Intensive LRRFIP1 neutrophil neutrophil activation proteomic reduced RNA splicing SARS-CoV-2 SARS-COV-2 infection sequencing data severe COVID-19 patient severe COVID-19 patients systematic analysis therapeutic activity therapy transcript Transcriptome transcriptome analysis transcriptomic transcripts viral infections widespread [DOI] 10.1371/journal.pgen.1010137 PMC 바로가기 [Article Type] Article
Clinical efficacy and safety of high-flow nasal cannula (HFNC) in acute hypoxaemic patients with COVID-19: a protocol for a systematic review and meta-analysisCOVID-19를 가진 급성 저산소병 환자에서 고유 유량 코 캐뉼라 (HFNC)의 임상 효능 및 안전성 : 체계적인 검토 및 메타 분석을위한 프로토콜Article Published on 2022-04-122022-08-31 Journal: BMJ Open [Category] meta-analysis, [키워드] Acute respiratory failure adult intensive & age and sex approach Caregivers clinical Clinical efficacy Cochrane Library Continuous data COVID-19 COVID-19 patient COVID-19 patients Critical Critical care data extraction determine develop disease severity Efficacy and safety eligibility criteria Ethical approval Ethics evaluate for inclusion HFNC High-flow nasal cannula hypoxaemic respiratory failure identify increased risk Infection transmission infections Intensive intensive care intensive care unit intubation mean difference meta-analyses Meta-analysis Mortality nasal nasal cannula outcome Participants Patient peer-reviewed performed Primary outcome PROSPERO protocol randomised controlled trial RCT RCTs registration number required respiratory Respiratory failure respiratory infections risk risk of bia risk ratio secondary outcome Secondary outcomes Subgroup analyses subgroup analysis systematic review the mean Treatment undergo Web of Science [DOI] 10.1136/bmjopen-2021-057743 PMC 바로가기 [Article Type] Article
Efficacy and safety of the sofosbuvir/velpatasvir combination for the treatment of patients with early mild to moderate COVID-19초기 경증 내지 중등도의 COVID-19 환자 치료를 위한 소포스부비르/벨파타스비르 조합의 효능 및 안전성Multicenter Study Published on 2022-04-062022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 신약개발, 임상, 치료법, 치료제, [키워드] Antiviral case-control study clearance clinical outcomes Combination conducted Control control group COVID-19 died Disease progression effective evaluated faster HCV Health health problem Infection Intensive median Mild Moderate COVID-19 multicenter nasal swabs once daily one patient oxygen Patient patients PCR performed prevent disease progression primary endpoint RdRP RdRp inhibitor Replication required RNA-dependent RNA polymerase Safe SARS-CoV-2 SARS-CoV-2 clearance SARS-COV-2 infection secondary endpoint Side effect sofosbuvir standard care Swab Tablet the patient treat treated Treatment Vaccines velpatasvir Ventilation viral clearance [DOI] 10.1038/s41598-022-09741-5 PMC 바로가기 [Article Type] Multicenter Study
Rapid attenuation of anti-SARS-CoV-2 antibodies in patients with musculoskeletal diseases in whom intensive immunosuppressive therapies were reinitiated after COVID-19: comment on the article by Curtis et alCOVID-19 이후 집중 면역억제 요법이 재개된 근골격계 질환 환자에서 항-SARS-CoV-2 항체의 급속한 약화: Curtis et al의 기사에 대한 논평Comment Published on 2022-04-012022-09-12 Journal: Arthritis & rheumatology (Hoboken, N.J.) [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] anti-SARS-CoV-2 antibody disease immunosuppressive therapy Intensive Musculoskeletal Patient Rapid [DOI] 10.1002/art.42003 PMC 바로가기 [Article Type] Comment
A fuzzy-enhanced deep learning approach for early detection of Covid-19 pneumonia from portable chest X-ray imagesResearch article Published on 2022-04-012022-10-05 Journal: Neurocomputing [Category] 치료기술, [키워드] Accuracy Algorithm Analysis approach approaches carried chest X-ray Chest X-ray image clinical decision Combination Convolutional neural network COVID-19 COVID-19 pneumonia CXR dataset deep learning Diagnosis early diagnosis effective Experimental result Explainable artificial intelligence facilitate feature Features Fuzzy logic Health help hospitalised Intensive Interpretation interstitial pneumonia management methodology pandemic Patient patients perceptron Portable systems Radiologists Spread Support virus [DOI] 10.1016/j.neucom.2022.01.055 [Article Type] Research article
The impact of COVID-19 on income and employment and willingness to become vaccinated among African Americans enrolled in a smoking cessation randomized trialRandomized Controlled Trial Published on 2022-03-152022-10-04 Journal: Vaccine [Category] COVID19(2023년), SARS, 임상, [키워드] African African American African Americans approach clinical trial coronavirus COVID COVID-19 COVID-19 vaccine development demonstrated employment enrolled finding Health highlight impacted IMPROVE Intensive MOST Population randomized trial smoker smoking subgroups the vaccine Vaccine Vaccine acceptance Vaccine hesitancy vaccine-hesitant with COVID-19 [DOI] 10.1016/j.vaccine.2022.01.064 PMC 바로가기 [Article Type] Randomized Controlled Trial
Clinical profile, risk factors and outcomes of ric COVID-19: a retrospective cohort multicentre study in Saudi ArabiaObservational Study Published on 2022-03-112022-10-04 Journal: BMJ Open [Category] 임상, [키워드] 1.26 95% CI adjusted Admission analysed Bacterial infection Chest children clinical clinical complications Clinical presentations Comorbidity Complication complications COVID-19 Critical Critical care D-dimer Dyspnoea elevated ferritin Health higher odd hospital Hospital stay ICU ICU admission increased risk increased the risk Intensive intensive care Laboratory lethargy mean participant age medical record multicentre outcome outcomes Paediatric intensive & paediatric patient paediatrics Patient patients PCR positive recruited retrospective retrospective cohort risk factor Risk factors Saudi Arabia supportive care tested the mean White blood cell [DOI] 10.1136/bmjopen-2021-053722 PMC 바로가기 [Article Type] Observational Study
Protocol summary and statistical analysis plan for I ntensive N utrition T herapy compar E d to usual care i N cri T ically ill adults (INTENT): a phase II randomised controlled trial집중 영양 치료에 대한 프로토콜 요약 및 통계 분석 계획과 일반 치료 비교 중환자(INTENT): 2상 무작위 대조 시험Article Published on 2022-03-082022-09-11 Journal: BMJ Open [Category] 임상, [키워드] adult intensive & Alfred Hospital analysed anticipated approval bloodstream Care conducted Controlled trial Critical Critical care Critically ill critically ill adult patients Critically ill patient critically ill patients Department determine dietetics disability Ethics ethics committee exclusion criteria feasible greater hospital hospital discharge Hospital stay Human Human Research Ethics Committee ICU include Inclusion infection rate Intensive intensive care intensive care unit intention-to-treat basis International Intervention media multicentre New Northern Territory nutrition nutrition & nutrition care Nutrition therapy nutritional support occur organ Organ failure organ system outcome outcomes parallel-group participant Patient peer-reviewed Primary outcome Protein randomisation randomised randomised controlled trial RCT receive recruited recruitment registration number rehabilitation rehabilitation medicine Research Ethics Result Sample size secondary Secondary outcomes social media Statistical analysis plan study period system failure therapy treat Trial usual care Ventilated Ventilation ventilator Ventilator-free days [DOI] 10.1136/bmjopen-2021-050153 PMC 바로가기 [Article Type] Article
Quantity of IgG response to SARS-CoV-2 spike glycoprotein predicts pulmonary recovery from COVID-19SARS-COV-2 스파이크 당 단백질에 대한 IgG 반응의 양은 COVID-19로부터 폐 회복을 예측한다.Observational Study Published on 2022-03-072022-09-01 Journal: Scientific Reports [Category] MERS, 바이오마커, 임상, 진단, 치료기술, 치료법, [키워드] Abnormalities acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 applied association Biomarker Biomarkers Care Chain Reaction Chest computed tomography Clinical data Clinical outcome Computed tomography Concentration convalescent phase coronavirus coronavirus disease coronavirus disease-2019 Coronavirus-2 correlated COVID-19 COVID-19 patient cut-off threshold Diagnosis elevated evaluated Follow-up Follow-up visit glycoprotein IgG IgG level IgG response immune activation immunological individual initial Intensive Laboratory tests marker multicenter Observational cohort study participant Patient polymerase chain reaction positive positively correlated predict predicted pulmonary CT Pulmonary function pulmonary injury quantity respiratory RT-PCR S glycoprotein SARS-CoV-2 SARS-CoV-2 spike glycoprotein serum serum concentrations serum IgG Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus typical symptom typical symptoms Viral viral infection viral spike [DOI] 10.1038/s41598-022-07489-6 PMC 바로가기 [Article Type] Observational Study