Association between tocilizumab treatment of hyperinflammatory patients with COVID-19 in a critical care setting and elevated incidence of hospital-acquired bacterial and invasive fungal infections중환자 환경에서 COVID-19 과염증 환자의 토실리주맙 치료와 병원 획득 세균 및 침습성 진균 감염의 발병률 증가 사이의 연관성Article Published on 2022-08-012022-09-12 Journal: The Journal of hospital infection [Category] COVID19(2023년), SARS, 진단, 치료기술, 치료법, [키워드] 95% CI 95% confidence interval adverse event Bacterial Characteristics COVID-19 COVID-19 mortality COVID-19 secondary infections Critical care elevated Frequency Fungal infection fungal infections greater hospital discharge Hospital stay Hyperinflammatory ICU ICU admission incidence increase in inhibitor intensive care interleukin-6 invasive Invasive mechanical ventilation median Mortality Non-COVID-19 occurred outcome Patient patients with COVID-19 reduce reported retrospective review serious infection severe coronavirus disease severe COVID-19 significantly higher significantly lower Survivors Tocilizumab Treatment [DOI] 10.1016/j.jhin.2022.04.007 PMC 바로가기 [Article Type] Article
Robust long-term immunity to SARS-CoV-2 in patients recovered from severe COVID-19 after interleukin-6 blockade인터루킨-6 차단 후 중증 COVID-19에서 회복된 환자에서 SARS-CoV-2에 대한 강력한 장기 면역Article Published on 2022-08-012022-09-11 Journal: EBioMedicine [Category] COVID19(2023년), SARS, 바이오마커, 진단, 치료법, [키워드] 1:1 Affect anti-IL-6 anti-IL-6 therapy anti-IL6 antibody Antibody responses blockade conducted COVID-19 Critical deleterious effect deleterious effects domain Effect evaluated Follow-up greater humoral IgG IgG antibody IL-6 IL-6 blockade Immunity incidence increase in Infection interferon interferon-γ interleukin interleukin-6 Interleukin-6 blockade Laboratory longitudinal cohort study magnitude median Neutralizing antibodies neutralizing antibody no increase Patient patients hospitalized patients with COVID-19 positive proportion Prospective protective immunity receiving Reinfection responded to vaccination response responses risk robust SARS-CoV-2 SARS-COV-2 infection Seropositivity severe COVID-19 Spain subject subjects T-cell T-cell immunity T-cell Response T-cell responses therapy Tocilizumab treated [DOI] 10.1016/j.ebiom.2022.104153 PMC 바로가기 [Article Type] Article
Treatment strategies of COVID-19: A rheumatology perspectiveCOVID-19의 치료 전략: 류마티스학적 관점Review Published on 2022-08-012022-09-12 Journal: European journal of internal medicine [Category] COVID19(2023년), SARS, 진단, 치료법, 치료제, [키워드] absence acute respiratory syndrome adaptive approved authority Colchicine Coronavirus-2 Corticosteroid COVID-19 Critical Critically ill patient Dexamethasone DMARDs effective host cell Immunity Inflammatory response inhibitors interleukin-6 janus Kinase inhibitor mAbs monoclonal antibody off-label Perspective plethora progression Proinflammatory cytokine Remdesivir Replication rheumatologist rheumatology SARS-CoV-2 SARS-CoV-2 mAbs. SARS-CoV-2 pneumonia therapeutic strategy Treatment viral entry [DOI] 10.1016/j.ejim.2022.05.014 PMC 바로가기 [Article Type] Review
Role of therapeutic plasma exchange in the management of COVID-19-induced cytokine storm syndromeReview article Published on 2022-08-012022-10-05 Journal: Transfusion and apheresis science : official journ [Category] SARS, 바이오마커, 임상, 치료제, [키워드] member 13 a disintegrin and metalloproteinase with a thrombospondin type 1 motif acute respiratory syndrome ADAMTS-13a disintegrin and metalloproteinase with a thrombospondin type 1 motif American Society for Apheresis approach ARDSacute respiratory syndrome article ASFAAmerican Society for Apheresis available data benefit C-reactive protein Case series Case-control CCPCOVID-19 convalescent plasma Clinical outcome Coagulopathy conducted Controlled clinical trial coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 convalescent plasma COVID-19coronavirus disease 2019 criteria Critically ill patient CRPC-reactive protein CSS CSScytokine storm syndrome Cytokine storm syndrome Cytokines D-dimer Effects Evidence excessive immune response feasibility ferritin FFPfresh frozen plasma fibrinogen level fresh frozen plasma hypercoagulable Hyperinflammatory ICUIntensive Care Unit identify IFNinterferon ILInterleukin immunomodulatory effect improvement Inflammatory factor intensive care unit interferon interleukin interleukin-6 Intervention Length of stay LOSlength of stay Lymphocyte count macrophage activation syndrome management MASmacrophage activation syndrome MODSmultiple organ dysfunction syndrome Mortality multiple organ dysfunction syndrome offer offset PaO2:FiO2pressure of arterial oxygen to fractional inspired oxygen concentration pathologic Patient patients patients with COVID-19 peer-reviewed potential clinical benefits pressure of arterial oxygen to fractional inspired oxygen concentration prevent disease progression Randomized Randomized controlled trial RCTrandomized controlled trial reduce reduce mortality resulting risk role Safe SARS-CoV-2severe acute respiratory syndrome coronavirus 2 secondary hemophagocytic lymphohistiocytosis selected Sequential Organ Failure Assessment severe acute respiratory syndrome coronavirus 2 sHLHsecondary hemophagocytic lymphohistiocytosis SOFASequential Organ Failure Assessment TAMOFthrombocytopenia-associated multiple organ failure Therapeutic plasma exchange thrombocytopenia-associated multiple organ failure TNFTumor Necrosis Factor TPE TPEtherapeutic plasma exchange treat Treatment tumor necrosis factor while with COVID-19 [DOI] 10.1016/j.transci.2022.103433 [Article Type] Review article
The association of airborne particulate matter and benzo[a]pyrene with the clinical course of COVID-19 in patients hospitalized in PolandResearch article Published on 2022-08-012022-10-05 Journal: Environmental pollution (Barking, Essex : 1987) [Category] 바이오마커, 변종, [키워드] Affect Air pollution association benzo(a)pyrene benzo[a]pyrene Clinical course coronavirus disease COVID-19 COVID-19 in patient death decrease elevated Epidemiology Evidence exposure exposure to higher odd Hospitalization Hospitalized hospitalized patients Hyperinflammatory immune response inflammation marker inflammation markers interleukin-6 limit measure outcome oxygen saturation Oxygen therapy pandemic parameter Particulate matter Patient Poland procalcitonin respiratory symptom severe COVID-19 severity severity of COVID-19 the disease the mean viral disease viral respiratory White blood cell [DOI] 10.1016/j.envpol.2022.119469 [Article Type] Research article
Diagnostic value of serum KL-6 and IL-6 levels in critically ill patients with COVID-19-associated pneumoniaCorrespondence Published on 2022-08-012022-10-05 Journal: The Journal of Infection [Category] 바이오마커, 진단, [키워드] COVID-19 Critically ill patient IL-6 level interleukin-6 Krebs von den Lungen-6 Mortality Pneumonia SARS-CoV-2 serum [DOI] 10.1016/j.jinf.2022.08.016 [Article Type] Correspondence
COVID-19 Severity and Mortality in Two Pandemic Waves in Poland and Predictors of Poor Outcomes of SARS-CoV-2 Infection in Hospitalized Young Adults폴란드의 두 가지 유행성 전염병의 COVID-19 심각도 및 사망률과 입원한 젊은 성인의 SARS-CoV-2 감염의 나쁜 결과 예측Article Published on 2022-07-312022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, [키워드] addition Adults adults hospitalized albumin Alpha Alpha variant analyzed blood cell blood cell counts C-reactive protein calcium Characteristics Clinical characteristics Comorbidities COVID-19 COVID-19 severity creatine creatine kinase creatinine D-dimer debatable decrease disease severity Factors filtration rate global public health glomerular filtration rate had no hematocrit hemoglobin Hospitalization identify increase in intensive care intensive care unit treatment interleukin interleukin-6 investigated Laboratory Lactate lactate dehydrogenase Leukocytosis Logistic regression lung involvement lymphocyte lymphopenia mechanical ventilation Mortality Myoglobin neutrophil Neutrophil-to-lymphocyte ratio neutrophilia no increase non-survivor obesity outcome pandemic Patient peptide performed Poland Poor predictor predictors procalcitonin red blood cell Retrospective study risk of death SARS-CoV-2 SARS-CoV-2 variants second wave severe COVID-19 severity survivor Treatment troponin I urea variant Vitamin Vitamin D3 Wave with COVID-19 young adults [DOI] 10.3390/v14081700 PMC 바로가기 [Article Type] Article
COVID-19 related acute necrotizing encephalopathy with extremely high interleukin-6 and RANBP2 mutation in a patient with recently immunized inactivated virus vaccine and no pulmonary involvement최근 면역 불활화 바이러스 백신을 접종하고 폐 침범이 없는 환자에서 매우 높은 인터루킨-6 및 RANBP2 돌연변이를 갖는 COVID-19 관련 급성 괴사성 뇌병증Case Reports Published on 2022-07-232022-09-11 Journal: BMC Infectious Diseases [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] Acute kidney injury Acute necrotizing encephalopathy ADE affecting alteration Analysis antibody blood pressure blood-brain barrier body temperature bpm Brain caused Celsius characteristic Chest Chest radiograph Clinical course Coma Computerized tomography consciousness COVID-19 COVID-19 vaccine cytokine cytokine signaling Cytokine storm Cytokines delta variant Encephalopathy examination Factor gene analysis heart rate hemorrhage hepatic failure heterozygous Hypothesis IL-6 immune response immunized inactivated Inactivated vaccine incidence of COVID-19 infiltration interleukin-6 lesion minute Missense mutation mitochondrial Mitochondrial function Mutation Necrosis oxygen oxygen saturation Pathogenesis Patient Potential treatment predictor preserved Previous studies Prognostic factor pulmonary disease pulmonary involvement pyelonephritis Ranbp2 RANBP2. reported respiratory respiratory rate role SARS-CoV-2 SARS-CoV2 infection Seizure Septic shock Sequencing Serum IL-6 Sinopharm Stupor Vaccine viral entry virus whole genome Whole genome sequencing [DOI] 10.1186/s12879-022-07610-0 PMC 바로가기 [Article Type] Case Reports
Human Lung Fibroblasts Exhibit Induced Inflammation Memory via Increased IL6 Gene Expression and Release인간 폐 섬유아세포는 증가된 IL6 유전자 발현 및 방출을 통해 유도된 염증 기억을 나타냅니다Article Published on 2022-07-222022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ACTA2 affected Analysis ANOVA Cell cell line cell lines chronic respiratory disease chronic respiratory diseases Col1a1 contribute COVID-19 determine determined by downregulated ELISA fibroblast fibroblasts fibrosis followed by Gene Expression Human human lung IL1B IL2 IL6 IL8 Immunity Increased induced Inflammatory inflammatory memory Inflammatory response inhibition inhibitor interleukin-6 investigated involved lung memory Mmp8 mRNA expression multiple groups NF-κB not affect pathway Pathways Poly (I:C) POSTN predict qRT-PCR Release respiratory diseases respond SARS-CoV-2 SARS-CoV-2 spike protein significantly significantly increased Simultaneous Simultaneous treatment Spike protein statistical significance subsequent TGFB1 TLR3 TNFα trained immunity treated Treatment two-way ANOVA viral infection was determined were measured were used Withdrawal [DOI] 10.3389/fimmu.2022.921728 PMC 바로가기 [Article Type] Article
Effects of yoga on cardiometabolic risks and fetomaternal outcomes are associated with serum nitric oxide in gestational hypertension: a randomized control trial Research Published on 2022-07-122022-10-05 Journal: Scientific Reports [Category] 바이오마커, 임상, 진단, [키워드] Analysis antenatal care APGAR score association baroreflex blood pressure cardiometabolic Cardiometabolic risk clinical conducted Control control group correlations CTRI decrease Decreased Effect Endothelial dysfunction endothelial function Factors gestation gestational hypertension HRV hypertension IMPROVE incidence increase India Inflammation insulin resistance interleukin-6 Intervention logistic regressions marker Neonatal nitric oxide outcome outcomes oxidative stress perinatal period Pregnancy pregnant women Randomized receiving reduce registry risk sensitivity serum significant decrease study group Trial Variability Vascular were assessed were given women [DOI] 10.1038/s41598-022-15216-4 [Article Type] Research