Impaired immune response drives age-dependent severity of COVID-19Article Published on 2022-12-052022-11-15 Journal: The Journal of Experimental Medicine [Category] COVID19(2023년), SARS, 치료제, [키워드] Adaptive immune response Aggravated Antiviral benefit caused characterized combinatorial treatment correlation COVID-19 disease disease severity function IFN IFN-γ IFN-λ immune response Immunity Immunotherapy Impaired increasing age individual interferon mice reversed SARS-COV-2 infection severe COVID-19 severe disease severity of COVID-19 susceptibility Therapeutic treatment type I virus replication [DOI] 10.1084/jem.20220621 PMC 바로가기
Finding a Mentor While “Storm” Chasing with Howard YoungArticle Published on 2022-12-012023-07-10 Journal: Journal of interferon & cytokine research : the of [Category] COVID19(2023년), [키워드] cytokine Cytokine storm Howard Young immunologist interferon mentorship Sepsis Toxic shock syndrome [DOI] 10.1089/jir.2022.0157
Clinical course of novel COVID-19 infection in pregnant womenObservational Study Published on 2022-12-012022-10-05 Journal: The journal of maternal-fetal & neonatal medicine [Category] COVID19(2023년), SARS, 임상, 치료기술, [키워드] alanine aminotransferase analyzed Anemia Anosmia antimicrobial APGAR score Asymptomatic C-reactive protein carbapenem change clinical Clinical course clinical symptom contribute coronavirus cough Course COVID-19 COVID-19 infection CPAP therapy creatinine CRP decrease demographic disease drug Elimination epidemiological erythrocyte excluded form Immunity increase in Infection interferon Laboratory lactate dehydrogenase LDH leukopenia low molecular weight lymphocyte manifestation maternal and perinatal outcomes. mechanical ventilation Mild moderate morbidity Neonatal Neonatal COVID-19 Neonate no evidence of occurred outcome outcomes Oxygenation PCR polymerase chain predictor Pregnancy pregnant women preterm delivery prospective observational study recommendations reported required SARS-CoV-2 Severe case severe COVID-19 Spontaneous Transmission virus women [DOI] 10.1080/14767058.2020.1850683 PMC 바로가기 [Article Type] Observational Study
3D Ex vivo tissue platforms to investigate the early phases of influenza a virus- and SARS-CoV-2-induced respiratory diseasesArticle Published on 2022-12-012022-11-15 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 신약개발, 진단, 치료제, [키워드] animal model animal models Antiviral Cell Cell culture comparable consequence Drug repurposing drug target early phase Ex vivo ex vivo infection Ex vivo infection model Health Host human lung IAV in vitro Infection Inflammatory cytokine Influenza influenza A virus Influenza virus Innate immunity interferon interferon response Intervention introduced lung tissue morbidity and mortality murine outbreak pathophysiological pharmacological platform Respiratory disease respiratory viruses responses SARS-CoV-2 therapy tissue Treatment viral infection viral life cycle viral replication virus while [DOI] 10.1080/22221751.2022.2117101 PMC 바로가기
Coronaviral PLpro proteases and the immunomodulatory roles of conjugated versus free Interferon Stimulated Gene product-15 (ISG15)Review Published on 2022-12-012023-07-09 Journal: Seminars in cell & developmental biology [Category] COVID19(2023년), [키워드] coronavirus Deubiquitinating enzymes DUB HERC5 interferon ISG15 MERS-CoV papain-like proteases PLPro SARS-CoV SARS-CoV2 ubiquitin Ubiquitin E3 ligases Ubiquitin-Like proteins Ubiquitin-specific proteases. USP [DOI] 10.1016/j.semcdb.2022.06.005 PMC 바로가기 [Article Type] Review
Nitazoxanide and COVID-19: A reviewArticle Published on 2022-11-012022-11-15 Journal: Molecular biology reports [Category] SARS, 치료제, [키워드] Activation acute lung injury acute respiratory distress acute respiratory distress syndrome addition Anti-inflammatory anti-parasitic drug anti-SARS-CoV-2 Antiviral antiviral activity antiviral property ARDS autophagic cause cell death clinical trial Coronavirus disease 2019 COVID-19 Cytokine storm Cytokines distress drug effective finding IFN immunological in silico in vitro study Infection inflammatory disorders inflammatory reaction inhibit Innate immunity interferon lung mammalian mitigate Multi-organ damage nitazoxanide oxidative stress pathogenesis of SARS-CoV-2 pro-inflammatory cytokines Prospective Study Protozoa Rapamycin reduce Respiratory Coronavirus SARS-CoV-2 SARS-CoV-2 infections severe cases syndrome therapy Treatment triggered viral infections Viral pneumonia [DOI] 10.1007/s11033-022-07822-2 PMC 바로가기
H1N1 Influenza A Virus Protein NS2 Inhibits Innate Immune Response by Targeting IRF7Article Published on 2022-10-312023-06-23 Journal: Viruses [Category] 신종인플루엔자, [키워드] influenza A virus interferon interferon regulatory factor 7 nonstructural protein 2. [DOI] 10.3390/v14112411 PMC 바로가기
Post-vaccination COVID Toes (Chilblains) Exacerbated by Rituximab Infusion Suggests Interferon Activation as MechanismArticle Published on 2022-10-292022-11-15 Journal: Military Medicine [Category] 진단, [키워드] Activation acute respiratory syndrome adverse effect chilblains coronavirus COVID disease infusion interferon mechanism Pfizer presenting rituximab significantly skin lesion Toe Vaccine worsened [DOI] 10.1093/milmed/usab314 PMC 바로가기
Boosting with Multiple Doses of mRNA Vaccine after Priming with Two Doses of Protein Subunit Vaccine MVC-COV1901 Elicited Robust Humoral and Cellular Immune Responses against Emerging SARS-CoV-2 VariantsArticle Published on 2022-10-262022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acute respiratory syndrome antibody AZD1222 booster vaccination cellular Cellular immune response cellular immune responses cellular immunity coronavirus COVID-19 Delta delta variant dose effective elevated elicit Emergency use authorization emerging variants evaluated Evidence Heterologous heterologous prime-boost heterologous vaccination humoral immune immune evasion immune response immune responses IMPROVE increase in induce Infection interferon mRNA mRNA vaccine mRNA-1273 Multiple Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody omicron Prevent priming promote Protein subunit protein subunit vaccine provided RBD Receptor binding domain reduced regimen response SARS-CoV-2 SARS-CoV-2 variants significantly subunit suggested T cell Taiwan vaccination vaccination schedule Vaccine variant variants Viral variants wild type [DOI] 10.1128/spectrum.00609-22 PMC 바로가기
SARS-CoV-2 Variant Delta Potently Suppresses Innate Immune Response and Evades Interferon-Activated Antiviral Responses in Human Colon Epithelial CellsArticle Published on 2022-10-262022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료제, [키워드] Activation Adaptive immune response association biochemical Caco2 caused changed chemokine Colon contributed COVID-19 cytokine declining Delta delta variant disease epithelial cell line evade Evolution expected fatality feature highlighting Host Human humans IFN IFN response Infection Innate innate antiviral innate immune response interferon Intervention mechanism multiple mechanism outcome pandemic pathophysiology pathway persistence receptor reduced Replication response resulting RLR pathway robust SARS-CoV-2 SARS-CoV-2 variant severe disease Severe infection severe symptom silent susceptible sustained the disease transcriptomic Treatment vaccination variant variants viral evolution virulence virus with COVID-19 [DOI] 10.1128/spectrum.01604-22 PMC 바로가기